Issues

The cover of this issue of Clinical Science (vol 137, iss 2) features an image from the study by Ishida et al, ‘Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis’. Upper images show cigarette smoke extract induces oxidative damage of mitochondrial DNA. Theresultant cytosolic DNA evokes chronic inflammation via the cGAS-STING pathway, and mitochondrial cell-free DNA in plasma may be a promising new biomarker for atherosclerosis. Read more on pages 163–180.