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Medical Research Society Meeting 5th February 2003

Communication

Identification of Mutations in the Fumarate Hydratase Gene in the Multiple Cutaneous and Uterine Leiomyomatosis and Renal Carcinoma Syndrome

N A Alam; I P M Tomlinson

Clin Sci (Lond) (2003) 104 (s49): 1P.

View Articletitled, Identification of Mutations in the Fumarate Hydratase Gene in the Multiple Cutaneous and Uterine Leiomyomatosis and Renal Carcinoma Syndrome

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The Balance of TIMPs and MMP-2 Determines Hepatic Stellate Cell Fate during Recovery from Liver Fibrosis

FR Murphy; X Zhou; R Issa; H Hussain; J Waung; N Patel; J Collins; K Brew; H Nagase; MJP Arthur; RC Benyon; JP Iredale

Clin Sci (Lond) (2003) 104 (s49): 2P–3P.

View Articletitled, The Balance of TIMPs and MMP-2 Determines Hepatic Stellate Cell Fate during Recovery from Liver Fibrosis

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Abciximab Inhibits Monocyte Chemotactic Protcin-1-Induced Extravasation of Leukocytes in a Rat Model of Inflammation

R Yadav; S. Nourshargh

Clin Sci (Lond) (2003) 104 (s49): 5P–6P.

View Articletitled, Abciximab Inhibits Monocyte Chemotactic Protcin-1-Induced Extravasation of Leukocytes in a Rat Model of Inflammation

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The Relationship between Plasma Natriuretic Peptide Levels and Left Ventricular Function in Hypertrophic Cardiomyopathy at Rest and Peak Stress

PR Kalra; R Sharma; A Duncan; C O'Sullivan; W Li; M Kemp; AJS Coats; M Henein

Clin Sci (Lond) (2003) 104 (s49): 7P.

View Articletitled, The Relationship between Plasma Natriuretic Peptide Levels and Left Ventricular Function in Hypertrophic Cardiomyopathy at Rest and Peak Stress

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Gap Junction Remodelling in Atrial Myocardium of Patients with Chronic Atrial Fibrillation-Relevance to Clinical Course

Riyaz A. Kaba, MRCP; Steven R. Coppen, PhD; Stephen Rothery, BSc; Emmanuel Dupont, PhD; Anthony C. De Souza, FRCS; John R. Pepper, FRCS; Magdi H. Yacoub, FRCS; Nicholas J. Severs, DSc

Clin Sci (Lond) (2003) 104 (s49): 15P–16P.

View Articletitled, Gap Junction Remodelling in Atrial Myocardium of Patients with Chronic Atrial Fibrillation-Relevance to Clinical Course

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A Comparison of the Haemodynamic Effects Pentaerythritol Tetranitrate and Isosorbide Mononitrate in Healthy Men

James J Oliver; Stella McGarry; Marieke Hoefman; David J Webb

Clin Sci (Lond) (2003) 104 (s49): 16P.

View Articletitled, A Comparison of the Haemodynamic Effects Pentaerythritol Tetranitrate and Isosorbide Mononitrate in Healthy Men

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Enhanced External Counterpulsation (EECP) Does Not Alter Arterial Stiffness in Patients with Angina

F Dockery; CJ Bulpitt; P Bagger; C Rajkumar

Clin Sci (Lond) (2003) 104 (s49): 16P.

View Articletitled, Enhanced External Counterpulsation (EECP) Does Not Alter Arterial Stiffness in Patients with Angina

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Accuracy of Cardiovascular Risk Estimation in Patients without Diabetes

Patrick Twomey; Anthony S. Wierzbicki; Timothy M Reynolds

Clin Sci (Lond) (2003) 104 (s49): 16P.

View Articletitled, Accuracy of Cardiovascular Risk Estimation in Patients without Diabetes

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Coronary Risk-Assessment: Framingham-Based Methods Overestimate Risk in British Middle-Aged Men

PM Brindle; JR Embcrson; FC Lampe; M Walker; PH Whincup; T Fahey; S Ebrahim

Clin Sci (Lond) (2003) 104 (s49): 17P.

View Articletitled, Coronary Risk-Assessment: Framingham-Based Methods Overestimate Risk in British Middle-Aged Men

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Adherence to the National Service Framework Guidelines for Secondary Prevention of Ischaemic Heart Disease. Are we Meeting the Targets?

E.R. Duncan; A.A. Mangoni; SHD Jackson

Clin Sci (Lond) (2003) 104 (s49): 17P.

View Articletitled, Adherence to the National Service Framework Guidelines for Secondary Prevention of Ischaemic Heart Disease. Are we Meeting the Targets?

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In Vitro and in vivo Characterisation of the Human, Mouse and Rat PGC1β Gene

VEF Crowley; A Meirbaeghe; C Lenaghan; K Green; A Stewart; C Montague; S O'Rahilly; AJ Vidal-Puig

Clin Sci (Lond) (2003) 104 (s49): 17P.

View Articletitled, In Vitro and in vivo Characterisation of the Human, Mouse and Rat PGC1β Gene

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Detection of a Novel Mutation in the Leptin Gene in a Boy with Delayed Puberty and An Abnormality of the Hypothalamic-Pituitary-Adrenal Axis

JA Trueman; D Payne; A Read; PE Clayton

Clin Sci (Lond) (2003) 104 (s49): 18P.

View Articletitled, Detection of a Novel Mutation in the Leptin Gene in a Boy with Delayed Puberty and An Abnormality of the Hypothalamic-Pituitary-Adrenal Axis

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Post Challenge Glucose and Lipid Changes with Nateglinide Stimulated Insulin Secretion in Type 2 Diabetic Subjects

N. Mohanlal; F Karpe; R.R. Holman

Clin Sci (Lond) (2003) 104 (s49): 18P.

View Articletitled, Post Challenge Glucose and Lipid Changes with Nateglinide Stimulated Insulin Secretion in Type 2 Diabetic Subjects

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Targeting Basal and Prandial Glucose Control in Type 2 Diabetes Mellitus in General Practice: The Glycaemic Optimisation Outcomes in Diabetes Study

N.J. Potts; R.R. Holman

Clin Sci (Lond) (2003) 104 (s49): 18P–19P.

View Articletitled, Targeting Basal and Prandial Glucose Control in Type 2 Diabetes Mellitus in General Practice: The Glycaemic Optimisation Outcomes in Diabetes Study

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Genetic Aetiology of Hyperglycaemia Alters Response to Treatment in Diabetes

Ewan R. Pearson; Lynette Shakespeare; Bryan Starkey; Roy Powell; Penny M. Clark; Andrew T Hattersley

Clin Sci (Lond) (2003) 104 (s49): 19P.

View Articletitled, Genetic Aetiology of Hyperglycaemia Alters Response to Treatment in Diabetes

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Pituitary Tumor Transforming Gene (PTTG): A Multifunctional Oncogene in Endocrine Neoplasia

K Boelaert; CJ McCabe; MC Eggo; MC Sheppard; JA Franklyn

Clin Sci (Lond) (2003) 104 (s49): 19P.

View Articletitled, Pituitary Tumor Transforming Gene (PTTG): A Multifunctional Oncogene in Endocrine Neoplasia

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A Bone to Pick with Local Glucocorticoid Activation

MS Cooper; A Blumsohn; PE Goddard; WA Bartlet; R Eastell; M Hewison; PM Stewart

Clin Sci (Lond) (2003) 104 (s49): 19P–20P.

View Articletitled, A Bone to Pick with Local Glucocorticoid Activation

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No Evidence for a Role for Mutations in the cAMP-Dependent Protein Kinase a Regulatory Subunit in Hyperfunctioning Adrenocortical Adenomas

FM Swords; LA Metherell; J Arola; AJ Clark

Clin Sci (Lond) (2003) 104 (s49): 20P.

View Articletitled, No Evidence for a Role for Mutations in the cAMP-Dependent Protein Kinase a Regulatory Subunit in Hyperfunctioning Adrenocortical Adenomas

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The Ectopic Expression of the Gastric Inhibitory Polypeptide Receptor in ACTH Dependant and Independent Adrenal Hyperplasia: In Vitro and in Vivo Studies

FM Swords; S Aylwin; L Perry; J Arola; AJL Clark

Clin Sci (Lond) (2003) 104 (s49): 20P.

View Articletitled, The Ectopic Expression of the Gastric Inhibitory Polypeptide Receptor in ACTH Dependant and Independent Adrenal Hyperplasia: In Vitro and in Vivo Studies

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Constitutive Activity of the ACTH Receptor: A Novel Cause of Adrenal Hyperplasia and a Novel Mechanism of Constitutive Activity

FM Swords; AH Baig; CD Malchoff; DF Malchoff; MO Thorner; L Hunyady; AJL Clark

Clin Sci (Lond) (2003) 104 (s49): 21P.

View Articletitled, Constitutive Activity of the ACTH Receptor: A Novel Cause of Adrenal Hyperplasia and a Novel Mechanism of Constitutive Activity

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The Isolation and Characterisation of CD34 Positive Cells from the Human Adult Liver

Vandana Matai; Nagy A Habib

Clin Sci (Lond) (2003) 104 (s49): 21P.

View Articletitled, The Isolation and Characterisation of CD34 Positive Cells from the Human Adult Liver

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Mechanisms and Dynamics of Adhesion of Lymphocytes Activated with the Novel Chemokine CXCL16 to Vcam

M. Heydtmann; P. Lalor; S.G. Hübscher; M. Briskin; DH Adams

Clin Sci (Lond) (2003) 104 (s49): 21P–22P.

View Articletitled, Mechanisms and Dynamics of Adhesion of Lymphocytes Activated with the Novel Chemokine CXCL16 to Vcam

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Disruption of Integrin αvβ3 Induces Apoptosis of Hepatic Stellate Cells

Xiaoying Zhou; John P Iredale; R Christopher Benyon

Clin Sci (Lond) (2003) 104 (s49): 22P.

View Articletitled, Disruption of Integrin αvβ3 Induces Apoptosis of Hepatic Stellate Cells

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Construction of a Predictive Model to Identify Rapid Fibrosis Progression in Patients with Chronic Hepatitis C Virus Infection

M Wright; RD Goldin; HC Thomas; MR Thursz

Clin Sci (Lond) (2003) 104 (s49): 22P.

View Articletitled, Construction of a Predictive Model to Identify Rapid Fibrosis Progression in Patients with Chronic Hepatitis C Virus Infection

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Modulated Mitochondrial Activity Corresponds with a Decline in Liver-Specific Function in 3-D Hepatocyte Culture

L.H. Damelin; I.J. Cox; N.J. Robertson; M. Khalil; R. Tootle; S. Coward; S. Choudhury; H.J.F. Hodgson; C. Selden

Clin Sci (Lond) (2003) 104 (s49): 22P–23P.

View Articletitled, Modulated Mitochondrial Activity Corresponds with a Decline in Liver-Specific Function in 3-D Hepatocyte Culture

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RNA-Mediated Inhibition of Hepatitis B Virus Replication

Kathryn L Nash; Graeme J Alexander; Andrew M Lever

Clin Sci (Lond) (2003) 104 (s49): 23P.

View Articletitled, RNA-Mediated Inhibition of Hepatitis B Virus Replication

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Liver-Specific Gene Therapy Using Lentiviral Vectors Based on Human Immunodeficiency Virus-1 (HIV-1)

Kathryn L Nash; Graeme J Alexander; Andrew M Lever

Clin Sci (Lond) (2003) 104 (s49): 23P.

View Articletitled, Liver-Specific Gene Therapy Using Lentiviral Vectors Based on Human Immunodeficiency Virus-1 (HIV-1)

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The Role of Macrophage Migration Inhibitory Factor in Intestinal Tumorigenesis

JM Wilson; N Scott; PJ Guillou; AF Markham; PL Coletta; MA Hull

Clin Sci (Lond) (2003) 104 (s49): 23P–24P.

View Articletitled, The Role of Macrophage Migration Inhibitory Factor in Intestinal Tumorigenesis

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Innate Immunogcnetics and Inflammatory Bowel Disease

D.P.B. McGovern; D.A. van Hcel; T. Ahmad; N. Lench; D.P. Jewell

Clin Sci (Lond) (2003) 104 (s49): 24P.

View Articletitled, Innate Immunogcnetics and Inflammatory Bowel Disease

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Seroprevalence, Characteristics and Correlates of Undetected Coeliac Disease in England

J West; RFA Logan; PG Hill; CA Lloyd; S Lewis; R Hubbard; R Reader; GKT Holmes; KT Khaw

Clin Sci (Lond) (2003) 104 (s49): 24P.

View Articletitled, Seroprevalence, Characteristics and Correlates of Undetected Coeliac Disease in England

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Decreased Post-Prandial 5-HT in Constipation-Predominant Irritable Bowel Syndrome (C-IBS)

SP Dunlop; NS Coleman; PE Blackshaw; AC Perkins; G Singh; CA Marsden; RC Spiller

Clin Sci (Lond) (2003) 104 (s49): 24P–25P.

View Articletitled, Decreased Post-Prandial 5-HT in Constipation-Predominant Irritable Bowel Syndrome (C-IBS)

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The Wilms' Tumour Antigen 1 (WT1) as a Potential Target Antigen for the Immunotherapy of Solid Tumours

Roopinder Gillmore; Hans Stauss; R Charles Coombes; Jonathan Waxman

Clin Sci (Lond) (2003) 104 (s49): 25P.

View Articletitled, The Wilms' Tumour Antigen 1 (WT1) as a Potential Target Antigen for the Immunotherapy of Solid Tumours

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Poster Withdrawn

Clin Sci (Lond) (2003) 104 (s49): 25P.

View Articletitled, Poster Withdrawn

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A Novel Reporter Gene Assay to Determine Estrogen Receptor Activity in Primary Breast Cancer Cells

Anjana Singh; Manuela T Debella; Manish Kothari; Clivc Smith; Emma Timms; Martin Slade; Brian Foxwell; Ali Simak; R Charles Coombes

Clin Sci (Lond) (2003) 104 (s49): 25P.

View Articletitled, A Novel Reporter Gene Assay to Determine Estrogen Receptor Activity in Primary Breast Cancer Cells

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Tumour Necrosis Factor: A Prometastatic Role in Breast Cancer

Ashita Waterston; Marc Feldmann; R Charles Coombes

Clin Sci (Lond) (2003) 104 (s49): 26P.

View Articletitled, Tumour Necrosis Factor: A Prometastatic Role in Breast Cancer

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The Expression of ERβ and ERβcx in Human Breast Cancer and the Relationship of ERβcx to Endocrine Therapy and Survival

C Palmieri; E Lam; RC Coombes

Clin Sci (Lond) (2003) 104 (s49): 26P.

View Articletitled, The Expression of ERβ and ERβcx in Human Breast Cancer and the Relationship of ERβcx to Endocrine Therapy and Survival

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Investigation of Estrogen Receptor Phosphorylation Using Phosphospecific Antibodies

Naveed Sarwar; Dongshen Chen; Demetra Constantinidou; R Charles Coombes; Simak Ali

Clin Sci (Lond) (2003) 104 (s49): 26P–27P.

View Articletitled, Investigation of Estrogen Receptor Phosphorylation Using Phosphospecific Antibodies

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Gene ICE as Applied to Studies of Hormonally-Responsive Cancers

D. Mazhar; L. Buluwela; S. Ali; J. Waxman; R.C. Coombes

Clin Sci (Lond) (2003) 104 (s49): 27P.

View Articletitled, Gene ICE as Applied to Studies of Hormonally-Responsive Cancers

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Alterations in mRNA Expression of Colon Cancer Cells Exposed to 5-Fluorouracil-Assessment Using cDNA Microarrays

JW Adlard; SD Richman; SD Shnyder

Clin Sci (Lond) (2003) 104 (s49): 27P.

View Articletitled, Alterations in mRNA Expression of Colon Cancer Cells Exposed to 5-Fluorouracil-Assessment Using cDNA Microarrays

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Delays in the Diagnosis of Colorectal Cancer: In-Depth, Patient-Centred, Qualitative Study

Emma Wood; Richard Neal; Phil Heywood; Karl Atkin

Clin Sci (Lond) (2003) 104 (s49): 28P.

View Articletitled, Delays in the Diagnosis of Colorectal Cancer: In-Depth, Patient-Centred, Qualitative Study

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Interaction between the C-Terminal Region of the Bloom's Syndrome Gene Product, BLM, and RAD51

Nicola C. Levitt; WU Leonard; Ian D. Hickson

Clin Sci (Lond) (2003) 104 (s49): 28P.

View Articletitled, Interaction between the C-Terminal Region of the Bloom's Syndrome Gene Product, BLM, and RAD51

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An in vitro 3D-Model of Invasive Squamous Cell Carcinoma (SCC) Recapitulates in vivo Pathology

ML Nystrom; GJ Thomas; IC MacKenzie; IR Hart; JF Marshall

Clin Sci (Lond) (2003) 104 (s49): 28P–29P.

View Articletitled, An in vitro 3D-Model of Invasive Squamous Cell Carcinoma (SCC) Recapitulates in vivo Pathology

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Meteor-a Novel Gene Involved in Centrosome Function

S. Blagden; Y. Inoue; C. Midgley; D. Glover

Clin Sci (Lond) (2003) 104 (s49): 29P.

View Articletitled, Meteor-a Novel Gene Involved in Centrosome Function

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In vitro Study of the p53 Pathway in Peripheral Blood Mononuclear Cells in Response to Doxorubicin Treatment

M Nasbed; G Thomson; F Paulin; J Wardrop; E M Rankin; D P Lane

Clin Sci (Lond) (2003) 104 (s49): 29P.

View Articletitled, In vitro Study of the p53 Pathway in Peripheral Blood Mononuclear Cells in Response to Doxorubicin Treatment

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Hdm2 Recruits the Hypoxia Sensitive Transcriptional Co-Repressor CtBP2 to Negatively Regulate p53-Dependant Transcription

Alexander H. F. Mirnezami; Sandra J. Campbell; John N. Primrose; Peter W. M. Johnson; Jeremy P. Blaydes

Clin Sci (Lond) (2003) 104 (s49): 29P.

View Articletitled, Hdm2 Recruits the Hypoxia Sensitive Transcriptional Co-Repressor CtBP2 to Negatively Regulate p53-Dependant Transcription

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The Role of Constitutional Polymorphisms and Mutations in the Fanconi Anaemia Group G Gene (FANCG) for Sporadic Childhood Myeloid Leukaemia

S Meyer; L Barber; AM Will; OB Eden; GM Taylor

Clin Sci (Lond) (2003) 104 (s49): 29P–30P.

View Articletitled, The Role of Constitutional Polymorphisms and Mutations in the Fanconi Anaemia Group G Gene (FANCG) for Sporadic Childhood Myeloid Leukaemia

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The Leukaemia-Associated AML1-ETO Fusion Protein Acts as a Sequence Specific Transcriptional Repressor in vivo by Altering the Chromatin Structure of Target Genes

George A. Follows; Hiromi Tagoh; Pascal Lefevre; Gareth J. Morgan; Constanze Bonifer

Clin Sci (Lond) (2003) 104 (s49): 30P.

View Articletitled, The Leukaemia-Associated AML1-ETO Fusion Protein Acts as a Sequence Specific Transcriptional Repressor in vivo by Altering the Chromatin Structure of Target Genes

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Two Novel Mutations in Severe Factor VII Deficiency

Keith Gomez; Michael A. Laffan; Geoffrey Kemball-Cook; John Pasi; Mark Layton; Edward G.D. Tuddenham; John McVey, II

Clin Sci (Lond) (2003) 104 (s49): 30P.

View Articletitled, Two Novel Mutations in Severe Factor VII Deficiency

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Association of Mismatch Repair Defects with Multiple Myeloma

AG Hall; JAE Irving; GH Jackson; PRA Taylor

Clin Sci (Lond) (2003) 104 (s49): 30P.

View Articletitled, Association of Mismatch Repair Defects with Multiple Myeloma

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Ontogeny-Related Changes in Integrin Expression and Cytokine Production by Fetal Mesenchymal Stem Cells (MSC)

Josu de la Fuente; Irene Roberts

Clin Sci (Lond) (2003) 104 (s49): 30P–31P.

View Articletitled, Ontogeny-Related Changes in Integrin Expression and Cytokine Production by Fetal Mesenchymal Stem Cells (MSC)

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Identification of Microdeletions at 1p36 by Fluorescence in Situ Hybridization in Cases of Malignant Lymphoma with Previously Normal Conventional Cytogenetic Findings

R Achuthan; IM Carr; SM Bell; P Roberts; DT Bonthron; AF Markham; KA MacLennan

Clin Sci (Lond) (2003) 104 (s49): 31P.

View Articletitled, Identification of Microdeletions at 1p36 by Fluorescence in Situ Hybridization in Cases of Malignant Lymphoma with Previously Normal Conventional Cytogenetic Findings

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Metabolism of Cytotoxic Drugs by Recombinant Human Cytochrome P450 Enzymes and Identification of Putative Metabolites by LC-MS/MS

Simon Brown; Clive Ward; Elaine Rankin; Roland Wolf

Clin Sci (Lond) (2003) 104 (s49): 31P.

View Articletitled, Metabolism of Cytotoxic Drugs by Recombinant Human Cytochrome P450 Enzymes and Identification of Putative Metabolites by LC-MS/MS

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Combination of OncoVEX with Chemotherapy for Cancer Treatment

J Hu; G Hallden; Z Han; B Liu; M Robinson; R Branston; RS Coffin; RC Coombes

Clin Sci (Lond) (2003) 104 (s49): 31P–32P.

View Articletitled, Combination of OncoVEX with Chemotherapy for Cancer Treatment

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Detection of Circulating Tumour Cells at 24 Hours after Primary Resection Predicts Colorectal Cancer Recurrence

T.K. McCullough; A.J. Evans; A.J. Hanna; R.Q. Wharton; H. Patel; T.G. Allen-Mersh

Clin Sci (Lond) (2003) 104 (s49): 32P.

View Articletitled, Detection of Circulating Tumour Cells at 24 Hours after Primary Resection Predicts Colorectal Cancer Recurrence

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MCM2 Demonstrates Altered Proliferative States in Colonic Mucosa, Adenomas, and Carcinomas More Accurately than Ki-67

AJ Hanna-Morris; P Cohen; TK McCuUough; S Saini; J Andreyev; TG Allen-Mersh

Clin Sci (Lond) (2003) 104 (s49): 32P.

View Articletitled, MCM2 Demonstrates Altered Proliferative States in Colonic Mucosa, Adenomas, and Carcinomas More Accurately than Ki-67

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A Novel Role for the Chemokine CCL2 in Pancreatic Adenocarcinoma Cell Invasion and Metastasis

C Bailey; S Ivanova; R Negus; D Peck; A Darzi

Clin Sci (Lond) (2003) 104 (s49): 32P–33P.

View Articletitled, A Novel Role for the Chemokine CCL2 in Pancreatic Adenocarcinoma Cell Invasion and Metastasis

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The Malignant Phenotype of Pancreatic Cancer is Enhanced by the Intense Desmoplastic Reaction

T. Armstrong; L. Murphy; G. Packham; R.C. Benyon; D.R. Fine; C.D. Johnson; J.P. Iredale

Clin Sci (Lond) (2003) 104 (s49): 33P.

View Articletitled, The Malignant Phenotype of Pancreatic Cancer is Enhanced by the Intense Desmoplastic Reaction

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The Possible Role of Heparin as a Therapeutic Intervention in Peritoneal Carcinomatosis via An ICAM-1 Mechanism

N. Alkhamesi; P. Ziprin; K. Pfistcrmuller; D. Peck; A. Darzi

Clin Sci (Lond) (2003) 104 (s49): 33P.

View Articletitled, The Possible Role of Heparin as a Therapeutic Intervention in Peritoneal Carcinomatosis via An ICAM-1 Mechanism

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Urine Dendritic Cells May Predict Recurrent Bladder Cancer in Patients Treated with Intravesical BCG

John D. Beatty; Angela Jones; Nicholas R. English; Margaret North; Christopher W. Ogden; Stella C. Knight

Clin Sci (Lond) (2003) 104 (s49): 34P.

View Articletitled, Urine Dendritic Cells May Predict Recurrent Bladder Cancer in Patients Treated with Intravesical BCG

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Extracorporeal Bypass Perfusion Using Central Venous Blood Prevents Ischaemia-Reperfusion Injury during Abdominal Aortic Aneurysm Repair

TL Luk; CJ Ryan; DF Harris; NJ Standfield

Clin Sci (Lond) (2003) 104 (s49): 34P.

View Articletitled, Extracorporeal Bypass Perfusion Using Central Venous Blood Prevents Ischaemia-Reperfusion Injury during Abdominal Aortic Aneurysm Repair

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Comparison of Muscle and Fasciocutaneous Flaps in Open Tibial Fractures

L Harry; A Sandison; E Paleolog; I McCarthy; M Pearse; J Nanchahal

Clin Sci (Lond) (2003) 104 (s49): 34P.

View Articletitled, Comparison of Muscle and Fasciocutaneous Flaps in Open Tibial Fractures

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Increased Expression of Galanin in Mucosal Nerves of Patients with Painful Diverticular Disease

J Simpson; F Sundler; D Jenkins; RC Spiller

Clin Sci (Lond) (2003) 104 (s49): 35P.

View Articletitled, Increased Expression of Galanin in Mucosal Nerves of Patients with Painful Diverticular Disease

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Clinical and Morphological Features Associated with Emboli during Carotid Angioplasty

CD Bicknell; MG Cowling; MW Clark; SA Thorn; AH Hughes; M Jenkins; Wolfe Jhn; AW Darzi; Cheshire Njw

Clin Sci (Lond) (2003) 104 (s49): 35P.

View Articletitled, Clinical and Morphological Features Associated with Emboli during Carotid Angioplasty

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Are Vertebrobasilar Territory Tia or Minor Strokes Really More Benign than Carotid Territory Events?

E Floßmann; PM Rothwell

Clin Sci (Lond) (2003) 104 (s49): 35P–36P.

View Articletitled, Are Vertebrobasilar Territory Tia or Minor Strokes Really More Benign than Carotid Territory Events?

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Neutrophil Recruitment, Neurological Status and Outcome in Acute Ischaemic Stroke: An Imaging Based Study

CJS Price; DK Menon; EA Warburton; R Barber; J Ballinger; MA Peters

Clin Sci (Lond) (2003) 104 (s49): 36P.

View Articletitled, Neutrophil Recruitment, Neurological Status and Outcome in Acute Ischaemic Stroke: An Imaging Based Study

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Pet Measurement of the Effect of Dietary Tyrosine Depletion on [¹¹C]Raclopride Binding: An [11C]Raclopride Pet Study

AJ Montgomery; SFB McTavish; PJ Cowen; PM Grasby

Clin Sci (Lond) (2003) 104 (s49): 36P.

View Articletitled, Pet Measurement of the Effect of Dietary Tyrosine Depletion on [11C]Raclopride Binding: An [11C]Raclopride Pet Study

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Mechanistic Comparisons between Trigeminal and Spinal Neuropathic Pain

Francis E O'Neill; Susan M Fleetwood-Walker

Clin Sci (Lond) (2003) 104 (s49): 36P.

View Articletitled, Mechanistic Comparisons between Trigeminal and Spinal Neuropathic Pain

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Differential Sympathetic Sudomotor and Cardiovascular Function in Human Spinal Cord Injury

A Nicotra; M Catley; P Ellauay; CJ Mathias

Clin Sci (Lond) (2003) 104 (s49): 37P.

View Articletitled, Differential Sympathetic Sudomotor and Cardiovascular Function in Human Spinal Cord Injury

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The Postnatal Expression of NMDA and AMPA Receptors in Dorsal Horn and Dorsal Root Ganglia Neurones

C.E. Urch; M. Fitzgerald

Clin Sci (Lond) (2003) 104 (s49): 37P.

View Articletitled, The Postnatal Expression of NMDA and AMPA Receptors in Dorsal Horn and Dorsal Root Ganglia Neurones

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A Role for Notch Signalling in Remyelination of the Central Nervous System

Mark F. Stidworthy; LI Wen-Wu; Robin J.M. Franklin

Clin Sci (Lond) (2003) 104 (s49): 37P.

View Articletitled, A Role for Notch Signalling in Remyelination of the Central Nervous System

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Visual Hallucinations

D H Ffytche

Clin Sci (Lond) (2003) 104 (s49): 38P.

View Articletitled, Visual Hallucinations

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A Double Dissociation of Distinct Prefrontal Cortical Regions during the Perceptual Modulation of Semantic Decision-Making

David J Sharp; Sophie K Scott; Richard JS Wise

Clin Sci (Lond) (2003) 104 (s49): 38P.

View Articletitled, A Double Dissociation of Distinct Prefrontal Cortical Regions during the Perceptual Modulation of Semantic Decision-Making

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Famous Person Knowledge: Insights from Semantic Dementia

Sian Thomson; Kim Graham; Karalyn Patterson; Narinder Kapur; John Hodges

Clin Sci (Lond) (2003) 104 (s49): 38P.

View Articletitled, Famous Person Knowledge: Insights from Semantic Dementia

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A 30-Year Prospective Analysis of Change in Body Weight and Incident Dementia

Robert Stewart, MD; Kamal Masaki, MD; Rita Peila, MSc; Helen Petrovitch, MD; Lon R. White, MD; Lenore J. Launer, PhD

Clin Sci (Lond) (2003) 104 (s49): 39P.

View Articletitled, A 30-Year Prospective Analysis of Change in Body Weight and Incident Dementia

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Elevated Glucocorticoid Levels Are Associated with Temporal Lobe Atrophy and Impaired Cognitive Function in Healthy Elderly Men

Alasdair MJ MacLullich; Karen J Ferguson; Joanna M Wardlaw; Ian J Deary; John M Starr; Jonathan R Seckl

Clin Sci (Lond) (2003) 104 (s49): 39P.

View Articletitled, Elevated Glucocorticoid Levels Are Associated with Temporal Lobe Atrophy and Impaired Cognitive Function in Healthy Elderly Men

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A Chromosome Breakpoint Mapping Strategy to Identify Candidate Genes for Nonsyndromic X-linked Mental Retardation within Xp11.2

Simon Holden; Andreas Schroer; Sabine Kuebart; Ilke Slosarek; Catherine Bovie; James Cox; Vera Kalscheuer; Hans-Hilger Ropers; Lucy Raymond

Clin Sci (Lond) (2003) 104 (s49): 39P–40P.

View Articletitled, A Chromosome Breakpoint Mapping Strategy to Identify Candidate Genes for Nonsyndromic X-linked Mental Retardation within Xp11.2

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Serotonin Studies Provide a Novel Clue to Pathogenesis in Motor Neuron Disease

MR Turner; EA Rabiner, MRC; M Doder, MRC; PM Grasby, MRC; CE Shaw, King's MND; DJ Brooks, MRC; PN Leigh, King's MND

Clin Sci (Lond) (2003) 104 (s49): 40P.

View Articletitled, Serotonin Studies Provide a Novel Clue to Pathogenesis in Motor Neuron Disease

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A Novel Locus for Motor Neurone Disease on Chromosome 16q12-13

Deborah Ruddy; Christopher Shaw

Clin Sci (Lond) (2003) 104 (s49): 40P.

View Articletitled, A Novel Locus for Motor Neurone Disease on Chromosome 16q12-13

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Motor Neurons and Microarrays-Understanding the Pathogenesis of Spinal Muscular Atrophy

Kirstie Anderson; Chris Pouting; Allyson Potter; Kay Davies

Clin Sci (Lond) (2003) 104 (s49): 40P–41P.

View Articletitled, Motor Neurons and Microarrays-Understanding the Pathogenesis of Spinal Muscular Atrophy

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Identification of a New Pmp22 Mouse Mutant and Trafficking Analysis of a Pmp22 Allelic Series Suggesting Protein Aggregates May Be Protective in Pmp22-Associated Peripheral Neuropathy

Alexander Jeans; Adrian M. Isaacs; Peter Oliver; Lucie Vizor; Steven D.M. Brown; Jackie Hunter; Kay E. Davies

Clin Sci (Lond) (2003) 104 (s49): 41P.

View Articletitled, Identification of a New Pmp22 Mouse Mutant and Trafficking Analysis of a Pmp22 Allelic Series Suggesting Protein Aggregates May Be Protective in Pmp22-Associated Peripheral Neuropathy

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Investigating the Association between Cigarette Smoking and Risk of Developing Schizophrenia in a Cohort Study

Stanley Zammit; Peter Allebeck; Christina Dalman; Ingvar Lundberg; Glyn Lewis

Clin Sci (Lond) (2003) 104 (s49): 41P.

View Articletitled, Investigating the Association between Cigarette Smoking and Risk of Developing Schizophrenia in a Cohort Study

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Emotional Memory in Depersonalisation Disorder: A Study Using fMRI

N. Medford; B. Brierley; M. Brammer; A.S. David; M.L. Phillips

Clin Sci (Lond) (2003) 104 (s49): 41P–42P.

View Articletitled, Emotional Memory in Depersonalisation Disorder: A Study Using fMRI

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Potentially Modifiable Correlates of Non-Adherence with Immunosuppressants following Renal Transplantation

J.A. Butler; R.C. Peveler; P.R. Roderick; R. Horne; J.C. Mason

Clin Sci (Lond) (2003) 104 (s49): 42P.

View Articletitled, Potentially Modifiable Correlates of Non-Adherence with Immunosuppressants following Renal Transplantation

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Does Liaison Psychiatry Improve the Cost-Effectiveness of Health Care Delivery to Depressed Elderly Medical Inpatients? A Randomised Controlled Trial and Cost-Effectiveness Analysis (work in Progress)

Sarah Cullum; Carol Brayne; Chris Todd

Clin Sci (Lond) (2003) 104 (s49): 42P.

View Articletitled, Does Liaison Psychiatry Improve the Cost-Effectiveness of Health Care Delivery to Depressed Elderly Medical Inpatients? A Randomised Controlled Trial and Cost-Effectiveness Analysis (work in Progress)

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Using Process and Outcome Information to Inform Mental Health Care

Mike Slade

Clin Sci (Lond) (2003) 104 (s49): 42P–43P.

View Articletitled, Using Process and Outcome Information to Inform Mental Health Care

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Characterisation of a Rare Inherited Disorder of Pain Sensation - Familial Rectal Pain

C R Fertleman; M Pollitzer; V Smith; P Anand

Clin Sci (Lond) (2003) 104 (s49): 43P.

View Articletitled, Characterisation of a Rare Inherited Disorder of Pain Sensation - Familial Rectal Pain

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A Novel Whole Blood Model to Investigate Immunogenicity of the BCG Vaccine in Neonates in a Tuberculosis-Endemic Setting in South Africa

Beate Kampmann; Gwen Tena; Shumikazi Mzazi; Mike Levin; Douglas Young

Clin Sci (Lond) (2003) 104 (s49): 43P.

View Articletitled, A Novel Whole Blood Model to Investigate Immunogenicity of the BCG Vaccine in Neonates in a Tuberculosis-Endemic Setting in South Africa

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Subcellular Targeting of Adenovirus Core Polypeptides Mu and VII

T.W.R. Lee; D.A. Matthews; G.E. Blair

Clin Sci (Lond) (2003) 104 (s49): 43P–44P.

View Articletitled, Subcellular Targeting of Adenovirus Core Polypeptides Mu and VII

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Computational Magnetic Resonance Image Processing Applied to the Developing Human Brain

J Boardman; D Rueckert; J Hajnal; Ms S Counsell; O Kapellou; Ms J Allsop; AD Edwards

Clin Sci (Lond) (2003) 104 (s49): 44P.

View Articletitled, Computational Magnetic Resonance Image Processing Applied to the Developing Human Brain

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Neural Differentiation of Fetal Mesenchymal Stem Cells

Nigel L. Kennea; Nicholas Fisk; A. David Edwards; Huseyin Mehmet

Clin Sci (Lond) (2003) 104 (s49): 44P.

View Articletitled, Neural Differentiation of Fetal Mesenchymal Stem Cells

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Treatment Decision-Making and Competence in Anorexia Nervosa

Jacinta O.A. Tan; Anne Stewart

Clin Sci (Lond) (2003) 104 (s49): 45P.

View Articletitled, Treatment Decision-Making and Competence in Anorexia Nervosa

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Autosomal Dominant Emery Dreifuss Muscular Dystrophy: Can Variation in Normal: Mutant mRNA Ratios Explain the Disease's Tissue Specificity and Variable Phenotypic Severity?

R. J. Piercy; M. Brockington; M. Vorgerd; F. Muntoni; S.C. Brown

Clin Sci (Lond) (2003) 104 (s49): 45P.

View Articletitled, Autosomal Dominant Emery Dreifuss Muscular Dystrophy: Can Variation in Normal: Mutant mRNA Ratios Explain the Disease's Tissue Specificity and Variable Phenotypic Severity?

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Profound Skeletal Muscle Depletion of α-Dystroglycan in Walker-Warburg Syndrome

Cecilia Jiménez-Mallebrera; Silvia Torelli; Susan C Brown; Lucy Feng; Martin Brockington; Caroline A Sewry; Daniel Beltrán-Valero de Bernabé; Francesco Muntoni

Clin Sci (Lond) (2003) 104 (s49): 45P.

View Articletitled, Profound Skeletal Muscle Depletion of α-Dystroglycan in Walker-Warburg Syndrome

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Rheumatology Training: A Trainees' Perspective

SG Dubcy; Roberts Chris; ML Snaith

Clin Sci (Lond) (2003) 104 (s49): 46P.

View Articletitled, Rheumatology Training: A Trainees' Perspective

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Treating Rheumatoid Tenosynovitis with Cytokine Inhibitors

Abhilash Jain; Fionula Brennan; Linda Troeberg; Jagdeep Nanchahal

Clin Sci (Lond) (2003) 104 (s49): 46P.

View Articletitled, Treating Rheumatoid Tenosynovitis with Cytokine Inhibitors

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Basic FGF Mediates ERK Activation in Articular Cartilage Explants upon Cyclical Loading

Tonia Vincent; Ulrich Hansen; Andrew Amis; Jeremy Saklatvala

Clin Sci (Lond) (2003) 104 (s49): 46P–47P.

View Articletitled, Basic FGF Mediates ERK Activation in Articular Cartilage Explants upon Cyclical Loading

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Expression and Function of Monocyte Chemoattractant Protein-3 (MCP-3) in Scleroderma

Voon H. Ong; Lowri A. Evans; Vineeth Rajkumar; XU Shiwen; David J. Abraham; Carol M. Black; Christopher P. Denton

Clin Sci (Lond) (2003) 104 (s49): 47P.

View Articletitled, Expression and Function of Monocyte Chemoattractant Protein-3 (MCP-3) in Scleroderma

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Relative Importance of Different Human aPL Derived Heavy and Light Chains in the Binding of aPL to Cardiolipin

Ian P. Giles, MRCP; Joanna Haley, BSc; Sylvia Nagl, PhD; David S. Latchman, DSc, FRCPath; Pojen P Chen, PhD; Reginald U. Chukwuocha, PhD; David A. Isenberg, MD, FRCP; Anisur Rahman, PhD, MRCP

Clin Sci (Lond) (2003) 104 (s49): 47P.

View Articletitled, Relative Importance of Different Human aPL Derived Heavy and Light Chains in the Binding of aPL to Cardiolipin

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The CD56^Bright Subset of NK Cells Is Greatly Expanded IN Inflammatory Synovial Fluid and Tissue

Dalbeth N; MFC Callan

Clin Sci (Lond) (2003) 104 (s49): 48P.

View Articletitled, The CD56Bright Subset of NK Cells Is Greatly Expanded IN Inflammatory Synovial Fluid and Tissue

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Differentiation of Antigen-Experienced CD4+ T Cells in Vivo

Elisabeth Amyes; Chris Hatton; Margaret Callan

Clin Sci (Lond) (2003) 104 (s49): 48P.

View Articletitled, Differentiation of Antigen-Experienced CD4+ T Cells in Vivo

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Phenotype and Influence of CD4+CD25+ T Cells in Inflammatory Arthritis

Anita Milicic; Andrew Loughry; Joseph Joseph; Frances Hall

Clin Sci (Lond) (2003) 104 (s49): 48P–49P.

View Articletitled, Phenotype and Influence of CD4+CD25+ T Cells in Inflammatory Arthritis

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Tolerance and Autoimmunity to Neoantigen Expressed in Retina

Janson C H Leung; Helen Ferry; Hui Rong Jiang; Tanya L Crockford; John V Forrester; John M Nickerson; Richard J Cornall

Clin Sci (Lond) (2003) 104 (s49): 49P.

View Articletitled, Tolerance and Autoimmunity to Neoantigen Expressed in Retina

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Phagocytosis of Apoptotic Cells is Impaired in the CD14 Knockout Mouse

Lucy A Truman; Kate Parker; Andrew Devitt; Christopher D Gregory

Clin Sci (Lond) (2003) 104 (s49): 49P.

View Articletitled, Phagocytosis of Apoptotic Cells is Impaired in the CD14 Knockout Mouse

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CD59 Deficiency Exacerbates Accelerated Nephrotoxic Nephritis

D. Turnberg; J. Warren; M. Botto; B. P. Morgan; M.J. Walport; H.T. Cook

Clin Sci (Lond) (2003) 104 (s49): 49P.

View Articletitled, CD59 Deficiency Exacerbates Accelerated Nephrotoxic Nephritis

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Both FcγRI and FcγRIII Mediate Disease in Nephrotoxic Nephritis

Ruth M Tarzi; Kevin A Davies; Jill WC Claassens; J Sjef Verbeek; Mark J Walport; H Terence Cook

Clin Sci (Lond) (2003) 104 (s49): 50P.

View Articletitled, Both FcγRI and FcγRIII Mediate Disease in Nephrotoxic Nephritis

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Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Induce Adhesion of Leucocytes to Endothelial Cells under Conditions of Flow

C.L. Smyth; C.D. Pusey; D.O. Haskard

Clin Sci (Lond) (2003) 104 (s49): 50P.

View Articletitled, Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Induce Adhesion of Leucocytes to Endothelial Cells under Conditions of Flow

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The Induction of Autoimmunity to MPO in WKY Rats Results in ANCA-Positive Small Vessel Vasculitis

C.L. Smyth; J. Smith; H.T. Cook; D.O. Haskard; C.D. Pusey

Clin Sci (Lond) (2003) 104 (s49): 50P–51P.

View Articletitled, The Induction of Autoimmunity to MPO in WKY Rats Results in ANCA-Positive Small Vessel Vasculitis

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Distinguishing Healthy and Diseased Cells: MHC Class I Homologues and their Receptors

CA O'Callaghan; JI Bell; SH Powis; LL Lanier; PJ Bjorkman

Clin Sci (Lond) (2003) 104 (s49): 51P.

View Articletitled, Distinguishing Healthy and Diseased Cells: MHC Class I Homologues and their Receptors

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Expression of MHC Class I Receptors Determines Natural Killer Cell Lysis of Vaccinia Virus Infected Cells

Salim Khakoo; Collin Brooks; Peter Parham; William MC Rosenberg

Clin Sci (Lond) (2003) 104 (s49): 51P.

View Articletitled, Expression of MHC Class I Receptors Determines Natural Killer Cell Lysis of Vaccinia Virus Infected Cells

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Clinical Evaluation of New Immunisation Strategies for Enhancing T Cell Responses against M. Tuberculosis

Helen McShane; Ansar Pathan; Nilu Goonetilleke; Roger Brookes; Adrian Hill

Clin Sci (Lond) (2003) 104 (s49): 51P.

View Articletitled, Clinical Evaluation of New Immunisation Strategies for Enhancing T Cell Responses against M. Tuberculosis

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Correlation of Cytotoxic Function with the Expression of Natural Killer (NK) Cell Markers: CD69, Killer Inhibitory Receptors (KIR2DL-p70/KIR2DS-p50), and Cytoplasmic Perforin and IFNγ

M Shamji; D.C. Henderson

Clin Sci (Lond) (2003) 104 (s49): 52P.

View Articletitled, Correlation of Cytotoxic Function with the Expression of Natural Killer (NK) Cell Markers: CD69, Killer Inhibitory Receptors (KIR2DL-p70/KIR2DS-p50), and Cytoplasmic Perforin and IFNγ

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Type 1 and 2 Cytokines in Myeloid and Lymphoid Cells of whole Blood: Healthy Blood is Dominated by IL-4 and IL-10 Whereas IL-12 and IFN-γ Predominate in Acute Myelogenous Leukaemia (AML)

Nicki Panoskaltsis; Stella C. Knight; Cecil D.L. Reid

Clin Sci (Lond) (2003) 104 (s49): 52P.

View Articletitled, Type 1 and 2 Cytokines in Myeloid and Lymphoid Cells of whole Blood: Healthy Blood is Dominated by IL-4 and IL-10 Whereas IL-12 and IFN-γ Predominate in Acute Myelogenous Leukaemia (AML)

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Type 1 and 2 Cytokine Production by Dendritic Cells (DC) Matured with Different Stimuli

Nicki Panoskaltsis; Cecil D.L. Reid; Stella C. Knight

Clin Sci (Lond) (2003) 104 (s49): 52P.

View Articletitled, Type 1 and 2 Cytokine Production by Dendritic Cells (DC) Matured with Different Stimuli

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Quantification and Cytokine Production of Circulating Lymphoid and Myeloid Cells in Acute Myelogenous Leukaemia (AML)

Nicki Panoskaltsis; Cecil D.L. Reid; Stella C. Knight

Clin Sci (Lond) (2003) 104 (s49): 53P.

View Articletitled, Quantification and Cytokine Production of Circulating Lymphoid and Myeloid Cells in Acute Myelogenous Leukaemia (AML)

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Dendritic Cells Derived from Acute Myelogenous Leukaemia (AML) Have a Type 2 Cytokine Bias

Nicki Panoskaltsis; Stella C. Knight; Cecil D.L. Reid

Clin Sci (Lond) (2003) 104 (s49): 53P.

View Articletitled, Dendritic Cells Derived from Acute Myelogenous Leukaemia (AML) Have a Type 2 Cytokine Bias

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Probiotic Bacteria Differentially Modulate the Maturation and Cytokine Expression of Human Dendritic Cells

A.L. Hart; M.A. Kamm; S.C. Knight; A. J. Stagg

Clin Sci (Lond) (2003) 104 (s49): 53P.

View Articletitled, Probiotic Bacteria Differentially Modulate the Maturation and Cytokine Expression of Human Dendritic Cells

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Infection of CD8 Lymphocytes with HIV in vivo

Alexandra Cochrane; Stuart Imlach; Ray Brettle; Clifford Leen; Gordon Scott; Peter Simmonds

Clin Sci (Lond) (2003) 104 (s49): 54P.

View Articletitled, Infection of CD8 Lymphocytes with HIV in vivo

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A Pilot Study of the Safety and Inununogenicity of An HIV-1 Clade a Gag/Multiepitope DNA Vaccine, pTHr.HIVA, in HIV-1 Seropositive Subjects Receiving Highly Active Antiretroviral Therapy

Lucy Dorrell; Hongbing Yang; Christopher Conlon; Annie Suttill; Mary Lancaster; Anne Edwards; Sarah Rowland-Jones; Tomas Hanke; Andrew McMichael

Clin Sci (Lond) (2003) 104 (s49): 54P.

View Articletitled, A Pilot Study of the Safety and Inununogenicity of An HIV-1 Clade a Gag/Multiepitope DNA Vaccine, pTHr.HIVA, in HIV-1 Seropositive Subjects Receiving Highly Active Antiretroviral Therapy

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A Role for HLA Class II in Determining Susceptibility to Streptococcal Toxic Shock

M Llewelyn; S Sriskandan; M Peakman; J Cohen; D Altmann

Clin Sci (Lond) (2003) 104 (s49): 54P–55P.

View Articletitled, A Role for HLA Class II in Determining Susceptibility to Streptococcal Toxic Shock

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The Synergistic up-Regulation of the Innate Immune Response by Endotoxin and Gram Positive Superantigens

Phil Hopkins; Shiranee Sriskandan

Clin Sci (Lond) (2003) 104 (s49): 55P.

View Articletitled, The Synergistic up-Regulation of the Innate Immune Response by Endotoxin and Gram Positive Superantigens

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The Role of Nitric Oxide and Vasp in Cytokine-Induced Renal Tubule Cell Shedding

Susan M. Crail; Thomas J. Evans

Clin Sci (Lond) (2003) 104 (s49): 55P.

View Articletitled, The Role of Nitric Oxide and Vasp in Cytokine-Induced Renal Tubule Cell Shedding

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Nitric Oxide and Carbon Monoxide: Pathogenic Factors in Human Septic Shock?

Michael C. Reade; J. Duncan Young; C.A.R. Boyd

Clin Sci (Lond) (2003) 104 (s49): 55P–56P.

View Articletitled, Nitric Oxide and Carbon Monoxide: Pathogenic Factors in Human Septic Shock?

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The Combined Chaperone and Adjuvant Functions of Mycobacterial HSP70 Are Essential for Generation of Human CTL

Babak Javid; Paul MacAry; Mahavir Singh; Paul J. Lehner

Clin Sci (Lond) (2003) 104 (s49): 56P.

View Articletitled, The Combined Chaperone and Adjuvant Functions of Mycobacterial HSP70 Are Essential for Generation of Human CTL

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Identification of Susceptibility Genes for Tuberculosis in Southern and West Africans Using Family-Based Linkage Analysis and Linkage Disequilibrium Mapping

Graham Cooke; Sarah Campbell; Richard Bellamy; Christian Lienhardt; Oumou Sow; Per Gustafson; Keith McAdm; Lifted Sichali; Lorren Mwaungulu; David Warndorff; Mia Crampin; Steve Chaguluka; Paul Fine; Nulda Beyers; Eileen Hoal-van Helden; Paul van Helden; Adrian Hill

Clin Sci (Lond) (2003) 104 (s49): 56P.

View Articletitled, Identification of Susceptibility Genes for Tuberculosis in Southern and West Africans Using Family-Based Linkage Analysis and Linkage Disequilibrium Mapping

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The Search for a Malaria Vaccine: Clinical Trials of DNA-MVA and other Prime-Boost Approaches

Clin Sci (Lond) (2003) 104 (s49): 56P–57P.

View Articletitled, The Search for a Malaria Vaccine: Clinical Trials of DNA-MVA and other Prime-Boost Approaches

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Targeting a Surface Cavity of α₁-Antitrypsin to Prevent Conformational Disease

Helen Parfrey; Neil Ravenhill; Ravi Mahadeva; Aiwu Zhou; Timothy R. Dafforn; Richard C. Foreman; David A. Lomas

Clin Sci (Lond) (2003) 104 (s49): 57P.

View Articletitled, Targeting a Surface Cavity of α1-Antitrypsin to Prevent Conformational Disease

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Alveolar Epithelial Re-Modelling in Acute Lung Injury

Gareth Clegg; David Harrison; Mary McElroy

Clin Sci (Lond) (2003) 104 (s49): 57P.

View Articletitled, Alveolar Epithelial Re-Modelling in Acute Lung Injury

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Intracellular Thioredoxin Mediates Inflammatory Activation of An Alveolar Epithelial Cell Lines through Effects on NF-κB

MEJ Calüster; GJ Quinlan; TW Evans; A Burke-Gaffney

Clin Sci (Lond) (2003) 104 (s49): 57P–58P.

View Articletitled, Intracellular Thioredoxin Mediates Inflammatory Activation of An Alveolar Epithelial Cell Lines through Effects on NF-κB

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Acceleration of Human Neutrophil Apoptosis by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Stephen A. Renshaw; Jasvir S Parmar; Vanessa Singleton; Sarah J. Rowe; Steven K. Dower; David H. Dockrell; Colin D. Bingle; Edwin R. Chilvers; Moira K.B. Whyte

Clin Sci (Lond) (2003) 104 (s49): 58P.

View Articletitled, Acceleration of Human Neutrophil Apoptosis by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

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The αvβ5 Integrin Induces Anoikis in Squamous Cell Carcinoma (SCC) cells by Activating the Intrinsic and Extrinsic Death Pathways and Inhibiting An Akt/PKB Survival Signal

S M Janes; F M Watt

Clin Sci (Lond) (2003) 104 (s49): 58P.

View Articletitled, The αvβ5 Integrin Induces Anoikis in Squamous Cell Carcinoma (SCC) cells by Activating the Intrinsic and Extrinsic Death Pathways and Inhibiting An Akt/PKB Survival Signal

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Transforming Growth Factor-β Activation is Diminished in Fibrosis-Resistant Neutrophil Elastase-Deficient Mice

Felix Chua; Sarah E. Dunsmore; Peter Clingen; Anthony W. Segal; Jurgen Roes; Geoffrey J. Laurent

Clin Sci (Lond) (2003) 104 (s49): 58P–59P.

View Articletitled, Transforming Growth Factor-β Activation is Diminished in Fibrosis-Resistant Neutrophil Elastase-Deficient Mice

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The Role of Effector T Cells in the Development of Pulmonary Fibrosis

HE Burgess; CM Lloyd

Clin Sci (Lond) (2003) 104 (s49): 59P.

View Articletitled, The Role of Effector T Cells in the Development of Pulmonary Fibrosis

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Wnt Signal Transduction in Adult Human Bronchial Epithelial Cells

MD Steel; DE Davies; SM Puddicombe; ST Holgate; JE Collins

Clin Sci (Lond) (2003) 104 (s49): 59P.

View Articletitled, Wnt Signal Transduction in Adult Human Bronchial Epithelial Cells

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Acetylcholine Stimulates Secretion of Chloride and Bicarbonate through Cystic Fibrosis Transmembrane Conductance Regulator in An Airway Epithelial Cell Line

Lisa Finlay; S. K. Inglis; S.M. Wilson; R.E. Olver

Clin Sci (Lond) (2003) 104 (s49): 59P–60P.

View Articletitled, Acetylcholine Stimulates Secretion of Chloride and Bicarbonate through Cystic Fibrosis Transmembrane Conductance Regulator in An Airway Epithelial Cell Line

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Phosphodiesterase 4D5 Expression in Human Airway Smooth Muscle Cells is Controlled by Cyclic AMP

I R Le Jeune; M D Houslay; I P Hall

Clin Sci (Lond) (2003) 104 (s49): 60P.

View Articletitled, Phosphodiesterase 4D5 Expression in Human Airway Smooth Muscle Cells is Controlled by Cyclic AMP

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A Pseudomonas Aeruginosa Exotoxin, Pyocyanin, Impairs Phagocytosis and Clearance of Apoptotic Cells

Stephen M Bianchi; LR Usher; DH Dockrell; GW Taylor; MKB Whyte

Clin Sci (Lond) (2003) 104 (s49): 60P.

View Articletitled, A Pseudomonas Aeruginosa Exotoxin, Pyocyanin, Impairs Phagocytosis and Clearance of Apoptotic Cells

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Agonist Action of “β-Blockers” Provide Evidence for Two Agonist Activation Sites on the Human β1-Adrenoceptor

Jillian G Baker; Ian P Hall; Stephen J Hill

Clin Sci (Lond) (2003) 104 (s49): 61P.

View Articletitled, Agonist Action of “β-Blockers” Provide Evidence for Two Agonist Activation Sites on the Human β1-Adrenoceptor

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Anti-Transforming Growth Factor-β2 Antibody (CAT-152) as a New Post-Operative Modulator of Scarring after Experimental Glaucoma Filtration Surgery

A.L. Mead; T.T.L. Wong; I.K. Anderson; M.F. Cordeiro; P.T. Khaw

Clin Sci (Lond) (2003) 104 (s49): 61P.

View Articletitled, Anti-Transforming Growth Factor-β2 Antibody (CAT-152) as a New Post-Operative Modulator of Scarring after Experimental Glaucoma Filtration Surgery

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Modulation of Matrix Metalloproteinases Controls Fibroblast Scarring Activity and Minimises Ocular Scarring following Experimental Surgery

Tina Wong; Julie Daniels; Anna Mead; Gill Murphy; Peng T. Khaw

Clin Sci (Lond) (2003) 104 (s49): 61P–62P.

View Articletitled, Modulation of Matrix Metalloproteinases Controls Fibroblast Scarring Activity and Minimises Ocular Scarring following Experimental Surgery

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Control of Choroidal Neovascularisation by Local Gene Transfer of Soluble VEGF Receptor sFlt-1

James WB Bainbridge; Ajay Mistry, PhD; Mahesh De Alwis; Adrian Thrasher; Robin R Ali

Clin Sci (Lond) (2003) 104 (s49): 62P.

View Articletitled, Control of Choroidal Neovascularisation by Local Gene Transfer of Soluble VEGF Receptor sFlt-1

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Dose-Response Functions for Occlusion Treatment of Amblyopia

Catherine E Stewart; Merrick Moseley; Alistair Fielder; David Stephens

Clin Sci (Lond) (2003) 104 (s49): 62P.

View Articletitled, Dose-Response Functions for Occlusion Treatment of Amblyopia

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A Population Based Case-Control Study of Cataract and Inhaled Corticosteroids

Liam Smeeth; Richard Hubbard

Clin Sci (Lond) (2003) 104 (s49): 62P–63P.

View Articletitled, A Population Based Case-Control Study of Cataract and Inhaled Corticosteroids

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Mortality Projections for Respiratory Disease in England and Wales Using a Bayesian age-Period-Cohort Model

A Hansell; L Knorr-Held; V Schmid

Clin Sci (Lond) (2003) 104 (s49): 63P.

View Articletitled, Mortality Projections for Respiratory Disease in England and Wales Using a Bayesian age-Period-Cohort Model

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Prevention of Adult Disease through Interventions in Early Life: A Systematic Review to Define Optimal Infant Growth

Janis Baird; Catherine Law; Jos Kleijnen; Helen Roberts

Clin Sci (Lond) (2003) 104 (s49): 63P.

View Articletitled, Prevention of Adult Disease through Interventions in Early Life: A Systematic Review to Define Optimal Infant Growth

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Poster withdrawn

Clin Sci (Lond) (2003) 104 (s49): 63P.

View Articletitled, Poster withdrawn

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Methodological Research to Enhance the Validity and Reliability of Group Decision-Making for Clinical Guideline Development

Rosalind Rainc; Nick Black; Tom Sensky

Clin Sci (Lond) (2003) 104 (s49): 64P.

View Articletitled, Methodological Research to Enhance the Validity and Reliability of Group Decision-Making for Clinical Guideline Development

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A Prospective Randomized Translational Study for the Molecular Individualization of Carboplatin and Paclitaxel Treatment of Advanced Epithelial Ovarian Cancer

Ahmed Ashour Ahmed; Charlie E Massie; James D Brenton

Clin Sci (Lond) (2003) 104 (s49): 64P.

View Articletitled, A Prospective Randomized Translational Study for the Molecular Individualization of Carboplatin and Paclitaxel Treatment of Advanced Epithelial Ovarian Cancer

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Differentiating Human Endometrial Cells Acquire Resistance to IFNγ Signalling: Role of the Progesterone Receptor (PR) and Protein Inhibitor of Activated Stat (PIASy)

Jan J Brosens; Georgia Zoumpoulidou; Mark Christian

Clin Sci (Lond) (2003) 104 (s49): 64P.

View Articletitled, Differentiating Human Endometrial Cells Acquire Resistance to IFNγ Signalling: Role of the Progesterone Receptor (PR) and Protein Inhibitor of Activated Stat (PIASy)

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Treatment, Immunological Changes and Pregnancy Outcome in HIV Infected Women

S Fiore; ML Newell; D Trabattoni; V Savasi; C Tibaldi; M Clerici

Clin Sci (Lond) (2003) 104 (s49): 65P.

View Articletitled, Treatment, Immunological Changes and Pregnancy Outcome in HIV Infected Women

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Inhalational Analgesia in Labour Using Sevoflurane

S. Yeo; A. Holdcroft; S. Yentis

Clin Sci (Lond) (2003) 104 (s49): 65P.

View Articletitled, Inhalational Analgesia in Labour Using Sevoflurane

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Therapeutic Inhibition of C-Reactive Protein-Novel Drugs, Novel Mechanisms

G M Hirschfield; M D Smith; S V Ley; S Kolstoe; D Thompson; S P Wood; M B Pepys

Clin Sci (Lond) (2003) 104 (s49): 65P–66P.

View Articletitled, Therapeutic Inhibition of C-Reactive Protein-Novel Drugs, Novel Mechanisms

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Phenotypic Analysis of a New Mouse Model for Genetic Deafness: “Hush Puppy”

Henry Pau; Helmut Fuchs; Martin Hrabe de Angelis; Karen P. Steel

Clin Sci (Lond) (2003) 104 (s49): 66P.

View Articletitled, Phenotypic Analysis of a New Mouse Model for Genetic Deafness: “Hush Puppy”

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Issues

Cover Image

Medical Research Society Meeting 5th February 2003

Communication