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January 1989
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ISSN 0143-5221
EISSN 1470-8736
Medical Research Society Meeting 5 and 6 January 1989
Communication
Endothelin is a Potent Constrictor with Prolonged Action in Forearm Resistance Vessels and Veins in Man
Clin Sci (Lond) (1989) 76 (s20): 1P.
Cloning a Portion of the Gene Sequence Encoding the Human Diabetes Associated Peptide
Clin Sci (Lond) (1989) 76 (s20): 2P.
Elevation of Plasma Atrial Natriuretic Factor by an Atriopeptidase Inhibitor has Beneficial Acute Effects in Mild Heart Failure
Clin Sci (Lond) (1989) 76 (s20): 2P.
A Comparison, in Asthmatics, between Distress Due to Respiratory Symptoms and Distress Due to Disturbances of Daily Life
Clin Sci (Lond) (1989) 76 (s20): 2P.
A Mathematical Model for Dynamic Analysis of the Ventilatory Response to Hypoxia in Normal Subjects
Clin Sci (Lond) (1989) 76 (s20): 3P.
Does Arterial Hypoxaemia on Upright Exercise in Pink Puffers Relate to the Degree of Anatomical Emphysema?
Clin Sci (Lond) (1989) 76 (s20): 3P.
Silent Ischaemia in the First 24 Hours after P.T.C.A Predicts Early Re-Occlusion
Clin Sci (Lond) (1989) 76 (s20): 4P.
Different Receptors are Involved in Cough following Capsaicin, Prostaglandin E2 and Water Inhalation
Clin Sci (Lond) (1989) 76 (s20): 4P–5P.
A Clinical Evaluation of the “Accutracker” — A 24 Hour Ambulatory Blood Pressure Monitor
Clin Sci (Lond) (1989) 76 (s20): 5P.
Tc-99m Ventriculography Defines Left Ventricular Functional Reserve in Chronic Heart Failure
Clin Sci (Lond) (1989) 76 (s20): 5P.
A New Intravascular Catheter for Ambulatory Pressure Measurement: Design and Validation
Clin Sci (Lond) (1989) 76 (s20): 6P.
Left Ventricular Filling and Regional Wall Motion as Parameters of Ischaemia during Dipyridamole Echocardiography
Clin Sci (Lond) (1989) 76 (s20): 6P.
Insulin Resistance — A Significant Risk Factor for Myocardial Infarction in Immigrant Asians
Clin Sci (Lond) (1989) 76 (s20): 6P–7P.
Detection of Subclinical Myocardial Necrosis by Antimyosin Imaging in Unstable Angina in the Absence of Conventional Markers
Clin Sci (Lond) (1989) 76 (s20): 7P.
Diurnal Variation in Silent Myocardial Ischaemia following Recovery from Acute Exacerbations of Chronic Airflow Limitation
Clin Sci (Lond) (1989) 76 (s20): 8P.
Lower Aortic Compliance in Non-Diabetic Gujerati Survivors of Myocardial Infarction & Controls than in Matched White Men
Clin Sci (Lond) (1989) 76 (s20): 8P.
Central versus Peripheral Adaptation to Prolonged Endurance Exercise Training in a Group of Fit Post Myocardial Infarction Patients
Clin Sci (Lond) (1989) 76 (s20): 8P–9P.
Low-Dose Acetylsalicylic Acid Reduces Hepatic Proliferation In Vivo But Not In Vitro
Clin Sci (Lond) (1989) 76 (s20): 9P.
Pancreatic Secretory Trypsin Inhibitor in Human Gastrointestinal Epithelia and Gastric Juice
Clin Sci (Lond) (1989) 76 (s20): 9P.
Decreased Number of Lysozyme Positive Hepatic Sinusoidal MacRophages Correlates with Radiolabelled Colloid Uptake in Alcoholic Liver Disease
Clin Sci (Lond) (1989) 76 (s20): 9P.
Erythrocyte Acetaldehyde Dehydrogenase I Deficiency in Caucasian Alcohol Flushers
Clin Sci (Lond) (1989) 76 (s20): 10P.
Cirrhosis Induces Alterations in Epidermal Growth Factor (EGF) Receptor Kinase Activity and Receptor Autophosphorylation in Rat Hepatocytes
Clin Sci (Lond) (1989) 76 (s20): 10P–11P.
Inverse Serum and Tissue α-L-Fucosidase Alterations in Hepatocellular Carcinoma
Clin Sci (Lond) (1989) 76 (s20): 11P.
Differential Lectin Binding of Glycoproteins in Hepatocellular Carcinoma and Fulminant Hepatic Failure
Clin Sci (Lond) (1989) 76 (s20): 11P.
Haemodynamic and Renal Effects of Large Volume Paracentesis in Cirrhosis and Long-Term Efficacy
Clin Sci (Lond) (1989) 76 (s20): 11P.
Chromosomal Analysis in Myelodysplastic Syndromes (Pre-Leukaemia): Introduced by AJ Bellingham
Clin Sci (Lond) (1989) 76 (s20): 13P.
Prenatal Differentiation of Primary Hyperoxaluria Type 1 Phenotypes in the First Trimester Using Immuno-Electron Microscopy
Clin Sci (Lond) (1989) 76 (s20): 13P.
The Hormonal Control of Fibrinolysis during Electroconvulsive Therapy in Man
Clin Sci (Lond) (1989) 76 (s20): 13P–14P.
Functional Characteristics of Beta-Adrenergic Receptors of the Intact Eosinophil
Clin Sci (Lond) (1989) 76 (s20): 14P.
Hormonal Influence on Sex Hormone Binding Protein (SHBP) Production by HEP G2 Cells
Clin Sci (Lond) (1989) 76 (s20): 14P–15P.
The Effects of Hydroxyl Rutosides on Capillary Filtration Coefficient, Urinary Albumin Excretion and Vibration Sensory Thresholds in Diabetes Mellitus
Clin Sci (Lond) (1989) 76 (s20): 15P.
Acute and Chronic Effects of Diltiazem Alone and in Combination with Atenolol and Isosorbide Dinitrate
Clin Sci (Lond) (1989) 76 (s20): 15P–16P.
Cognitive Function and Quality of Life in Hypertension — A Community Based Study
C. Battersby; K. Hartley; A.E. Fletcher; H.L.J. Markowe; R.G. Brown; W. Styles; H. Sapper; C.J. Bulpitt
Clin Sci (Lond) (1989) 76 (s20): 16P.
Effect of Almitrine Bismesylate on Indices of Gas Mixing Efficiency in Patients with Chronic Bronchitis and Emphysema
Clin Sci (Lond) (1989) 76 (s20): 17P.
The Effect of an Oral Protein Load on Renal Haemodynamics in Cyclosporin and Azathioprine Renal Allograft Recipients
Clin Sci (Lond) (1989) 76 (s20): 17P.
Increased Platelet Aggregation in Hypertension — Relationship to Intraplatelet Calcium
Clin Sci (Lond) (1989) 76 (s20): 17P.
Detection and Variation in Circulating Levels of Vitamin K2 (Menaquinones) with Age
Clin Sci (Lond) (1989) 76 (s20): 17P–18P.
Fractionation of Hind-Limb Skeletal Muscle Proteins by Electrophoresis and Differential Solubilisation in the Young Alcohol-FED Rat
Clin Sci (Lond) (1989) 76 (s20): 18P–19P.
Induction of Hepatic Alkaline Phosphatase Activity by the Acute Phase Protein Response in Vitro
Clin Sci (Lond) (1989) 76 (s20): 19P.
The Sequence and Gene Organization of Human Herpes Virus-6 Resembles that of Human Cytomegalovirus
Clin Sci (Lond) (1989) 76 (s20): 19P.
A New Organ Culture Technique to Investigate the Interaction of Bacteria and Human Respiratory Epithelium
Clin Sci (Lond) (1989) 76 (s20): 19P.
Fat Absorption and Exocrine Pancreatic Function in Acquired Immunodeficiency Syndrome
Clin Sci (Lond) (1989) 76 (s20): 20P.
Regulation of Ion Transport through the Nasal Epithelium in Response to Hypotonic Challenge
Clin Sci (Lond) (1989) 76 (s20): 20P–21P.
Effect of Hypoxia on Platelet Aggregate Formation in Patients with Chronic Airflow Obstruction
Clin Sci (Lond) (1989) 76 (s20): 21P.
Contribution of Individual Proteins of Respiratory Syncytial Virus (RSV) to Immunopathology in the Lung
Clin Sci (Lond) (1989) 76 (s20): 21P.
A Mechanism for Neutrophil Sequestration in the Lungs' during Cigarette Smoking
Clin Sci (Lond) (1989) 76 (s20): 21P–22P.
Cellular Infiltration in the Upper Respiratory Tract and the Effect of Exposure to Allergen
S. Lozewicz; E. Gomez; S. Chalstrey; D. Gatland; S. Jordan; J. D'Ardenne; Y. Harmanyeri; R.J. Davies
Clin Sci (Lond) (1989) 76 (s20): 22P.
Effect of Histamine and Haemophilus Influenzae on Human Bronchial Eptihellal Cells, in Vitro
Clin Sci (Lond) (1989) 76 (s20): 22P.
Demonstration of a Ventilatory Threshold for CO2 in Normoxia in a Conscious Man
Clin Sci (Lond) (1989) 76 (s20): 22P.
Changes in the Flow Properties of White Blood Cells following Myocardial Infarction
Clin Sci (Lond) (1989) 76 (s20): 23P.
Noninvasive Measurement of Coronary Flow Reserve in Patients with Coronary Artery Disease with 0–15 Water and Positron Emission Tomography (PET)
Clin Sci (Lond) (1989) 76 (s20): 23P.
Endothelin Constricts the Hindlihb Vasculature of the Dog in Vivo
Clin Sci (Lond) (1989) 76 (s20): 23P.
Endothelin Induces Transmural Myocardial Ischaemia during Intracoronary Infusion in the Dog
Clin Sci (Lond) (1989) 76 (s20): 24P.
Mechanism of Impaired Excretion of Fluid Load following Cardiac Denervation in Dogs
Clin Sci (Lond) (1989) 76 (s20): 24P.
Neuroendocrine Responses to Head-Up Tilt are Altered after Heart-Lung Transplantation
Clin Sci (Lond) (1989) 76 (s20): 24P.
Stimulation of Proteoglycan Synthesis in Rat Mesangial Cells in Response to Tumour Necrosing Factor
Clin Sci (Lond) (1989) 76 (s20): 25P.
Sequential Images of Venous Thrombus in Postoperative Patients Using a Labelled Monoclonal Antibody to Platelets
Clin Sci (Lond) (1989) 76 (s20): 25P.
Effect of Dose, Binding Affinity and Molecular Size on Tumour Uptake of Antibody or Ligand
Clin Sci (Lond) (1989) 76 (s20): 26P.
Killer T-Cell Cytolysis is Mediated by Activation of Target-Cell Ornithine Decarboxylase
Clin Sci (Lond) (1989) 76 (s20): 26P.
Neutrophil Activation: An Important Mechanism of Graft Damage during Rejection of Human Liver Transplants?
Clin Sci (Lond) (1989) 76 (s20): 26P–27P.
A Method for the Preparation of RNA from Human Colonic Mucosa Obtained by Colonoscopic Biopsy
Clin Sci (Lond) (1989) 76 (s20): 27P.
Non-Steroidal Anti-Inflammatory Drugs Increase Colonic Rather than Small Intestinal Permeability
Clin Sci (Lond) (1989) 76 (s20): 27P.
Primary Biliary Cirrhosis: Characterisation of the Main Immunogenic Region on the Major M2 Mitochondrial Autoantigen
Clin Sci (Lond) (1989) 76 (s20): 28P.
Impaired Glucose Tolerance Precedes but Does Not Predict Insulin-Dependent Diabetes: A Study of Identical Twins
Clin Sci (Lond) (1989) 76 (s20): 28P.
Evidence for a Finite Critical Period of Exposure to an Enviromental Agent as a Cause of Insulin Dependent Diabetes
Clin Sci (Lond) (1989) 76 (s20): 28P.
Does Beta-Hydroxybutyrate Stimulate Plasma Vasopressin in the Streptozotocin-Diabetic Rat?
Clin Sci (Lond) (1989) 76 (s20): 28P.
Human Chorionic Gonadotrophin (HCG) and Thyroid Function in Early and Late Pregnancy
Clin Sci (Lond) (1989) 76 (s20): 29P.
The Preclinical Pharmacology of UK-69,578, a Novel Atriopeptidase Inhibitor
G.M.R. Samuels, BSc PhD; P.L. Barclay, BSc PhD; C.T. Alabaster, BSc PhD; C.J. Peters, BSc PhD; P. Ellis, BSc PhD
Clin Sci (Lond) (1989) 76 (s20): 29P.
Inhibition of ANP Degradation by the Atriopeptidase Inhibitor UK 69,578 in Normal Man
Clin Sci (Lond) (1989) 76 (s20): 29P.
Effect of Flurbiprofen on Airways Reactivity and Urinary Thromboxane Metabolite Levels in Smokers, with Airway Hyperreactivity
Clin Sci (Lond) (1989) 76 (s20): 29P–30P.
Prior Treatment with Diuretic Augments the Hypokalaemic and Electrocardiographic Effects of Inhaled Salbutamol in Man
Clin Sci (Lond) (1989) 76 (s20): 30P.
Myocardial Ischaemia in the Ambulatory Setting: A Comparative Study of Patients with Restrictive Angina and Those Well Controlled on Medical Therapy
David Mulcahy, MRCPI; Jennifer Keegan, MSc; Jane Sparrow, BEd; Amanda Park, SRN; Christine Wright, SRN; Kim Fox, MD
Clin Sci (Lond) (1989) 76 (s20): 30P.
Renal Blood Flow Changes Induced by Captopril before and after Angioplasty in Renal Arterty Stenosis
Clin Sci (Lond) (1989) 76 (s20): 30P.
Tachyphylaxis to Systemic but Not Airways Responses during Prolonged Therapy with High Dose Inhaled Salbutamol in Asthmatics
Clin Sci (Lond) (1989) 76 (s20): 30P–31P.
Microvascular Permeability in Hypertension and its Response to Angiotensin Converting Enzyme (ACE) Blockade
Clin Sci (Lond) (1989) 76 (s20): 31P.
Does Increasing Haemoglobin (Hb) or Haematocrit (Hct) Have a Pressor Effect in Dialysis Patients?
Clin Sci (Lond) (1989) 76 (s20): 31P.
Endothelin has Prolonged Biological Activity but a Short Plasma Half Life in the Rat
Clin Sci (Lond) (1989) 76 (s20): 32P.
Atrial Natriuretic Factor Inhibits Both Captopril and Prostaglandin E2 Stimulated Renin Release in Man
Clin Sci (Lond) (1989) 76 (s20): 32P.
The Effects of Dietary Saturated Fat Supplementation on Erythrocyte Sodium Transport and Blood Pressure in Normotensive Human Volunteers
Clin Sci (Lond) (1989) 76 (s20): 33P.
Determination of Histtdine Decarboxylase Activity in Respiratory Tract Bacteria
Clin Sci (Lond) (1989) 76 (s20): 33P.
In-Vivo Measurement of the Local Metabolic Response to Lung Inflammation in Rabbits by Positron Emission Tomography (PET)
Clin Sci (Lond) (1989) 76 (s20): 33P–34P.
Pulmonary Vasodilator Action of Adenosine and an A2 Agonist in Control and Chronically Hypoxic Rats
Clin Sci (Lond) (1989) 76 (s20): 34P.
Radionuclide Assessment of Right Ventricular Function in Chronic Obstructive Pulmonary Disease
Clin Sci (Lond) (1989) 76 (s20): 34P.
A New Spirometric Parameter for the Assessment of Lung Function and the Effect of Broncodilatation
Clin Sci (Lond) (1989) 76 (s20): 34P–35P.
Is there Clinically-Useful Information in Patients' Descriptions of Their Respiratory Discomfort?
Clin Sci (Lond) (1989) 76 (s20): 35P.
Comparison of TLC and RV Single Breath/Multibreath Helium Dilution Tests in the Detection of Obstructive Airways Disease
Clin Sci (Lond) (1989) 76 (s20): 35P.
Influence of Symptoms, Spirometry and Exercise Tolerance on General Health (‘Quality of Life’) in Chronic Airflow Limitation
Clin Sci (Lond) (1989) 76 (s20): 36P.
Phosphorus Magnetic Resonance Spectroscopic Imaging of the Transmural Distribution of Metabolttes in Systole and Diastole in the Pig Heart
Clin Sci (Lond) (1989) 76 (s20): 36P.
Within Patient Assessment of Catheter-Based Indices of Left Ventricular Contractility
Clin Sci (Lond) (1989) 76 (s20): 36P.
Earlier Recanalisation Follows Bolus Administration of Tissue-Plasminogen Activator in Patients with Acute Myocardial Infarction
Clin Sci (Lond) (1989) 76 (s20): 37P.
Left Ventricular Function during Atrial Pacing Induced Angina as Assessed with a Miniature Nuclear Probe
Clin Sci (Lond) (1989) 76 (s20): 37P.
Characteristics of Transient St Segment Deviation during Ambulatory Electrocardiographic Monitoring after Acute Myocardial Infarction
Clin Sci (Lond) (1989) 76 (s20): 38P.
A Comparison of Treadmill Exercise Testing and Ambulatory Electrocardiographic Monitoring after Acute Myocardial Infarction
Clin Sci (Lond) (1989) 76 (s20): 38P.
Hyperpnoea during Steady-State Exercise in Chronic Cardiac Failure (Introduced by K.D. Buchanan)
Clin Sci (Lond) (1989) 76 (s20): 39P.
NON-Invasive Blood Pressure Monitor Overestimates Night-Time Blood Pressure
Clin Sci (Lond) (1989) 76 (s20): 39P.
Acid Exposure Times Do Not Identify Patients with Symptomatic Gastro-Oesophageal Reflux
Clin Sci (Lond) (1989) 76 (s20): 40P.
Markers of Free Radical Activity in Alcoholics and Controls and the Decline of the Diene Conjugate of Linoleic Acid after Abstinence
Clin Sci (Lond) (1989) 76 (s20): 40P.
Age Related Changes in Duodenal 1,25-(OH)2D3 Receptors, Alkaline Phosphatase Activity, and Calcium Absorption in Female Rats
Clin Sci (Lond) (1989) 76 (s20): 40P.
Improved Absorption Rates of Water and Solutes from Hypotonic Compared with Isotonic Oral Rehydration Solutions (ORS) in the Intact Human Jejunum
Clin Sci (Lond) (1989) 76 (s20): 41P.
Kinetics of Intestinal Transport of Peptides and Amino Acids, Relative Absorption Rates and the Lipophilic Side-Chain Hypothesis
Clin Sci (Lond) (1989) 76 (s20): 41P.
Mitotic Indices Correlates Directly with Crypt Hyperplasia Irrespective of Diagnosis
Clin Sci (Lond) (1989) 76 (s20): 41P–42P.
Use of Isolated Intestinal Brush Border Membrane Vesicles as a Model for Membrane Partitioning of Drugs
Clin Sci (Lond) (1989) 76 (s20): 42P.
The Ability of Pepsins to Degrade Gastroduodenal Mucus Glycoproteins
Clin Sci (Lond) (1989) 76 (s20): 42P.
Comparison of Glucose Polymer and Natural Complex Carbohydrate as Substrate in Oral Rehydration Solutions
Clin Sci (Lond) (1989) 76 (s20): 42P–43P.
One Day Combined 14C-Triolein Breath Test & PABA Test in the Differentiation of Pancreatic and Intestinal Causes of Malabsorption
Clin Sci (Lond) (1989) 76 (s20): 43P.
Impaired Endothelium Dependent Relaxation in the Spontaneously Hypertensive Rat: Role of Thromboxane A2
Clin Sci (Lond) (1989) 76 (s20): 44P.
Platelet-Activating Factor Does Not Mediate Hypoxic Pulmonary Vasoconstriction in the Pig
Clin Sci (Lond) (1989) 76 (s20): 44P.
Leukotriene B4 Generation by Polymorphonuclear Leukocytes and Mononuclear Leukocytes Stimulated by Uropathogenic Escherichia coli Strains
Clin Sci (Lond) (1989) 76 (s20): 44P.
Platelet Activating Factor (PAF) Stimulates Phosphoinositide (PI) Metabolism in Guinea Pig Eosinophils
Clin Sci (Lond) (1989) 76 (s20): 45P.
Suppressed Serum TSH with Normal Free Thyroid Hormone Levels in Patients with No History of Thyroid Disorder
Clin Sci (Lond) (1989) 76 (s20): 45P.
Neurotensin Synthesis in the Anterior Pituitary is Regulated by Oestrogen Status
Clin Sci (Lond) (1989) 76 (s20): 46P.
Interassay Variations in Digoxin-Like Doiunoreactive Substance(s) in Serum and Bile - What are we Measuring?
Clin Sci (Lond) (1989) 76 (s20): 47P–48P.
Abnormalities in Phosphorus Metabolites in Patients with Primary Brain Disorders Detected by 31-Phosphorus Magnetic Resonance Spectroscopy
Clin Sci (Lond) (1989) 76 (s20): 48P.
Phosphorus Magnetic Resonance Spectroscopy of Leg Muscle in Heart Failure
Clin Sci (Lond) (1989) 76 (s20): 48P–49P.
Plasma Ammonia is Reduced by Glucose and Branched Chain Keto-Acids during Exercise in McArdle's Disease
Clin Sci (Lond) (1989) 76 (s20): 49P.
Monoclonal Antibody (Mab) to Recombinant Human Tumour Necrosis Factor (rhTNF) in the Prophylaxis and Treatment of Endotoxic Shock in Cynomolgus Monkeys
Clin Sci (Lond) (1989) 76 (s20): 50P.
Reduced Vibration Sensation in the Right Hands of Normal Individuals: An Intrinsic Difference or Acquired Abnormality?
Clin Sci (Lond) (1989) 76 (s20): 50P.
Effects of Chronic Infusion of Dopa and Carbidopa on Plasma and Kidney Renin Concentrations in the Rat
Clin Sci (Lond) (1989) 76 (s20): 50P–51P.
Selective Enhancement of Cardiac Sympathetic Activity during Exertional Angina: A Radiotracer Kinetic Study
Clin Sci (Lond) (1989) 76 (s20): 51P.
Aortic Blood Acceleration Correlates Well with Ejection Fraction Post Infarction
Clin Sci (Lond) (1989) 76 (s20): 51P–52P.
Low Maximum Acceleration on Peak Exercise Combined with Exercise Testing Identifies those Myocardial Infarction Patients Most at Risk of Cardiac Death
Clin Sci (Lond) (1989) 76 (s20): 52P.
Abnormal Oxidative Metabolism in Skeletal Muscle in Myocardial Infarction in the Rat
Clin Sci (Lond) (1989) 76 (s20): 52P.
Inositol Phosphate Production in the Left Ventricle following Induction of Acute Hypertension
Clin Sci (Lond) (1989) 76 (s20): 52P.
Lack of Relation between Action Potential Duration (and QT Interval) and Simultaneous Contractility in Man
Clin Sci (Lond) (1989) 76 (s20): 52P–53P.
Alternating Solvent Treatment for Cholesterol Gallstones: In vitro Studies with Methyl Tertiary Butyl Ether (MTBE) and Bile Acid-Edta Solutions
Clin Sci (Lond) (1989) 76 (s20): 54P.
Is 99m Tc Human Serum Albumin a Suitable Label to Assess Nebulisation of Pentamidine Isethionate?
Clin Sci (Lond) (1989) 76 (s20): 54P.
Increased Regional Myocardial Glucose Utilisation in Patients with Chronic Stable Angina as Assessed by Positron Emission Tomography (PET)
Clin Sci (Lond) (1989) 76 (s20): 55P.
31P Magnetic Resonance Study of Mild and Severe Encephalopathy in the New-Born after Birth Asphyxia
Clin Sci (Lond) (1989) 76 (s20): 55P.
Characterisation of the Spleen by Image Guided In-Vivo 31P Magnetic Resonance Spectroscopy
Clin Sci (Lond) (1989) 76 (s20): 55P.
The Changes in Erythrocyte Sodium Transport Early in Normal Human Pregnancy
Clin Sci (Lond) (1989) 76 (s20): 56P.
Oxalate Concentration and Oxalate Clearance in Patients Receiving Haemodialysis
Clin Sci (Lond) (1989) 76 (s20): 56P.
Low Dose Atrial Natriuretic Factor (ANF) Infusion Increases Albuminuria in Renal Disease
Clin Sci (Lond) (1989) 76 (s20): 56P–57P.
Phosphorus Magnetic Resonance Spectroscopy of Patients with Alcoholic Liver Disease
Clin Sci (Lond) (1989) 76 (s20): 57P.
Does Release of Cytosolic Enzymes from Skeletal Muscle Represent a Loss of Celll Viability?
Clin Sci (Lond) (1989) 76 (s20): 57P.