1. Serum, urinary and erythrocyte magnesium concentrations were measured in groups of premenopausal, postmenopausal and oophorectomized women. 2. Serum and urinary magnesium were both significantly higher in postmenopausal and oophorectomized women than in the premenopausal group. 3. Oestrogen therapy reduced both serum and urinary magnesium values in oophorectomized women to premenopausal concentrations. 4. Erythrocyte magnesium concentrations were not affected by menstrual status or oestrogen therapy.
1. The value of progestogen therapy in the prevention of postmenopausal bone loss was assessed in 30 women, by a preliminary randomized controlled trial of gestronol or mestranol, in comparison with a placebo. 2. When the skeletal response was measured by photon absorptiometry, bone mineral loss was prevented by both the oestrogen and the progestogen. 3. We confirm that mestranol significantly reduced the urinary output of hydroxyproline-containing peptide, but this did not occur during gestronol therapy, suggesting that progestogen has a different action on bone, perhaps stimulating bone formation.
1. The effects on the serum electrolytes of long-term treatment with either mestranol or a placebo were determined in 175 healthy middle-aged oophorectomized women. In forty of these women the packed cell volume (PCV), serum albumin, serum and urinary osmolality, inulin space and total exchangeable sodium (Na e ) were also measured. 2. The mean serum sodium and chloride concentrations were significantly lower in the mestranol-treated women, and this was associated with a significant reduction in the mean PCV and the mean serum albumin concentration by comparison with the placebo-treated group. 3. The mean urinary osmolality was higher and the mean serum osmolality lower in the mestranol group such that there was a significant increase in the mean urine/serum osmolality ratio as compared with the placebo group. 4. The mean inulin space was significantly higher in the mestranol group as compared with the controls, but there was no significant difference in Na e . 5. These findings support the hypothesis that oestrogen-induced fluid retention is the result of primary water retention with secondary redistribution of body sodium.