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June 2020
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Cover Image
Cover Image
Immunofluorescent staining in mouse tubular epithelial cells shows that KD025, the first-in-class ROCK2 selective inhibitor, decreased the TGF-β1-induced expression of fibronectin (green). In this issue of Clinical Science (volume 134, issue 12) You et al. demonstrate the therapeutic potential of ROCK2 inhibition by KD025 in the tubulointerstitial fibrosis.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Editorial
Adipose biology, cardiovascular, and cardiometabolic disease: novel insights and new targets for intervention
Clin Sci (Lond) (2020) 134 (12): 1473–1474.
Review Articles
Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets
Manal Muin Fardoun; Dina Maaliki; Nabil Halabi; Rabah Iratni; Alessandra Bitto; Elias Baydoun; Ali H. Eid
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Targeting mitochondrial fitness as a strategy for healthy vascular aging
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Perspective
SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure
Clin Sci (Lond) (2020) 134 (12): 1295–1300.
Commentaries
Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy
Clin Sci (Lond) (2020) 134 (12): 1301–1304.
Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers
Clin Sci (Lond) (2020) 134 (12): 1399–1401.
Impaired insulin exocytosis in chronic hepatitis C infection: contributory role of p38δ MAPK–protein kinase D–golgi complex axis
Clin Sci (Lond) (2020) 134 (12): 1449–1456.
Research Articles
The Krüppel-like factor 15-NFATc1 axis ameliorates podocyte injury: a novel rationale for using glucocorticoids in proteinuria diseases
Caoshuai Dou; Hong Zhang; Guibao Ke; Li Zhang; Zhiwen Lian; Xueqin Chen; Xingchen Zhao; Yuanhan Chen; Ruizhao Li; Jianchao Ma; Zhuo Li; Ting Lin; Wenjian Wang; Zhi ming Ye; Xinling Liang; Wei Shi; Bin Zhang; Shuangxin Liu
Clin Sci (Lond) (2020) 134 (12): 1305–1318.
TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling
Clin Sci (Lond) (2020) 134 (12): 1319–1331.
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells
Clin Sci (Lond) (2020) 134 (12): 1357–1376.
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
Simeng Liu; Zhimin Huang; Anna Tang; Xiaoqing Wu; Jeffrey Aube; Liang Xu; Changying Xing; Yufeng Huang
Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway
Clin Sci (Lond) (2020) 134 (12): 1457–1472.
Sphingosine-1-phosphate receptor modulator FTY720 attenuates experimental myeloperoxidase-ANCA vasculitis in a T cell-dependent manner
Luo-Yi Wang; Xiao-Jing Sun; Chen Wang; Su-Fang Chen; Zhi-Ying Li; Min Chen; Mark A. Little; Ming-Hui Zhao
Clin Sci (Lond) (2020) 134 (12): 1475–1489.
Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis
Clin Sci (Lond) (2020) 134 (12): 1521–1535.
Metformin alleviates hyperuricaemia-induced serum FFA elevation and insulin resistance by inhibiting adipocyte hypertrophy and reversing suppressed white adipose tissue beiging
Mengqi Su; Li Sun; Wenpeng Li; He Liu; Yang Liu; Ying Wei; Yue Yuan; Linqun Zheng; Shuangli Yin; Chenguang Dai; Chenyang Zhao; Zhenwei Pan; Yue Li
Clin Sci (Lond) (2020) 134 (12): 1537–1553.
DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways
Clin Sci (Lond) (2020) 134 (12): 1555–1572.