Shifting paradigms in immunity: New cells, or new functions for old cells.

Open for submissions

In the last two decades, increased knowledge of the cellular and molecular mechanisms of immune responses have challenged the traditional framework of innate (phagocytes, neutrophils, NK cells, epithelial surfaces) and adaptive (B and T lymphocytes) immunity in both healthy and pathological states.  For example, the canonical mechanisms of the adaptive immune system, which are based on clonal selection of antigen receptors, is not the only type of immune memory.  The discovery of innate lymphoid cells with transcription factor and cytokine profiles similar to T helper subsets, and the concept of “trained immunity,” or functional reprogramming of innate immune cells to evoke memory to stimuli, are two such examples.  In addition, some innate inflammatory effector cells, such as neutrophils and eosinophils, have recently been shown to play a role in homeostasis in healthy tissues.  Immune cells have also emerged as mediators of inter-organ crosstalk in health and disease.  Finally, in addition to “professional” immune cells, there are several lines of evidence showing that parenchymal and mucosal cells are involved in the regulation of innate and adaptive immunity both in health and disease. 

This special themed collection in Clinical Science aims to collect high-quality research papers with experimental models of different diseases exploring the functions of recently described immune cell populations or identifying new functions of both traditional immune and non-immune cells.

This Clinical Science themed collection, will be Guest edited by:

Professor Ilja Striz, Institute for Clinical and Experimental Medicine (IKEM)

Assistant Professor Erin Taylor, University of Mississippi Medical Center

We welcome you to submit your best original research papers and note that all submissions will be subject to the standard peer review process.
 
Please contact the Editorial Office for any additional information.