1. Normal volunteers were given standard oral loads of cream, dextrose and skimmed milk. Serum alkaline phosphatase rose by a mean of 26%, 5 hr after fat ingestion. The rise was due, predominantly, to the appearance of intestinal alkaline phosphatase in the circulation.

2. Sera of secretors show greater intestinal alkaline phosphatase activities after fat ingestion than sera of non-secretors.

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