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Volume 93, Issue s37

August 1997

ISSN 0143-5221

EISSN 1470-8736

Medical Research Society Meeting 15 May 1997

Adenoviral Transfer of the Marker Gene for β Galactosidase to the Pig Coronary Artery: The Effect of Pre-Esisting Lesions

W Andrews; L Packwood; CM Dollery; P Yiu; A McClelland; SE Humphries; JR McEwan

Clin Sci (Lond) (1997) 93 (s37): 1P.

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β₂-Adrenoceptor Stimulation Increases Dispersion of Cardiac Repolarisation

MD Lowe; PF Ludman; E Rowland; AA Grace

Clin Sci (Lond) (1997) 93 (s37): 1P.

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Measurement of Cell Proliferation in Man with Stable Isotopes by Endogenous Labelling of DNA

DC MacAllan; CA Fullerton; RA Neese; MK Hellerstein

Clin Sci (Lond) (1997) 93 (s37): 1P–2P.

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The Effects of 17 β-Oestradiol on Isolated Rat Coronary and Systemic Vascular Smooth Muscle Tone

D. Otter; C. O. Brien; C. Austin

Clin Sci (Lond) (1997) 93 (s37): 2P.

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IS Cholelithiasis an Intestinal Disease? a Study of Five Inter-Related Factors

L.A. Thomas; M.J. Veysey; G.M. Murphy; R.H. Dowling; T. Bathgate; A. King; G.R. French

Clin Sci (Lond) (1997) 93 (s37): 2P.

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Calmodulin in Mast Cells Regulates the Secretory Response to Polyamines and IgE Independently of the F-Actin Cytoskeleton

R Sullivan; K Török; A Koffer

Clin Sci (Lond) (1997) 93 (s37): 2P.

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Impairment of Endothelial Cyclooxygenase and Nitric Oxide Synthase Leads to Severe Pulmonary Hypertension in Rats

O. Kapellerova; E. Laude; X. Liu; G. R. Barer

Clin Sci (Lond) (1997) 93 (s37): 3P.

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Myocardial Nadh Measurements as an Indicator of Mitochondrial Function and Organ Viability

EO Balogun; MS Thorniley; CJ Green

Clin Sci (Lond) (1997) 93 (s37): 3P.

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Characterisation of Genes Expressed during the Early Stages of Vegf-Induced Angiogenesis

M Kale; RP Boot-Handford; AM Heagerty; AE Canfield

Clin Sci (Lond) (1997) 93 (s37): 3P.

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Influence of Plaque Lipid Composition and Morphology on the Stability of Human Aortic Plaques

CV Felton; D Crook; MJ Davies; MF Oliver

Clin Sci (Lond) (1997) 93 (s37): 3P–4P.

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Ethnic Variation in the Size of Coronary Arteries

VS Rathore; R Katira; C Gibbs; IF Islim; TA Azeem; GYH Lip; RDS Watson; S P Singh

Clin Sci (Lond) (1997) 93 (s37): 4P.

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A Comparison of the Impact on Blood Pressure of Medical and Surgical Procedures at the Carotid Sinus

R Steeds; A Sivaguru; P Gaines; J Beard; G Venables; K Channer

Clin Sci (Lond) (1997) 93 (s37): 4P.

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S-100 Protein Release in a Range of Cardiothoracic Surgical Procedures

P Kumar; K Dhital; M Hossein-Nia; S Patel; D Holt; T Treasure

Clin Sci (Lond) (1997) 93 (s37): 4P.

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Serum Lipid Changes following Stroke

V Bolarum; A Chauhan; M D Fotherby

Clin Sci (Lond) (1997) 93 (s37): 5P.

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Orthostatic Fall in Blood Pressure in the Very Elderly Hypertensive (Pilot Trial Results from the Hypertension in the Very Elderly Trial (HYVET))

CJ Bulpitt; M Connor; AE Fletcher on behalf of the HYVET investigators

Clin Sci (Lond) (1997) 93 (s37): 5P.

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Plasma Nitrate/Nitrite and Polyamine Concentrations in Patients with Myocardial Infarction on Admission

I Das; JI Galbraith; RJ Pennington; J Alaghband-Zadeh; PJ Stubbs; JF Laycock

Clin Sci (Lond) (1997) 93 (s37): 5P.

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Efficacy and Mechanism of Action of Atorvastatin Compared with Simvastatin in Refractory Familial Hypercholesterolaemia

RP Naoumova; S Dunn; C Neuwirth; NB Rendell; GW Taylor; GR Thompson

Clin Sci (Lond) (1997) 93 (s37): 5P–6P.

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Exercise Capacity and Ventilation in Patients with Mitochondrial Myopathy

D Harrington; TP Chua; J Morgan-Hughes; PA Poole-Wilson; AJS Coats

Clin Sci (Lond) (1997) 93 (s37): 6P.

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Skeletal Muscle Dysfunction in Chronic Heart Failure: Mechanisms and Relation to Exercise Capacity

D Harrington; SD Anker; TP Chua; PA Poole-Wilson; AJS Coats

Clin Sci (Lond) (1997) 93 (s37): 6P.

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Increased Levels of Soluble P Selectin and Von Willebrand Factor in Cancer: Influence of Radiotherapy and Surgery

AD Blann; S Kumar; AD Baildam

Clin Sci (Lond) (1997) 93 (s37): 6P.

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Angiogenesis and Endothelial Growth Factor in Atherosclerosis

A D Blann; LI J-L; JB Weiss; CN McCollum

Clin Sci (Lond) (1997) 93 (s37): 6P–7P.

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Antioxidants Prevent Endothelial Damage in HIV Infection

AD Blann; M Seigneur; C Conri; J Constans; M Boisseau

Clin Sci (Lond) (1997) 93 (s37): 7P.

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Endothelial Cell Markers and the Prediction of Cardiovascular Events

AD Blann; J Amiral; CN McCollum

Clin Sci (Lond) (1997) 93 (s37): 7P.

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Endothelial Cell Markers and the Extent of Symptomatic Atherosclerosis

AD Blann; M Seigneur; M Steiner

Clin Sci (Lond) (1997) 93 (s37): 7P.

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Insulin Vasodilatation is Abolished by Both L-NMMA and Angiotensin II

SJ Cleland; JR Petrie; S Ueda; HL Elliott; JMC Connell

Clin Sci (Lond) (1997) 93 (s37): 8P.

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Vascular Endothelial Growth Factor (VEGF) Alters Endothelial Cell Function

J C Brockelsby; R P Wellings; P N Baker

Clin Sci (Lond) (1997) 93 (s37): 8P.

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Anti-Phospholipid Autoantibody-Positive Sera Interfere with Phosphatidylserine (PS)-Dependent Recognition of Apoptotic Cells by Macrophages (Mø)

H Church; S Brown; Y Ren; S Loziou; M Walport; J Savill

Clin Sci (Lond) (1997) 93 (s37): 8P.

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QT Dispersion is Related to Autonomic Tone in Patients with Chronic Heart Failure

CE Bonnar; RJ Mac Fadyen; J Robson; A Duncan; AD Struthers

Clin Sci (Lond) (1997) 93 (s37): 8P–9P.

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Relationship between Daily Activity Levels and Cardiac Ambulatory Monitoring (Introduced BY SW Davies)

C Davidson; D Ribbans; LB Rose

Clin Sci (Lond) (1997) 93 (s37): 9P.

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Cardiac Sympathetic Activity with Ageing and Relationship to Diastolic Function

C Rajkumar; AM Dart; J Wong; J Cameron; R Mazzeo; M Vaz; N Christophidis; GL Jennings; M Esler; CJ Bulpitt

Clin Sci (Lond) (1997) 93 (s37): 9P.

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Percutaneous Balloon Valvuloplasty for Congenital Pulmonary Stenosis in Adults

GYH Lip; R Katira; VS Rathore; J De Giovanni; SP Singh

Clin Sci (Lond) (1997) 93 (s37): 10P.

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Long-Term Followup following Surgical Correction of Tetralogy of Fallot

GYH Lip; V Rathore; R Katira; J De Giovanni; SP Singh

Clin Sci (Lond) (1997) 93 (s37): 10P.

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PIA Polymorphism and M.I. under 60

R Steeds; SV Osborn; ME Daly; KK Hampton; D Smillie; KS Channer; IR Peake

Clin Sci (Lond) (1997) 93 (s37): 10P.

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Increased QT Dispersion during Ischaemia is Unaffected BY β₁-Adrenoceptor Antagonists

MD Lowe; SA Newell; E Rowland; AA Grace

Clin Sci (Lond) (1997) 93 (s37): 10P–11P.

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Cardiogenic Shock in 1996: Insights from the Heroics Trial Registry

MI Walters; R Lim; RS Clark; GC Kaye; JL Caplin; MS Norell

Clin Sci (Lond) (1997) 93 (s37): 11P.

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Why Thrombolysis is Not a ‘Fire and Forget’ Therapy: Data from an ST Resolution Analysis

MI Walters; R Lowe; JL Caplin; MS Norell

Clin Sci (Lond) (1997) 93 (s37): 11P.

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A New Regimen for Starting Warfarin Therapy in Out-Patients

A. Oates; PR Jackson; CA Austin; KS Channer

Clin Sci (Lond) (1997) 93 (s37): 11P.

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A Role for Integrins in the Differentiation of Oligodendrocytes

PC Buttery; C Streuli; C Ffrench-Constant

Clin Sci (Lond) (1997) 93 (s37): 11P–12P.

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Production of Interleukin 8 and Macrophage Inflammatory Protein 1 during Monocyte: Hepatoma Cell Interaction is Differentially Regulated

KJ Simpson; NW Lukacs; H Evanoff; RM Strieter; SL Kunkel

Clin Sci (Lond) (1997) 93 (s37): 12P.

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Responses to Angioplasty of Pre-Injured (Sclerotic) Coronary Arteries in the Pig

L Packwood; D Parums; J R McEwan

Clin Sci (Lond) (1997) 93 (s37): 12P.

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Does the Rate of Progression of Diabetic Nephropathy Differ between Two Ethnic Groups - Whites and Indo-Asians

NP Koppiker; AC Burden; J Feehally

Clin Sci (Lond) (1997) 93 (s37): 12P–13P.

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Foscarnet Related Alterations in Plasma Ionised, Plasma Total and Urinary Magnesium Status in HIV Seropositive Patients

FH Noormohamed; MS Youle; AF Lant

Clin Sci (Lond) (1997) 93 (s37): 13P.

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Renal Clearance of ⁵¹Chromium-Edta Compared with Estimates of Creatinine Clearance, Derived from Plasma and Urinary Creatinine, in HIV Sero-Positive Patients

FH Noormohamed; MS Youle; AF Lant

Clin Sci (Lond) (1997) 93 (s37): 13P.

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Plasma Lipoprotein(a) [LP(a)] Concentrations and Apoprotein(a) [APO(a)] Isoforms in Chronic Renal Disease

DA Reaveley; M Misra; N Al-Khalaf; E Brown; J Alaghband-Zadeh

Clin Sci (Lond) (1997) 93 (s37): 13P.

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Interleukin 1β and Tumour Necrosis Factor α Induce Apoptosis in Renal Mesangial Cells In Vitro

E Justice; E Stylianou; J Savill

Clin Sci (Lond) (1997) 93 (s37): 13P–14P.

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Induction of Hyperglycaemia in CD1 Mice by the Betel-Nut (Areca catechu) Nitrosamine MNPN, Inhibition by Beta Carotene and Enhancement by Vitamins a and E

V Motahar; BJ Boucher

Clin Sci (Lond) (1997) 93 (s37): 14P.

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Insulin Levels following Islet- Cell Autotransplantation

NP Koppiker; AC Burden; M Davies

Clin Sci (Lond) (1997) 93 (s37): 14P.

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The Effect of Angiotensin II and Angiotensin II Receptor Antagonists on In Vitro Maturation of Mouse Oocytes

R Edwards; S D Fleming; A Pitten; F Broughton Pipkin

Clin Sci (Lond) (1997) 93 (s37): 14P.

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Circadian Homeostasis of Water and Electrolyte Excretion during Volume Expansion in Normal Man (Introduced by Mrs Member — JP O'HARE)

PMS Evans; TS Purewal; A Taylor; SL Lightman; JP O'Hare

Clin Sci (Lond) (1997) 93 (s37): 15P.

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Exogenous Administration of Subcutaneous Glucagon-Like Peptide-1 (7–36) Amide Causes Hypoglycaemia in Fasted Healthy Volunteers

CMB Edwards; JF Todd; MA Ghatei; SR Bloom

Clin Sci (Lond) (1997) 93 (s37): 15P.

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Hyperinsulinameia Induces Hyperphagia in the Rat without Changes in Hypothalamic Neuropeptide Y (NPY) or Obese Gene Expression

Simon Dryden; Lynne Henderson; Lucy Pickavance; Gareth Williams

Clin Sci (Lond) (1997) 93 (s37): 15P.

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The Cytotoxic Effects of Nitric Oxide on HT29 Colonic Epithelial Cells

PJ Roberts; M Shorthouse; JO Hunter; SJ Middleton

Clin Sci (Lond) (1997) 93 (s37): 16P.

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Inducible NOS (iNOS) is Expressed in the Normal Human Colon

PJ Roberts; K Morgan; M Shorthouse; JO Hunter; SJ Middleton

Clin Sci (Lond) (1997) 93 (s37): 16P.

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Fluoride - An Activator of Histamine Methyl Transferase

C. Bruce; W.H. Taylor

Clin Sci (Lond) (1997) 93 (s37): 17P.

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Effect of DFMO on the Kinetics of Putrescine Uptake by Caco-2 Cells

V Milovic; GM Murphy; RH Dowling

Clin Sci (Lond) (1997) 93 (s37): 17P.

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Clinical Xenotransplantation of Porcine Organs: Immune Barriers beyond Hyperacute Rejection

A Dorling; RI Lechler

Clin Sci (Lond) (1997) 93 (s37): 18P.

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A Variant of the Endothelial Nitric Oxide Synthase Gene is a Risk Factor for Coronary Atherosclerosis

AD Hingorani; C Liang; J Fatibene; A Parsons; R Hopper; D Trutwein; NG Stephens; KM O'Shaughnessy; MJ Brown

Clin Sci (Lond) (1997) 93 (s37): 18P.

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Identification of CD8+ Cytotoxic T Lymphocytes (CTL) Specific for Plasmodium falcipaarum and Mycobacterium Tuberculosis in Naturally Infected Humans

A Lalvani; M Aidoo; R Brookes; AVS Hill

Clin Sci (Lond) (1997) 93 (s37): 18P.

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Two-Stage Genome-Wide Search in Inflammatory Bowel Disease: Strong Evidence for Susceptibility LOCI on Chromosomes 3, 7 and 12

Jack Satsangi; Miles Parkes; Eduoard Louis; KEN Welsh; John I Bell; Derek P Jewell

Clin Sci (Lond) (1997) 93 (s37): 18P–19P.

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Studies on Adenosine Deaminase (ADA) Deficiency and Hereditary Haemorrhagic Telangiectasia (HHT)

Claire L. Shovlin

Clin Sci (Lond) (1997) 93 (s37): 19P.

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Genetic Variation in the Human Stromelysin Promoter: Effects on Gene Expression and Progression of Coronary Atherosclerosis

S Ye; P Eriksson; A Hamsten; GF Watts; M Kurkinen; SE Humphries; AM Henney

Clin Sci (Lond) (1997) 93 (s37): 19P.

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Disease Characterisation & Identification of a Novel Gene Locus for Arrhythmogenic Right Ventricular Cardiomyopathy

AS Coonar; N Protonotarios; A Tsatsopoulou; EWA Needham; RS Houlston; S Cliff; MI Otter; VA Murday; RK Mattu; WJ McKenna

Clin Sci (Lond) (1997) 93 (s37): 19P.

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Transgenic Analysis of Hox Gene Expression

A Morrison; A Gould; R Krumlauf

Clin Sci (Lond) (1997) 93 (s37): 20P.

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Cytotoxic T-Lymphocyte Activity Selects Immune Escape Variants during Primary HIV-1 Infection

D A Price; P J R Goulder; P Klenerman; A K Sewell; P J Easterbrook; M Troop; C R M Bangham; R E Phillips

Clin Sci (Lond) (1997) 93 (s37): 20P.

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Aspects of the Control of the Retinal and Choroidal Circulations in Normal and Diabetic Human Subjects

MJ Dumskyj

Clin Sci (Lond) (1997) 93 (s37): 20P–21P.

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Bacille Calmette Guerin as a Vector for Expressing the B Subunit of Escherichia coli Heat Labile Enterotoxin; a Model for Oral Immunisation

C Hayward; P. O'Gaora; D. Young; G Griffin; T Hirst; D Lewis

Clin Sci (Lond) (1997) 93 (s37): 21P.

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Detoxifying Enzyme Gene Polymorphisms and Susceptibility to Skin Cancer

JT Lear

Clin Sci (Lond) (1997) 93 (s37): 22P.

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Azithromycin Reduces Haemostatic Markers, Inflammation and Monocyte Activation in Post-Infarct Patients with Elevated Chlamydia Pneumoniae Antibodies

S Gupta; M Mendall; EW Leatham; D Carrington; J Tooze; N Ireson; D Bevan; AJ Camm; JC Kaski

Clin Sci (Lond) (1997) 93 (s37): 22P–23P.

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The Demonstration of Fetal Lung and Placental Maturation by Measurement of Echo-Planar Magnetic Resonance Relaxation Parameters

KR Duncan; R Moore; PA Gowland; IR Johnson; PN Baker

Clin Sci (Lond) (1997) 93 (s37): 23P.

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Are Angiotensin Converting Enzyme Inhibitors a New Therapeutic Option in Hypercholesterolaemia?

AFC Lee; JBC Dick; CE Bonnar; AD Struthers

Clin Sci (Lond) (1997) 93 (s37): 24P.

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Insulins Depressor Action on Skeletal Muscle Vasculature: A Novel Mechanism for Postprandial Hypotension in the Elderly

MT Kearney; AJ Cowley; IA MacDonald

Clin Sci (Lond) (1997) 93 (s37): 24P.

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Limb Anomalies in Craniosynostosis Syndromes Resulting from Mutations of the FGFR 2 Gene

PJ Anderson; C Hall; RD Evans; RD Hayward; BM Jones

Clin Sci (Lond) (1997) 93 (s37): 24P.

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Engineering Stable Mini-Chromosome Derivatives of the Human Y Chromosome

R Heller; KE Brown; C Burgtorf; WRA Brown

Clin Sci (Lond) (1997) 93 (s37): 25P.

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Gene Expression following Experimental Cerebral Ischaemia and Head Injury in Man

PC Whitfield; R Laing; H Richards; R Williams; JD Pickard

Clin Sci (Lond) (1997) 93 (s37): 25P.

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Randomised Controlled Trial of a 12-Week Exercise Intervention and Omega-3 Fatty Acids in Improving Insulin Sensitivity among South Asians and Europeans

G Davey; J Roberts; S Patel; B Davies; PM McKeigue

Clin Sci (Lond) (1997) 93 (s37): 25P.

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The Chemokine Network in Anca-Associated Renal Vasculitis

P. Cockwell

Clin Sci (Lond) (1997) 93 (s37): 26P.

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Cytokine-Mediated Induction of no Synthesis in Humans In Vivo - eNOS Masquerading as iNOS

K Bhagat; A Hingorani; I Charles; P Vallance

Clin Sci (Lond) (1997) 93 (s37): 27P.

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Therapeutic Regulation of the Cytokine Network in Experimental Glomerulonephritis

F. W. K. Tam; J. Smith; A. M. Karkar; S. Agarwal; D. Morel; E. M. Thompson; A. J. Rees; C. D. Pusey

Clin Sci (Lond) (1997) 93 (s37): 27P.

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In Vivo and in Vitro Vascular Gene Transfer of Timp-1 Using an Adenoviral Vector

CM Dollery; A McClelland; M Rollence; SC Stevenson; DS Latchman; AM Henney; SE Humphries; JR McEwan

Clin Sci (Lond) (1997) 93 (s37): 28P.

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Patients with Acute Pulmonary Tuberculosis (TB) have Subtle but Crucial Abnormalities of Steroid Metabolism Which May Persist after Cure or be Constitutive

R.W. Baker; R.J. Shaw; G.A.W Rook; J. Honour; S.L. Lightman; B. Walker; A. Zumla

Clin Sci (Lond) (1997) 93 (s37): 28P.

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Persistent Immaturity of Counter-Regulatory Ketogenesis in Preterm Infants

SA Deshpande; MP Ward Platt

Clin Sci (Lond) (1997) 93 (s37): 28P.

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The Role of Sex in the Genetic Aetiology of Schizophrenia

N J Bass

Clin Sci (Lond) (1997) 93 (s37): 29P.

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Perinatal Necropsy by MRI

JAS Brookes; MA Hall-Craggs; VR Sams; WR Lees

Clin Sci (Lond) (1997) 93 (s37): 30P.

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The Plasminogen Activators in Intimal Hyperplasia

MY Salame; RS More; NJ Samani; DP deBono

Clin Sci (Lond) (1997) 93 (s37): 30P.

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The Value of Natriuretic Peptides in Confirming the Diagnosis of New Heart Failure in General Practice

MR Cowie; AD Struthers; DA Wood; A Coats; SG Thompson; PA Poole-Wilson; GC Sutton

Clin Sci (Lond) (1997) 93 (s37): 31P.

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Medical Research Society Meeting 15 May 1997

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