Clin. Sci. (2017) volume 131, issue 19, pages 2409–2426;, http://doi.org/10.1042/CS20171053
The published article featured errors in the Y-axes labels of Figure 1A,B and Figure 4B; corrected versions of Figures 1 and 4 are presented here.
Increased time of exposure to THS stimulates hyperglycemia and insulinemia in a time-dependent manner
THS exposure results in (A) increased fasting glucose levels at 4 months, (B) increased fasting insulin levels at 4 months, and (C) increased HOMA-IR index (fasting blood glucose × fasting insulin/22.5) at 4 months of exposure. All data are expressed mean ± S.D.; *P<0.05, n = 9.P-values were adjusted for the number of times each test was run.
THS exposure results in (A) increased fasting glucose levels at 4 months, (B) increased fasting insulin levels at 4 months, and (C) increased HOMA-IR index (fasting blood glucose × fasting insulin/22.5) at 4 months of exposure. All data are expressed mean ± S.D.; *P<0.05, n = 9.P-values were adjusted for the number of times each test was run.
THS induces oxidative stress and oxidative stress mediated molecular damage in the brain
THS-exposed mice have higher levels of H2O2 at 4 months of exposure (A), normal levels of SOD activity (B), but lower levels of catalase activity at 6 months (C), lower GPx enzymatic activity at 6 months (D), higher levels of nitrotyrosine at 2 months of exposure (E), higher levels of DNA damage at 6 months of exposure (F), and higher levels of lipid peroxidation at 6 months of exposure (G). All data are expressed as mean ± S.D.; *P<0.05, n = 9. P-values were adjusted for the number of times each test was run.
THS-exposed mice have higher levels of H2O2 at 4 months of exposure (A), normal levels of SOD activity (B), but lower levels of catalase activity at 6 months (C), lower GPx enzymatic activity at 6 months (D), higher levels of nitrotyrosine at 2 months of exposure (E), higher levels of DNA damage at 6 months of exposure (F), and higher levels of lipid peroxidation at 6 months of exposure (G). All data are expressed as mean ± S.D.; *P<0.05, n = 9. P-values were adjusted for the number of times each test was run.