1. Four women suffering from senile osteoporosis have been treated for 55–60 days with 25 MRC Units per day of porcine thyrocalcitonin with the following metabolic results:
slight diminution of plasma, urinary and endogenous faecal calcium levels;
slight diminution of plasma phosphate level and urinary phosphate clearance;
lowering of serum alkaline phosphatase values;
diminution of urinary hydroxyproline excretion;
modification of calcium balance toward positive, due to decreased urinary and faecal calcium and to an improvement in intestinal absorption.
2. 47Calcium kinetic studies demonstrated:
a slower decline in the specific activity curve after thyrocalcitonin treatment;
a slower decline in bone uptake values;
a decrease of ‘calcium miscible pool’, ‘calcium turnover rate’, ‘accretion rate’ and ‘resorption rate’ calculated by the method of Aubert & Milhaud (1960).
3. Differences in radiological bone patterns were not observed despite an improvement in the pain after treatment.