1. We have investigated the effect of intermittent doses of ammonia and octanoic acid on liver regeneration in the rat after partial hepatectomy. Regeneration was assessed by uptake of tritiated thymidine into liver deoxyribonucleic acid. 2. We have found a reduction in hepatic regenerative response in animals treated with ammonium acetate as a source of ammonia. 3. No inhibiting effect of octanoic acid on liver regeneration was found, at the dose used. 4. The implications of the results for management of fulminant hepatic failure are discussed.
1. Sixteen plasma amino acids were measured serially in an experimental model of acute hepatic failure produced in the pig by devascularization of the liver. 2. Significant increases in the concentration of glycine, alanine and methionine were observed. 3. Altered concentrations in plasma of neutral amino acids which compete with tryptophan for transport into the brain had no apparent influence on brain tryptophan concentration.
1. The concentrations of a number of plasma proteins in patients with haemochromatosis were determined by quantitative immunoelectrophoresis, particular attention being paid to the three iron transporting proteins. 2. Transferrin and haptoglobin were within normal limits; haemopexin was significantly greater than normal ( P < 0·001). 3. Other changes observed were a significant ( P < 0·001) increase of α 1 antitrypsin, of α 2 macroglobulin and β 1A-C ; these changes are discussed.