During acute hyperglycaemia, gastric emptying is delayed and the compliance of the proximal stomach is increased significantly. It is not known whether the effect of hyperglycaemia on proximal gastric motor function in healthy volunteers results from endogenous hyperinsulinaemia. Therefore we studied the effects of acute hyperglycaemia and hyperinsulinaemia on proximal gastric function, measured using an electronic barostat. Eight healthy volunteers were studied on three separate occasions during: (a) normoglycaemia, (b) hyperglycaemic hyperinsulinaemic clamping, and (c) euglycaemic hyperinsulinaemic clamping. Gastric compliance was significantly (P < 0.01) increased during hyperglycaemia (44±5 ml/mmHg), and also during hyperinsulinaemia (38±4 ml/mmHg), compared with during normoglycaemia (31±3 ml/mmHg). During pressure distension, sensations of fullness were greater during hyperglycaemia and during hyperinsulinaemia compared with controls. At a set pressure of minimal distension pressure +2 mmHg, the intrabag volume was significantly higher during hyperglycaemia (292±36 ml; P < 0.05), but not during hyperinsulinaemia (161±35 ml), compared with during normoglycaemia (129±10 ml). Postprandial relaxation was significantly (P < 0.01) decreased during hyperglycaemia (93±64 ml) and hyperinsulinaemia (101±64 ml) compared with normoglycaemia (224±56 ml). Thus not only hyperglycaemia, but also hyperinsulinaemia, influences proximal gastric compliance, postprandial relaxation and symptom perception.
Skip Nav Destination
Article navigation
Research Article|
June 06 2000
Effects of hyperglycaemia and hyperinsulinaemia on proximal gastric motor and sensory function in humans
A. S. VAN PETERSEN;
A. S. VAN PETERSEN
*Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Search for other works by this author on:
M. K. VU;
M. K. VU
†Department of Gastroenterology-Hepatology, Leiden University Medical Center, Building 1, C4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Search for other works by this author on:
W. F. LAM;
W. F. LAM
†Department of Gastroenterology-Hepatology, Leiden University Medical Center, Building 1, C4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Search for other works by this author on:
C. B. H. W. LAMERS;
C. B. H. W. LAMERS
†Department of Gastroenterology-Hepatology, Leiden University Medical Center, Building 1, C4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Search for other works by this author on:
J. RINGERS;
J. RINGERS
*Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Search for other works by this author on:
A. A. M. MASCLEE
†Department of Gastroenterology-Hepatology, Leiden University Medical Center, Building 1, C4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Correspondence: Dr A. A. M. Masclee (e-mail [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
November 10 1999
Revision Received:
February 08 2000
Accepted:
March 08 2000
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 99 (1): 37–46.
Article history
Received:
November 10 1999
Revision Received:
February 08 2000
Accepted:
March 08 2000
Citation
A. S. VAN PETERSEN, M. K. VU, W. F. LAM, C. B. H. W. LAMERS, J. RINGERS, A. A. M. MASCLEE; Effects of hyperglycaemia and hyperinsulinaemia on proximal gastric motor and sensory function in humans. Clin Sci (Lond) 1 July 2000; 99 (1): 37–46. doi: https://doi.org/10.1042/cs0990037
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |