Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction
Vidya K. Nagalakshmi; Minghong Li; Soham Shah; Joseph C. Gigliotti; Alexander L. Klibanov; Frederick H. Epstein; Robert L. Chevalier; R. Ariel Gomez; Maria Luisa S. Sequeira-Lopez
Clin Sci (Lond) (2018) 132 (23): 2519–2545.
Cover ImageRegeneration of the renal vasculature after release of ureteral obstruction. This study by Nagalakshmi et al. shows that partial ureteral obstruction in neonatal mice leads to a significant loss of the renal vasculature, whereas release of obstruction results in remarkable regeneration of the renal arterial tree; for details, see pages 2519–2545 of Clinical Science volume 132, issue 23.