The effects of colectomy on acid–base status, extra-osseous and bone minerals, calciotropic hormones and bone morphology have not yet been studied. To rectify this, groups of normally fed male rats were subjected to distal (n = 11), proximal (n = 12) or total (n = 12) colectomy. Sham-operated rats (n = 12) served as controls. At 112 (±2) days after colectomy the following changes were noted: (1) weight gain was delayed; (2) faecal excretion of calcium and phosphorus was normal, whereas that of magnesium was increased; (3) intestinal calcium secretion and absorption of calcium and phosphorus were normal, but magnesium absorption was decreased; (4) urinary excretion of magnesium was also decreased, that of phosphorus was increased, and that of pyridinium and deoxypyridinium tended to be high; (5) the serum levels of ionized magnesium, total calcium, 25-hydroxyvitamin D and parathyroid hormone were normal, while that of 1,25-dihydroxyvitamin D was markedly elevated; and (6) bone magnesium and phosphorus content were decreased, but bone calcium was normal, and thus the bone calcium/phosphorus ratio was high. These abnormalities were associated with moderate metabolic acidosis, as reflected by high urinary ammonium, low citrate and low total CO2, but normal blood gases. Significant structural abnormalities of bone were not detectable, but trabecular bone tended to show rarefication. Distal colectomy had the least effect, whereas proximal and total colectomies had a distinct effect, on these parameters. It is concluded that colectomy in the rat causes: (1) a syndrome of magnesium deficiency of intestinal origin, compensated metabolic acidosis, urinary phosphorus loss, and high circulating 1,25-dihydroxyvitamin D levels, with the degree depending on the extent of surgical resection; and (2) brittle bones, a feature characteristic of low bone magnesium and more generalized magnesium deficiency. The mechanisms leading to this syndrome are unknown, but altered tissue levels of magnesium and phosphorus may play a key role.
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May 10 2000
Effects of partial and total colectomy on mineral and acid–base homoeostasis in the rat: magnesium deficiency, hyperphosphaturia and osteopathy, in the presence of high serum 1,25-dihydroxyvitamin D but normal parathyroid hormone
R. CRONER;
R. CRONER
*Division of Experimental Surgery, University of Erlangen, Erlangen, Germany
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P. O. SCHWILLE;
*Division of Experimental Surgery, University of Erlangen, Erlangen, Germany
Correspondence: Dr Paul O. Schwille, University Hospital - Department of Surgery, Maximiliansplatz 2, D-91054 Erlangen, Germany.
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R. G. ERBEN;
R. G. ERBEN
†Institute of Animal Physiology, Biochemistry and Nutrition, Ludwig Maximilian University, Munich, Germany
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H. GEPP;
H. GEPP
*Division of Experimental Surgery, University of Erlangen, Erlangen, Germany
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K. STAHR;
K. STAHR
†Institute of Animal Physiology, Biochemistry and Nutrition, Ludwig Maximilian University, Munich, Germany
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G. RÜMENAPF;
G. RÜMENAPF
‡Department of Surgery, University of Erlangen, Erlangen, Germany
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R. PARTH;
R. PARTH
‡Department of Surgery, University of Erlangen, Erlangen, Germany
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H. SCHEUERLEIN
H. SCHEUERLEIN
*Division of Experimental Surgery, University of Erlangen, Erlangen, Germany
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Publisher: Portland Press Ltd
Received:
October 08 1999
Revision Received:
January 04 2000
Accepted:
February 11 2000
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 98 (6): 649–659.
Article history
Received:
October 08 1999
Revision Received:
January 04 2000
Accepted:
February 11 2000
Citation
R. CRONER, P. O. SCHWILLE, R. G. ERBEN, H. GEPP, K. STAHR, G. RÜMENAPF, R. PARTH, H. SCHEUERLEIN; Effects of partial and total colectomy on mineral and acid–base homoeostasis in the rat: magnesium deficiency, hyperphosphaturia and osteopathy, in the presence of high serum 1,25-dihydroxyvitamin D but normal parathyroid hormone. Clin Sci (Lond) 1 June 2000; 98 (6): 649–659. doi: https://doi.org/10.1042/cs0980649
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