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Cover ImageIn this issue of Clinical Science (volume 134, issue 18), Zhang, Wang and Huang et al. discuss how renal AdipoR1 hyperphosphorylation impairs adiponectin-mediated natriuresis and diuresis, leading to hypertension. Adiponectin receptor type 1 (AdipoR1, green) was expressed in all nephron segments, including the renal proximal tubule, at the apical and basolateral membranes, which is phosphorylated and desensitized by GRK4.Close Modal
In this Issue
Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Vascular toxicity associated with anti-angiogenic drugs
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes
Hung-Tsung Wu; Lin Kang; Yu-Chu Su; Horng-Yih Ou; Fu-Yu Chan; Yi-Cheng Chen; Bing-Hua Su; Yi-Shiang Wang; Chao-Liang Wu; Ai-Li Shiau; Pensée Wu
Clin Sci (Lond) (2020) 134 (18): 2435–2445.
GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension
Yan Zhang; Shaoxiong Wang; Hefei Huang; Andi Zeng; Yu Han; Cindy Zeng; Shuo Zheng; Hongmei Ren; Yajing Wang; Yu Huang; Pedro A. Jose; Xin-Liang Ma; Chunyu Zeng; Ken Chen
Clin Sci (Lond) (2020) 134 (18): 2453–2467.
Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function
Clin Sci (Lond) (2020) 134 (18): 2469–2487.
Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model
Vianne Nsengiyumva; Smriti M. Krishna; Corey S. Moran; Joseph V. Moxon; Susan K. Morton; Michael W. Clarke; Sai-Wang Seto; Jonathan Golledge
Clin Sci (Lond) (2020) 134 (18): 2521–2534.