ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Guest edited by Professor Michael Bader, Professor Anthony J. Turner and Dr Natalia Alenina.

Twenty years after its discovery, angiotensin-converting enzyme 2 (ACE2) has become one of the most studied proteins. Since ACE2 was identified as the SARS-coronavirus 2 receptor, it has held centre stage with already around 3000 peer-reviewed publications in 2020. On this occasion Clinical Science has compiled a themed collection ‘ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19’ with reviews and original papers on the physiological and pathophysiological roles of the multiple known tasks of ACE2 including carboxypeptidase, amino acid transport regulator, and virus receptor functions.

Collection image featured in 10.1042/CS20200477. Modified from 10.1126/science.abb2762.