Endothelin-1 has potent vasoconstrictor and vasopressor actions contributing to basal vascular tone and maintenance of blood pressure acting predominantly through endothelin-A receptors. Endothelin antagonists may be of value in the treatment of hypertension and heart failure. However, the role of endothelin-1 in the regulation of vascular tone and the potential benefits of endothelin antagonists in non-insulin-dependent diabetes mellitus (Type II diabetes) are less clear. Vasoconstriction to exogenous endothelin-1 is impaired in Type II diabetes. The purpose of this study was to determine whether vasoconstriction to endogenous endothelin-1 acting through the endothelin-A receptor is impaired in Type II diabetes. In ten patients with Type II diabetes and nine controls the endothelin-A receptor antagonist BQ123 was infused intra-arterially at 100 nmol/min for 60 min followed by normal saline for 30 min. Forearm blood flow was measured using venous occlusion plethysmography. Control subjects showed gradual onset of vasodilation in response to BQ123 (P < 0.001). Diabetic subjects, however, showed no significant response (P > 0.05). There was a significant difference between the diabetic and control groups (P < 0.05). Blockade of the endothelin-A receptor is associated with impaired vasodilation in Type II diabetes indicating vasoconstriction to endogenous endothelin-1 mediated by the endothelin-A receptor is impaired.
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August 02 2000
Vasoconstriction to endogenous endothelin-1 is impaired in patients with Type II diabetes mellitus
Daniel F. MCAULEY;
*Department of Therapeutics and Pharmacology, The Whitla Medical Building, The Queen's University of Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
Correspondence: Dr Daniel F. McAuley.
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Ailish G. NUGENT;
Ailish G. NUGENT
*Department of Therapeutics and Pharmacology, The Whitla Medical Building, The Queen's University of Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
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Colm MCGURK;
Colm MCGURK
*Department of Therapeutics and Pharmacology, The Whitla Medical Building, The Queen's University of Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
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Suzanne MAGUIRE;
Suzanne MAGUIRE
*Department of Therapeutics and Pharmacology, The Whitla Medical Building, The Queen's University of Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
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J. Randal HAYES;
J. Randal HAYES
†Department of Medicine, The Whitla Medical Building, The Queen's University of Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
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G. Dennis JOHNSTON
G. Dennis JOHNSTON
*Department of Therapeutics and Pharmacology, The Whitla Medical Building, The Queen's University of Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
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Publisher: Portland Press Ltd
Received:
January 04 2000
Revision Received:
March 23 2000
Accepted:
April 28 2000
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 99 (3): 175–179.
Article history
Received:
January 04 2000
Revision Received:
March 23 2000
Accepted:
April 28 2000
Citation
Daniel F. MCAULEY, Ailish G. NUGENT, Colm MCGURK, Suzanne MAGUIRE, J. Randal HAYES, G. Dennis JOHNSTON; Vasoconstriction to endogenous endothelin-1 is impaired in patients with Type II diabetes mellitus. Clin Sci (Lond) 1 September 2000; 99 (3): 175–179. doi: https://doi.org/10.1042/cs0990175
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