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Medical Research Society Meeting 7 and 8 July 1988

Communication

A Novel Unidirectional Pathway for Intrahepatic Cholesterol Transport, and its Derangement in Cholesterol Cholelithiasis

JM Graham; H Ahmed; TC Northfield

Clin Sci (Lond) (1988) 75 (s19): 1P.

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The Effect of Hydrocortisone, Indomethacin and 5 Aminosalicylic Acid (5 ASA) on γ-Interferon(γ-IFN) Induced HLA-DR Expression on a Colonic Epithelial Cell Line

J.R. Lowes; P. Radwan; J.D. Priddle; D.P. Jewell

Clin Sci (Lond) (1988) 75 (s19): 1P.

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Induction of Early Atherosclerosis by Perivascular Manipulation

J.F. Martin; A.C. Honey; D.G. Hassall; S. Moncada; R.F.G. Booth

Clin Sci (Lond) (1988) 75 (s19): 1P.

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Enhanced Production of Tumour Necrosis Factor by Pulmonary Alveolar MacRophages in Sarcoidosis and Tuberculosis

NM Foley; AB Millar; GAW Rook; NMcI Johnson

Clin Sci (Lond) (1988) 75 (s19): 2P.

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Tropical Spastic Paraparesis & HTLV-1: Viral Prevalence among Relatives of UK Patients in Britain & Jamaica

JK Cruickshank; J Porter; P Klenerman; J Knight; O. Morgan; A Newell; AG Dalgleish; J Richardson; C. McManus; P Rudge

Clin Sci (Lond) (1988) 75 (s19): 2P.

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Intermittent Measurements of FEV₁ are not Adequate to Follow Changes in Pulmonary Resistance Raised by Methacholine During Chemically-Stimulated Breathing

R Lane; S Freedman; A Guz

Clin Sci (Lond) (1988) 75 (s19): 2P.

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Ventilatory Responses to Added Deadspace during Sleep in Normal Men

J Stradling; M Clarke; A Warley

Clin Sci (Lond) (1988) 75 (s19): 2P–3P.

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The Defence of Tidal Volume by Asthmatic Athletes during Endurance Running

W Freeman; MGL Nute; C Williams

Clin Sci (Lond) (1988) 75 (s19): 3P.

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Membrane Lipids and Leucocyte Ionised Calcium in Atopic Asthma

IK Taylor; GC Booth; P Ebden; JB Cookson; RF Bing

Clin Sci (Lond) (1988) 75 (s19): 3P.

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Changes in Cardiac Output and Peripheral Vascular Resistance during Weight Training in Athletes

LO Hughes; Mary E Heber; H Harries; A Lahiri; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 3P.

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Effects of Combined Beta Blockade and Calcium Antagonists on Myocardial Ischaemia and Ventricular Function in Stable Angina

EA Rodrigues; ADB Hains; A Lahiri; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 4P.

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Intracellular Metabolic Abnormalities in Cardiac Muscle in Impaired Glucose Tolerance

DA Robertson; EJ Flint; K Falholt; LG Heding; M Nattrass

Clin Sci (Lond) (1988) 75 (s19): 4P.

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Effects of Temperature and Experimental Conditions on Responses of Perfused and Superfused Myocardium to Alpha-Adrenoceptor Stimulation

N.A. Flores; D.J. Sheridan

Clin Sci (Lond) (1988) 75 (s19): 4P.

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Effects of Atrial Natriuretic Peptide on the Systemic Haemodynamics and Cardiac Function in Normal Man

MJ Allen; SM Gilmour; ED Bennett

Clin Sci (Lond) (1988) 75 (s19): 4P–5P.

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Arterial Blood Row during Valsalvas Manoeuvre: Analysis by Computer Assisted Doppler Ultrasound

J N W West; M S Salih; W A Littler

Clin Sci (Lond) (1988) 75 (s19): 5P.

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Mitral Rexlurgitation Assessed by Comparioon of Ejection Fraction with Forward Flow

MN Wiseman; R Sobnack; LJ Dyke; T Crowther; KE Britton; DS Dymond

Clin Sci (Lond) (1988) 75 (s19): 5P.

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The use of Dobutamine to Determine Functional Cardiac Reserve in Heart Failure

RJI Bain; LB Tan; MK Davies; RG Murray; WA Littler

Clin Sci (Lond) (1988) 75 (s19): 5P.

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Measurement of Right Ventricular Dimensions in Chronic Obstructive Pulmonary Disease (COPD) Using Magnetic Resonance Imaging (MRI)

LW Turnbull; JP Ridgway; W Biernacki; H MacRitchie; AL Muir; JJK Best; W MacNee

Clin Sci (Lond) (1988) 75 (s19): 6P.

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Is the Proportion of Silent to Symptomatic Myocardial Ischaemia Altered by Coronary Artery Bypass Surgery?

EA Rodrigues; H Pelling; PMM Cashman; A Lahiri; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 6P.

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The Importance of Ambulatory Heart Rate in Spontaneously Occurring Silent Myocardial Ischaemia

EA Rodrigues; A Lahiri; H Pelling; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 6P.

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The Effect of Surgical Revascularisation on Ventricular Function in Patients with Chronic Stable Angina

EA Rodrigues; ME Heber; A Lahiri; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 6P–7P.

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Non-Invasive Determination of Changes in Left Ventricular Filling, Inotropy and Systemic Vascular Resistance

M. Singer; J. Clarke; E. D. Bennett

Clin Sci (Lond) (1988) 75 (s19): 7P.

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Abnormal Left Ventricular Diastolic Function after Coronary Bypass Surgery - Benefits of Transdermal Nitrate Therapy

DF Ettles; E Maro; U Nair; GJ Williams

Clin Sci (Lond) (1988) 75 (s19): 7P.

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Mathematical Theory of Conduction Networks - Specification of Cardiac Conduction Models

M Malik; AJ Camm

Clin Sci (Lond) (1988) 75 (s19): 7P.

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Solution to the Pacemaker Inverse Problem

M Malik; AJ Camm

Clin Sci (Lond) (1988) 75 (s19): 7P–8P.

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Computer Modelling of Cardiac Repolarisation Sequences and Recovery Processes

M Malik; AJ Camm

Clin Sci (Lond) (1988) 75 (s19): 8P.

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Success of Defibrillating Shocks by Two Protocols with Contoured Patches and a Biphasic Waveform in Man: Implications for Implantable Defibrillator Design

ES Barin; JE Elstob; SJ Edmondson; MG Hakim; GM Rees; AW Nathan

Clin Sci (Lond) (1988) 75 (s19): 8P.

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Measurement of Intestinal Permeability by High Performance Liquid Chromatography, the Effect of Cigarette Smoking

GF Cope; HF Goode; J Kelleher; RV Heatley; MS Losowsky

Clin Sci (Lond) (1988) 75 (s19): 8P.

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Assessment of ¹²³I-Cholylglycyltyrosine and 99MTC-Iodida as Hepatobiliary Imaging Agents in Jaundiced Patients

C.O. Mills; R.G.P. Watson; S. Chandler; J. Trifunovic; E. Elias

Clin Sci (Lond) (1988) 75 (s19): 8P–9P.

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Cholyl-Lysyl-Fluorescein Isothiocyanate: Biliary Kinetics in Vivo and during Single-Pass Perfusion of Isolated Perfused Rat Liver

CO Mills; K Rahman; R Coleman; E Elias

Clin Sci (Lond) (1988) 75 (s19): 9P.

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Facilitation of Arachidonic Acid Absorption in the Rat Intestine

AT Green; EU Cynk; RPH Thompson

Clin Sci (Lond) (1988) 75 (s19): 9P.

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Effect of a Shall dose of Poorly Absorbed Solute on Intestinal Absorption

E Heduan; S D Catt; A P Jenkins; I S Menzies; M B Segal

Clin Sci (Lond) (1988) 75 (s19): 9P.

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A Test for Colonic Permeation?

A P Jenkins; E Heduan; C Myers; B J Crump; I S Menzies; B Creamer

Clin Sci (Lond) (1988) 75 (s19): 9P–10P.

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Why are Geriatric Patients Incontinent of Faeces?

J A Barrett; E B Faragher; E S Kiff; G Ferguson; J C Brocklehurst

Clin Sci (Lond) (1988) 75 (s19): 10P.

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Does Starvation Affect Gastric Mucosal Ornithine Decarboxylase Activity?

PR Taylor; RC Mason; S Vaja; GM Murphy; HD Dowling; I McColl

Clin Sci (Lond) (1988) 75 (s19): 10P.

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Leucocyte Electrolytes and Sodiun Pump Activity in Hyponatraemic Cirrhotics with Ascites

ID Cameron; DN Baron

Clin Sci (Lond) (1988) 75 (s19): 10P.

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Peripheral total Parenteral Nutrition (TPN): A new Approach

HT Khawaja; PC Weaver

Clin Sci (Lond) (1988) 75 (s19): 11P.

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Transdermal Glyceryl Trinitrate (GIN) to Reduce the Incidence of Peripheral Intravenous Infusion Failure: A Cost-Effectiveness Study

HT Khawaja; BJ O'brien; MJ Buxton

Clin Sci (Lond) (1988) 75 (s19): 11P.

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The Association of HLA-DR Types and DQβ Gene Fragments with Insulin Dependent Diabetes in Afro-Caribbeans

D Jenkins; C Mijovic; JA Fletcher; E MacKay; O Odugbesan; K Cruickshank; AR Bradwell; AH Barnett

Clin Sci (Lond) (1988) 75 (s19): 11P.

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Linkage Analysyis with Restriction Fragment Length Polymorphisms (RFLP's) to Locate Immunoglobulin E Responsiveness Gene

WOCM Cookson; JM Hopkin

Clin Sci (Lond) (1988) 75 (s19): 11P.

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Microalbuminuria is a Powerful Predictor of Vascular Disease in Non-Diabetic Subjects - The Islington Diabetes Survey

JS Yudkin; RD Forrest; CA Jackson

Clin Sci (Lond) (1988) 75 (s19): 12P.

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Hyperglycaemia at the onset of Stroke Relates to Short-Term Mortality

JS Gill; SK Gill; DG Beevers

Clin Sci (Lond) (1988) 75 (s19): 12P.

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Albumin Excretion Rate and Plasma Renin Activity in Insulin Dependent Diabetes Mellitus

MJ O'donnell; N Lawson; AH Barnett

Clin Sci (Lond) (1988) 75 (s19): 12P.

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Effect of Age on Extracellular Digestion of Fibronectin by Neutrophils

A. Chamba; S. L. Hill; R. A. Stockley; D. Burnett

Clin Sci (Lond) (1988) 75 (s19): 12P.

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Effect of Native, Oxidised and Proteolysed Alpha₁ Antitrypsin on Neutrophil Migration

R. A. Stockley; J. Shaw; H. M. Morrison; S. C. Afford; D. Burnett

Clin Sci (Lond) (1988) 75 (s19): 13P.

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Role of Monocytes in Cellular Sensitivity to Steroids

MB Allen; SG Ray; RM Hogg; AG Leitch; AH Wyllie

Clin Sci (Lond) (1988) 75 (s19): 13P.

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Capillary Red Cell Velocity is Reduced in Fever without Hypotension

F Boyle; K Thomas; JR Weinberg

Clin Sci (Lond) (1988) 75 (s19): 13P.

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A Sensitive and Specific HPLC Assay for Carnosine and 3-Methylhistidine in Human Muscle, Serum and Urine

K. Teahon; J.M. Rideout; C.K. Lim; T.J. Peters

Clin Sci (Lond) (1988) 75 (s19): 13P.

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TSH Responsiveness to TRH (“The TRH Test”) - of No Diagnostic Value in Depression

JA Vaughan; BP O'Malley; S Barker; KL Woods; RL Palmer; FD Rosenthal

Clin Sci (Lond) (1988) 75 (s19): 14P.

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Low Serum TSH with Normal Total Thyroid Hormone Levels; An Indicator of T4 Thyrotoxicosis

BP O'malley; FD Rosenthal; AR Exley; JF Falconersmith; J Mahabir; KL Woods

Clin Sci (Lond) (1988) 75 (s19): 14P.

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Abnormal Basal Intermediary Metabolism in Obese Patients with Normal Glucose Tolerance

DA Robertson; BM Singh; AJ Krentz; PJ Hale; M Nattrass

Clin Sci (Lond) (1988) 75 (s19): 14P.

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Capillary Fragility at High Altitude

PJG Forster; AD Wright

Clin Sci (Lond) (1988) 75 (s19): 14P.

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Insulin and Proinsulin Concentrations in Patients with Insulinoma before and after Surgical Treatment

PJ Hale; I Jensen; RM Baddeley; M Nattrass

Clin Sci (Lond) (1988) 75 (s19): 15P.

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Purification and Characterization of Ferrochelatase from Human Erythroid Cells

A. V. W. Nunn; T. M. Cox

Clin Sci (Lond) (1988) 75 (s19): 15P.

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Sodium Lithium Countertransport and Family History of Hypertension in Essential and Secondary Hypertension

SJ Carr; TH Thomas; R Wilkinson

Clin Sci (Lond) (1988) 75 (s19): 15P.

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The Effect of Active and Passive Changes in Posture on Autonomic Function

M Heber; EA Rodrigues; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 15P.

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Elderly Subjects with Idiopathic Postural Hypotension have a Low Erythrocyte Potassium Concentration - A Suitable Case for Treatment?

D. Heseltine; T.H. Thomas; O.F.W. James; J.F. Potter

Clin Sci (Lond) (1988) 75 (s19): 16P.

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Does Dopamine Contribute to Heating Induced Vasodilatation?

A.D. Hughes; P.L. Goldberg; P.S. Sever

Clin Sci (Lond) (1988) 75 (s19): 16P.

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Human Parathyroid Peptide (HPTH 1–34) Treatment Increases the Mean Wall Thickness of Iliac Trabecular Packets of New Bone in Patients with Crush Fracture Osteoporosis

JN Bradbeer; M Arlot; J Reeve; PJ Meunier

Clin Sci (Lond) (1988) 75 (s19): 16P.

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Measuring Resistivity of Tissue Bath Solutions

MJ Jamieson; RD Selbie

Clin Sci (Lond) (1988) 75 (s19): 16P–17P.

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Degradation of Oxytocin by Human Non-Pregnant, Pregnant and Post Natal Plasma

S Thornton; JM Davison; JM Burd; PH Baylis

Clin Sci (Lond) (1988) 75 (s19): 17P.

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Seasonal Variation in Serum 25-Hydroxy Vitamin D (25-Oh D) and Risk of Osteomalacia in Adult Asians in London

Liza Ang; KW Colston; JD Maxwell

Clin Sci (Lond) (1988) 75 (s19): 17P.

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Plasma Renin Activity in Paget's Disease of Bone

W.H. Taylor

Clin Sci (Lond) (1988) 75 (s19): 17P.

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Studies on Insulin Secretion, Insulin Resistance & Red Cell Sodium Transport in Postpartum Gestational Diabetes

A Samanta; H Kinghorn; A C Burden; A Heagerty; R C Turner

Clin Sci (Lond) (1988) 75 (s19): 17P–18P.

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Haemodynamic Effects of Intravenous Nifedipine in Hypertensive and Normotensive Subjects

T Walley; A Heagerty; K Woods; R Bing; J Pohl; D Barneit

Clin Sci (Lond) (1988) 75 (s19): 18P.

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The Effects of Pharmacological Autonomic Blockade on Intraocular Pressure Changes during Insulin-Induced Hypoglycaemia in Normal Humans

DA Hepburn; BM Fisher; BM Frier

Clin Sci (Lond) (1988) 75 (s19): 18P.

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How Safe is Epoprostenol (Prostacyclin PCI₂) as a Pulmonary Vasodilator in Secondary Pulmonary Hypertension?

TW Evans; A Bush; YM Mudaliar; C Morgan

Clin Sci (Lond) (1988) 75 (s19): 18P.

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Bleeding Complications in Elderly Patients Discontinuing Oral Anticoagulants

D Crossley; P.A. O'Neill; D Taberner; D.S. Fairweather

Clin Sci (Lond) (1988) 75 (s19): 18P–19P.

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Domperidone Enhances the Ventilatory Effect of Hypoxia in Chronically Hypoxic Rats

Denise Bee; Gwenda Barer

Clin Sci (Lond) (1988) 75 (s19): 19P.

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Serum Placental-Like Alkaline Phosphatase (PLAP): Determination Using 2 Monoclonal Antibodies and their Value in Monitoring Ovarian Cancer

J Fisken; J Morrison; A Bowman; RCF Leonard; JE Roulston

Clin Sci (Lond) (1988) 75 (s19): 19P.

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Erythrocyte Sodium and Water and Proximal Tubular Sodium Reabsorption in Hypertensive Non-Insulin Dependent Diabetics: Effect of Captopril

TH Thomas; J-C Mbanya; R Taylor; Kgmm Alberti; R Wilkinson

Clin Sci (Lond) (1988) 75 (s19): 19P.

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Problems with Leucocyte Cation Content and Transport Measurement

J Main; TH Thomas; R Wilkinson

Clin Sci (Lond) (1988) 75 (s19): 19P–20P.

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The Effect of Inspiratory Resistive Loading on Breathing Pattern during Resting & Co2 Stimulated Breathing

J Clague; J Carter; MG Pearson; PMA Calverley

Clin Sci (Lond) (1988) 75 (s19): 20P.

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Respiratory Drive & Dyspnoea during Co2 Rebreathing in Normal Man

J Clague; J Carter; MG Pearson; PMA Calverley

Clin Sci (Lond) (1988) 75 (s19): 20P.

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Cardiac Arrhythmias during Acute Exacerbations of Chronic Airflow Limitation and following Recovery: Effect of Beta Agonists Delivered by Home Nebulisers

R Lim; MJ Walshaw; S Saltissi; CRK Hind

Clin Sci (Lond) (1988) 75 (s19): 20P.

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Evidence for Platelet-Activatinc Factor as a Mediator of Hypoxic Pulmonary Vasoconstriction

DM McCormack; PJ Barnes; TW Evans

Clin Sci (Lond) (1988) 75 (s19): 21P.

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The Effect of Amiloride on Carbachol-Induced Contraction of Bovine Tracheal Smooth Muscle

AJ Knox; P Kemp; JR Britton; AE Tattersfield

Clin Sci (Lond) (1988) 75 (s19): 21P.

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Enhanced Reactivity of Pulmonary Vessels to Angiotensin 1 and Bradykinin in Chronically Hypoxic Rats

P.C. Russell; C.J. Emery; YN Cai; G.R. Barer

Clin Sci (Lond) (1988) 75 (s19): 21P.

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Effect of Mild Induced Bronchoconstriction on Exercise Ventilation (VE) in Normal Subjects

AH Kendrick; JF O'reilly; G Laszlo

Clin Sci (Lond) (1988) 75 (s19): 21P–22P.

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Bioelectrical Potential Difference across the Respiratory Mucosa following Heart-Lung Transplantation

AM Wood; TW Higenbottam; JL Wallwork

Clin Sci (Lond) (1988) 75 (s19): 22P.

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Evidence in Man for the Role of Voltage in Successful Catheter Ablation

A.J. Ahsan; A.D. Cunningham; E. Rowland; A.F. Rickards; K.M. Fox

Clin Sci (Lond) (1988) 75 (s19): 22P.

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A Clinically Relevant Computer Model of Cardiac Rhythm and Heart-Pacemaker Interaction

M Malik; AJ Camm

Clin Sci (Lond) (1988) 75 (s19): 22P.

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Effect of Exercise on Circulating Atrial Naturetic Factor in Heart Transplant Recipients

J Pepke-Zaba; A Morice; TW Higenbottam; A Raine; J Wallwork

Clin Sci (Lond) (1988) 75 (s19): 22P–23P.

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Inositol Phosphate Production in Response to Agonist Stimulation of Cultured Neonatal Rat Ventricular Myocytes

MD Gammage; A Logan; E McDermott; SD Logan

Clin Sci (Lond) (1988) 75 (s19): 23P.

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The Effect of Sustained Increase in Wall Stress on Arrhythmia in Hypertensive Hearts

M A James; J V Jones

Clin Sci (Lond) (1988) 75 (s19): 23P.

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Clinical Implications of Cerebral Blood Flow Changes during Cardiopulmonary Bypass

GE Venn; K Sherry; L Klinger; S Newman; M Harrison; T Treasure

Clin Sci (Lond) (1988) 75 (s19): 23P.

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Regulation of Intracellular ph in Beating Mammalian Cardiac Cells

P.L. Weissberg; P.J. Little; E.J. Cragoe; A. Bobik

Clin Sci (Lond) (1988) 75 (s19): 23P–24P.

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The Haemodynamic Consequences of Acutely Raising Right Atrial Pressure in Chronic Heart Failure

RJI Bain; LB Tan; MK Davies; RG Murray; WA Littler

Clin Sci (Lond) (1988) 75 (s19): 24P.

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Serum Potassium Concentrations during Acute Exacerbations of Chronic Airflow Limitation and following Recovery: Effect of Beta Agonists Delivered by Home Nebulisers

R Lim; MJ Walshaw; S Saltissi; CRK Hind

Clin Sci (Lond) (1988) 75 (s19): 24P.

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Comparison of Absorption Rates from two Hypotonic and Two Isotonic Rehydration Solutions in the Intact Human Jejunum

J.B. Leiper; R.J. Maughan

Clin Sci (Lond) (1988) 75 (s19): 24P.

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Noradrenaline Attenuates the Natriuretic Effect of ANF in Man

J McMurray; PH Seidelin; AD Struthers

Clin Sci (Lond) (1988) 75 (s19): 25P.

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Clinical and Prognostic Significance of Diffuse Uptake Pattern on in-111 Antimyosin Imaging following Acute Myocardial Infarction

D Jain; A Lahiri; U Raval; T Smith; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 25P.

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Effects of Amiodarone on Inositol Phosphate Production in Cultured Neonatal Rat Ventricular Myocytes

MD Gammage; A Logan; E McDermott; SD Logan

Clin Sci (Lond) (1988) 75 (s19): 25P.

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The Role of Vagus and Carotid Sinus Nerves on Systemic and Renal Responses to Somatic Afferent Stimulation in the Rat

G Davis; E J Johns

Clin Sci (Lond) (1988) 75 (s19): 25P–26P.

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Stimulation and Inhibition of Extracellular Proteolysis by Neutrophils

A. Chamba; R. A. Stockley; D. Burnett

Clin Sci (Lond) (1988) 75 (s19): 26P.

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Hypoxic Ventilatory Response and Acute Mountain Sickness

JS Milledge; PS Thomas; JM Beeley; JSC English

Clin Sci (Lond) (1988) 75 (s19): 26P.

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Atrial Natriuretic Peptide and Acute Mountain Sickness

JS Milledge; JM Beeley; S McArthur; AH Morice

Clin Sci (Lond) (1988) 75 (s19): 26P.

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Effect of Acetazolamide on Hypercapnic and Hypoxic (ISO & Hypocapnic) Ventilatory Responses in Humans

Y Bashir; M Kann; J Stradling

Clin Sci (Lond) (1988) 75 (s19): 26P–27P.

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The Effect of Oral Digoxin on Bronchial Reactivity in Man

AJ Knox; JR Britton; AE Tattersfield

Clin Sci (Lond) (1988) 75 (s19): 27P.

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NA/K Atpase, NA/H Exchange and Bronchomotor Tone in Bovine Airways

AJ Knox; P Kemp; JR Britton; AE Tattersfield

Clin Sci (Lond) (1988) 75 (s19): 27P.

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Prognostic Implications of Lung Uptake of Thallium-201 at Best following Acute Myocardial Infarction or Unstable Angina

D Jain; A Lahiri; U Raval; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 27P.

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Right Ventricular Function in Response to Acut Hypoxia in Healthy Adults

R.M. Oliver; J.M. Gray; V.F. Challenor; D.G. Waller

Clin Sci (Lond) (1988) 75 (s19): 27P–28P.

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Carotid Body Doppler Spectral Analysis: Correlation between Various Doppler Parameters and Baroreceptor Function

JNW West; PJ Champion de Crespigny; WA Littler

Clin Sci (Lond) (1988) 75 (s19): 28P.

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Anti-Arrhythmic Role of Left Ventricular Hypertrophy

M A James; J V Jones

Clin Sci (Lond) (1988) 75 (s19): 28P.

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The Role of Potassium and Magnesium in Wall Stress Arrhythmia

M A James; J V Jones

Clin Sci (Lond) (1988) 75 (s19): 28P.

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Atrial Systole - Its Role in Modulating Cardiac Output

K.S. Channer; J.V. Jones

Clin Sci (Lond) (1988) 75 (s19): 28P–29P.

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Matching of Donor and Recipient Lung Size in Heart-Lung Transplantation

BA Otulana; BA Mist; TW Higenbottam; J Hutter; J Wallwork

Clin Sci (Lond) (1988) 75 (s19): 29P.

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Urinary Kallikrein - Like Activity in Normal Volunteers and Essential Hypertensives

S K Campbell; JDM Albano; G Venkat Raman

Clin Sci (Lond) (1988) 75 (s19): 29P.

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Left Ventricular Ejection Fraction Response to Rapid Weight Reduction in Obesity

P DasGupta; G Brigden; E Ramhamdany; A Lahiri; IM Baird; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 29P.

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Glucose Intolerance, Diabetes and Lipid Abnormalities in Asian Males with Early Coronary Atherogenesis

LO Hughes; U Raval; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 30P.

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Exercise Testing in Patients with Asymptomatic Familial Hypercholesterolaemia

AP Wojciechowski; LO Hughes; AF Winder; JEF Pohl; EB Raftery

Clin Sci (Lond) (1988) 75 (s19): 30P.

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Temporal Changes in Haemodynamic and Respiratory Characteristics of a Model of Chronic Heart Failure

P Thomas; M.A. Turner; D.J. Sheridan

Clin Sci (Lond) (1988) 75 (s19): 30P.

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Does Arterial Line Filtration Affect the Bypass Related Cerebral Impairment Observed in Patients Undergoing Coronary Artery Surgery?

WB Pugsley; L Klinger; C Paschalis; S Newman; M Harrison; T Treasure

Clin Sci (Lond) (1988) 75 (s19): 30P–31P.

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Rapid Atrial Pacing in Cardiac Denervated Dogs Causes Sodium Retention and Not Natriuresis

T D M Williams; K P Walsh; M I M Noble; A J Drake-Holland; E Pitts; S L Lightman; R Sutton

Clin Sci (Lond) (1988) 75 (s19): 31P.

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Effects of Coronary Ligation on Arrhythmias, Haemodynamics and Extent of Myocardial Damage in Rabbits Anaesthetised with Different Anaesthetics

S. Chakrabarty; P. Thomas; D.J. Sheridan

Clin Sci (Lond) (1988) 75 (s19): 31P.

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Platelet Mediated Arrhythmogenic and Haemodynamic Changes during Acute Coronary Occlusion and Reperfusion

S. Chakrabarty; P. Thomas; T. Williams; D.J. Sheridan

Clin Sci (Lond) (1988) 75 (s19): 31P.

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A New System for Catheter Ablation: Performance in VITRO and in VIVO

A.J. Ahsan; A.D. Cunningham; E. Rowland; A.F. Rickards

Clin Sci (Lond) (1988) 75 (s19): 31P.

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Coeliac Disease: Quantitation of the barley (Gluten) Content of Beer

H.J. Ellis; A.R. Freedman; P.J. Ciclitira

Clin Sci (Lond) (1988) 75 (s19): 32P.

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Restriction Fragment Length Polymorphism of the Hla-Dp Subregion in Coeliac Disease

M.A. Hall; W.J. Bolsover; P.J. Ciclitira

Clin Sci (Lond) (1988) 75 (s19): 32P.

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Detection of Anti-Giardia IgG Antibody in Intravenous Gamma Globulin Preparations: Possible Therapeutic Implications

AS Arvind; PD Butcher; ADP Webster; MJG Farthing

Clin Sci (Lond) (1988) 75 (s19): 32P.

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Increased Urinary Excretion of Nitrogenous Substances in the Alcohol-Fed Rat

V.R. Preedy; J.P. Ashby; K. Teahon; J.D. Gandy; P.A. Edwards; B. Hammond; T.J. Peters

Clin Sci (Lond) (1988) 75 (s19): 32P–33P.

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The Chronic Effects of Ethanol Feeding on Hepatic Protein Metabolism in Immature and Mature Rats

Victor R. Preedy; Timothy J. Peters

Clin Sci (Lond) (1988) 75 (s19): 33P.

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The Response of Skeletal Muscle Protein Synthesis to 6 Hour Infusions of Glucose and/or Amino Acids in the Rat

V.R. Preedy; P.J. Garlick

Clin Sci (Lond) (1988) 75 (s19): 33P.

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Chronic Alcohol Administration to the Rat Causes Hepatic Oxidant Stress and Vitamin a Deficiency

M Noble; AJK Williams; OTG Jones; RE Barry

Clin Sci (Lond) (1988) 75 (s19): 33P.

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Calcium (CA) Distribution in Human Bile

KA Hood; GM Murphy; RH Dowling

Clin Sci (Lond) (1988) 75 (s19): 33P–34P.

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Effect of Chronic Ethanol Feeding on Hepatic APO B Synthesis in RAT

C.R. Pullinger; S. Venkatesan; K.J. Simpson; L.M. Powell; J. Scott; T.J. Peters

Clin Sci (Lond) (1988) 75 (s19): 34P.

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Microsomal Desaturases (Δ⁹, Δ⁶, Δ⁵) and Membrane Phospholipid Fatty Acid Profile in Rat Liver after Chronic Ethanol Consumption

S. Venkatesan; K.J. Simpson; J.M. Rideout; T.J. Peters

Clin Sci (Lond) (1988) 75 (s19): 34P.

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The Effect of High Dose Inhaled Beclomethasone Dipropionate (BDP) on Glucose Tolerance and Lipids in Diet Controlled Diabetics

P. Ebden; P. McNally; G.J. Fancourt

Clin Sci (Lond) (1988) 75 (s19): 34P.

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Haemostatic Variables in Patients with Insulin Dependent Diabetes Mellitus

MJ O'Donnell; CA Leguen; N Lawson; AH Barnett

Clin Sci (Lond) (1988) 75 (s19): 34P–35P.

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Lipid Peroxidation Products in Patients with Insulin Dependent Diabetes Mellitus

MJ O'Donnell; CA LeGuen; N Lawson; AH Barnett

Clin Sci (Lond) (1988) 75 (s19): 35P.

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Abnormal Intermediary Metabolism in Obese Patients with Impaired Glucose Tolerance

DA Robertson; BM Singh; M Nattrass

Clin Sci (Lond) (1988) 75 (s19): 35P.

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Cigarette Smoking, Limited Joint Mobility and Retinopathy in Type I (Insulin-Dependent) Diabetes

DW Eadington; AW Patrick; A Collier; BM Frier

Clin Sci (Lond) (1988) 75 (s19): 35P.

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DNA Sequence Polymorphisms in the Apolipoprotein AI/CIII Genes, Hyperlipidaemia and Coronary Heart Disease in Men Aged 30–59 Years

S W Morris; P R S Burgon; P R Wenham; J L Lowther; A H Kitchin; P M Donald; W H Price

Clin Sci (Lond) (1988) 75 (s19): 35P–36P.

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Leucocyte Coproforphyrinogen III Oxidase: Development and Clinical Applications of a Sensitive and Specific HPLC Assay

Rong Guo; C K Lim; K J Simpson; T J Peters

Clin Sci (Lond) (1988) 75 (s19): 36P.

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Influence of the Acute Phase Response on Circulating Insulin-Like Growth Factor 1 (IGF-1) in Haemodialysis Patients

B Sampson; G Carter; J Alaghband-Zadeh; JR Curtis

Clin Sci (Lond) (1988) 75 (s19): 36P.

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Whole Body Leucine Kinetics and Fractional Quadriceps Muscle Synthetic Rate (MPSR) in Alcoholic Patients

P.J. Pacy; M Read; V. Preedy; T.J. Peters; D Halliday

Clin Sci (Lond) (1988) 75 (s19): 36P.

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Post-Absorptive Whole Body Leucine Kinetics and Quadriceps Muscle Protein Synthetic Rate (MPSR) in the Post-Viral Syndrome

P.J. Pacy; M. Read; T.J. Peters; D. Halliday

Clin Sci (Lond) (1988) 75 (s19): 36P–37P.

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Measurement of Whole Body Protein Turnover in Man Using a (²H₅) Phenylalanine Model

GN Thompson; PJ Pacy; GC Ford; H Merritt; MA Read; AJ Noble; D Halliday

Clin Sci (Lond) (1988) 75 (s19): 37P.

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Body cell mass following major electice surgery

F. Carli; C. Freemantle

Clin Sci (Lond) (1988) 75 (s19): 37P.

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The Role of Atrial Natriuretic Peptide in the Natriuresis of Head-Down Tilt

MJ Allen; VTY Ang; ED Bennett

Clin Sci (Lond) (1988) 75 (s19): 37P.

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Effect of Abnormal Negative Intrathoracic Pressure on Atrial Natriuretic Peptide (ANP) Release and Renal Function in Healthy Men

A Warley; F Fontes; M Wilson; A Raine; J Stradling

Clin Sci (Lond) (1988) 75 (s19): 37P–38P.

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Frusemide Pretreatment Blunts the Renal Tubular Effects of ANF in Man

J McMurray; AD Struthers

Clin Sci (Lond) (1988) 75 (s19): 38P.

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Identifying Affected Offspring of Parents with Raised Sodium-Lithium Countertransport

SJ Carr; TH Thomas; R Wilkinson

Clin Sci (Lond) (1988) 75 (s19): 38P.

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Plasma Viscosity and Haemodilution following Exercise

J D Robertson; R J Maughan; K A Walker

Clin Sci (Lond) (1988) 75 (s19): 38P.

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Vibrotactile Sensation and the Response to Vasodilator Therapy in Primary Raynaud's Phenomenon

V.F. Challenor; D.G. Waller; R.A. Hayward; M.J. Griffin; O.S. Roath

Clin Sci (Lond) (1988) 75 (s19): 38P–39P.

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Acetylcholine Increases Inositol Polyphosphate Levels in RAT Subcutaneous Resistance Arterioles

N Adeeb; JD Ollerenshaw; AM Heagerty

Clin Sci (Lond) (1988) 75 (s19): 39P.

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Abnormal Resistance Arteriole Inositol Phosphate Production during Noradrenaline Stimulation in SHR

H Durkin; JD Ollerenshaw; AM Heagerty

Clin Sci (Lond) (1988) 75 (s19): 39P.

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Magnetic Resonance Anthropometry of Muscles Stabilising the Lumbar Spine

R Millerchip; RA Savage; RHT Edwards

Clin Sci (Lond) (1988) 75 (s19): 39P.

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Mechanisms of Inhibition of Intracellular Enzyme Efflux from Damaged Skeletal Muscle by α-Tocopherol and Related Compounds

J Phoenix; R H T Edwards; M J Jackson

Clin Sci (Lond) (1988) 75 (s19): 40P.

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Effect of Low Frequency Fatigue on Muscle Endurance Capacity

RG Cooper; MJ Stokes; RHT Edwards

Clin Sci (Lond) (1988) 75 (s19): 40P.

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Glutathione Peroxidase Activity and Selenium Therapy in Muscular Dystrophies

JH Coakley; MJ Stokes; O Oster; RHT Edwards; MJ Jackson

Clin Sci (Lond) (1988) 75 (s19): 40P.

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No Ischaemic Recovery of the Evoked Compound Muscle Action Potential in McArdle's Disease

H Gibson; RHT Edwards

Clin Sci (Lond) (1988) 75 (s19): 40P–41P.

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Exhaustion and Replenishment of Readily Releasable Atrial Natriuretic Peptide Stores

T D M Williams; K P Walsh; J Charmann; S L Lightman; R Sutton

Clin Sci (Lond) (1988) 75 (s19): 41P.

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The Exercise-Dose Response Curve to Nifedipine in β-Blocked Patients with Stable Angina Pectoris

OJ Carey; P Ebden; KL Woods

Clin Sci (Lond) (1988) 75 (s19): 41P.

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The Effect of Etomoxir on Blood Concentrations of Glucose, β-Hydroxybutyrate and Acetoacetate in the Streptozotocin-Diabetic Rat

JA Charlton; CJ Thompson; PH Baylis

Clin Sci (Lond) (1988) 75 (s19): 41P.

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The Influence of Nifedipine and Diltiazem on Serum Theophylline Profiles

SR Smith; MJ Kendall

Clin Sci (Lond) (1988) 75 (s19): 41P–42P.

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Hormonal changes post beta-blockade on withdrawal of atenolol and bopindolol

R J Walden; B Tomlinson; B Graham; J Liu; BNC Prichard

Clin Sci (Lond) (1988) 75 (s19): 42P.

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A Longitudinal Assessment of Renal Function during Treatment with Lithium

Derek G. Waller; J. Guy Edwards

Clin Sci (Lond) (1988) 75 (s19): 42P.

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Renal Lithium Clearance in Essential Hypertension

HLA Yee-Yee; DRJ Singer; ND Markandu; DG Shirley; GA MacGregor

Clin Sci (Lond) (1988) 75 (s19): 42P.

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Oxalate Metabolism and Removal in End Stage Renal Disease Treated with High-Flux Haemodialysis (HFD)

S.H. Morgan; D. Sethi; P. Purkiss; J.R. Curtis; R.W.E. Watts

Clin Sci (Lond) (1988) 75 (s19): 42P–43P.

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Carnitine Dynamics: Evidence for Tissue Uptake and Esterification during Haemodialysis

JM Jackson; HT Khawaja; HA Lee

Clin Sci (Lond) (1988) 75 (s19): 43P.

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Plasma Glutathione Peroxidase Activity in Preeclampsia

R.M. Berry; N.A. Punchard; N.A. MacLachlan; R.P.H. Thompson

Clin Sci (Lond) (1988) 75 (s19): 43P.

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Urinary Albumin Excretion and Blood Pressure in an Unselected Population

P. Gosling; D G Beevers

Clin Sci (Lond) (1988) 75 (s19): 43P.

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Is B2-Microglobdlin Polymerised in the Synovial Fluid of Patients with Dialysis Amyloid?

D Sethi; PE Gower

Clin Sci (Lond) (1988) 75 (s19): 43P–44P.

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Leucocyte Response following Endurance Exercise

J D Robertson; R J L Davidson; R J Maughan

Clin Sci (Lond) (1988) 75 (s19): 44P.

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Inhibition of Lymphocyte Chemotaxis in VITRO by Cyclosporin

L Wang; DH Adams; D Burnett; RA Stockley; E Elias; J Neuberger

Clin Sci (Lond) (1988) 75 (s19): 44P.

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Interaction of Senescent Neutrophils with Fibroblasts in VITRO

C. Haslett; S. Hall; P.M. Henson

Clin Sci (Lond) (1988) 75 (s19): 44P.

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MacRophage Phagocytosis of AGED Neutrophils Represents a Novel Function for the Arginine-Glycine-Aspartate-Serine (RGDS) Adhesion Signal of the Integrin Family of Cell-Surface Receptors

J. Savill; C. Haslett

Clin Sci (Lond) (1988) 75 (s19): 44P–45P.

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Monocyte Adherence in Bronchiectasis and the Effect of Bacterial Lipopolysaccharide

C. A. Owen; S. C. Afford; S. L. Hill; D. Burnett; R. A. Stockley

Clin Sci (Lond) (1988) 75 (s19): 45P.

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Clinical Studies of the Post-Viral Fatigue Syndrome (PVFS) with Special Reference to Skeletal Muscle Function

K. Teahon; V.R. Preedy; D.G. Smith; T.J. Peters

Clin Sci (Lond) (1988) 75 (s19): 45P.

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The Effects of Drug Therapy upon Human Resistance Arteriole Morphology in Essential Hypertension

AM Heagerty; SJ Bund; C Aalkjaer

Clin Sci (Lond) (1988) 75 (s19): 45P.

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BRL 34915 is a Selective Arteriolar Dilator in Upper Limb Vessels in Man

N. Benjamin; D.J. Webb; P.J.T. Vallance; J.G. Collier

Clin Sci (Lond) (1988) 75 (s19): 46P.

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Decline of Atrial Natriuretic Peptide Release during Sustained Stimulation

T D M Williams; K P Walsh; S L Lightman; R Sutton

Clin Sci (Lond) (1988) 75 (s19): 46P.

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Phorbol Ester-Induced Contraction in Resistance Arterioles of SHR

AS Izzard; AM Heagerty

Clin Sci (Lond) (1988) 75 (s19): 46P.

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Aortic Compliance Measured by Non-Invasive Doppler Ultrasound: Description of a Method and its Repeatability

J Wright; JK Cruickshank; S Kontis; RF Mahler; RG Gosling

Clin Sci (Lond) (1988) 75 (s19): 46P–47P.

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The effect of Neuropeptide Y on Sympathetically-Induced Constriction of Forearm Resistance Vessels in Man

S Larkin; N Benjamin; J Clarke; D Webb; G Davies; A Maseri

Clin Sci (Lond) (1988) 75 (s19): 47P.

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The Effect of Dietary Manipulation on Post Prandial Blood Pressure Changes in the Elderly

J.F. Potter; D. Heseltine; G. Hartley; O.F.W. James

Clin Sci (Lond) (1988) 75 (s19): 47P.

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Measurement of Internal PH in Resistance Arterioles: Evidence that Intracellular PH is more Alkaline in SHR than WKY Animals

AS Izzard; AM Heagerty

Clin Sci (Lond) (1988) 75 (s19): 47P.

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The Effect of ANF on Urinary Protein Excretion in Man

J McMurray; AD Struthers; PH Seidelin; JEA Howey

Clin Sci (Lond) (1988) 75 (s19): 47P–48P.

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Evidence for a Role of Reactive Oxygen Species in the ‘Browning’ of Albumin

CA LE Guen; AF Jones; CM Florkowski; J Lunec; AH Barnett

Clin Sci (Lond) (1988) 75 (s19): 48P.

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Interaction between Insulin and Thyrotrophin (TSH) in Cultured Thyroid Cells

RL Kennedy; R Davies; R Metcalfe

Clin Sci (Lond) (1988) 75 (s19): 48P.

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Determinants of Plasma Atrial Natriuretic Factor (ANF) in Chronic Renal Failure

AS Woolf; JC Kingswood; A Kumar; TL Lyon; MA Mansell; PJA Moult

Clin Sci (Lond) (1988) 75 (s19): 48P.

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Serum Cortisol Response in Acute Myocardial Ischaemia and Infraction

RJI Bain; VJI Poeppinghaus; GM Jones; MJT Peaston

Clin Sci (Lond) (1988) 75 (s19): 48P–49P.

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Transferrinuria in Diabetes Mellitus

MJ O'Donnell; P Martin; CM Plorkowski; MJ Toop; C Chapman; AH Barnett

Clin Sci (Lond) (1988) 75 (s19): 49P.

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Peripheral Blood Mononuclear Cell Sub-Populations in Newly Diagnosed and Recurrent Graves' Thyrotoxicosis

RL Kennedy

Clin Sci (Lond) (1988) 75 (s19): 49P.

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Adipose Tissue Fatty Acid Profiles in IDD Subjects Reflect Increased Risk of Microvascular Disease (MVD) in Hales but Not Females

DM Cassidy; R Taylor; J Farndon; MF Laker

Clin Sci (Lond) (1988) 75 (s19): 49P.

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Inorganic and Bound Sulphate in the Urine of Patients with Primary Biliary Cirrhosis and other Forms of Liver Disease

C Vickers; CO Mills; R Waring; E Elias

Clin Sci (Lond) (1988) 75 (s19): 50P.

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Acetaldehyde-Modified Hepatocyte Membranes Activate Complement via the Alternate Pathway

AJK Williams; RE Barry

Clin Sci (Lond) (1988) 75 (s19): 50P.

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Effect of Urogastrone/EGF on Shall Intestinal Weight, Protein Content and Brush Border Enzyme Activities in Parenterally-Fed (TON) Rats

K.B. Raja; R.A. Goodlad; N.A. Wright; W. Lenton; T.J. Peters

Clin Sci (Lond) (1988) 75 (s19): 50P.

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Is Alcohol Directly Toxic to the Small Bowel Mucosa?

P. Smethurst; I.S. Menzies; A.J. Levi; I. Bjarnason

Clin Sci (Lond) (1988) 75 (s19): 50P–51P.

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Analysis of Colonic Mucin Sub Units by Sds-Page and Lectin Blotting: Absence of Non-Glycosylated Core Protein

D Iddon; N Parker; A Raouf; Jonathan M Rhodes

Clin Sci (Lond) (1988) 75 (s19): 51P.

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Is the Intestine the Sole Source of Post-Heparin Plasma Diamine Oxidase (DAO)?

T. Rokkas; S. Vaja; P. Taylor; G.M. Murphy; R.H. Dowling

Clin Sci (Lond) (1988) 75 (s19): 51P.

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Abnormal Platelet Function and Fibrinolysis in Inflammatory Bowel Disease

M J Webberley; M T Donnan; V Melikian

Clin Sci (Lond) (1988) 75 (s19): 51P.

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Immunoglobulin Production by Human Intestinal Mononuclear Cells from Normal and Inflamed Mucosa

KC Wu; YR Mahida; DP Jewell

Clin Sci (Lond) (1988) 75 (s19): 51P–52P.

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The Effect of Parathyroidectomy on Blood Pressure in Renal Transplant Patients

I. AL-Khursany; T.H. Thomas; R. Wilkinson

Clin Sci (Lond) (1988) 75 (s19): 52P.

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Autoimmunity to Glomerular Antigens in Henochschonlein Purpura (HSP) and IgA Nephropathy (IgAN)

D J O'donoghue; P E C Brenchley; F W Ballardie

Clin Sci (Lond) (1988) 75 (s19): 52P.

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Dialysis Amyloid: Systemic or Local?

D Sethi; DF Woodrow; EA Brown; NRB Cary; PE Gower

Clin Sci (Lond) (1988) 75 (s19): 52P.

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A Comparison of Erythrocyte and Leucocyte Cation Content and Transport in Uraemia and CAPD

J Main; TH Thomas; R Wilkinson

Clin Sci (Lond) (1988) 75 (s19): 52P–53P.

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Effects of High Dose Pyridoxine on Plasma Oxalate Concentration in Dialysis Patients

CRV Tomson; SM Channon; WL Sheldon; IS Parkinson; MK Ward; MF Laker

Clin Sci (Lond) (1988) 75 (s19): 53P.

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Effect of Dietary Sodium Restriction on Plasma Phosphate in Patients with Idiopathic Hypercalciuria

E.M.C. Santry; W.H. Taylor

Clin Sci (Lond) (1988) 75 (s19): 53P.

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Effect of Vagotohy on Systemic and Renal Responses to Somatic Afferent Stimulation in the RAT

G Davis; E J Johns

Clin Sci (Lond) (1988) 75 (s19): 53P.

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Renal Sodium Handling Defect in Hypertensive Non Insulin Dependent Diabetics

J-C Mbanya; TH Thomas; R Taylor; Kgmm Alberti; R Wilkinson

Clin Sci (Lond) (1988) 75 (s19): 54P.

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The Effect of Captopril on Active and Inactive Renin

A Farrer; JDM Albano; G Venkat Raman

Clin Sci (Lond) (1988) 75 (s19): 54P.

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Noradrenaline Levels in Heart Failure [Introduced by K. D. Buchanan]

JS Elborn; WJ Leahey; DP Nicholls

Clin Sci (Lond) (1988) 75 (s19): 54P.

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Do Single dose Bronchial Provocation Tests Provide a Quantitative Measure of Drug Effect on Bronchial Reactivity?

AS Vathenen; AE Tattersfield

Clin Sci (Lond) (1988) 75 (s19): 54P–55P.

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Pulmonary Vascular Action of Ligustrazine, Principle of a Traditional Chinese Remedy

YN Cai; D Bee; G.R. Barer

Clin Sci (Lond) (1988) 75 (s19): 55P.

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Metabolic Effects of Nebulised Salbutamol during Submaximal Exercise in Asthmatics

W Freeman; A Javaid; GE Packe; M Nattrass; AD Wright; RM Cayton

Clin Sci (Lond) (1988) 75 (s19): 55P.

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The In VIVO Disposition of Lithium in Patients with Untreated Essential Hypertension

CJ Brearley; AJ Wood; JK Aronson; DG Grahame-Smith

Clin Sci (Lond) (1988) 75 (s19): 55P.

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Effects of Angiotensin Converting Enzyme Inhibition on Insulin Sensitivity and Metabolic Control in Hypertensive Diabetic Patients

J-C Mbanya; TH Thomas; R Taylor; R Wilkinson; KGMM Alberti

Clin Sci (Lond) (1988) 75 (s19): 55P–56P.

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The Metabolic Effects of Nebulised Oxitropium Bromide in Normal Volunteers: A Comparison with Salbutamol and Placebo

N M Foley; N McI Johnson

Clin Sci (Lond) (1988) 75 (s19): 56P.

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Issues

Cover Image

Medical Research Society Meeting 7 and 8 July 1988

Communication