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Articles

Immunogenicity, toxicology, pharmacokinetics and pharmacodynamics of growth hormone ligand–receptor fusions

Eric Ferrandis, Sarbendra L. Pradhananga, Caroline Touvay, Carol Kinoshita, Ian R. Wilkinson, Kevin Stafford, Zida Wu, Christian J. Strasburger, Jon R. Sayers, Peter J. Artymiuk, Richard J. Ross
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (11): 483–491.
https://doi.org/10.1042/CS20100241
Published: 17 August 2010
View article titled, Immunogenicity, toxicology, pharmacokinetics and pharmacodynamics of growth hormone ligand–receptor fusions
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Articles

Neutrophil Adherence in Immunoglobulin a Nephropathy

S. Ahmed, R. Wilkinson, P.A. Mead, T.H. Thomas
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (s48): 12P–13P.
https://doi.org/10.1042/cs104012Pb
Published: 01 January 2003
View article titled, Neutrophil Adherence in Immunoglobulin a Nephropathy
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Articles

A Thiol Protein Affecting Associations between Enzymes and the Cell Membrane

SL Watkins, IC West, R Wilkinson, TH Thomas
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (s40): 7P–8P.
https://doi.org/10.1042/cs096007Pc
Published: 01 February 1999
View article titled, A Thiol Protein Affecting Associations between Enzymes and the Cell Membrane
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Articles

Functional Cell Membrane Abnormality in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

SL Watkins, IC West, R Wilkinson, TH Thomas
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (s40): 8P.
https://doi.org/10.1042/cs096008P
Published: 01 February 1999
View article titled, Functional Cell Membrane Abnormality in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
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Articles

Abnormalities in Intracellular Vesicle Trafficking in Essential Hypertension

NJM Fardon, R Wilkinson, TH Thomas
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (s40): 9P.
https://doi.org/10.1042/cs096009Pb
Published: 01 February 1999
View article titled, Abnormalities in Intracellular Vesicle Trafficking in Essential Hypertension
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Articles

Functional Effects of Oxidative Stress on Mononuclear Leucocytes

JG Anderton, TH Thomas, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (s35): 5P.
https://doi.org/10.1042/cs091005Pa
Published: 01 July 1996
View article titled, Functional Effects of Oxidative Stress on Mononuclear Leucocytes
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Articles

Protein Thiol Oxidation in Mononuclear Leucocytes

JG Anderton, TH Thomas, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (s35): 5P.
https://doi.org/10.1042/cs091005P
Published: 01 July 1996
View article titled, Protein Thiol Oxidation in Mononuclear Leucocytes
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Articles

A Familial Study of Na/Li CT in Patients with IGA Nephropathy (IGA N)

HO Kkl, TH Thomas, PA Rutherford, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (s33): 21P.
https://doi.org/10.1042/cs089021P
Published: 01 July 1995
View article titled, A Familial Study of Na/Li CT in Patients with IGA Nephropathy (IGA N)
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Articles

Increased Susceptibility to Membrane Lipid Peroxidation amd Increased Membrane Fluidity in Renal Failure

JG Anderton, TH Thomas, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (s33): 21P.
https://doi.org/10.1042/cs089021Pa
Published: 01 July 1995
View article titled, Increased Susceptibility to Membrane Lipid Peroxidation amd Increased Membrane Fluidity in Renal Failure
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Articles

Abnormal Erythrocyte Membrane Cytoskeleton in Adult Polycystic Kidney Disease (APCKD)

K. Vareesangthip, T.H. Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (s33): 21P.
https://doi.org/10.1042/cs089021Pb
Published: 01 July 1995
View article titled, Abnormal Erythrocyte Membrane Cytoskeleton in Adult Polycystic Kidney Disease (APCKD)
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Articles

Lymphocyte Activation and Membrane Fluidity in IGA Nephropathy

T R Ringrose, T H Thomas, J Kirby, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (s33): 4P.
https://doi.org/10.1042/cs089004P
Published: 01 July 1995
View article titled, Lymphocyte Activation and Membrane Fluidity in IGA Nephropathy
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Articles

Cytoskelton Modulates Membrane Fluidity in Intact L6 Myoblasts

PC Tong, TH Thomas, R Wilkinson, Kgmm Alberti
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (s33): 4P.
https://doi.org/10.1042/cs089004Pa
Published: 01 July 1995
View article titled, Cytoskelton Modulates Membrane Fluidity in Intact L6 Myoblasts
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Articles

Cholesterol Alters Membrane Fluidity and Increases HLA Expression of Lymphocytes

T R. Ringrose, T.H. Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (s31): 4P.
https://doi.org/10.1042/cs045004P_pt2
Published: 01 December 1994
View article titled, Cholesterol Alters Membrane Fluidity and Increases HLA Expression of Lymphocytes
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Articles

Effect of Uraemia and Haemodialysis (HD) ON SH-Group Control of Erythrocyte Sodium-Lithium Countertransport (SLC) Kinetics

P.A. Rutherford, T.H. Thomas, J O'Kelly, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (s31): 4P.
https://doi.org/10.1042/cs045004Pa_pt2
Published: 01 December 1994
View article titled, Effect of Uraemia and Haemodialysis (HD) ON SH-Group Control of Erythrocyte Sodium-Lithium Countertransport (SLC) Kinetics
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Articles

Membrane Fluidity Gradient is Altered in Diabetic Mononuclear Leukocytes

P Tong, T Thomas, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (s30): 18P.
https://doi.org/10.1042/cs086018Pb
Published: 01 February 1994
View article titled, Membrane Fluidity Gradient is Altered in Diabetic Mononuclear Leukocytes
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Articles

Specific Labelling of Erythrocyte Membrane Protein Associated with Sodium-Lithium Countertransport (Slc)

T.H. Thomas, S. Thompson, P. A. Rutherford, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (s30): 9P.
https://doi.org/10.1042/cs086009Pa
Published: 01 February 1994
View article titled, Specific Labelling of Erythrocyte Membrane Protein Associated with Sodium-Lithium Countertransport (Slc)
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Articles

The Inheritance of Erythrocyte Sodium-Lithium Countertransport (Slc) Kinetics in Essential Hypertension

PA Rutherford, TH Thomas, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (s29): 3P.
https://doi.org/10.1042/cs085003P
Published: 01 July 1993
View article titled, The Inheritance of Erythrocyte Sodium-Lithium Countertransport (Slc) Kinetics in Essential Hypertension
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Articles

The Relationship between the Temperature Sensitivity and the Kinetic Characteristics of Erythrocyte Sodium-Lithium Countertransport Activity (Slc)

PA Rutherford, TH Thomas, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (s29): 3P.
https://doi.org/10.1042/cs085003Pa
Published: 01 July 1993
View article titled, The Relationship between the Temperature Sensitivity and the Kinetic Characteristics of Erythrocyte Sodium-Lithium Countertransport Activity (Slc)
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Articles

Sodium-Lithium Countertransport (Slc) Kinetics Are Altered by a High-Affinity Modifier Site

T.H. Thomas, P.A. Rutherford, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (s29): 3P.
https://doi.org/10.1042/cs085003Pb
Published: 01 July 1993
View article titled, Sodium-Lithium Countertransport (Slc) Kinetics Are Altered by a High-Affinity Modifier Site
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Articles

Inhibition of Sodium-Lithium Countertransport (SLC) by a Fluorescent Labelling of a Sulphydrl Group

A Dowd, T H Thomas, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (s29): 3P.
https://doi.org/10.1042/cs085003Pc
Published: 01 July 1993
View article titled, Inhibition of Sodium-Lithium Countertransport (SLC) by a Fluorescent Labelling of a Sulphydrl Group
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Articles

Erythrocyte Ghosts do Not Show the Effect of Spectrin Conformation on Membrane Fluidity

P Tong, T Thomas, R Wilkinson, Kgmm Alberti
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (s29): 16P.
https://doi.org/10.1042/cs085016P
Published: 01 July 1993
View article titled, Erythrocyte Ghosts do Not Show the Effect of Spectrin Conformation on Membrane Fluidity
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Articles

Erythrocyte Sodium-Lithium Countertransport Activity (SLC) is Related to Membrane Fluidity in Hyperlipidaemia

A. Dowd, T.H. Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (s27): 1P.
https://doi.org/10.1042/cs083001P
Published: 01 July 1992
View article titled, Erythrocyte Sodium-Lithium Countertransport Activity (SLC) is Related to Membrane Fluidity in Hyperlipidaemia
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Articles

Inhibition of Sodium-Lithium Countertransport (SLC) by Nem Depends on Sodium and Cytoskeletal Spectrin: Effect of Diabetic Nephropathy

T.H. Thomas, P.A. Rutherford, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (s27): 26P.
https://doi.org/10.1042/cs083026Pb
Published: 01 July 1992
View article titled, Inhibition of Sodium-Lithium Countertransport (SLC) by Nem Depends on Sodium and Cytoskeletal Spectrin: Effect of Diabetic Nephropathy
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Articles

Characterisation of the Response of Sodiumlithium Countertransport Activity (SLC) to Inhibitors

PA Rutherford, TH Thomas, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (s27): 26P.
https://doi.org/10.1042/cs083026Pc
Published: 01 July 1992
View article titled, Characterisation of the Response of Sodiumlithium Countertransport Activity (SLC) to Inhibitors
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Articles

Erythrocyte sodium-lithium countertransport: clinically useful, pathophysiologically instructive or just phenomenology?

P. A. Rutherford, T. H. Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (4): 341–352.
https://doi.org/10.1042/cs0820341
Published: 01 April 1992
View article titled, Erythrocyte sodium-lithium countertransport: clinically useful, pathophysiologically instructive or just phenomenology?
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Articles

Haemodynamic Improvements following Closure of Arterio-Venous Fistulae

C Doig, C Herath, A Heads, T Goodship, S Hunter, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 21P.
https://doi.org/10.1042/cs081021P
Published: 01 October 1991
View article titled, Haemodynamic Improvements following Closure of Arterio-Venous Fistulae
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Articles

Erythrocyte (RBC) Membrane Alterations and Sodium-Lithium Countertransport (SLC) in Essential Hypertension (EHT) and Hyperlipidaemia (HL)

T.H. Thomas, P.A. Rutherford, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 7P.
https://doi.org/10.1042/cs081007P
Published: 01 October 1991
View article titled, Erythrocyte (RBC) Membrane Alterations and Sodium-Lithium Countertransport (SLC) in Essential Hypertension (EHT) and Hyperlipidaemia (HL)
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Articles

Maximum Velocity (VMax) not Sodium Affinity (KNa) of Sodium-Lithium Countertransport (SLC) Activity is Affected by Hyperlipidaemia (HL): Distinction from Essential Hypertension (EHT)

PA Rutherford, TH Thomas, MF Laker, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 7P.
https://doi.org/10.1042/cs081007Pa
Published: 01 October 1991
View article titled, Maximum Velocity (VMax) not Sodium Affinity (KNa) of Sodium-Lithium Countertransport (SLC) Activity is Affected by Hyperlipidaemia (HL): Distinction from Essential Hypertension (EHT)
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Articles

Changes in Erythrocyte Sodium-Lithium Countertransport (SLC) Kinetics in Diabetic Nephropathy

PA Rutherford, TH Thomas, SJ Carr, R Taylor, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 7P.
https://doi.org/10.1042/cs081007Pb
Published: 01 October 1991
View article titled, Changes in Erythrocyte Sodium-Lithium Countertransport (SLC) Kinetics in Diabetic Nephropathy
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Articles

Changes in Sodium-Lithium Countertransport Kinetics in Normal and Hypertensive Pregnancy

PA Rutherford, TH Thomas, S MacPhail, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1991) 80 (s24): 29P.
https://doi.org/10.1042/cs080029Pb
Published: 01 March 1991
View article titled, Changes in Sodium-Lithium Countertransport Kinetics in Normal and Hypertensive Pregnancy
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Articles

A Serial Study of Erythrocyte Sodium Content and Sodium Pump Kinetics in Pregnancy

S. MacPhail, T. H. Thomas, R. Wilkinson, J. M. Davison, W. Dunlop
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (6): 631–638.
https://doi.org/10.1042/cs0790631
Published: 01 December 1990
View article titled, A Serial Study of Erythrocyte Sodium Content and Sodium Pump Kinetics in Pregnancy
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Articles

Relationship between the Maximum Velocity and Sodium Affinity of the Erythrocyte Sodium Pump and its Rate Constant in Blood

T. H. Thomas, S. MacPhail, V. Mott, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (6): 625–630.
https://doi.org/10.1042/cs0790625
Published: 01 December 1990
View article titled, Relationship between the Maximum Velocity and Sodium Affinity of the Erythrocyte Sodium Pump and its Rate Constant in Blood
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Articles

Increased Erythrocyte Sodium-Lithium Countertransport Activity in essential Hypertension is Due to an Increased Affinity for Extracellular Sodium

P. A. Rutherford, T. H. Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (4): 365–369.
https://doi.org/10.1042/cs0790365
Published: 01 October 1990
View article titled, Increased Erythrocyte Sodium-Lithium Countertransport Activity in essential Hypertension is Due to an Increased Affinity for Extracellular Sodium
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Articles

Sodium Lithium Countertransport Activity during Human Pregnancy

S MacPhail, TH Thomas, R Wilkinson, JM Davison, W Dunlop
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (s23): 11P.
https://doi.org/10.1042/cs079011P
Published: 01 October 1990
View article titled, Sodium Lithium Countertransport Activity during Human Pregnancy
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Articles

Increased Erythrocyte Sodium-Lithium Countertransport (SLC) in Essential Hypertension (EHT) is Due to an Increased Affinity for Sodium

PA Rutherford, TH Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (s23): 22P.
https://doi.org/10.1042/cs079022Pb
Published: 01 October 1990
View article titled, Increased Erythrocyte Sodium-Lithium Countertransport (SLC) in Essential Hypertension (EHT) is Due to an Increased Affinity for Sodium
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Articles

Lipid Lowering Therapy Leads to a Reduction in Sodium-Lithium Countertransport (SLC)

SJ Carr, TH Thomas, M. Laker, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (s23): 8P–9P.
https://doi.org/10.1042/cs079008Pc
Published: 01 October 1990
View article titled, Lipid Lowering Therapy Leads to a Reduction in Sodium-Lithium Countertransport (SLC)
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Articles

Development of a New Isotopic Technique to Measure Blood Volume in the Rat

NB Argent, D Rodham, PH Baylis, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (s23): 23P.
https://doi.org/10.1042/cs079023Pc
Published: 01 October 1990
View article titled, Development of a New Isotopic Technique to Measure Blood Volume in the Rat
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Articles

Measurement of leucocyte sodium content

J. Main, T. Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (1): 117.
https://doi.org/10.1042/cs0780117
Published: 01 January 1990
View article titled, Measurement of leucocyte sodium content
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Articles

Relationship between Erythrocyte (RBC) Cation Changes During Pregnancy

S MacPhail, T Thomas, R Wilkinson, JM Davison, W Dunlop
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (s22): 35P.
https://doi.org/10.1042/cs078035P
Published: 01 January 1990
View article titled, Relationship between Erythrocyte (RBC) Cation Changes During Pregnancy
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Articles

Characterisation of Osmotically Induced Thirst and Vasopressin Release in End Stage Renal Failure

NB Argent, THJ Goodship, R Wilkinson, PH Baylis
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (s22): 19P.
https://doi.org/10.1042/cs078019Pa
Published: 01 January 1990
View article titled, Characterisation of Osmotically Induced Thirst and Vasopressin Release in End Stage Renal Failure
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Articles

The Sodium Pump and Hypertensive Pregnancy

S MacPhail, T Thomas, R Wilkinson, JM Davison, W Dunlop
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (s22): 20P.
https://doi.org/10.1042/cs078020P
Published: 01 January 1990
View article titled, The Sodium Pump and Hypertensive Pregnancy
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Articles

Changes in Intra- and Extracellular Water and Ions During Exercise

T Thomas, S Furniss, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (s22): 9P.
https://doi.org/10.1042/cs078009Pb
Published: 01 January 1990
View article titled, Changes in Intra- and Extracellular Water and Ions During Exercise
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Articles

Do Abnormal Plasma Lipids Explain Elevated Sodium-Lithium Countertransport in Hypertension?

S. Carr, T. Thomas, M Lakey, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (s21): 10P.
https://doi.org/10.1042/cs077010Pa
Published: 01 December 1989
View article titled, Do Abnormal Plasma Lipids Explain Elevated Sodium-Lithium Countertransport in Hypertension?
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Articles

Sodium-Lithium Countertransport: A Genetic Marker of Hyperlipidaemia and Hypertension?

S. Carr, T Thomas, M Laker, R Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (s21): 10P.
https://doi.org/10.1042/cs077010Pb
Published: 01 December 1989
View article titled, Sodium-Lithium Countertransport: A Genetic Marker of Hyperlipidaemia and Hypertension?
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Articles

Plasma Osmolality and Sodium Pump Kinetics are Altered in Pregnancy Induced Hypertension (PIH)

S MacPhail, T Thomas, R Wilkinson, JM Davison, W Dunlop
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (s21): 29P.
https://doi.org/10.1042/cs077029Pa
Published: 01 December 1989
View article titled, Plasma Osmolality and Sodium Pump Kinetics are Altered in Pregnancy Induced Hypertension (PIH)
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Articles

Decreased Plasma Osmolality in Human Pregnancy is Secondary to a Reduction in Intracellular Osmoles

S MacPhail, T Thomas, R Wilkinson, J M Davison, W Dunlop
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (s21): 29P–30P.
https://doi.org/10.1042/cs077029Pc
Published: 01 December 1989
View article titled, Decreased Plasma Osmolality in Human Pregnancy is Secondary to a Reduction in Intracellular Osmoles
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Articles

Effect of a High Protein Diet in Patients with the Nephrotic Syndrome

H. Mansy, T. H. J. Goodship, J. S. Tapson, G. H. Hartley, Pauline Keavey, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (4): 445–451.
https://doi.org/10.1042/cs0770445
Published: 01 October 1989
View article titled, Effect of a High Protein Diet in Patients with the Nephrotic Syndrome
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Articles

Hepatic and Peripheral Insulin Action in Chronic Renal Failure before and during Continuous Ambulatory Peritoneal Dialysis

A. Heaton, R. Taylor, D. G. Johnston, M. K. Ward, R. Wilkinson, K. G. M. M. Alberti
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (4): 383–388.
https://doi.org/10.1042/cs0770383
Published: 01 October 1989
View article titled, Hepatic and Peripheral Insulin Action in Chronic Renal Failure before and during Continuous Ambulatory Peritoneal Dialysis
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Articles

Problems in Measuring Human Leucocyte Cation Content: Effects of Cell Preparation and Handling

J. Main, T. H. Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (2): 157–160.
https://doi.org/10.1042/cs0770157
Published: 01 August 1989
View article titled, Problems in Measuring Human Leucocyte Cation Content: Effects of Cell Preparation and Handling
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Articles

Hypertension and renal dysfunction in primary hyperparathyroidism: effect of parathyroidectomy

A. K. Salahudeen, T. H. Thomas, L. Sellars, S. Tapster, P. Keavey, J. R. Farndon, I. D. A. Johnston, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1989) 76 (3): 289–296.
https://doi.org/10.1042/cs0760289
Published: 01 March 1989
View article titled, Hypertension and renal dysfunction in primary hyperparathyroidism: effect of parathyroidectomy
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