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Volume 136, Issue 4
February 2022
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    In this issue of Clinical Science (volume 136, issue 4), Liang et al. identify microbial metabolite butyrate as a novel mediator of macrophage-goblet cell crosstalk in Ulcerative colitis. The cover image features the representative immunohistochemically stained sections counterstained with Alcian blue, showing enhanced expression of SPDEF in mouse colon tissue after butyrate treatment.
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ISSN 0143-5221
EISSN 1470-8736
In this Issue

Research Articles

Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms
Lunbo Tan; Zhilong Chen; Fen Sun; Zhuoqun Zhou; Baozhen Zhang; Baobei Wang; Jie Chen; Mengxia Li; Tianxia Xiao; Rugina I. Neuman; Jianmin Niu; Koen Verdonk; Xifeng Lu; Jian V. Zhang; A.H. Jan Danser; Qing Yang; Xiujun Fan
Clin Sci (Lond) (2022) 136 (4): 257–272.
View Articletitled, Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms
Supplementary data
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Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway
Bohao Liu; Zhong Wang; Ruyuan He; Rui Xiong; Guorui Li; Lin Zhang; Tinglv Fu; Chenyuan Li; Ning Li; Qing Geng
Clin Sci (Lond) (2022) 136 (4): 273–289.
View Articletitled, Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway
Supplementary data
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Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway
Liping Liang; Le Liu; Wanyan Zhou; Chenghai Yang; Genghui Mai; Haolin Li; Ye Chen
Clin Sci (Lond) (2022) 136 (4): 291–307.
View Articletitled, Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway
Supplementary data
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Assessing hypothalamic pituitary gonadal function in reproductive disorders
Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by Angiotensin-(1-7)
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose
Circular RNAs and acute kidney injury: a Clinical Science commentary on Cao et al.
  • Online ISSN 1470-8736
  • Print ISSN 0143-5221

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