Skip Nav Destination
Issues
September 2020
-
Cover Image
Cover Image
Glomerular staining of synaptopodin, a podocyte protein, in db/H control mice. In this issue of Clinical Science (volume 134, issue 17) Toffoli et al. show that the protein TRAIL (TNF-related apoptosis-inducing ligand) increases the expression of synaptopodin in the db/db mouse, which is a model of diabetic nephropathy. Overall, in this study, TRAIL treatment ameliorated glomerular morphological changes and this was associated with a significant reduction of the TGF-beta1-induced epithelial-to-mesenchymal transition in vitro.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies
Danlin Liu; Gavin Richardson; Fehmi M. Benli; Catherine Park; João V. de Souza; Agnieszka K. Bronowska; Ioakim Spyridopoulos
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
The molecular mechanism of mechanotransduction in vascular homeostasis and disease
Clin Sci (Lond) (2020) 134 (17): 2399–2418.
Research Articles
Antiepileptic effects of long-term intracerebroventricular infusion of angiotensin-(1-7) in an animal model of temporal lobe epilepsy
Karina Pereira Gomes; Pedro Paulo Pereira Braga; Claudio Quintino de Lima, Jr; Poliana Peres Ghazale; Gustavo Rodrigues Pedrino; Elizabeth Pereira Mendes; Aline Priscila Pansani; Carlos Henrique Xavier; Carlos Henrique Castro; Diego Basile Colugnati
Clin Sci (Lond) (2020) 134 (17): 2263–2277.
DUSP12 protects against hepatic ischemia–reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo
Clin Sci (Lond) (2020) 134 (17): 2279–2294.
High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation
Clin Sci (Lond) (2020) 134 (17): 2295–2313.
TRAIL treatment prevents renal morphological changes and TGF-β-induced mesenchymal transition associated with diabetic nephropathy
Barbara Toffoli; Federica Tonon; Veronica Tisato; Andrea Michelli; Giorgio Zauli; Paola Secchiero; Bruno Fabris; Stella Bernardi
Clin Sci (Lond) (2020) 134 (17): 2337–2352.
Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation
Clin Sci (Lond) (2020) 134 (17): 2353–2368.
Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress
Joshua A. Beckman; Jiun-Ruey Hu; Shi Huang; Eric Farber-Eger; Quinn S. Wells; Thomas J. Wang; Robert E. Gerszten; Jane F. Ferguson
Clin Sci (Lond) (2020) 134 (17): 2369–2379.
AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle
Miao Chen; Caoyu Ji; Qingchen Yang; Shuya Gao; Yue Peng; Zhe Li; Xingyu Gao; Yaoting Li; Nan Jiang; Yubin Zhang; Xiaohong Bian; Caiping Chen; Kaidi Zhang; Daniel Sanchis; Fangrong Yan; Junmei Ye
Clin Sci (Lond) (2020) 134 (17): 2381–2398.
Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy
Di Zhao; Yanyan Zhao; Jiao Wang; Lina Wu; Yanling Liu; Shuiying Zhao; Feng Guo; Xiaojun Ma; Haohao Zhang; Zhizhen Li; Dongdong Meng; Lijun Xu; Lixia Zhang; Junqi Liu; Guijun Qin
Clin Sci (Lond) (2020) 134 (17): 2419–2434.
Corrections
Correction: Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission
Clin Sci (Lond) (2020) 134 (17): 2315–2317.
Correspondence
Using serpins cysteine protease cross-specificity to possibly trap SARS-CoV-2 Mpro with reactive center loop chimera
Clin Sci (Lond) (2020) 134 (17): 2235–2241.
