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November 2022
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Cover Image
Cover Image
The cover of this issue of Clinical Science (volume 136, issue 22) features an image from Radnaa et al. featuring a reconstructed amnion membrane using WT (top panel) and p38 KO (bottom panel) AEC-RFP cells seeded onto Col-F labeled (green) nude membranes. Reconstructed amnion membranes were stained for Vimentin (yellow). DAPI (blue) shows the nuclei of amnion membrane cells. These reconstructed amnion membranes were used to study the EMT of two different genotypes of AEC cells.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
Non-invasive prenatal diagnosis (NIPD): how analysis of cell-free DNA in maternal plasma has changed prenatal diagnosis for monogenic disorders
Clin Sci (Lond) (2022) 136 (22): 1615–1629.
Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease
Clin Sci (Lond) (2022) 136 (22): 1631–1651.
Research Articles
Stress signaler p38 mitogen-activated kinase activation: a cause for concern?
Enkhtuya Radnaa; Lauren Richardson; Brett Goldman; Jared K. Burks; Tuvshintugs Baljinnyam; Natasha Vora; Hui-juan Zhang; Elizabeth A. Bonney; Arum Han; Ramkumar Menon
Clin Sci (Lond) (2022) 136 (22): 1591–1614.
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice
Hajed O. Alharbi; Michelle A. Hardyman; Joshua J. Cull; Thomais Markou; Susanna T.E. Cooper; Peter E. Glennon; Stephen J. Fuller; Peter H. Sugden; Angela Clerk
Clin Sci (Lond) (2022) 136 (22): 1661–1681.
CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2
Clin Sci (Lond) (2022) 136 (22): 1691–1710.
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling
Shuya Gao; Qingchen Yang; Zekun Liu; Weixian Kong; Jiawen Chen; Xie Li; Yue Peng; Mengmeng Bao; Xiaohong Bian; Yuexin Zhang; Qizhou Jiang; Zhe Li; Yubin Zhang; Fangrong Yan; Junmei Ye
Clin Sci (Lond) (2022) 136 (22): 1711–1730.
Commentaries
Quantifying muscle blood flow: a transformative breakthrough in the science of human exercise physiology
Clin Sci (Lond) (2022) 136 (22): 1653–1656.
