Clin. Sci. (2017) volume 131, issue 19, pages 2409–2426;, http://doi.org/10.1042/CS20171053

The published article featured errors in the Y-axes labels of Figure 1A,B and Figure 4B; corrected versions of Figures 1 and 4 are presented here.

Figure 1
THS exposure results in (A) increased fasting glucose levels at 4 months, (B) increased fasting insulin levels at 4 months, and (C) increased HOMA-IR index (fasting blood glucose × fasting insulin/22.5) at 4 months of exposure. All data are expressed mean ± S.D.; *P<0.05, n = 9.P-values were adjusted for the number of times each test was run.
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Increased time of exposure to THS stimulates hyperglycemia and insulinemia in a time-dependent manner

THS exposure results in (A) increased fasting glucose levels at 4 months, (B) increased fasting insulin levels at 4 months, and (C) increased HOMA-IR index (fasting blood glucose × fasting insulin/22.5) at 4 months of exposure. All data are expressed mean ± S.D.; *P<0.05, n = 9.P-values were adjusted for the number of times each test was run.

Figure 1
THS exposure results in (A) increased fasting glucose levels at 4 months, (B) increased fasting insulin levels at 4 months, and (C) increased HOMA-IR index (fasting blood glucose × fasting insulin/22.5) at 4 months of exposure. All data are expressed mean ± S.D.; *P<0.05, n = 9.P-values were adjusted for the number of times each test was run.
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Increased time of exposure to THS stimulates hyperglycemia and insulinemia in a time-dependent manner

THS exposure results in (A) increased fasting glucose levels at 4 months, (B) increased fasting insulin levels at 4 months, and (C) increased HOMA-IR index (fasting blood glucose × fasting insulin/22.5) at 4 months of exposure. All data are expressed mean ± S.D.; *P<0.05, n = 9.P-values were adjusted for the number of times each test was run.

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Figure 4
THS-exposed mice have higher levels of H2O2 at 4 months of exposure (A), normal levels of SOD activity (B), but lower levels of catalase activity at 6 months (C), lower GPx enzymatic activity at 6 months (D), higher levels of nitrotyrosine at 2 months of exposure (E), higher levels of DNA damage at 6 months of exposure (F), and higher levels of lipid peroxidation at 6 months of exposure (G). All data are expressed as mean ± S.D.; *P<0.05, n = 9. P-values were adjusted for the number of times each test was run.
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THS induces oxidative stress and oxidative stress mediated molecular damage in the brain

THS-exposed mice have higher levels of H2O2 at 4 months of exposure (A), normal levels of SOD activity (B), but lower levels of catalase activity at 6 months (C), lower GPx enzymatic activity at 6 months (D), higher levels of nitrotyrosine at 2 months of exposure (E), higher levels of DNA damage at 6 months of exposure (F), and higher levels of lipid peroxidation at 6 months of exposure (G). All data are expressed as mean ± S.D.; *P<0.05, n = 9. P-values were adjusted for the number of times each test was run.

Figure 4
THS-exposed mice have higher levels of H2O2 at 4 months of exposure (A), normal levels of SOD activity (B), but lower levels of catalase activity at 6 months (C), lower GPx enzymatic activity at 6 months (D), higher levels of nitrotyrosine at 2 months of exposure (E), higher levels of DNA damage at 6 months of exposure (F), and higher levels of lipid peroxidation at 6 months of exposure (G). All data are expressed as mean ± S.D.; *P<0.05, n = 9. P-values were adjusted for the number of times each test was run.
View largeDownload slide
THS induces oxidative stress and oxidative stress mediated molecular damage in the brain

THS-exposed mice have higher levels of H2O2 at 4 months of exposure (A), normal levels of SOD activity (B), but lower levels of catalase activity at 6 months (C), lower GPx enzymatic activity at 6 months (D), higher levels of nitrotyrosine at 2 months of exposure (E), higher levels of DNA damage at 6 months of exposure (F), and higher levels of lipid peroxidation at 6 months of exposure (G). All data are expressed as mean ± S.D.; *P<0.05, n = 9. P-values were adjusted for the number of times each test was run.

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© 2018 The Author(s).
2018
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).