During positive pressure mechanical ventilation, percentile systolic pressure variation (%SPV) or respiratory-related arterial pressure variability (RAPV) have both been used in assessment of graded haemorrhage. We aimed to investigate whether changes in %SPV and RAPV are correlated during graded haemorrhage (by 5, 10 or 20% of the estimated blood volume) in anaesthetized positive pressure ventilated rats and to investigate the involvement of autonomic regulation. Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage. Propranolol significantly decreased baseline %SPV and RAPV and changes induced in %SPV and RAPV by graded haemorrhage. Phentolamine significantly enhanced baseline %SPV and RAPV, and further enhancement of %SPV and RAPV by graded haemorrhage did not occur until 20% of the estimated blood volume was removed. RAPV was significantly correlated with %SPV in all experimental groups. We conclude that RAPV is comparable with%SPV as an indicator of graded haemorrhage and that, in anaesthetized and positive pressure ventilated rats, both are dependent on autonomic function, especially β-adrenoceptors.
Respiratory-related arterial pressure variability as an indicator of graded blood loss: involvement of the autonomic nervous system
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Hsien Yong LAI, Cheryl C. H. YANG, Fan-Yen HUANG, Yi LEE, Yu Ling KUO, Terry B. J. KUO; Respiratory-related arterial pressure variability as an indicator of graded blood loss: involvement of the autonomic nervous system. Clin Sci (Lond) 1 October 2003; 105 (4): 491–497. doi: https://doi.org/10.1042/CS20030080
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