Volume 52 Issue 2 | Clinical Science

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Medical Research Society Meeting Friday and Saturday, 10 and 11 December 1976

Symposium: Control of Circulation to the Tissues

A. Guz

Clin Sci Mol Med (1977) 52 (2): 1P.

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Communication

A Study of the Regional Oxygen Utilization: Blood Flow Relationships within the Brain of Controls and Neurological Patients by Non-Invasive Monitoring with Oxygen-15

T. Jones; G. L. Lenzi; D. J. Thomas; C. G. McKenzi; S. Moss

Clin Sci Mol Med (1977) 52 (2): 1P–2P.

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Subcutaneous Ancrod Therapy in Peripheral Arterial Disease: Improvement in Blood Viscosity and Nutritional Blood Flow

G. D. O. Lowe; J. J. Morrice; C. D. Forbes; C. R. M. Prentice; J. C. Barbenel

Clin Sci Mol Med (1977) 52 (2): 1P.

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Blood Flow in a Limb with a Tourniquet

L. Klenerman; J. C. W. Crawley

Clin Sci Mol Med (1977) 52 (2): 1P–2P.

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The Effects of Glyceryl Trinitrate and Isosorbide Dinitrate on Hand Vein Diameter and Left Ventricle Filling Pressure in Patients with Acute Myocardial Infarction

E. D. Bennett; A. Pullen; D. Robson

Clin Sci Mol Med (1977) 52 (2): 2P.

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Intracellular pH in Rat Cardiac and Skeletal Muscle in Acute and Chronic Respiratory Acidosis and Diabetic Ketoacidosis

N. T. Bateman; C. J. Fox; I. R. Cameron

Clin Sci Mol Med (1977) 52 (2): 2P.

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The Effects of Acidosis on Myocardial Function and the Uptake of Calcium during and after Hypoxia

P. A. Poole-Wilson; E. G. Lakatta; W. G. Nayler

Clin Sci Mol Med (1977) 52 (2): 2P–3P.

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Acute Myocardial Infarction Associated with Coxsackie Virus Infection

A. C. Nicholls; M. Thomas

Clin Sci Mol Med (1977) 52 (2): 3P.

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The Effect of SAR¹ ALA⁸ Angiotensin II on Basal and Stimulated Steroidogenesis in Isolated Rat Adrenal Glomerulosa Cells

R. F. Bing; D. Schulster; J. D. Swales

Clin Sci Mol Med (1977) 52 (2): 3P–4P.

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Aldosterone Response to Angiotensin II in the Dog: Effect of Changes in Sodium Balance

M. G. Nicholls; M. Tree; R. Fraser; J. J. Morton

Clin Sci Mol Med (1977) 52 (2): 4P.

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Effect of Angiotensin II on Plasma Levels of Corticosteroids and Acth in Man

P. F. Semple; P. A. Mason; J. C. Buckingham; R. Fraser

Clin Sci Mol Med (1977) 52 (2): 4P.

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Role of Angiotensin during Dietary Sodium Restriction in Normal Man

G. A. MacGregor; N. D. Markandu; T. Adam; V. H. T. James; G. A. Wilson

Clin Sci Mol Med (1977) 52 (2): 4P–5P.

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The Renin-Aldosterone System in Cirrhosis with Unimpaired Renal Function: Evidence for Increased Renal Tubular Sensitivity and Renin-Aldosterone Dissociation

S. P. Wilkinson; T. P. Jowett; I. K. Smith; J. Keenan; J. D. H. Slater; Roger Williams

Clin Sci Mol Med (1977) 52 (2): 5P.

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The Effect of Propranolol on the Response of Plasma Arginine Vasopressin and Plasma Renin to Orthostasis

R. Davies; Mary Forsling; J. D. H. Slater

Clin Sci Mol Med (1977) 52 (2): 5P–6P.

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The Role of the Central Nervous System and the Renin Angiotensin System in Renovascular Hypertension in the Rat

H. J. Dargie; J. L. Reid

Clin Sci Mol Med (1977) 52 (2): 6P.

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The Mechanism of Raised Intracellular Sodium in Fulminant Hepatic Failure

L. Poston; A. N. Alam; S. P. Wilkinson; C. Golindano; Roger Williams

Clin Sci Mol Med (1977) 52 (2): 6P.

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Plasma Levels of Short-Chain Fatty Acids and Bile Acids in Patients with Fulminant Hepatic Failure

J. C. K. Lai; B. Bron; D. B. A. Silk; Roger Williams

Clin Sci Mol Med (1977) 52 (2): 6P–7P.

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Modification of Liver Regeneration by Ammonia and Short-Chain Fatty Acids

W. R. Ellis; P. K. Chu; Iain M. Murray-Lyon

Clin Sci Mol Med (1977) 52 (2): 7P.

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Pharmacokinetics of ¹⁴C-Cholylglycine Uptake by the Liver in Man

I. T. Gilmore; S. Beresford; R. P. H. Thompson

Clin Sci Mol Med (1977) 52 (2): 7P.

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Changes in Rat Bile Amino Acid Concentrations following Exposure to Oral Oxytetracycline, Phenobarbitone and Paracetamol

C. W. I. Owens; Z. P. Albuquerque

Clin Sci Mol Med (1977) 52 (2): 7P–8P.

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Alterations in Hepatic Metabolism of Isoniazid and Acetanilid with Increasing Age and in Liver Disease

O. James; M. Rawlins; Fatima Farah; Wendy Taylor

Clin Sci Mol Med (1977) 52 (2): 8P.

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Hepatic Mitochondrial Enzyme Changes in Alcoholics

W. J. Jenkins; T. J. Peters; C. C. Booth

Clin Sci Mol Med (1977) 52 (2): 8P.

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Metabolic Studies in Thyroid Disease before and after Treatment

J. Saunders; S. E. H. Hall; P. H. Sönksen

Clin Sci Mol Med (1977) 52 (2): 8P–9P.

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Erythrocyte Carbonic Anhydrase I in Thyroid Disease and Pregnancy

D. V. Morris; J. Auton; J. M. Barragry; N. Carter; R. D. Cohen

Clin Sci Mol Med (1977) 52 (2): 9P.

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Thyroid Radiation Protection during Investigations Involving the Administration of Radioiodine-Labelled Pharmaceuticals

R. Wootton; B. J. Hammond

Clin Sci Mol Med (1977) 52 (2): 9P–10P.

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Integrated Concentrations of Growth Hormone, Prolactin, Insulin and Glucose in Normal Subjects

P. Daggett; S. J. G. Semple

Clin Sci Mol Med (1977) 52 (2): 10P.

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Growth Hormone Response to Insulin Induced Hypoglycaemia in Alcoholics

R. J. Chalmers; E. H. Bennie; R. H. Johnson; H. G. Kinnell

Clin Sci Mol Med (1977) 52 (2): 10P.

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The Nature of the Inhibitor Mediating the Refractory Period of Hormone Action on Lipolysis in Rat Adipose Tissue

D. J. Galton; R. D. Cohen

Clin Sci Mol Med (1977) 52 (2): 10P–11P.

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Response to Stimulatory and Inhibitory Tests of Antidiuretic Hormone Release in Diabetes Insipidus

P. H. Baylis; D. A. Heath

Clin Sci Mol Med (1977) 52 (2): 11P.

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Plasma Exchange in Severe Myasthenia Gravis

A. J. Pinching; D. K. Peters; J. Newsom Davis

Clin Sci Mol Med (1977) 52 (2): 11P.

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The Refractory Period after Exercise Induced Asthma

A. T. Emunds; M. Tooley; S. Godfrey

Clin Sci Mol Med (1977) 52 (2): 11P.

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Hypertestosteronaemia: A Reversible Abnormality in Men with Coeliac Disease

J. R. B. Green; H. L. Goble; C. R. W. Edwards; A. M. Dawson

Clin Sci Mol Med (1977) 52 (2): 12P.

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Hypoxic Vasoconstriction in Chronic Airways Obstruction

Noemi M. Eiser; Hazel A. Jones; J. M. B. Hughes

Clin Sci Mol Med (1977) 52 (2): 12P.

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Evaluation of the Occlusion Pressure Response to Hypercapnia

N. N. Stanley

Clin Sci Mol Med (1977) 52 (2): 12P.

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The Effect of Resistive Loading upon the Ventilatory Tidal Volume and Frequency Response to Inhaled Co₂

J. R. W. Lyall; I. R. Cameron

Clin Sci Mol Med (1977) 52 (2): 13P.

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Drive and Timing Components of Ventilation in Isoxic Steady State Co₂ Responses, Exercise and Progressive Hypoxia in Normal Man

D. C. Flenley; P. K. Wraith; A. G. Leitch; H. M. Brash

Clin Sci Mol Med (1977) 52 (2): 13P.

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The Resting Reflex Hypoxic Drive to Respiration in Normal Man

R. A. Stockley

Clin Sci Mol Med (1977) 52 (2): 13P–14P.

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Use of Diazepam to Relieve Breathlessness in the ‘Pink Puffer’ Syndrome

A. Guz; P. Mitchell-Heggs; K. Murphy; S. Patterson; M. Peat; P. R. W. Tasker

Clin Sci Mol Med (1977) 52 (2): 14P.

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The Aetiology of Gastric Cancer in Pernicious Anaemia

W. S. J. Ruddell; E. S. Bone; C. L. Walters

Clin Sci Mol Med (1977) 52 (2): 14P–15P.

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Pepsin 1 Secretion, Cigarette Smoking, and Chronic Peptic Ulceration

Valerie Walker; W. H. Taylor

Clin Sci Mol Med (1977) 52 (2): 15P.

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Adaptive Response of the Rat Colon to Bile Acids after Ileectomy

J. H. B. Scarpfllo; B. A. Cary; G. E. Sladen

Clin Sci Mol Med (1977) 52 (2): 15P.

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Gastrointestinal and Islet Hormones in the Migraine Syndrome

J. C. McLoughlin; K. D. Buchanan

Clin Sci Mol Med (1977) 52 (2): 15P–16P.

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Impaired Secretin Release in Coeliac Disease

F. A. O'Connor; J. C. McLoughlin; K. D. Buchanan

Clin Sci Mol Med (1977) 52 (2): 16P.

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Subcellular Distribution of Di- and Tri-Peptidase in Human Jejunum

J. A. Nicholson; T. J. Peters; C. C. Booth

Clin Sci Mol Med (1977) 52 (2): 16P.

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Effect of Long-Term Haemodialysis on the Duration of Ankle Reflex: Further Evidence That Haemodialysis May Cause Hypothyroidism

D. Newton; D. Betts; P. Dandona; M. M. Platts; P. Moorhead; N. McIntyre

Clin Sci Mol Med (1977) 52 (2): 16P–17P.

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Some Results Obtained by Measuring Protein Turnover with [¹⁵N]glycine as Tracer and Urinary Ammonia as End-Product

J. C. Waterlow; P. J. Garlick; S. Ell; P. J. Reeds

Clin Sci Mol Med (1977) 52 (2): 17P.

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Increased Ratio of Type III to Type I Collagen in Skin of Patients with Osteogenesis Imperfecta

B. Sykes; M. J. O. Francis; R. Smith

Clin Sci Mol Med (1977) 52 (2): 17P.

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Urine 3-Methyl Histidine in Man as a Measure of Muscle Protein Catabolism after Injury

D. H. Williamson; Rose Farrell; Alison Kerr; R. Smith

Clin Sci Mol Med (1977) 52 (2): 17P–18P.

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Serial Measurements of Plasma Proteins for Monitoring Patients with Carcinoma of the Lung

A. R. Bradwell; D. Burnett; C. Ford; C. Newman; R. Hoffenberg

Clin Sci Mol Med (1977) 52 (2): 18P.

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N5-Methyltetrahydrofolate-Homocysteine Methyl-Transferase in Tumour Tissues

A. J. Gulya; R. L. Woods; J. S. Tobias; M. H. N. Tattersall; W. A. Seed

Clin Sci Mol Med (1977) 52 (2): 18P.

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Abnormal Low-Density Lipoprotein Composition in Familial Hyper-Cholesterolaemia

A. V. Jadhav; G. R. Thompson

Clin Sci Mol Med (1977) 52 (2): 18P–19P.

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The Effect of Serum, Lipid-Free Serum and High-Density Lipoprotein on Sterol Synthesis in Cultured Arterial Smooth Muscle Cells

R. W. Stout

Clin Sci Mol Med (1977) 52 (2): 19P.

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Sequential Measurement of Plasma Catecholamines and Dopamine-β-Hydroxylase (DBH) in Patients Who Have Undergone Corrective Surgery for Coarctation of the Aorta

C. R. Benedict; D. G. Grahame-Smith; A. Fisher

Clin Sci Mol Med (1977) 52 (2): 19P–20P.

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Plasma Noradrenaline and Selective Venous Sampling in the Diagnosis of Phaeochromocytoma

D. H. Jones; J. L. Reid; C. A. Hamilton; D. J. Allison

Clin Sci Mol Med (1977) 52 (2): 20P.

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Increased Urinary Dopamine in Salt Loaded Rats

S. G. Ball; M. R. Lee

Clin Sci Mol Med (1977) 52 (2): 20P–21P.

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Measurement of Rectal Potential Difference: Effects of Amiloride and Spironolactone in Man

F. I. Mohamed; P. McSorley; A. Polak; B. Parsons

Clin Sci Mol Med (1977) 52 (2): 21P.

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Evidence for a Reduction in Interstitial Space Compliance following Plasma Volume Expansion in Human Essential Hypertension: A Factor Controlling the Distribution of a Saline Load

A. J. S. Brain; J. Lucas; M. A. Floyer

Clin Sci Mol Med (1977) 52 (2): 21P.

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Forearm Venous Tone in Normal Subjects with Salt and Water Depletion and Retention

D. J. McHaffie; A. Guz

Clin Sci Mol Med (1977) 52 (2): 21P–22P.

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Cerebral Oedema in an Experimental Model of Fulminant Hepatic Failure: Effect of Corticosteroids

A. Hanid; R. L. Mackenzie; P. J. Mellon; M. Davis; Roger Williams

Clin Sci Mol Med (1977) 52 (2): 22P.

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Effect of Nitrazepam on Blood Gases and Ventilatory Response to co₂ in Paltients with Chronic Bronchitis

M. Rudolf; D. M. Geddes; J. A. McM. Turner; K. B. Saunders

Clin Sci Mol Med (1977) 52 (2): 22P–23P.

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The Effect of Insulin on the Metabolism of the Perfused in Situ Rat Lung

W. A. Stubbs; I. Morgan; K. G. M. M. Alberti

Clin Sci Mol Med (1977) 52 (2): 23P.

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Glucose Control of Secretin in Health and Diabetes

K. D. Buchanan; E. R. Trimble; R. W. Henry; J. C. McLouchlin

Clin Sci Mol Med (1977) 52 (2): 23P.

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The Effect of Insulin on Plasma 3-Hydroxybutyrate and Cyclic Amp Response to Glucagon in Diabetes

R. S. Elkeles; J. Hambley; P. G. Frost

Clin Sci Mol Med (1977) 52 (2): 23P–24P.

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Comparison of Treatment of Mild Diabetes with a Basal Insulin Supplement or Sulphonylurea

R. R. Holman; E. Harris; P. Harding; R. C. Turner

Clin Sci Mol Med (1977) 52 (2): 24P.

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Attempted Beta Cell Salvage by a Regular Meal/Insulin Infusion Regime in New Severe Ketotic Diabetics

R. C. Turner; R. R. Holman

Clin Sci Mol Med (1977) 52 (2): 24P.

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Long-Term Study of Nerve Conduction Velocity in Streptozotocin-Diabetic Rats

C. Fox; C. Lowy; P. H. Sönksen

Clin Sci Mol Med (1977) 52 (2): 24P.

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Blood Viscosity and Metabolic Control in Diabetes Mellitus

A. J. Barnes; P. Locke; T. L. Dormandy; J. A. Dormandy

Clin Sci Mol Med (1977) 52 (2): 24P–25P.

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Transient Glucose Intolerance in the Intensive Care Patient

D. B. McWilliam; E. Sherwood Jones

Clin Sci Mol Med (1977) 52 (2): 25P.

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Prostaglandins (Pgs) in Intrinsic Bronchial Asthma

M. E. Conolly; A. R. Brash; J. K. Greenacre

Clin Sci Mol Med (1977) 52 (2): 25P–26P.

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The Regional Pulmonary Distribution of Inhaled Krypton-81M in Normal and Emphysematous Subjects at Rest and during Exercise

D. C. S. Hutchison; M. B. Clarke; D. E. Dowd; J. M. Reed; T. Stokes

Clin Sci Mol Med (1977) 52 (2): 26P.

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The Effect of Lung Function and Mode of Inhalation on Penetration of Aerosol into the Human Lung

D. Pavia; M. L. Thomson; S. W. Clarke; H. S. Shannon

Clin Sci Mol Med (1977) 52 (2): 26P–27P.

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Changes Suggesting Emphysema in Heterozygotes for Alpha₁-Antitrypsin Deficiency

S. F. Tattersall; D. M. Hunter; G. Blundell; N. B. Pride

Clin Sci Mol Med (1977) 52 (2): 27P.

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The Relative Distribution of Airflow Resistance in Normal Subjects and Patients with Airway Obstruction

A. Kanbour; N. J. Douglas; M. F. Sudlow; D. C. Flenley

Clin Sci Mol Med (1977) 52 (2): 27P.

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Single Breath Washouts in Exercise-Induced Asthma

Malcolm Green; N. McC. Schofield; R. J. Davies

Clin Sci Mol Med (1977) 52 (2): 27P–28P.

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Beta Agonist Resistance in Human Bronchial Muscle

C. Davis; M. E. Conolly

Clin Sci Mol Med (1977) 52 (2): 28P.

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Partial Characterization, and Mechanisms of Action of Nephritic Factor

J. G. P. Sissons; H. Amos; D. K. Pfters

Clin Sci Mol Med (1977) 52 (2): 28P.

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Plasma Exchange in Management of Crescentic Nephritis

C. M. Lockwood; A. J. Rees; B. Pussell; D. K. Peters

Clin Sci Mol Med (1977) 52 (2): 28P–29P.

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Vitamin D Deficiency in the Osteomalacia of Chronic Renal Failure

J. B. Eastwood; E. Harris; T. C. B. Stamp; H. E. de Wardener

Clin Sci Mol Med (1977) 52 (2): 29P.

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A Therapeutic Advantage of 1α-Hydroxylated Compounds over Vitamin D

J. A. Kanis; G. Heynen; R. G. G. Russell; R. Smith; R. J. Walton

Clin Sci Mol Med (1977) 52 (2): 29P.

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Serum 24,25-Dihydroxycholecalciferol Levels in Primary Hyperparathyroidism

Carol M. Taylor; S. W. Stanbury

Clin Sci Mol Med (1977) 52 (2): 29P–30P.

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1-α-Hydroxycholecalciferol in Patients with Renal Osteodystrophy

A. M. Brownjohn; S. E. Papapoulos; F. J. Goodwin; W. Hately; F. P. Marsh; J. L. H. O'Riordan

Clin Sci Mol Med (1977) 52 (2): 30P.

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The Relationship between Alkaline Phosphatase and Pentose Shunt Activities of Periosteal Cells in Healing Fractures

Jane Dunham; R. G. Shedden; A. Catterall; Lucille Bitensky; J. Chayen

Clin Sci Mol Med (1977) 52 (2): 30P.

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Platelet Depletion in Nephrotoxic Nephritis

M. Sindrey; T. L. Marshall; P. Naish

Clin Sci Mol Med (1977) 52 (2): 30P–31P.

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The Action of Neutrophil Proteases on Human Glomerular Basement Membrane

M. Davies; E. Sanders; G. A. Coles

Clin Sci Mol Med (1977) 52 (2): 31P.

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Phenylbutazone Induced Granulocytopenia

Susan Chinn; Christine Smith; R. W. E. Watts

Clin Sci Mol Med (1977) 52 (2): 31P.

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Migration of Human Lymphocytes in the Mouse

K. Morgan; P. J. L. Holt

Clin Sci Mol Med (1977) 52 (2): 31P–32P.

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A Defect in the Regulation of Isoprenoid Synthesis in Leucocytes of Patients with Acute Myeloblastic Leukaemia

D. J. Betteridge; D. J. Galton

Clin Sci Mol Med (1977) 52 (2): 32P.

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The Effect of Exercise upon Platelet MAOB Activity

Marek Gawel; Vivette Glover; D. Park; F. Clifford Rose; M. Sandler

Clin Sci Mol Med (1977) 52 (2): 32P.

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Studies of Horse and Human Spleen Ferritin Using Electron Spin Resonance Spectroscopy

M. J. Leyland; N. G. Hargreaves; R. C. Connolly; P. Brown; L. H. Sutcliffe; A. J. Bellingham

Clin Sci Mol Med (1977) 52 (2): 32P–33P.

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Editorial: Controversy in Clinical Science

High Arterial Pressure versus Humoral Factors in the Pathogenesis of the Vascular Lesions of Malignant Hypertension the Case for Pressure Alone

L. J. Beilin; F. S. Goldby

Clin Sci Mol Med (1977) 52 (2): 111–117.

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Articles

Lack of Dependence of Urine P_co₂ upon Reduction of Glomerular Filtration Rate in Alkalotic Dogs

B. J. Stinebaugh; T. H. Hostetter; R. A. Peraino; F. X. Schloeder; W. N. Suki

Clin Sci Mol Med (1977) 52 (2): 119–123.

Abstract

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Effects of Metabolic Alkalosis, Metabolic Acidosis and Uraemia on Whole-Body Intracellular pH in Man

A. Tizianello; G. De Ferrari; G. Gurreri; N. Acquarone

Clin Sci Mol Med (1977) 52 (2): 125–135.

Abstract

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Effect of Pentobarbitone Sodium on Serum Creatine Kinase of Normal and Dystrophic Hamsters

J. S. Neerunjun; V. Dubowitz

Clin Sci Mol Med (1977) 52 (2): 137–142.

Abstract

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Epitaxial Relationships in Urolithiasis: The Brushite—Whewellite System

J. L. Meyer; J. H. Bergert; L. H. Smith

Clin Sci Mol Med (1977) 52 (2): 143–148.

Abstract

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Inhibition of Frusemide-Induced Natriuresis by Indomethacin in Patients with the Nephrotic Syndrome

R. G. W. L. Tiggeler; R. A. P. Koene; P. G. A. B. Wijdeveld

Clin Sci Mol Med (1977) 52 (2): 149–151.

Abstract

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Resolution of Hypoxic Changes in the Heart and Pulmonary Arterioles of Rats during Intermittent Correction of Hypoxia

Enid Leach; P. Howard; R. Barer Gwenda

Clin Sci Mol Med (1977) 52 (2): 153–162.

Abstract

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The Course of Arterial Pressure and the Effect of Sarxd¹-Thr⁸-Angiotensin II in a New Model of Two-Kidney Hypertension in Conscious Dogs

Z. Masaki; C. M. Ferrario; F. M. Bumpus; E. L. Bravo; M. C. Khosla

Clin Sci Mol Med (1977) 52 (2): 163–170.

Abstract

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Comparison of the Effect of Two Groups of Diuretics on Renin Secretion in the Anaesthetized Dog

J. L. Imbs; M. Schmidt; J. Velly; J. Schwartz

Clin Sci Mol Med (1977) 52 (2): 171–182.

Abstracts

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The Development of a Radioimmunoassay Procedure for the Estimation of Tamm—Horsfall Glycoprotein in Human Serum

P. J. G. Avis

Clin Sci Mol Med (1977) 52 (2): 183–191.

Abstract

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Metabolism of Intravenously Administered Dipeptides in Rats: Effects on Amino Acid Pools, Glucose Concentration and Insulin and Glucagon Secretion

S. A. Adibi; B. A. Krzysik; A. L. Drash

Clin Sci Mol Med (1977) 52 (2): 193–204.

Abstract

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Effect of Nephrectomy and Enterectomy on Plasma Clearance of Intravenously Administered Dipeptides in Rats

S. A. Adibi; B. A. Krzysik

Clin Sci Mol Med (1977) 52 (2): 205–213.

Abstract

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Short Communication

The Forms of Vitamin B₁₂ on the Transcobalamins

Caroline M. L. A. MacDonald; J. Farquharson; R. G. Bessent; J. F. Adams

Clin Sci Mol Med (1977) 52 (2): 215–218.

Abstract

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Accentuation of Ethanol-Induced Fatty Liver by Phenobarbitone

A. R. Marsh; H. S. Fraser; A. Breckenridge; B. Lewis; G. R. Thompson

Clin Sci Mol Med (1977) 52 (2): 219–222.

Abstract

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Issues

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Medical Research Society Meeting Friday and Saturday, 10 and 11 December 1976

Symposium: Control of Circulation to the Tissues

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Editorial: Controversy in Clinical Science

Articles

Short Communication

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