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Articles

Essential metabolism required for T and B lymphocyte functions: an update

Vinicius Leonardo Sousa Diniz, Anuska Marcelino Alvares-Saraiva, Tamires Duarte Afonso Serdan, Laiane Cristina dos Santos-Oliveira, Vinicius Cruzat, Tiago Bertola Lobato, Richelieau Manoel, Amanda Lins Alecrim, Otavio Augusto Machado, Sandro M. Hirabara, Laureane Nunes Masi, Tania Cristina Pithon-Curi, Rui Curi, Renata Gorjão, Philip Newsholme

Clin Sci (Lond) (2023) 137 (10): 807–821.

https://doi.org/10.1042/CS20220869

Published: 23 May 2023

View article titled, Essential metabolism required for T and B lymphocyte functions: an update

Articles

Host cell glutamine metabolism as a potential antiviral target

Sandro Massao Hirabara, Renata Gorjao, Adriana Cristina Levada-Pires, Laureane Nunes Masi, Elaine Hatanaka, Maria Fernanda Cury-Boaventura, Eliane Borges da Silva, Laiane Cristina dos Santos-Oliveira, Vinicius Leonardo Sousa Diniz, Tamires Afonso Duarte Serdan, Vivian Araujo Barbosa de Oliveira, Diego Ribeiro de Souza, Raquel Bragante Gritte, Talita Souza-Siqueira, Raquel Freitas Zambonatto, Tania Cristina Pithon-Curi, Roberto Barbosa Bazotte, Philip Newsholme, Rui Curi

Clin Sci (Lond) (2021) 135 (2): 305–325.

https://doi.org/10.1042/CS20201042

Published: 22 January 2021

View article titled, Host cell glutamine metabolism as a potential antiviral target

Articles

A past and present overview of macrophage metabolism and functional outcomes

Rui Curi, Renata de Siqueira Mendes, Luiz Aurélio de Campos Crispin, Giuseppe Danilo Norata, Sandra Coccuzzo Sampaio, Philip Newsholme

Clin Sci (Lond) (2017) 131 (12): 1329–1342.

https://doi.org/10.1042/CS20170220

Published: 07 June 2017

View article titled, A past and present overview of macrophage metabolism and functional outcomes

Articles

Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway

Yujia Yuan, Meimei Shi, Lan Li, Jingping Liu, Bo Chen, Younan Chen, Xingxing An, Shuyun Liu, Ruixi Luo, Dan Long, Wengeng Zhang, Philip Newsholme, Jingqiu Cheng, Yanrong Lu

Clin Sci (Lond) (2016) 130 (23): 2181–2198.

https://doi.org/10.1042/CS20160235

Published: 26 October 2016

View article titled, Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway

Includes: Supplementary data

Articles

The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

Mauricio Krause, Patricia Martins Bock, Hilton Kenji Takahashi, Paulo Ivo Homem De Bittencourt, Jr, Philip Newsholme

Clin Sci (Lond) (2015) 128 (11): 789–803.

https://doi.org/10.1042/CS20140695

Published: 19 March 2015

View article titled, The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

Articles

The impact of cryopreservation on human peripheral blood leucocyte bioenergetics

Kevin N. Keane, Emily K. Calton, Vinicius F. Cruzat, Mario J. Soares, Philip Newsholme

Clin Sci (Lond) (2015) 128 (10): 723–733.

https://doi.org/10.1042/CS20140725

Published: 10 March 2015

View article titled, The impact of cryopreservation on human peripheral blood leucocyte bioenergetics

Articles

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Mauricio Krause, Kevin Keane, Josianne Rodrigues-Krause, Domenico Crognale, Brendan Egan, Giuseppe De Vito, Colin Murphy, Philip Newsholme

Clin Sci (Lond) (2014) 126 (10): 739–752.

https://doi.org/10.1042/CS20130678

Published: 03 February 2014

View article titled, Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Articles

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

Deirdre C. Keane, Hilton K. Takahashi, Shalinee Dhayal, Noel G. Morgan, Rui Curi, Philip Newsholme

Clin Sci (Lond) (2011) 120 (5): 195–206.

https://doi.org/10.1042/CS20100282

Published: 19 November 2010

View article titled, Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

Articles

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

Philip Newsholme, Paulo I. Homem De Bittencourt, Jr, Ciara O' Hagan, Giuseppe De Vito, Colin Murphy, Mauricio S. Krause

Clin Sci (Lond) (2010) 118 (5): 341–349.

https://doi.org/10.1042/CS20090433

Published: 23 November 2009

View article titled, Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

Articles

Overexpression of the malate–aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

Katrin Bender, Pierre Maechler, Neville H. McClenaghan, Peter R. Flatt, Philip Newsholme

Clin Sci (Lond) (2009) 117 (9): 321–330.

https://doi.org/10.1042/CS20090126

Published: 01 September 2009

View article titled, Overexpression of the malate–aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

Articles

Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic β-cells

Neville H. McClenaghan, Siobhan M. Scullion, Brian Mion, Chandralal Hewage, J. Paul G. Malthouse, Peter R. Flatt, Philip Newsholme, Lorraine Brennan

Clin Sci (Lond) (2009) 116 (4): 341–351.

https://doi.org/10.1042/CS20080138

Published: 15 January 2009

View article titled, Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic β-cells

Articles

Life and death decisions of the pancreatic β-cell: the role of fatty acids

Philip Newsholme, Deirdre Keane, Hannah J. Welters, Noel G. Morgan

Clin Sci (Lond) (2007) 112 (1): 27–42.

https://doi.org/10.1042/CS20060115

Published: 01 December 2006

View article titled, Life and death decisions of the pancreatic β-cell: the role of fatty acids

Articles

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

Grainne A. Cunningham, Neville H. Mcclenaghan, Peter R. Flatt, Philip Newsholme

Clin Sci (Lond) (2005) 109 (5): 447–455.

https://doi.org/10.1042/CS20050149

Published: 24 October 2005

View article titled, L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

Includes: Supplementary data

Articles

New insights into amino acid metabolism, β-cell function and diabetes

Philip NEWSHOLME, Lorraine BRENNAN, Blanca RUBI, Pierre MAECHLER

Clin Sci (Lond) (2005) 108 (3): 185–194.

https://doi.org/10.1042/CS20040290

Published: 18 February 2005

View article titled, New insights into amino acid metabolism, β-cell function and diabetes

Articles

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic β-cell insulin secretion, growth and functional integrity

Gordon DIXON, John NOLAN, Neville H. McCLENAGHAN, Peter R. FLATT, Philip NEWSHOLME

Clin Sci (Lond) (2004) 106 (2): 191–199.

https://doi.org/10.1042/CS20030261

Published: 01 February 2004

View article titled, Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic β-cell insulin secretion, growth and functional integrity

Articles

Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line

Declan A. HEALY, R. William G. WATSON, Philip NEWSHOLME

Clin Sci (Lond) (2003) 104 (2): 171–179.

https://doi.org/10.1042/cs1040171

Published: 17 January 2003

View article titled, Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line

Articles

Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils

Declan A. HEALY, R. William G. WATSON, Philip NEWSHOLME

Clin Sci (Lond) (2002) 103 (2): 179–189.

https://doi.org/10.1042/cs1030179

Published: 17 July 2002

View article titled, Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils

Articles

Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils

Carolina GARCIA, Tania C. PITHON-CURI, Maria DE LOURDES FIRMANO, Mariza PIRES DE MELO, Philip NEWSHOLME, Rui CURI

Clin Sci (Lond) (1999) 96 (6): 549–555.

https://doi.org/10.1042/cs0960549

Published: 28 April 1999

View article titled, Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils

Articles

Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette–Gue´rin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism

Colin MURPHY, Philip NEWSHOLME

Clin Sci (Lond) (1998) 96 (1): 89–97.

https://doi.org/10.1042/cs0960089

Published: 01 January 1999

View article titled, Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette–Gue´rin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism

Articles

Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production

Colin MURPHY, Philip NEWSHOLME

Clin Sci (Lond) (1998) 95 (4): 397–407.

https://doi.org/10.1042/cs0950397

Published: 01 October 1998

View article titled, Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production

NARROW

Essential metabolism required for T and B lymphocyte functions: an update

Host cell glutamine metabolism as a potential antiviral target

A past and present overview of macrophage metabolism and functional outcomes

Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway

The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

The impact of cryopreservation on human peripheral blood leucocyte bioenergetics

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

Overexpression of the malate–aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic β-cells

Life and death decisions of the pancreatic β-cell: the role of fatty acids

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

New insights into amino acid metabolism, β-cell function and diabetes

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic β-cell insulin secretion, growth and functional integrity

Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line

Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils

Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils

Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette–Gue´rin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism

Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production

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