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Volume 101, Issue s45

August 2001

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Table of Contents
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ISSN 0143-5221

EISSN 1470-8736

In this Issue

Communications for the Spring Meeting of the Medical Research Society Meeting I June 2001

Communications for the Spring Meeting of the Medical Research Society Meeting I June 2001

Anp Regulates Venous Capacitance in Man

M Schmitt; AK Nightingale; A Broadley; J Taylor; R Campbell; J Cockcroft; MP Frenneaux

Clin Sci (Lond) (2001) 101 (s45): 1P.

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Mutations in α-Synuclein Disrupt Axonal Transport, a Mechanism for Lewy Body Disease

AR Saha; DP Hanger; PN Leigh; BH Anderton

Clin Sci (Lond) (2001) 101 (s45): 1P.

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The Evaluation of Prime-Boost Immunisation Strategies in a Murine Model of Tuberculosis

H McShane; N Goonetilleke; R Brookes; Avs Hill

Clin Sci (Lond) (2001) 101 (s45): 1P–2P.

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Expression and Function of Novel Isoforms of the Apoptosis Regulating Protein, Bid, in Human Neutrophils

SA Renshaw; CD Bingle; MKB Whyte

Clin Sci (Lond) (2001) 101 (s45): 2P.

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Diurnal Variation in Stroke Onset in Atrial Fibrillation

S Kamath; KH Tan; CKY Lau; GYH Lip

Clin Sci (Lond) (2001) 101 (s45): 2P.

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Platelet Aggregation in Atrial Fibrillation

S Kamath; AD Blann; GYH Lip

Clin Sci (Lond) (2001) 101 (s45): 2P.

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Ethnic Differences in Patient Perceptions of Atrial Fibrillation and Anticoagulation therapy

S. Kamath; M Jafri; A Mohammed; GYH Lip

Clin Sci (Lond) (2001) 101 (s45): 2P–3P.

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High Energy DC Cardioversion for Atrial Fibrillation: Gain without Pain?

C Boos; G Wilbourne; M Thomas; R More

Clin Sci (Lond) (2001) 101 (s45): 3P.

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Endothelial Dysfunction is Not the Limiting Factor in Skeletal Muscle Function of Patients with Chronic Heart Failure

AK Nightingale; JG Crilley; NC Pegge; M Schmitt; R Field; C Mumford; MP Frenneaux

Clin Sci (Lond) (2001) 101 (s45): 3P.

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Effect of Vitamin C on Ventricular Vascular Coupling in Patients with CHF

AK Nightingale; M Schmitt; NC Pegge; R Field; C Mumford; MP Frenneaux

Clin Sci (Lond) (2001) 101 (s45): 3P–4P.

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Development of Intrinsic Tone in Rat Coronary Arteries IN-VITRO

PJ Pugh; RD Jones; TH Jones; KS Channer

Clin Sci (Lond) (2001) 101 (s45): 4P.

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A Markedly Reduced Exercise Tolerance May Suggest Co-Existent Left Ventricular Dysfunction in Patients with Chronic Airways Disease

K Mahmood; N Goenka; S Thwaites; PD Higham; BC Thwaites

Clin Sci (Lond) (2001) 101 (s45): 4P.

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Acute Effects of GTN and Salbutamol on Peripheral & Central Pressure Waveforms in Hypertensive & Normotensive Subjects

G Manning; H Nagata; K.R. Davis; MW Millarcraig; R Donnelly

Clin Sci (Lond) (2001) 101 (s45): 4P.

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Do Cardiovascular and Cerebrovascular Risk Scores Based on the Framingham Equation Correlate with von Willebrand Factor, a Marker for Endothelial Damage and Vascular Endothelial Growth Factor, a Marker for Angiogenesis?

DC Felmeden; CGC Spencer; F Belgore; AD Blann; DG Beevers; GYH Lip

Clin Sci (Lond) (2001) 101 (s45): 5P.

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Relationship between Endothelial Damage, Angiogenesis and Cardiovascular Risk Factors in Healthy Controls and Hypertensive Patients

DC Felmeden; AD Blann; CGC Spencer; DG Beevers; F Belgore; GYH Lip

Clin Sci (Lond) (2001) 101 (s45): 5P.

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The Change in Endothelial Damage and Vascular Endothelial Growth Factor An Index of Angiogenesis, following Intensified Blood Pressure Treatment in High-Risk Hypertensives

DC Felmeden; CGC Spencer; F Belgore; AD Blann; DG Beevers; GYH Lip

Clin Sci (Lond) (2001) 101 (s45): 5P.

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Oxidative Stress and Endothelial Damage in Chronic Heart Failure: Effects of Carvedilol and Bisoprolol

B Chin; S Nuttall; M Kendall; C Gibbs; AD Blann; GYH Lip

Clin Sci (Lond) (2001) 101 (s45): 5P–6P.

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The Effect of Intensified Blood Pressure Treatment on Endothelial Function and Vascular Endothelial Growth Factor. An Index of Angiogenesis in High-Risk Hypertensives

DC Felmeden; CGC Spencer; F Belgore; AD Blann; DG Beevers; GYH Lip

Clin Sci (Lond) (2001) 101 (s45): 6P.

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A New Therapeutic Approach to Atherosclerosis and Cardiovascular Disease: Inhibition of Binding of C-Reactive Protein

G Hirschfield; MB Pepys

Clin Sci (Lond) (2001) 101 (s45): 6P.

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Defective APO A1-Mediated Cholesterol Efflux from Dermal Fibroblasts in a Patient with Absent HDL-Cholesterol

KCR Baynes; S Schepelmann; SR Johnstone; AK Soutar; JS Owen; S Davies; MD Feher

Clin Sci (Lond) (2001) 101 (s45): 6P–7P.

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Mechanisms of Oxidative Free Radical Generation in Human Arteries

C Berry; MJ Brosnan; MY Alexander; CA Hamilton; JJV McMurray; AF Dominiczak

Clin Sci (Lond) (2001) 101 (s45): 7P.

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The Leukotriene Pathway in Human Airway Smooth Muscle Cells

AJ James; PM Lackie; AJ Knox; AP Sampson; ST Holgate

Clin Sci (Lond) (2001) 101 (s45): 7P.

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Nasal Lavage Expression of LTC₄ Synthase and COX-1 Immunopositive Cells in Allergic and Idiopathic Rhinosinusitis

V Westergren; A Sami; P Moore; S T Holgate; J Penrose; K Austen; P Howarth; A Sampson

Clin Sci (Lond) (2001) 101 (s45): 7P.

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Use of Anti-Platelet Agents to Prevent in Vitro Activation During Sampling for Thrombospondin

G. McDowell; B Keevil

Clin Sci (Lond) (2001) 101 (s45): 8P.

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Production of Granulocyte Colony Stimulating Factor Enhances Host Resistance to Bacterial Infection in the Acute Phase Response

M. Noursadeghi; M.C.M. Bickerstaff; J. Herbert; J. Cohen; M.B. Pepys

Clin Sci (Lond) (2001) 101 (s45): 8P.

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Vitamin D Receptor Genotypes in Chronic Renal Failure

E Mercer; KW Colston; JB Eastwood

Clin Sci (Lond) (2001) 101 (s45): 8P.

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Tolbutamide Administration Results in a Kaliuresis That is Not Enhanced by Volume Expansion

N Goenka; N Abyaneh; JN Basey; L Gill; JP O'Hare

Clin Sci (Lond) (2001) 101 (s45): 8P–9P.

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Impaired Sodium Excretion in Response to Acute Volume Expansion in Type 2 Diabetic Subjects

N Goenka; K Mahmood; N Abyaneh; JN Basey; L Gill; JP O'hare

Clin Sci (Lond) (2001) 101 (s45): 9P.

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Comparative Sequence Analysis of the Human and Rat Endoglin Promoter

M Chaudhary; CL Shovlin

Clin Sci (Lond) (2001) 101 (s45): 9P.

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Plasma Homocysteine and Orlistat-Induced Weight Loss in Obesity

G Jones; C Leroux; D Jackson; J Stuttard; G Frost; J Alaghband-Zadeh; JF Laycock; D Reaveley

Clin Sci (Lond) (2001) 101 (s45): 9P.

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Plasma Homocysteine Concentration in Myxoedema

J Hoffman; DA Reaveley; D Jackson; CLE Roux; J Alaghband-Zadeh

Clin Sci (Lond) (2001) 101 (s45): 10P.

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Allometric Relationships between Mri-Determined LVM and Body Size Variables

KP George; SG Myerson; KM Birch; MJ World; DJ Pennell

Clin Sci (Lond) (2001) 101 (s45): 10P.

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Divergent Roles of IGF-1 and Tnfα upon Human Preadipocyte Differentiation and Cortisol Metabolism

J Tomlinson; I Bujalska; J Moore; M Hewison; PM Stewart

Clin Sci (Lond) (2001) 101 (s45): 10P.

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Reduced Hepatic Protein Synthesis in Response to Osmotic Diarrhoea

RJ Hunter; VB Patel; JS Marway; VR Preedy

Clin Sci (Lond) (2001) 101 (s45): 10P–11P.

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Reduced Skeletal Muscle Protein Content in Response to a High-Fat/Low-Carbohydrate Alcohol Diet in Male and Female Rats

RJ Hunter; KO Lindros; HA Jarvelainen; VR Preedy

Clin Sci (Lond) (2001) 101 (s45): 11P.

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Alcohol Induced Muscle Disease Does Not Alter Myostatin Expression in Rats

RJ Hunter; M Wehling; E Want; R Rajendram; J Tidball; VR Preedy

Clin Sci (Lond) (2001) 101 (s45): 11P.

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Nitric Oxide Synthase in Coeliac Disease

I Daniels; IA Murray; RG Long

Clin Sci (Lond) (2001) 101 (s45): 11P.

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The Study of the Ibd Susceptibility Genes on Chromosome 5 and Chromosome 19

Hong Li Jin; B Dechairo; F Williams; NJ Lench; DP Jewell

Clin Sci (Lond) (2001) 101 (s45): 12P.

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Cardiac Changes in An Animal Model of Liver Disease Using Bile Duct Ligation

RJ Hunter; VB Patel; AJ Baker; PJ Richardson; VR Preedy

Clin Sci (Lond) (2001) 101 (s45): 12P.

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Genetics of Severe Childhood Obesity

IS Farooqi; S O'Rahilly

Clin Sci (Lond) (2001) 101 (s45): 12P.

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Molecular Pathophysiology of Intestinal Iron Transport in Haemochromatosis

WJH Griffiths; WS Sly; TM Cox

Clin Sci (Lond) (2001) 101 (s45): 12P–13P.

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Regulation of Macrophage Phagocytosis of Apoptotic Cells by CD44

SP Hart; C Haslett; I Dransfield

Clin Sci (Lond) (2001) 101 (s45): 13P.

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Relating Visual Attention and Visual Awareness; Neuroimaging in Patients and Normal Subjects

Geraint Rees

Clin Sci (Lond) (2001) 101 (s45): 13P.

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Attention to Action: Specific Modulation of Cortico-Cortical Connectivity Measured Using FMRI

Jame B Rowe; Karl Friston; Richard Frackowiak; Richard Passingham

Clin Sci (Lond) (2001) 101 (s45): 13P.

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Molecular Characterization of the Chromosome 9Q Deletion in Aml

LE Side; AJ Peniket; ER Levy; H Williamson; SJ Humphray; SE Langabeer; H Walker; AH Goldstone; DC Linch; AK Burnett; J Boultwood; JS Wainscoat

Clin Sci (Lond) (2001) 101 (s45): 14P.

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Effects of Conductive Hearing Loss on Auditory Temporal Resolution

Deh Hartley

Clin Sci (Lond) (2001) 101 (s45): 14P.

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Nutritional and Genetic Determinants of Hormone Levels in Relation to Prostate Cancer Risk

Naomi E. Allen

Clin Sci (Lond) (2001) 101 (s45): 14P.

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Magnetic Resonance Imaging in-Utero, Neonatal and Post Mortem

EH Whitby

Clin Sci (Lond) (2001) 101 (s45): 14P–15P.

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A Genetic Approach to the Analysis of Cellular Oxygen Sensing

EC Vaux

Clin Sci (Lond) (2001) 101 (s45): 15P.

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A Novel Rheumatoid Arthritis (RA) Susceptibility Locus on Chromosome 17 Identified Using Syntenic Mapping Approaches

A Barton; W Ollier; A Silman; J Worthington

Clin Sci (Lond) (2001) 101 (s45): 15P.

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Early Life Programming of Cortisol Secretion and Action: Mechanisms Underlying the Metabolic Syndrome in Adult Life

RM Reynolds

Clin Sci (Lond) (2001) 101 (s45): 15P–16P.

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Interferon-γ Mediated Host Cell Resistance to Cryptosporidium Parvum Infection

RCG Pollok; MJG Farthing; M Bajaj-Eliott; I Sanderson; V McDonald

Clin Sci (Lond) (2001) 101 (s45): 16P.

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The Role of Sonic Hedgehog Signalling in Early Tooth Development

MT Cobourne; L Sarkar; S Naylor; M Smalley; T Dale; PT Sharpe

Clin Sci (Lond) (2001) 101 (s45): 16P.

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CD40-Ligation in Vivo Promotes Activation and Migration of Dendritic Cells and Enhances Resistance to Infection with Mycobacterium tuberculosis

Stephen Jolles; Ricardo Tascon; Gerry Klaus; Ann Ager; M. Jo Colston

Clin Sci (Lond) (2001) 101 (s45): 16P.

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The Role of Orexins in the Regulation of Appetite, Sleep and Arousal

S Taheri; M Ghatei; SR Bloom

Clin Sci (Lond) (2001) 101 (s45): 17P.

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Studies on Apolipoprotein-E Gene Transfer to Skeletal Muscle Cells in Vitro and in Vivo

T Athanasopoulos; J Owen; I Graham; J Harris; MG Dunckley; DG Hassall; J Goodman; J Drew; S Fabb; AD Tagalakis; S Shepelmann; JG Dickson

Clin Sci (Lond) (2001) 101 (s45): 17P.

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Subcellular Localisation of the X Protein in HBV Infected Hepatocytes

Jonathan Hoare; Frank Henkler; Rober D Goldin; Ian A King; Howard C Thomas; Michael J McGarvey

Clin Sci (Lond) (2001) 101 (s45): 17P.

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The Role of Human Intestinal Myofirboblasts in Intestinal Wound Repair and Remodelling

BC McKaig; YR Mahida

Clin Sci (Lond) (2001) 101 (s45): 17P–18P.

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A Study of Ras Gtpases and Prenylation in Human Mesangial Cell Proliferation in Vitro

S.A.I. Khwaja; CC Sharpe; BP Monia; SM Sebti; BM Hendry

Clin Sci (Lond) (2001) 101 (s45): 18P.

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Corticotrophin Releasing Hormone (CRH) and the Pathogenesis of Anorexia Nervosa

F Connan; IC Campbell; SL Lightman; S Landau; M Wheeler; J Treasure

Clin Sci (Lond) (2001) 101 (s45): 18P.

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Identification and Characterization of a Novel Meningococcal Autotransporter Protein: A New Virulence Factor?

DPJ Turner; KG Wooldridge; Daa Ala'aldeen

Clin Sci (Lond) (2001) 101 (s45): 18P–19P.

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The Role of Nutritional Peptides in the Control of the Hypothalamo-Pituitary (H-P) Axes

SH Russell; CJ Small; MA Ghatei; SR Bloom

Clin Sci (Lond) (2001) 101 (s45): 19P.

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Molecular Mechanisms of Thrombosis in Meningococcal Septicaemia: The Role of the Protein C Pathway in Vivo

SN Faust; RS Heyderman; CT Esmon; M Levin

Clin Sci (Lond) (2001) 101 (s45): 19P.

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Host Genetic and Immunologic Responses Mediating Survival in HIV-1 Infected African Children

R Chakraborty; JK Sutton; V Appay; M Otsyula; A D'Agostino; SL Rowland—Jones

Clin Sci (Lond) (2001) 101 (s45): 19P.

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Investigation of the Inflammatory Bowel Disease Susceptibility Locus on Chromosome 12 (IBD2)

DA Van Heel; AH Carey; DP Jewell

Clin Sci (Lond) (2001) 101 (s45): 20P.

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Direct Thrombin Inhibition Reduces Lung Collagen Accumulation and Connective Tissue Growth Factor Mrna Levels in Bleomycin-Induced Pulmonary Fibrosis

DCJ Howell; GJ Laurent; RC Chambers

Clin Sci (Lond) (2001) 101 (s45): 20P.

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Nitric Oxide Maintains Endothelial Integrity and Microvascular Flow in Health but Mediates Increased Permeability in Rodent Endotoxaemic Sepsis

S Singh; PB Anning; CP Winlove; TW Evans

Clin Sci (Lond) (2001) 101 (s45): 20P.

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The Anti-Arrhythmic and Anti-Ischaemic Effects of Angina in Patients with and without Collaterals

RJ Edwards; S Redwood; P Lambiase; MS Marber

Clin Sci (Lond) (2001) 101 (s45): 20P–21P.

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Sarcomere Protein Mutations Cause Dilated Cardiomyopathy

SD Sharma; M Kamisago; SR DePalma; S Solomon; P Sharma; B McDonough; J Jarcho; L Smoot; MP Mullen; LR Shapiro; PK Woolf; ED Wigle; JG Seidman; CE Seidman

Clin Sci (Lond) (2001) 101 (s45): 21P.

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Mutations in the Tgfβ Superfamily Receptors, BMPR2 and ALK-1, Cause Pulmonary Hypertension

JR Thomson; RD MacHado; NV Morgan; M Humbert; JE Loyd; WC Nichols; RC Trembath

Clin Sci (Lond) (2001) 101 (s45): 21P.

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Failure to Precondition Pathological Human Myocardium

S Ghosh; NB Standen; M Galiñanes

Clin Sci (Lond) (2001) 101 (s45): 21P–22P.

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Effects of Flow on the Permeability of the Rabbit Aortic Wall near Branches

T. J. Staughton; M. J. Lever; PD Weinberg

Clin Sci (Lond) (2001) 101 (s45): 22P.

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NF-κB is Essential for Metalloproteinase Secretion by Smooth Muscle Cells and Foam Cells

Ale J Chase; Andre C Newby

Clin Sci (Lond) (2001) 101 (s45): 22P.

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Is There a Second Voltage Dependent Mechanism for EC Coupling in Heart?

K C R Patel; JV Jones; AJ Levi

Clin Sci (Lond) (2001) 101 (s45): 22P.

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Molecular Analysis of FBN1 Mutations in Marfan Syndrome and Related Disorders

DJ Halliday; P Wordsworth; PA Handford

Clin Sci (Lond) (2001) 101 (s45): 23P.

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Investigating Sepsis-Associated Myocardial Dysfunction: Purification and Analysis of Myocardial Depressant Factors Released by Peripheral Blood Mononuclear Cells upon Exposure to N.MENINGITIDIS

N Pathan; S Harding; M Levin

Clin Sci (Lond) (2001) 101 (s45): 23P.

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Blood Pressure, Cholesterol and Common Causes of Death: Towards the Real Relationships

S Lewington; R Collins; R Clarke; R Peto

Clin Sci (Lond) (2001) 101 (s45): 23P.

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