1. The metabolism of glycerol by isolated rat-kidney tubules was investigated.

2. Indomethacin, at a concentration of 0.1 mmol/l, markedly inhibited the utilization of glycerol and its conversion into glucose and CO2.

3. The glycerol 3-phosphate production rose significantly when indomethacin was present, indicating a fall in the rate at which glycerol 3-phosphate was oxidized.

4. The results are discussed in relation to the observation that indomethacin increases the severity of glycerol-induced acute renal failure.

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