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Issues
Medical Research Society Meeting 4 February 2002
Communication
Functional Implications of Genetic Variation in Non-Coding DNA for Disease Susceptibility and Gene Regulation
Clin Sci (Lond) (2002) 103 (s47): 1P–2P.
Identification and Characterisation of Derp1-Specific CD8+ T Cells in the Peripheral Blood of Atopic Individuals
Clin Sci (Lond) (2002) 103 (s47): 2P.
Alterations of Thrombogenesis, Endothelial Damage and Platelet Function following Percutaneous Peripheral Artery Angiography and Angioplasty
Clin Sci (Lond) (2002) 103 (s47): 4P.
Alterations of Thrombogenesis, Endothelial Damage and Oxidative Stress with Reperfusion during Femoral Artery Bypass Surgery for Peripheral Vascular Disease
Clin Sci (Lond) (2002) 103 (s47): 4P–5P.
Does Vascular Endothelial Growth Factor Mediate the Hypercoagulable State in Atrial Fibrillation?
Clin Sci (Lond) (2002) 103 (s47): 5P.
The Effect of Blood Pressure on Plasma Levels of von Willebrand factor and Soluble P-Selectin in Patients with Atrial Fibrillation
Clin Sci (Lond) (2002) 103 (s47): 5P.
Clinical Risk of Stroke in Atrial Fibrillation is Unrelated to Platelet Activation
Clin Sci (Lond) (2002) 103 (s47): 5P–6P.
Oxidised Ldl Induces Increased Expression of Angiopoietin-2 in Human Endothelial Cells
Clin Sci (Lond) (2002) 103 (s47): 6P.
The Role of Nitric Oxide in Therapeutic and Endogenous Angiogenesis and Arteriogenesis
Clin Sci (Lond) (2002) 103 (s47): 6P–7P.
Plethysmography without Venous Occlusion for Forearm Blood Flow Measurement – a Comparison with Venous Occlusive Method
Clin Sci (Lond) (2002) 103 (s47): 7P.
Upright Posture Impairs Microvascular Vasodilation in Patients with Varicose Veins – Possible Role in Ulcer Formation
Clin Sci (Lond) (2002) 103 (s47): 7P–8P.
Endothelial Dysfunction and Impaired Endogenous Fibrinolysis Do Not Contribute to Acute Stent Thrombosis or In-stent Restenosis
Clin Sci (Lond) (2002) 103 (s47): 8P.
Alterations in Single-Cell Calcium Handling Could Contribute to Diastolic Dysfunction and Arrhythmogenesis in Heart Failure
Clin Sci (Lond) (2002) 103 (s47): 8P–9P.
Effects of Overexpression of Igf Binding Protein-1 on Vascular Function and Blood Pressure Homeostasis in Mice
Clin Sci (Lond) (2002) 103 (s47): 9P.
Androgen Suppression in Men Leads to Increased Arterial Stiffness and Hyperinsulinaemia
Clin Sci (Lond) (2002) 103 (s47): 10P–11P.
Effects of Blood Pressure and Anemia on Functional Abnormalities in the Uraemic Heart Using Cardiovascular Magnetic Resonance
Clin Sci (Lond) (2002) 103 (s47): 11P.
Arrhythmogenic Right Ventricular Cardiomyopathy: Is there an Extended Phenotype?
M.S. Hamid; M. Norman; J.R. Gimeno; S. Firoozi; A. Quareshi; B. Sachdev; R. Thaman; P. Elliott; W.J. McKenna
Clin Sci (Lond) (2002) 103 (s47): 12P.
Relaxin, a Newly Described Cardiac Hormone, is a More Potent Vasodilator than Atrial Natriuretic Factor in Human Resistance arteries
Clin Sci (Lond) (2002) 103 (s47): 12P.
First Demonstration in Humans of Systemic Neutral Endopeptidase and Endothelin Converting Enzyme Inhibition Using a New, Orally Active, Dual Metalloprotease Inhibitor, Slv 306
Alison Seed; Rhoda Kuc; Anthony Davenport; Michael Ashby; Chris Hillier; Paul Passier; Hans Essers; John McMurray
Clin Sci (Lond) (2002) 103 (s47): 13P.
Interaction between Neutral Endopeptidase and Angiotensin Converting Enzyme Inhibition
Alison Seed; Chris Hillier; Colin Berry; Fiona Johnston; Amanda Brown; Mark Petrie; John JV McMurray
Clin Sci (Lond) (2002) 103 (s47): 13P.
Evidence that a Novel Orally Active Nep/Ece Inhibitor Blocks the Vasoconstrictor Response to Big Endothelin in Human Resistance Arteries
Clin Sci (Lond) (2002) 103 (s47): 14P.
Metabolism of Endogenous Nos Inhibitors Lowers Blood Pressure and Regulates Nitric Oxide Synthesis following Hindlimb Ischaemia
Clin Sci (Lond) (2002) 103 (s47): 15P.
Uncomplicated Acute Myocardial Infarction Results in Protracted Sympathetic Hyperactivity after Discharge from Hospital
Clin Sci (Lond) (2002) 103 (s47): 16P.
Genetic Variation of the Beta-1 Adrenoceptor Affects Left Ventricular Mass
T Stanton; S Padmanabhan; A G Jardine; A Mc Connachie; M Upton; G Watt; A F Dominiczak; J M C Connell
Clin Sci (Lond) (2002) 103 (s47): 16P.
A Cardiac Nitric Oxide Synthase 1 Regulates Contraction and Calcium Fluxes – a Novel Mechanism Involved in the Autocrine Control of Cardiac Function
Clin Sci (Lond) (2002) 103 (s47): 17P.
Diazoxide and Ischaemic Preconditioning Act Differently on the Mitochondria: Is the Mitokatp Channel a Red Herring?
Clin Sci (Lond) (2002) 103 (s47): 18P.
Elevated Circulating Interleukin-6 Levels in Acute Ischaemic Stroke Are Correlated with Ct Infarct Volume and Poor Clinical Outcome
Clin Sci (Lond) (2002) 103 (s47): 18P–19P.
Lack of Ketone Body Response Associated with Hyperglycaemia following Pancreatectomy for Hyperinsulinism (Hi)
Clin Sci (Lond) (2002) 103 (s47): 19P.
Frequent Occurrence of An Intron 4 Mutation in Multiple Endocrine Neoplasia Type 1 (Men1)
Clin Sci (Lond) (2002) 103 (s47): 20P.
A Digenic Basis for Severe Insulin Resistance in a Large Human Kindred
DB Savage; M Gurnell; I Barroso; M Agostini; O Rajanayagam; M Soos; G Ihrke; A Schafer; R Ross; S O'Rahilly; VKK Chatterjee
Clin Sci (Lond) (2002) 103 (s47): 21P–22P.
Autocrine Activation of Glucocorticoids in Osteoblasts Increases with Age and Glucocorticoid Exposure
Clin Sci (Lond) (2002) 103 (s47): 22P–23P.
A2B Adenosine Receptors Mediate the Adenosine-Induced Increase in Cell Growth and IL-6 Expression in Pituitary Folliculostellate Cells
Clin Sci (Lond) (2002) 103 (s47): 23P.
Reduced Adipose Tissue Sympathetic Nervous System (SNS) Activity in Human Obesity despite Increased Whole Body Norepinephrine Spillover
Clin Sci (Lond) (2002) 103 (s47): 23P–24P.
Optimisation of Hydrocortisone Replacement Therapy
P.M. Mah; R.C. Jenkins; A. Rostami-Hodjegan; J. Newell-Price; A. Doane; V. Ibbotson; G. Tucker; R.J. Ross
Clin Sci (Lond) (2002) 103 (s47): 24P.
Mapping of Familial Juvenile Hyperuricaemic Nephropathy on Chromosome 16P12 in Six Families
J J O Turner; J M Stacey; B Harding; M A Nesbit; P Kotanko; K Lhotta; J G Puig; R J Torres; R V Thakker
Clin Sci (Lond) (2002) 103 (s47): 24P.
Tolerance Induction Using Nondepleting Anti-Cm, Soluble Interleukin-1 Receptor and Insulin in Nod Syngeneic Islet Grafts
Clin Sci (Lond) (2002) 103 (s47): 24P.
The Phenotype of the Cd4+ T Lymphocyte Response May Influence the Severity of Liver Damage in Chronic Hepatitis C Infection
Clin Sci (Lond) (2002) 103 (s47): 25P.
Short Course Antiretroviral Therapy in Primary Hiv-1 Infection
Clin Sci (Lond) (2002) 103 (s47): 25P–26P.
A Novel Inducible Stroke Phenotype Created by Correction of Salt-Water Loss during Accelerated Hypertension
Clin Sci (Lond) (2002) 103 (s47): 26P.
Optimisation of the Mhc Class I Peptide Cargo is Catalysed by Tapasin
Clin Sci (Lond) (2002) 103 (s47): 27P.
Factor H Mutations in Haemolytic Uracmic Syndrome Cluster in Scrs 18-20, a Domain Important for Host Cell Recognition
Clin Sci (Lond) (2002) 103 (s47): 28P.
Cd8 Cytotoxic Lymphocyte Responses against Cytomegalovirus in Renal Transplant Patients and Healthy Individuals
Frank M Mattes; Ana L Vargas; Aycan F Hassan-Walker; Paul Sweny; Andrew Davenport; Rodney E Phillips; Paul D Griffiths; Vincent C Emery
Clin Sci (Lond) (2002) 103 (s47): 28P–29P.
The Role of CD4+CD25+ Regulatory Cells in a Mouse Transplantation Tolerance Model: CTLA-4 and IL-10-Dependent Regulation of Skin Allograft Rejection
Clin Sci (Lond) (2002) 103 (s47): 29P.
Vigorous HIV-Specific CD4 T Cell Responses in IIIV-1 Infected African Children and Adults in the Absence of Antiretroviral Therapy
JK Sutton; R Chakraborty; R Kaul; T Rostron; A D'Agostino; P Kiama; J Kimani; J Bwayo; SL Rowland-Jones
Clin Sci (Lond) (2002) 103 (s47): 29P–30P.
Cd8+ T Cell Evasion by K3 during Gamma-Herpesvirus Latency Establishment
Clin Sci (Lond) (2002) 103 (s47): 30P.
Increases in Urinary Nitrate Excretion at Porcine Vascular Surgery Are Delayed by Methylprednisolone
Clin Sci (Lond) (2002) 103 (s47): 31P.
Manipulating a Pro-Inflammatory T Cell Epitope from a Synovial Autoantigen
Clin Sci (Lond) (2002) 103 (s47): 31P.
Linkage Disequilibrium at the Fc Gamma Receptor (Fcγr) Locus and Association of An Fcγr Haplotype with Rheumatoid Arthritis (RA)
Clin Sci (Lond) (2002) 103 (s47): 33P.
Highly Selected Autologous Stem Cell Transplantation in Severe Rheumatoid Arthritis with Studies of Peripheral Blood Lymphocyte (Pbl) Reconstitution, Synovial Response and Thymic Function
Sarah Bingham; Fredrique Ponchel; Douglas Veale; Richard Reece; Ursula Fearon; John Isaacs; Dennis McGonagle; John Snowden; Gareth Morgan; Paul Emery
Clin Sci (Lond) (2002) 103 (s47): 33P.
Magnetic Resonance Imaging Advances Our Understanding of Disease Pathogenesis in Spondyloarthropathy
Clin Sci (Lond) (2002) 103 (s47): 34P.
Magnetic Resonance Imaging as a Predictor of Neuropathic Joint Disease in Diabetes Mellitus
Clin Sci (Lond) (2002) 103 (s47): 34P.
The Use of Mri in Elucidating the Pathogenesis of Rheumatoid Arthritis (Ra) and Its Use in Understanding Response to Therapy
Clin Sci (Lond) (2002) 103 (s47): 35P.
Ultrasonography Detects Synovitis in Patients with Rheumatoid Arthritis despite ACR Remission
Andrew K. Brown; Mark A. Quinn; Zunaid Karim; Richard J. Wakefield; Philip G. Conaghan; Philip J. O'Connor; Paul Emery
Clin Sci (Lond) (2002) 103 (s47): 35P–36P.
Anticipation Plays a Major Role in the Brain Processing of Human Visceral Pain
Clin Sci (Lond) (2002) 103 (s47): 37P.
The Novel Chemokine Sexckine and its Receptor Bonzo are Important in T Cell Positioning within the Liver
Clin Sci (Lond) (2002) 103 (s47): 39P–40P.
Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Timp-1 is Mediated via Effects on Mmp Inhibition: Implications for Reversibility of Liver Fibrosis
F. Murphy; R. Issa; X. Zhou; H. Hussain; S. Ratnarajah; P. Soloway; H. Nagase; Arthur Mjp; RC Benyon; JP Iredale
Clin Sci (Lond) (2002) 103 (s47): 40P.
Assessment of Patient Satisfaction: An Important Outcome in Upper Gastrointestinal Tract Cancer
Clin Sci (Lond) (2002) 103 (s47): 40P.
Factor V Leiden Polymorphism and the Rate of Fibrosis Development in Chronic Hepatitis C Virus Infection
Mark Wright; Robert Goldin; Simon Hellier; Adrian Hill; RAY Apple; Suzanne Cheung; Howard Thomas; Mark Thursz
Clin Sci (Lond) (2002) 103 (s47): 41P.
Faecal Calprotectin: A Link between Lifestyle and Colonic Neoplasia Risk
Clin Sci (Lond) (2002) 103 (s47): 41P–42P.
An N-Terminally Truncated Cytoplasmic Form of Oxygen-Regulated Protein 150 (orp150), the Major Intracellular Ligand for the Anti-Proliferative Mushroom Lectin, is Essential for Nuclear Localisation Sequence (Nls)-Dependent Nuclear Protein Import in Human Intestinal Cancer Cells
Clin Sci (Lond) (2002) 103 (s47): 42P.
Altered Colonic Glycoprotein Expression in Unaffected Monozygotic Twins of Inflammatory Bowel Disease Patients
Clin Sci (Lond) (2002) 103 (s47): 42P.
Stress Protein Expression in Human Hepatocyte Cell Lines Cultured as in Three-Dimensional (3-D) Spheroids in Alginate
Clin Sci (Lond) (2002) 103 (s47): 42P–43P.
Jagged and Notch Expression in Developing Human Biliary Epithelium and Reactivation in Disease on Abnormal Ductular Proliferative Cells
Clin Sci (Lond) (2002) 103 (s47): 44P.
The Role of Fanconi Anaemia FANCC and FANCG Genetic Variants for Susceptibility to Sporadic Childhood Myeloid Leukaemia
Clin Sci (Lond) (2002) 103 (s47): 45P–46P.
Antisense Bcl-xl Knockout Switches the Response of Colon Cancer Cells to Topoisomerase I Inhibition from Senescence to Apoptosis
Clin Sci (Lond) (2002) 103 (s47): 47P–48P.
Computer-Administered Individual Quality of LD7E Assessments in Oncology Practice
Clin Sci (Lond) (2002) 103 (s47): 48P–49P.
Candidate Genes for the 11Q Abnormality in Chronic Lymphocytic Leukaemia (CLL)
Clin Sci (Lond) (2002) 103 (s47): 49P.
Telomere Shortening at Diagnosis Correlates with Prognostic Score and Predicts Early Disease Progression in CML
Clin Sci (Lond) (2002) 103 (s47): 49P.
BCL10 and Chromosome 1p in Malignant Lymphoma-an Evaluation with Fluorescent In-Situ Hybridisation
Clin Sci (Lond) (2002) 103 (s47): 49P–50P.
Promoter Region Polymorphism in the TNF Gene and Risk of Osteolysis after Total Hip Arthroplasty
Clin Sci (Lond) (2002) 103 (s47): 50P.
TaqI Polymorphism in the 3′ Flanking Region of the Alpha-1 Antitrypsin Gene in Children with Meningococcal Septicaemia
Clin Sci (Lond) (2002) 103 (s47): 50P.
Replication and Transcription in Fibroblasts from Patients with Emery-Dreifuss Muscular Dystrophy and Familial Partial Lipodystrophy
Clin Sci (Lond) (2002) 103 (s47): 51P.
Analysis of a Large Kindred with Benign Familial Infantile Convulsions Confirms the Existence of a Locus on Chromosome 19q and Extends the Phenotype
Clin Sci (Lond) (2002) 103 (s47): 51P.
A Genome Wide Scan Reveals a Locus for Primary Ciliary Dyskinesia (Pcd) in the Druze Population
Clin Sci (Lond) (2002) 103 (s47): 52P.
Impact of Congenital Diaphragmatic Hernia on Lung Development: Parenchymal and Vascular Changes in an Ovine Model
SM Nelson; CA Hajivassiliou; AD Cameron; G Haddock; P Dunkley; A Cuschieri; L Robertson; RE Olver; R Hume
Clin Sci (Lond) (2002) 103 (s47): 53P.
Can Beta Tubulin Mutations Detected in Serum DNA Predict for Docetaxel Resistance in Advanced Non-Small Cell Lung Cancer
Clin Sci (Lond) (2002) 103 (s47): 53P.
ATP-Mediated Killing of Intracellular Mycobacteria by Macrophages is a P2X7-Dependent Process Inducing Bacterial Death by Phagosome-Lysosome Fusion
Clin Sci (Lond) (2002) 103 (s47): 54P.
A Hydrophobic Cavity in α1-Antitrypsin Is a Target for Rational Drug Design to Prevent Polymerisation and Disease
Clin Sci (Lond) (2002) 103 (s47): 55P.
The Effect of Respirable Particles on IL-8 Release from Airway Epithelial Cells
Clin Sci (Lond) (2002) 103 (s47): 56P.
Variation in Gene Polymorphisms between London and San Francisco Clinical Isolates of Mycobacterium Tuberculosis.
Clin Sci (Lond) (2002) 103 (s47): 58P.
Th-2 Cytokines Regulate Transforming Growth Factor Alpha (TGFα) and Endothelin (ET-1) Production by Asthmatic Bronchial Epithelial Cells
Clin Sci (Lond) (2002) 103 (s47): 58P.
Inflammatory Cell Populations in Peripheral Blood and Airways following Lps Inhalation in Healthy Volunteers
Clin Sci (Lond) (2002) 103 (s47): 59P.
Agonist-specific Temporal Characteristics of β2-Adrenoceptor-Stimulated Gene Transcription Response in CHO-K1 Cells Transfected with the Human β2-Adrenoceptor
Clin Sci (Lond) (2002) 103 (s47): 59P–60P.
Novel Polymorphisms in the Angiotensin II type 2 Receptor Gene: Common Haplotypes and Implications for Intrauterine Growth Restriction (IUGR)
Clin Sci (Lond) (2002) 103 (s47): 60P–61P.
Ischaemic Burden following Traumatic Brain Injury: Monitoring Correlates and Relevance to Outcome
JP Coles; TD Fryer; DA Parry; P. Smieleswiksi; J. Matthews; T. Donovan; D. Day; F. Aigbrhio; JC Clark; JD Pickard; DK Menon
Clin Sci (Lond) (2002) 103 (s47): 62P.
Linkage Analysis between Childhood Absence Epilepsy and Genes Encoding GABAA and GABAB Receptors
Clin Sci (Lond) (2002) 103 (s47): 62P.
Multiple Deaths due to Homoplasmic Mitochondrial DNA Mutations
Clin Sci (Lond) (2002) 103 (s47): 62P–63P.
The Effect of Serotonergic Dysfunction and Hypercortisolaemia on the Neural Correlates of Episodic Memory and Executive Function
Clin Sci (Lond) (2002) 103 (s47): 64P.
PET Measurement of the Influence of Corticosteroids on Serotonin-1A Receptor Number
Clin Sci (Lond) (2002) 103 (s47): 64P.
A Susceptibility Region for Autism on Chromosome 2: Linkage Disequilibrium Screen and Candidate Gene Studies
Clin Sci (Lond) (2002) 103 (s47): 65P.
Fmri Imaging of Verbal Self Monitoring in Monozygotic Twins Discordant for Schizophrenia
MM Picchioni; XA Chitnis; FU Chy; N Vythelingum; C Andrew; T Toulopoulou; SCR Williams; RM Murray; PK McGuire
Clin Sci (Lond) (2002) 103 (s47): 65P.
Long-Term Survival of Porcine Expanded Neural Precursors in the Rat Model of Parkinson's Disease
Clin Sci (Lond) (2002) 103 (s47): 67P.
Boundary Formation in the Developing Chick Forebrain: A Possible Role for the Neuronal Leucine Rich Repeat Proteins
Clin Sci (Lond) (2002) 103 (s47): 67P–68P.
Autoantibodies to the Muscle Specific Kinase, MuSK in Myasthenia Gravis seronegative for Acetylcholine Receptor Antibodies
Clin Sci (Lond) (2002) 103 (s47): 68P.
Neuroserpin Phenotypes in Transgenic Drosophila are Rescued by the Alzheimer's β-amyloid peptide: In Vitro and in Vivo Correlations
Clin Sci (Lond) (2002) 103 (s47): 69P.
Mutations in COL8A2, the Gene Encoding the α2 Chain of Type VIII Collagen, Cause Two Forms of Corneal Endothelial Dystrophy
Graeme C. M. Black; Susmito Biswas; Francis L. Munier; Edwin. M. Stone; Richard Bonshek; David McLeod
Clin Sci (Lond) (2002) 103 (s47): 69P–70P.
Modeling Human Proliferative Vitreoretinopathy (PVR): The Commonest Cause of Anatomical Failure in Retinal Detachment (RD)
Clin Sci (Lond) (2002) 103 (s47): 70P.
Areca Gastritis: A New Clinical Entity in Patients with Oral Submucous Fibrosis (OSF)
Clin Sci (Lond) (2002) 103 (s47): 70P–71P.
Identification and Utilisation of the ORF 73 Latency-Associated Regulatory Region in Herpesvirus Saimiri-Based Vectors
Clin Sci (Lond) (2002) 103 (s47): 72P.
The Anti-Inflammatory Properties of Monoclonal Antibody 7E3, Parent Molecule of the Gpiib/IIIa Inhibitor Abciximab, Are Stimulus Specific
Clin Sci (Lond) (2002) 103 (s47): 73P.
Antibody Targeted Gene Transfer to Endothelium; a Strategy to Target Inflammatory Sites
Clin Sci (Lond) (2002) 103 (s47): 73P.
Pro-Adhesive Effects of Staphylococcal Lipoteichoic Acid on Leukocyte Trafficking In Vivo.
Clin Sci (Lond) (2002) 103 (s47): 74P.
Mitomycin C Acts through a p53 Dependent Pathway in Transtional Carcinoma of Bladder (TCCB)
Clin Sci (Lond) (2002) 103 (s47): 75P–76P.
