Skip Nav Destination
Issues
December 2021
-
Cover Image
Cover Image
Augmentation of CCL5/CCR5 signaling in brown adipose tissue significantly suppresses BAT-mediated adaptive thermogenesis and energy expenditure via inhibiting AMPK-mediated lipolysis, and oxidative metabolism and further worsens the development of obesity and associated insulin resistance. Find out more in the study by Chan et al. in this issue of Clinical Science (volume 135, issue 24).
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
Sex differences in white adipose tissue expansion: emerging molecular mechanisms
Clin Sci (Lond) (2021) 135 (24): 2691–2708.
Asthma and obesity: endotoxin another insult to add to injury?
Nikita Lad; Alice M. Murphy; Cristina Parenti; Carl P. Nelson; Neil C. Williams; Graham R. Sharpe; Philip G. McTernan
Clin Sci (Lond) (2021) 135 (24): 2729–2748.
Research Articles
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease
Elisa Avolio; Michele Carrabba; Rachel Milligan; Maia Kavanagh Williamson; Antonio P. Beltrami; Kapil Gupta; Karen T. Elvers; Monica Gamez; Rebecca R. Foster; Kathleen Gillespie; Fergus Hamilton; David Arnold; Imre Berger; Andrew D. Davidson; Darryl Hill; Massimo Caputo; Paolo Madeddu
Clin Sci (Lond) (2021) 135 (24): 2667–2689.
Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats
Hui-Chun Huang; Ming-Hung Tsai; Ching-Chih Chang; Chon Kit Pun; Yi-Hsiang Huang; Ming-Chih Hou; Fa-Yauh Lee; Shao-Jung Hsu
Clin Sci (Lond) (2021) 135 (24): 2709–2728.
Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats
Sheon Mary; Philipp Boder; Giacomo Rossitto; Lesley Graham; Kayley Scott; Arun Flynn; David Kipgen; Delyth Graham; Christian Delles
Clin Sci (Lond) (2021) 135 (24): 2749–2761.
AT2R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet
Raquel González-Blázquez; Martín Alcalá; José Miguel Cárdenas-Rebollo; Marta Viana; Ulrike Muscha Steckelings; William A. Boisvert; Thomas Unger; María S. Fernández-Alfonso; Beatriz Somoza; Marta Gil-Ortega
Clin Sci (Lond) (2021) 135 (24): 2763–2780.
Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection
Martin Sebastian Winkler; Ralf Alexander Claus; Mareike Schilder; Stefan Pöhlmann; Sina M. Coldewey; Julian Grundmann; Torben Fricke; Onnen Moerer; Konrad Meissner; Michael Bauer; Heike Hofmann-Winkler; Markus H. Gräler
Clin Sci (Lond) (2021) 135 (24): 2781–2791.
Corrections
Correction: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS
Clin Sci (Lond) (2021) 135 (24): 2665.