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Issues
January 2021
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Cover Image
Cover Image
The cover of this issue of Clinical Science (volume 135, issue 1) features an image from Elgazzaz and Lazartigues' study on epigenetic modifications of the renin-angiotensin system in cardiometabolic diseases. It depicts protein interactions within the renin-angiotensin system components and their functional partners. (Figure created using STRING database v.11 accessed on 12/24/2020).
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases
Clin Sci (Lond) (2021) 135 (1): 1–17.
Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression
Clin Sci (Lond) (2021) 135 (1): 35–52.
Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease
Clin Sci (Lond) (2021) 135 (1): 109–126.
Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases
Clin Sci (Lond) (2021) 135 (1): 127–142.
Inflammation: a putative link between phosphate metabolism and cardiovascular disease
Clin Sci (Lond) (2021) 135 (1): 201–227.
The GCN5: its biological functions and therapeutic potentials
Clin Sci (Lond) (2021) 135 (1): 231–257.
Commentaries
The CAT-1 is out of the bag: endothelial Cationic Amino Acid Transporter-1 is a critical player in cardiorenal syndrome type 2
Clin Sci (Lond) (2021) 135 (1): 105–108.
DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway
Clin Sci (Lond) (2021) 135 (1): 161–166.
Research Articles
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
Mariana Rodrigues Davanso; Amanda Rabello Crisma; Tárcio Teodoro Braga; Laureane Nunes Masi; Cátia Lira do Amaral; Vinícius Nunes Cordeiro Leal; Dhêmerson Souza de Lima; Thiago Andrade Patente; José Alexandre Barbuto; Maria L. Corrêa-Giannella; Mario Lauterbach; Carl Christian Kolbe; Eicke Latz; Niels Olsen Saraiva Camara; Alessandra Pontillo; Rui Curi
Clin Sci (Lond) (2021) 135 (1): 19–34.
Role of endoplasmic reticulum stress in renal damage after myocardial infarction
Beatriz Delgado-Valero; Lucía de la Fuente-Chávez; Ana Romero-Miranda; María Visitación Bartolomé; Bunty Ramchandani; Fabián Islas; María Luaces; Victoria Cachofeiro; Ernesto Martínez-Martínez
Clin Sci (Lond) (2021) 135 (1): 143–159.
Changes in the expression and functional activities of Myosin II isoforms in human hyperplastic prostate
Weixiang He; Xiao Wang; Daxing Zhan; Mingzhou Li; Qian Wang; Jianmin Liu; Daoquan Liu; Xun Fu; Qiaofeng Qian; Yan Li; Ping Chen; Guang Zeng; Xinghuan Wang; Michael E. DiSanto; Xinhua Zhang
Clin Sci (Lond) (2021) 135 (1): 167–183.
Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids
Helena L. Fisk; Caroline E. Childs; Elizabeth A. Miles; Robert Ayres; Paul S. Noakes; Carolina Paras-Chavez; Ondrej Kuda; Jan Kopecký; Elie Antoun; Karen A. Lillycrop; Philip C. Calder
Clin Sci (Lond) (2021) 135 (1): 185–200.