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September 2024
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Cover Image
Cover Image
This cover of Clinical Science features representative images of immunohistology stained slides for pulmonary arteries from NC (Normal controls), NLFS (Normal lung function smokers), SAD (patients with small airway disease), COPD-CS (COPD-current smoker) and COPD-ES (COPD-ex-smoker) groups to show the drivers of EndMT in pulmonary arteries. Read more in ‘TGF?1, SMAD and β-catenin in pulmonary arteries of smokers, patients with small airway disease and COPD: potential drivers of EndMT’ by Sohal and colleagues on pp 1055–1070.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Research Articles
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate
Clin Sci (Lond) (2024) 138 (17): 1039–1054.
TGFβ1, SMAD and β-catenin in pulmonary arteries of smokers, patients with small airway disease and COPD: potential drivers of EndMT
Prem Bhattarai; Wenying Lu; Ashutosh Hardikar; Archana Vijay Gaikwad; Surajit Dey; Affan Mahmood Shahzad; Stephen Myers; Andrew Williams; Darren Sutherland; Gurpreet Kaur Singhera; Tillie-Louise Hackett; Mathew S. Eapen; Sukhwinder Singh Sohal
Clin Sci (Lond) (2024) 138 (17): 1055–1070.
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity
Anna Flavia R. Lima; Daniel Rodrigues; Mirele R. Machado; José Teles Oliveira-Neto; Alecsander F. M. Bressan; Carina A. Pedersoli; Juliano V. Alves; Júlio A. Silva-Neto; Paula R. Barros; Thiago B. Dias; Luis V. Garcia; Ariane Bruder-Nascimento; Thiago Bruder-Nascimento; Fernando S. Carneiro; Luiz Osório S. Leiria; Rita C. Tostes; Rafael M. Costa
Clin Sci (Lond) (2024) 138 (17): 1071–1087.
Candesartan restores blood–brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis
Clin Sci (Lond) (2024) 138 (17): 1089–1110.