Vitamin B12 is able to cleave the anaesthetic gas nitrous oxide and in the process is itself oxidized to an inactive form. This has provided an opportunity for exploring the effect of vitamin B12 deficiency in the experimental animal as well as in man, and hence for unravelling some of the tangled skeins of vitamin B12-folate interrelations.
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I. Chanarin; Nitrous Oxide and the Cobalamins. Clin Sci (Lond) 1 September 1980; 59 (3): 151–154. doi: https://doi.org/10.1042/cs0590151
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