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Philip NEWSHOLME
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Articles

Essential metabolism required for T and B lymphocyte functions: an update

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Vinicius Leonardo Sousa Diniz, Anuska Marcelino Alvares-Saraiva, Tamires Duarte Afonso Serdan, Laiane Cristina dos Santos-Oliveira, Vinicius Cruzat, Tiago Bertola Lobato, Richelieau Manoel, Amanda Lins Alecrim, Otavio Augusto Machado, Sandro M. Hirabara, Laureane Nunes Masi, Tania Cristina Pithon-Curi, Rui Curi, Renata Gorjão, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 807–821.
https://doi.org/10.1042/CS20220869
Published: 23 May 2023
View articletitled, Essential metabolism required for T and B lymphocyte functions: an update
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Articles

Host cell glutamine metabolism as a potential antiviral target

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Sandro Massao Hirabara, Renata Gorjao, Adriana Cristina Levada-Pires, Laureane Nunes Masi, Elaine Hatanaka, Maria Fernanda Cury-Boaventura, Eliane Borges da Silva, Laiane Cristina dos Santos-Oliveira, Vinicius Leonardo Sousa Diniz, Tamires Afonso Duarte Serdan, Vivian Araujo Barbosa de Oliveira, Diego Ribeiro de Souza, Raquel Bragante Gritte, Talita Souza-Siqueira, Raquel Freitas Zambonatto, Tania Cristina Pithon-Curi, Roberto Barbosa Bazotte, Philip Newsholme, Rui Curi
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (2): 305–325.
https://doi.org/10.1042/CS20201042
Published: 22 January 2021
View articletitled, Host cell glutamine metabolism as a potential antiviral target
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Articles

A past and present overview of macrophage metabolism and functional outcomes

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Rui Curi, Renata de Siqueira Mendes, Luiz Aurélio de Campos Crispin, Giuseppe Danilo Norata, Sandra Coccuzzo Sampaio, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1329–1342.
https://doi.org/10.1042/CS20170220
Published: 07 June 2017
View articletitled, A past and present overview of macrophage metabolism and functional outcomes
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Articles

Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway

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Yujia Yuan, Meimei Shi, Lan Li, Jingping Liu, Bo Chen, Younan Chen, Xingxing An, Shuyun Liu, Ruixi Luo, Dan Long, Wengeng Zhang, Philip Newsholme, Jingqiu Cheng, Yanrong Lu
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (23): 2181–2198.
https://doi.org/10.1042/CS20160235
Published: 26 October 2016
View articletitled, Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway
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Includes: Supplementary data
Articles

The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

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Mauricio Krause, Patricia Martins Bock, Hilton Kenji Takahashi, Paulo Ivo Homem De Bittencourt, Jr, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (11): 789–803.
https://doi.org/10.1042/CS20140695
Published: 19 March 2015
View articletitled, The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes
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Articles

The impact of cryopreservation on human peripheral blood leucocyte bioenergetics

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Kevin N. Keane, Emily K. Calton, Vinicius F. Cruzat, Mario J. Soares, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (10): 723–733.
https://doi.org/10.1042/CS20140725
Published: 10 March 2015
View articletitled, The impact of cryopreservation on human peripheral blood leucocyte bioenergetics
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Articles

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

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Mauricio Krause, Kevin Keane, Josianne Rodrigues-Krause, Domenico Crognale, Brendan Egan, Giuseppe De Vito, Colin Murphy, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (10): 739–752.
https://doi.org/10.1042/CS20130678
Published: 03 February 2014
View articletitled, Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro
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Articles

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

Open Access
Deirdre C. Keane, Hilton K. Takahashi, Shalinee Dhayal, Noel G. Morgan, Rui Curi, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (5): 195–206.
https://doi.org/10.1042/CS20100282
Published: 19 November 2010
View articletitled, Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line
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Articles

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

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Philip Newsholme, Paulo I. Homem De Bittencourt, Jr, Ciara O' Hagan, Giuseppe De Vito, Colin Murphy, Mauricio S. Krause
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (5): 341–349.
https://doi.org/10.1042/CS20090433
Published: 23 November 2009
View articletitled, Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide
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Articles

Overexpression of the malate–aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

Open Access
Katrin Bender, Pierre Maechler, Neville H. McClenaghan, Peter R. Flatt, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (9): 321–330.
https://doi.org/10.1042/CS20090126
Published: 01 September 2009
View articletitled, Overexpression of the malate–aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism
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Articles

Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic β-cells

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Neville H. McClenaghan, Siobhan M. Scullion, Brian Mion, Chandralal Hewage, J. Paul G. Malthouse, Peter R. Flatt, Philip Newsholme, Lorraine Brennan
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (4): 341–351.
https://doi.org/10.1042/CS20080138
Published: 15 January 2009
View articletitled, Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic β-cells
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Articles

Life and death decisions of the pancreatic β-cell: the role of fatty acids

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Philip Newsholme, Deirdre Keane, Hannah J. Welters, Noel G. Morgan
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (1): 27–42.
https://doi.org/10.1042/CS20060115
Published: 01 December 2006
View articletitled, Life and death decisions of the pancreatic β-cell: the role of fatty acids
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Articles

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

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Grainne A. Cunningham, Neville H. Mcclenaghan, Peter R. Flatt, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (5): 447–455.
https://doi.org/10.1042/CS20050149
Published: 24 October 2005
View articletitled, L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis
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Includes: Supplementary data
Articles

New insights into amino acid metabolism, β-cell function and diabetes

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Philip NEWSHOLME, Lorraine BRENNAN, Blanca RUBI, Pierre MAECHLER
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (3): 185–194.
https://doi.org/10.1042/CS20040290
Published: 18 February 2005
View articletitled, New insights into amino acid metabolism, β-cell function and diabetes
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Articles

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic β-cell insulin secretion, growth and functional integrity

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Gordon DIXON, John NOLAN, Neville H. McCLENAGHAN, Peter R. FLATT, Philip NEWSHOLME
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (2): 191–199.
https://doi.org/10.1042/CS20030261
Published: 01 February 2004
View articletitled, Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic β-cell insulin secretion, growth and functional integrity
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Articles

Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line

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Declan A. HEALY, R. William G. WATSON, Philip NEWSHOLME
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (2): 171–179.
https://doi.org/10.1042/cs1040171
Published: 17 January 2003
View articletitled, Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line
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Articles

Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils

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Declan A. HEALY, R. William G. WATSON, Philip NEWSHOLME
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (2): 179–189.
https://doi.org/10.1042/cs1030179
Published: 17 July 2002
View articletitled, Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils
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Articles

Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils

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Carolina GARCIA, Tania C. PITHON-CURI, Maria DE LOURDES FIRMANO, Mariza PIRES DE MELO, Philip NEWSHOLME, Rui CURI
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (6): 549–555.
https://doi.org/10.1042/cs0960549
Published: 28 April 1999
View articletitled, Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils
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Articles

Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette–Gue´rin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism

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Colin MURPHY, Philip NEWSHOLME
Journal: Clinical Science
Clin Sci (Lond) (1998) 96 (1): 89–97.
https://doi.org/10.1042/cs0960089
Published: 01 January 1999
View articletitled, Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette–Gue´rin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism
Open the PDF for Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette–Gue´rin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism in another window
Articles

Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production

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Colin MURPHY, Philip NEWSHOLME
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (4): 397–407.
https://doi.org/10.1042/cs0950397
Published: 01 October 1998
View articletitled, Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production
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