Various liver diseases lead to significant alterations of the hepatic microcirculation. Therefore, quantification of hepatic perfusion has the potential to improve the assessment and management of liver diseases. Most methods used to quantify liver perfusion are invasive or controversial. This paper describes and validates a non-invasive method for the quantification of liver perfusion using computed tomography (CT). Dynamic single-section CT of the liver was performed after intravenous bolus administration of a low-molecular-mass iodinated contrast agent. Hepatic, aortic and portal-venous time—density curves were fitted with a dual-input one-compartmental model to calculate liver perfusion. Validation studies consisted of simultaneous measurements of hepatic perfusion with CT and with radiolabelled microspheres in rabbits at rest and after adenosine infusion. The feasibility and reproducibility of the CT method in humans was assessed by three observers in 10 patients without liver disease. In rabbits, significant correlations were observed between perfusion measurements obtained with CT and with microspheres (r = 0.92 for total liver perfusion, r = 0.81 for arterial perfusion and r = 0.85 for portal perfusion). In patients, total liver plasma perfusion measured with CT was 112±28 ml·min-1·100 ml-1, arterial plasma perfusion was 18±12 ml·min-1·100 ml-1 and portal plasma perfusion was 93±31 ml·min-1·100 ml-1. The measurements obtained by the three observers were not significantly different from each other (P > 0.1). Our results indicate that dynamic CT combined with a dual-input one-compartmental model provides a valid and reliable method for the non-invasive quantification of perfusion in the normal liver.
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November 15 2000
Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one-compartmental model
Roland MATERNE;
*Department of Radiology, Université Catholique de Louvain, St-Luc University Hospital, B-1200 Brussels, Belgium
Correspondence: Dr R. Materne (e-mail [email protected]).
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Bernard E. VAN BEERS;
Bernard E. VAN BEERS
*Department of Radiology, Université Catholique de Louvain, St-Luc University Hospital, B-1200 Brussels, Belgium
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Anne M. SMITH;
Anne M. SMITH
*Department of Radiology, Université Catholique de Louvain, St-Luc University Hospital, B-1200 Brussels, Belgium
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Isabelle LECONTE;
Isabelle LECONTE
*Department of Radiology, Université Catholique de Louvain, St-Luc University Hospital, B-1200 Brussels, Belgium
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Jacques JAMART;
Jacques JAMART
†Center of Biostatistics and Medical Documentation, Université Catholique de Louvain, Mont-Godinne University Hospital, B-5530 Yvoir, Belgium
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Jean-Paul DEHOUX;
Jean-Paul DEHOUX
‡Laboratory of Experimental Surgery, Université Catholique de Louvain, St-Luc University Hospital, B-1200 Brussels, Belgium
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André KEYEUX;
André KEYEUX
§Laboratory of Nuclear Medicine, Université Catholique de Louvain, St-Luc University Hospital, B-1200 Brussels, Belgium
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Yves HORSMANS
Yves HORSMANS
║Laboratory of Gastroenterology, Université Catholique de Louvain, St-Luc University Hospital, B-1200 Brussels, Belgium
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Publisher: Portland Press Ltd
Received:
March 21 2000
Revision Received:
June 09 2000
Accepted:
August 02 2000
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 99 (6): 517–525.
Article history
Received:
March 21 2000
Revision Received:
June 09 2000
Accepted:
August 02 2000
Citation
Roland MATERNE, Bernard E. VAN BEERS, Anne M. SMITH, Isabelle LECONTE, Jacques JAMART, Jean-Paul DEHOUX, André KEYEUX, Yves HORSMANS; Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one-compartmental model. Clin Sci (Lond) 1 December 2000; 99 (6): 517–525. doi: https://doi.org/10.1042/cs0990517
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