Dipeptidyl peptidase IV (DPP IV, also known as CD26; EC 3.4.14.5) is a non-integrin receptor glycoprotein with multiple functions, including cell adhesion, cellular trafficking through the extracellular matrix and co-stimulatory potential during T cell activation. By virtue of its exopeptidase activity, DPP IV plays a key regulatory role in the metabolism of peptide hormones. Based on data emerging from different biomedical specialties, it appears worthwhile to highlight the different facets of DPP IV in nutrition, immune responses and peptide hormone metabolism. The presentation of the complex regulatory circuits in which DPP IV appears to be involved may also serve as a note of caution, in view of attempts to apply selective inhibitors of DPP IV enzymic activity for the treatment of disease, e.g. Type II diabetes.
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July 10 2000
A guardian angel: the involvement of dipeptidyl peptidase IV in psychoneuroendocrine function, nutrition and immune defence
Martin HILDEBRANDT;
*Charité Campus Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin, Medizinische Klinik m.S. Psychosomatik, Augustenburgerplatz 1, D-13353 Berlin, Germany
Correspondence: Dr Martin Hildebrandt, Department of Internal Medicine, Charité Campus Virchow-Klinikum, Medical Faculty of the Humboldt University Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany (e-mail [email protected]).
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Werner REUTTER;
Werner REUTTER
†Fachbereich Humanmedizin der Freien Universität Berlin, Institut für Molekularbiologie und Biochemie, Arnimallee 22, D-14195 Berlin, Germany
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Petra ARCK;
Petra ARCK
*Charité Campus Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin, Medizinische Klinik m.S. Psychosomatik, Augustenburgerplatz 1, D-13353 Berlin, Germany
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Matthias ROSE;
Matthias ROSE
*Charité Campus Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin, Medizinische Klinik m.S. Psychosomatik, Augustenburgerplatz 1, D-13353 Berlin, Germany
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Burghard F. KLAPP
Burghard F. KLAPP
*Charité Campus Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin, Medizinische Klinik m.S. Psychosomatik, Augustenburgerplatz 1, D-13353 Berlin, Germany
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Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 99 (2): 93–104.
Citation
Martin HILDEBRANDT, Werner REUTTER, Petra ARCK, Matthias ROSE, Burghard F. KLAPP; A guardian angel: the involvement of dipeptidyl peptidase IV in psychoneuroendocrine function, nutrition and immune defence. Clin Sci (Lond) 1 August 2000; 99 (2): 93–104. doi: https://doi.org/10.1042/cs0990093
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