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Issues
September 2020
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In this issue of Clinical Science (volume 134, issue 18), Zhang, Wang and Huang et al. discuss how renal AdipoR1 hyperphosphorylation impairs adiponectin-mediated natriuresis and diuresis, leading to hypertension. Adiponectin receptor type 1 (AdipoR1, green) was expressed in all nephron segments, including the renal proximal tubule, at the apical and basolateral membranes, which is phosphorylated and desensitized by GRK4.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Commentaries
The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Research Articles
Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes
Hung-Tsung Wu; Lin Kang; Yu-Chu Su; Horng-Yih Ou; Fu-Yu Chan; Yi-Cheng Chen; Bing-Hua Su; Yi-Shiang Wang; Chao-Liang Wu; Ai-Li Shiau; Pensée Wu
Clin Sci (Lond) (2020) 134 (18): 2435–2445.
GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension
Yan Zhang; Shaoxiong Wang; Hefei Huang; Andi Zeng; Yu Han; Cindy Zeng; Shuo Zheng; Hongmei Ren; Yajing Wang; Yu Huang; Pedro A. Jose; Xin-Liang Ma; Chunyu Zeng; Ken Chen
Clin Sci (Lond) (2020) 134 (18): 2453–2467.
Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function
Clin Sci (Lond) (2020) 134 (18): 2469–2487.
Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model
Vianne Nsengiyumva; Smriti M. Krishna; Corey S. Moran; Joseph V. Moxon; Susan K. Morton; Michael W. Clarke; Sai-Wang Seto; Jonathan Golledge
Clin Sci (Lond) (2020) 134 (18): 2521–2534.
