1. In this study an acute anti-hypertensive effect of three anti-oxidant agents (vitamin C, thiopronine and glutathione) in hypertensive subjects and in both hypertensive and non-hypertensive diabetic patients is reported. 2. The anti-oxidants had no effect on blood pressure in healthy normal subjects at a dose of 6 mmol, but thiopronine and glutathione produced a significant hypotensive effect at a dose of 12 mmol. 3. These data suggest that anti-oxidants might have a dilatatory effect and that an imbalance of the nitric oxide-free radical interaction might facilitate the development of hypertension in humans.
1. Erythrocyte cation transport pathways have been investigated in a family with pseudohyperkalaemia. 2. Ouabain- and bumetanide-resistant Na + and K + effluxes in three pseudohyperkalaemic patients were not different from those of control subjects when assessed at 37°C. 3. When the temperature was decreased to 20°C and 9°C, K + passive permeability markedly increased and Na + permeability remained unchanged in these patients. In contrast, in control subjects a reduction in temperature caused a marked reduction in Na + and K + passive permeability. 4. These findings could account for the marked increase in plasma K + concentration observed at sub-physiological temperatures. 5. The Na + −K + co-transport pathway was reduced in all members of the family, but the Na + −K + pump was reduced in only two of them. These alterations were independent from the pseudohyperkalaemic state.