The purpose of the present study was to evaluate prospectively blood pressure and the renal haemodynamic response to salt during the normal menstrual cycle. A total of 35 healthy normotensive young women not on oral contraceptives were enrolled; 17 were studied in the follicular phase and 18 in the luteal phase of the menstrual cycle. The women in each group were then randomly allocated to receive a low-sodium (40 mmol/day) or a high-sodium (250 mmol/day) diet for a 7-day period in two consecutive menstrual cycles. At the end of each dietary period, 24 h ambulatory blood pressure, urinary sodium excretion, plasma renin activity, plasma catecholamine levels and renal haemodynamics were measured. Our results show that the blood pressure response to salt is comparable during the luteal and the follicular phases of the normal menstrual cycle and is characterized by a salt-resistant pattern. In the kidney, effective renal plasma flow was significantly greater and the filtration fraction lower (P < 0.05) after salt loading in women studied in the luteal phase compared with women investigated in the follicular phase. This study thus demonstrates that the female hormone status does not affect the blood pressure response to sodium in young normotensive women. However, in contrast with systemic haemodynamics, the renal response to salt varies during the normal menstrual cycle, suggesting that female sex hormones play a role (direct or indirect) in the regulation of renal haemodynamics.
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June 2000
Research Article|
May 10 2000
Blood pressure and renal haemodynamic response to salt during the normal menstrual cycle
Antoinette PECHÈRE-BERTSCHI;
Antoinette PECHÈRE-BERTSCHI
*Policlinique de Médecine et Département de Médecine Interne, University Hospital, Geneva, Switzerland
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Marc MAILLARD;
Marc MAILLARD
†Division d'Hypertension et Médecine Vasculaire, University Hospital, Lausanne, Switzerland
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Hans STALDER;
Hans STALDER
*Policlinique de Médecine et Département de Médecine Interne, University Hospital, Geneva, Switzerland
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Hans R. BRUNNER;
Hans R. BRUNNER
†Division d'Hypertension et Médecine Vasculaire, University Hospital, Lausanne, Switzerland
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Michel BURNIER
†Division d'Hypertension et Médecine Vasculaire, University Hospital, Lausanne, Switzerland
Correspondence: Dr Michel Burnier, Division of Hypertension and Vascular Medicine, CHUV, 1011 Lausanne, Switzerland (e-mail Michel.Burnier@chuv.hospvd.ch).
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Clin Sci (Lond) (2000) 98 (6): 697–702.
Article history
Received:
January 11 2000
Revision Received:
February 17 2000
Accepted:
March 16 2000
Citation
Antoinette PECHÈRE-BERTSCHI, Marc MAILLARD, Hans STALDER, Hans R. BRUNNER, Michel BURNIER; Blood pressure and renal haemodynamic response to salt during the normal menstrual cycle. Clin Sci (Lond) 1 June 2000; 98 (6): 697–702. doi: https://doi.org/10.1042/cs0980697
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