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Articles

Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Karen Horsburgh, Joanna M. Wardlaw, Tom van Agtmael, Stuart M. Allan, Mike L.J. Ashford, Philip M. Bath, Rosalind Brown, Jason Berwick, M. Zameel Cader, Roxana O. Carare, John B. Davis, Jessica Duncombe, Tracy D. Farr, Jill H. Fowler, Jozien Goense, Alessandra Granata, Catherine N. Hall, Atticus H. Hainsworth, Adam Harvey, Cheryl A. Hawkes, Anne Joutel, Rajesh N. Kalaria, Patrick G. Kehoe, Catherine B. Lawrence, Andy Lockhart, Seth Love, Malcolm R. Macleod, I. Mhairi Macrae, Hugh S. Markus, Chris McCabe, Barry W. McColl, Paul J. Meakin, Alyson Miller, Maiken Nedergaard, Michael O'Sullivan, Terry J. Quinn, Rikesh Rajani, Lisa M. Saksida, Colin Smith, Kenneth J. Smith, Rhian M. Touyz, Rebecca C. Trueman, Tao Wang, Anna Williams, Steven C.R. Williams, Lorraine M. Work
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (8): 851–868.
https://doi.org/10.1042/CS20171620
Published: 30 April 2018
View article titled, Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology
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Articles

Understanding a role for hypoxia in lesion formation and location in the deep and periventricular white matter in small vessel disease and multiple sclerosis

Santiago Martinez Sosa, Kenneth J. Smith
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (20): 2503–2524.
https://doi.org/10.1042/CS20170981
Published: 13 October 2017
View article titled, Understanding a role for hypoxia in lesion formation and location in the deep and periventricular white matter in small vessel disease and multiple sclerosis
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Articles

Impact of transient hypotension on regional cerebral blood flow in humans

Nia C.S. Lewis, Kurt J. Smith, Anthony R. Bain, Kevin W. Wildfong, Tianne Numan, Philip N. Ainslie
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (2): 169–178.
https://doi.org/10.1042/CS20140751
Published: 24 April 2015
View article titled, Impact of transient hypotension on regional cerebral blood flow in humans
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Articles

Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia

Philip N. Ainslie, Andrew D. Shaw, Kurt J. Smith, Christopher K. Willie, Keita Ikeda, Joseph Graham, David B. Macleod
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (9): 661–670.
https://doi.org/10.1042/CS20130343
Published: 17 January 2014
View article titled, Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia
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Articles

The Induction of Autoimmunity to MPO in WKY Rats Results in ANCA-Positive Small Vessel Vasculitis

C.L. Smyth, J. Smith, H.T. Cook, D.O. Haskard, C.D. Pusey
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (s49): 50P–51P.
https://doi.org/10.1042/cs104050Pb
Published: 01 April 2003
View article titled, The Induction of Autoimmunity to MPO in WKY Rats Results in ANCA-Positive Small Vessel Vasculitis
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Articles

Elevated Circulating Interleukin-6 Levels in Acute Ischaemic Stroke Are Correlated with Ct Infarct Volume and Poor Clinical Outcome

Hedley CA Emsley, Craig J Smith
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s47): 18P–19P.
https://doi.org/10.1042/cs103018Pb
Published: 01 July 2002
View article titled, Elevated Circulating Interleukin-6 Levels in Acute Ischaemic Stroke Are Correlated with Ct Infarct Volume and Poor Clinical Outcome
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Articles

Plasma-volume contraction and exercise-induced hypoxaemia modulate erythropoietin production in healthy humans

D. ROBERTS, D. J. SMITH, S. DONNELLY, S. SIMARD
Journal: Clinical Science
Clin Sci (Lond) (2000) 98 (1): 39–45.
https://doi.org/10.1042/cs0980039
Published: 22 November 1999
View article titled, Plasma-volume contraction and exercise-induced hypoxaemia modulate erythropoietin production in healthy humans
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Articles

Preventing Stroke: Implementing Antithrombotic Guidelines

KS Channer, H Brown, J Smith
Journal: Clinical Science
Clin Sci (Lond) (1999) 97 (s41): 4P–5P.
https://doi.org/10.1042/cs097004Pc
Published: 01 July 1999
View article titled, Preventing Stroke: Implementing Antithrombotic Guidelines
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Articles

Therapeutic Regulation of the Cytokine Network in Experimental Glomerulonephritis

F. W. K. Tam, J. Smith, A. M. Karkar, S. Agarwal, D. Morel, E. M. Thompson, A. J. Rees, C. D. Pusey
Journal: Clinical Science
Clin Sci (Lond) (1997) 93 (s37): 27P.
https://doi.org/10.1042/cs093027Pa
Published: 01 August 1997
View article titled, Therapeutic Regulation of the Cytokine Network in Experimental Glomerulonephritis
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Articles

Reproducibility of a Non-Powered Treadmill (NPT) to Assess An Older Population with Exercise Limitation Due to Heart Failure (HF)

S J Smith
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (s35): 10P.
https://doi.org/10.1042/cs091010Pb
Published: 01 July 1996
View article titled, Reproducibility of a Non-Powered Treadmill (NPT) to Assess An Older Population with Exercise Limitation Due to Heart Failure (HF)
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Articles

Increasing the Prescription of Drugs for Secondary Prevention following Myocardial Infarction

J Smith, K S Channer
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (s32): 24P.
https://doi.org/10.1042/cs088024P
Published: 01 February 1995
View article titled, Increasing the Prescription of Drugs for Secondary Prevention following Myocardial Infarction
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Articles

The Effect of Observer Status on the Fall in Blood Pressure with Repeat Measurements in Older Out-Patients with Hypertension

S J Smith, T Gregson, M Lye
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (s30): 4P.
https://doi.org/10.1042/cs086004P
Published: 01 February 1994
View article titled, The Effect of Observer Status on the Fall in Blood Pressure with Repeat Measurements in Older Out-Patients with Hypertension
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Articles

Increased Expression of Glomerular Interleukin-1β and Interleukin-1 Receptor antagonist Messenger RNA in Experimental Glomerulonephritis

FWK Tam, J Smith, S Cashman, Y Wang, EM Thompson, AJ Rees
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (s28): 3P.
https://doi.org/10.1042/cs084003P
Published: 01 March 1993
View article titled, Increased Expression of Glomerular Interleukin-1β and Interleukin-1 Receptor antagonist Messenger RNA in Experimental Glomerulonephritis
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Articles

Non-Toxic Inhibition of Proliferation of a Human Colonic Carcinoma Cell Line (HT-29) by Agaricus Bisporus (Edible Mushroom) Lectin

L Yu, D Fernig, J Smith, JD Milton, JM Rhodes
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (s28): 4P.
https://doi.org/10.1042/cs084004P
Published: 01 March 1993
View article titled, Non-Toxic Inhibition of Proliferation of a Human Colonic Carcinoma Cell Line (HT-29) by Agaricus Bisporus (Edible Mushroom) Lectin
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Articles

Effects of Cyclosporin a on Lipid Metabolism following Liver Transplantation in Man

AJ Krentz, R Cramb, J Smith, B Dousset, AD Mayer, J Buckels, P McMaster, M Nattrass
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (s28): 30P–31P.
https://doi.org/10.1042/cs084030Pc
Published: 01 March 1993
View article titled, Effects of Cyclosporin a on Lipid Metabolism following Liver Transplantation in Man
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Articles

Chronic Volume Depletion in Patients with Addisons Disease Due to Undertreatment with Fludrocortisone; Further Evidence for the Role of Aldosterone

S J Smith, N D Markandu, R A Banks, J Bayliss, M G Prentice, P Dorrington-Ward, P H Wise, G A MacGregor
Journal: Clinical Science
Clin Sci (Lond) (1983) 64 (2): 36P–37P.
https://doi.org/10.1042/cs064036Pb
Published: 01 February 1983
View article titled, Chronic Volume Depletion in Patients with Addisons Disease Due to Undertreatment with Fludrocortisone; Further Evidence for the Role of Aldosterone
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Articles

The Effect of Alterations of pH on Ketogenesis in Isolated Rat Hepatocytes

P.G. Kopelman, J. Smith, S. Gofford, R.D. Cohen, R.A. Iles
Journal: Clinical Science
Clin Sci (Lond) (1982) 63 (3): 25P.
https://doi.org/10.1042/cs063025Pa
Published: 01 September 1982
View article titled, The Effect of Alterations of pH on Ketogenesis in Isolated Rat Hepatocytes
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Articles

Plasma and Interstitial Volumes in Essential Hypertension: Relationship to Blood Pressure

R. F. Bing, A. J. Smith
Journal: Clinical Science
Clin Sci (Lond) (1981) 61 (3): 287–293.
https://doi.org/10.1042/cs0610287
Published: 01 September 1981
View article titled, Plasma and Interstitial Volumes in Essential Hypertension: Relationship to Blood Pressure
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Articles

Long-term Regulation of Arterial Pressure, Glomerular Filtration and Renal Sodium Reabsorption by Angiotensin II in Dogs

J. E. Hall, A. C. Guyton, M. J. Smith, Jr., T. G. Coleman
Journal: Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 87s–90s.
https://doi.org/10.1042/cs059087s
Published: 01 December 1980
View article titled, Long-term Regulation of Arterial Pressure, Glomerular Filtration and Renal Sodium Reabsorption by Angiotensin II in Dogs
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Articles

Biochemical Screening in Hypertension. A Study in 502 Patients

M. A. Martin, A. J. Smith, G. P. Mulley, R. F. Bing
Journal: Clinical Science
Clin Sci (Lond) (1980) 59 (3): 16P–17P.
https://doi.org/10.1042/cs059016Pc
Published: 01 September 1980
View article titled, Biochemical Screening in Hypertension. A Study in 502 Patients
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Articles

Prostaglandin Synthesis by Human Gingiva in Culture

M. Greaves, A. Clark, S. M. D'souza, J. Smith, M. B. McGuire, R. G. G. Russell
Journal: Clinical Science
Clin Sci Mol Med (1978) 55 (3): 29P.
https://doi.org/10.1042/cs055029P
Published: 01 September 1978
View article titled, Prostaglandin Synthesis by Human Gingiva in Culture
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Articles

Compliance, Response and Resistance to Hypotensive Therapy with Debrisoquine

J. H. Silas, G. T. Tucker, A. J. Smith
Journal: Clinical Science
Clin Sci Mol Med (1978) 55 (3): 19P.
https://doi.org/10.1042/cs055019Pa
Published: 01 September 1978
View article titled, Compliance, Response and Resistance to Hypotensive Therapy with Debrisoquine
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Articles

Plasma and Interstitial Fluid Volumes in Primary Hypertension

R. F. Bing, A. J. Smith
Journal: Clinical Science
Clin Sci Mol Med (1978) 54 (2): 26P.
https://doi.org/10.1042/cs054026Pa
Published: 01 February 1978
View article titled, Plasma and Interstitial Fluid Volumes in Primary Hypertension
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Articles

The Effect of Exercise, Isoprenaline and Propranolol on Ejection Fraction as Determined by Nuclear Angiography

R. P. Sapru, W. J. Hannan, H. J. Smith, A. L. Muir
Journal: Clinical Science
Clin Sci Mol Med (1978) 54 (2): 27P.
https://doi.org/10.1042/cs054027P
Published: 01 February 1978
View article titled, The Effect of Exercise, Isoprenaline and Propranolol on Ejection Fraction as Determined by Nuclear Angiography
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Articles

The Urinary Excretion of Catecholamines and Their Derivatives in Primary Hypertension in Man

R. F. Bing, J. Harlow, A. J. Smith, M. M. Townshend
Journal: Clinical Science
Clin Sci Mol Med (1977) 52 (3): 319–323.
https://doi.org/10.1042/cs0520319
Published: 01 March 1977
View article titled, The Urinary Excretion of Catecholamines and Their Derivatives in Primary Hypertension in Man
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Articles

Factors Influencing the Urinary Excretion of Free Catecholamines in Man

Mary M. Townshend, A. J. Smith
Journal: Clinical Science
Clin Sci Mol Med (1973) 44 (3): 253–265.
https://doi.org/10.1042/cs0440253
Published: 01 March 1973
View article titled, Factors Influencing the Urinary Excretion of Free Catecholamines in Man
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Articles

The Mechanism of the Diuretic Response to Porcine Calcitonin in Normal Subjects

I. R. Edwards, A. J. Smith
Journal: Clinical Science
Clin Sci (1972) 42 (1): 5P.
https://doi.org/10.1042/cs042005Pa
Published: 01 January 1972
View article titled, The Mechanism of the Diuretic Response to Porcine Calcitonin in Normal Subjects
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Articles

Renal Effects of Porcine Calcitonin in the Rabbit

L. A. Salako, A. J. Smith, R. N. Smith
Journal: Clinical Science
Clin Sci (1970) 39 (1): 2P–3P.
https://doi.org/10.1042/cs039002Pb
Published: 01 July 1970
View article titled, Renal Effects of Porcine Calcitonin in the Rabbit
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