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January 2020
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Cover Image
Cover Image
In this issue of Clinical Science (volume 134, issue 2) Chang et al. investigate how T-regulatory cells may suppress type 2 inflammation via eosinophil recruitment. This cover features a micro-CT scan of an eosinophilic chronic sinusitis mouse, showing abnormal sinonasal structure with swollen mucosa in the left nasal septum and ethmoid sinus and the empyema in left ethmoid sinus.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders
Clin Sci (Lond) (2020) 134 (2): 315–330.
Hypothesis
Double-stranded RNA and Toll-like receptor activation: a novel mechanism for blood pressure regulation
Clin Sci (Lond) (2020) 134 (2): 303–313.
Research Articles
Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women
Clin Sci (Lond) (2020) 134 (2): 87–101.
Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7
Qin Yang; Hai-Yong Chen; Jia-nan Wang; Huai-Qin Han; Ling Jiang; Wei-Feng Wu; Biao Wei; Li Gao; Qiu-ying Ma; Xue-qi Liu; Qi Chen; Jia-gen Wen; Juan Jin; Yan Huang; Wei-jian Ni; Tao-tao Ma; Jun Li; Xiao-Ming Meng
Clin Sci (Lond) (2020) 134 (2): 103–122.
Type 2 inflammation suppression by T-regulatory cells attenuates the eosinophil recruitment in mucosa of chronic sinusitis
Lihong Chang; Zhiyuan Wang; Shuaixiang Li; Xiaohong Chen; Xia Li; Jun Zhao; Xiaoping Lai; Jiancong Huang; Xifu Wu; Zizhen Huang; Joseph A. Bellanti; Song Guo Zheng; Gehua Zhang
Clin Sci (Lond) (2020) 134 (2): 123–138.
Transcriptome sequencing of circular RNA reveals a novel circular RNA-has_circ_0114427 in the regulation of inflammation in acute kidney injury
Clin Sci (Lond) (2020) 134 (2): 139–154.
SPZ1 promotes deregulation of Bim to boost apoptosis resistance in colorectal cancer
Xiao-Yu Liu; Chang-Bo Zheng; Teng Wang; Jian Xu; Meng Zhang; Ling-Shan Gou; Linfang Jin; Xiaowei Qi; Xianhai Zeng; Hongwen Li; Shuqi Qiu; Peng Zhang
Clin Sci (Lond) (2020) 134 (2): 155–167.
The TERT copy number gain is sensitive to telomerase inhibitors in human melanoma
Clin Sci (Lond) (2020) 134 (2): 193–205.
Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease
Peter Cuthbertson; Sam R. Adhikary; Nicholas J. Geraghty; Thomas V. Guy; Amirazin Hadjiashrafi; Stephen J. Fuller; Diane Ly; Debbie Watson; Ronald Sluyter
Clin Sci (Lond) (2020) 134 (2): 207–223.
IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease
Lauretta D. Low; Liangjian Lu; Chang-Yien Chan; Jinmiao Chen; Henry H. Yang; Hanry Yu; Caroline G.L. Lee; Kar-Hui Ng; Hui-Kim Yap
Clin Sci (Lond) (2020) 134 (2): 225–237.
Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D
Runa S.J. Lindblom; Gavin C. Higgins; Tuong-Vi Nguyen; Maryann Arnstein; Darren C. Henstridge; Cesare Granata; Matthew Snelson; Vicki Thallas-Bonke; Mark E. Cooper; Josephine M. Forbes; Melinda T. Coughlan
Clin Sci (Lond) (2020) 134 (2): 239–259.
Acute myeloid leukemia immune escape by epigenetic CD48 silencing
Zhiding Wang; Yang Xiao; Wei Guan; Mengzhen Wang; Jinghong Chen; Linlin Zhang; Yan Li; Qian Xiong; Hong Wang; Maoquan Wang; Yuyan Li; Na Lv; Yonghui Li; Lixin Wang; Li Yu
Clin Sci (Lond) (2020) 134 (2): 261–271.
SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels
Yanan Zhang; Zhongzhou Guo; Tongwei Wu; Jichen Liu; Bin Zhang; Wenyan Lai; Wenwei Tu; Zhigang Guo; Tiantian Luo
Clin Sci (Lond) (2020) 134 (2): 273–287.
Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia
Clin Sci (Lond) (2020) 134 (2): 289–302.
