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Rhian M. Touyz
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Articles

Skin-specific mechanisms of body fluid regulation in hypertension

Jun Yu Chen, Khai Syuen Chew, Sheon Mary, Philipp Boder, Domenico Bagordo, Gian Paolo Rossi, Rhian M. Touyz, Christian Delles, Giacomo Rossitto
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (3): 239–250.
https://doi.org/10.1042/CS20220609
Published: 07 February 2023
View article titled, Skin-specific mechanisms of body fluid regulation in hypertension
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Includes: Supplementary data
Articles

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

In Collection
Cardiovascular-Oncology
Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (9): 675–694.
https://doi.org/10.1042/CS20220182
Published: 10 May 2022
View article titled, Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage
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Includes: Supplementary data
Articles

Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity

In Collection
Cardiovascular-Oncology
Ninian N. Lang, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2661–2663.
https://doi.org/10.1042/CS20210986
Published: 09 December 2021
View article titled, Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity
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Articles

Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Josiane Fernandes da Silva, Juliano V. Alves, Julio A. Silva-Neto, Rafael M. Costa, Karla B. Neves, Rheure Alves-Lopes, Livia L. Carmargo, Francisco J. Rios, Augusto C. Montezano, Rhian M. Touyz, Rita C. Tostes
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1845–1858.
https://doi.org/10.1042/CS20210468
Published: 04 August 2021
View article titled, Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis
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Includes: Supplementary data
Articles

Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Karla B. Neves, Hannah E. Morris, Rhéure Alves-Lopes, Keith W. Muir, Fiona Moreton, Christian Delles, Augusto C. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 753–773.
https://doi.org/10.1042/CS20201412
Published: 17 March 2021
View article titled, Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway
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Includes: Supplementary data
Articles

ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease

In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Jithin Kuriakose, Augusto C. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (2): 387–407.
https://doi.org/10.1042/CS20200480
Published: 29 January 2021
View article titled, ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease
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Articles

Time to fiddle with your unpublished data

In Collection
Translational meta-research
Michael J. Ryan, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 101–103.
https://doi.org/10.1042/CS20201298
Published: 06 January 2021
View article titled, Time to fiddle with your unpublished data
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Articles

Cardiotoxic effects of angiogenesis inhibitors

In Collection
Cardiovascular-Oncology
Stephen J.H. Dobbin, Mark C. Petrie, Rachel C. Myles, Rhian M. Touyz, Ninian N. Lang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 71–100.
https://doi.org/10.1042/CS20200305
Published: 06 January 2021
View article titled, Cardiotoxic effects of angiogenesis inhibitors
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Articles

Clinical Science Editorial 2020 – a year gone by and the year ahead

Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3233–3235.
https://doi.org/10.1042/CS20201502
Published: 14 December 2020
View article titled, Clinical Science Editorial 2020 – a year gone by and the year ahead
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Articles

Vascular toxicity associated with anti-angiogenic drugs

In Collection
Cardiovascular-Oncology
Karla B. Neves, Augusto C. Montezano, Ninian N. Lang, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
https://doi.org/10.1042/CS20200308
Published: 29 September 2020
View article titled, Vascular toxicity associated with anti-angiogenic drugs
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Articles

Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function

Zhi-Guo Zou, Francisco J. Rios, Karla B. Neves, Rheure Alves-Lopes, Jiayue Ling, George S. Baillie, Xing Gao, William Fuller, Livia L. Camargo, Thomas Gudermann, Vladimir Chubanov, Augusto C. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2019–2035.
https://doi.org/10.1042/CS20200827
Published: 04 August 2020
View article titled, Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function
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Includes: Multimedia, Supplementary data
Articles

ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19

In Collection
Coronavirus
Rhian M. Touyz, Hongliang Li, Christian Delles
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 747–750.
https://doi.org/10.1042/CS20200363
Published: 07 April 2020
View article titled, ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19
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Articles

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Paula K. Bautista-Niño, Eliana Portilla-Fernandez, Eloisa Rubio-Beltrán, Janette J. van der Linden, René de Vries, Richard van Veghel, Martine de Boer, Matej Durik, Yanto Ridwan, Renata Brandt, Jeroen Essers, Robert I. Menzies, Rachel Thomas, Alain de Bruin, Dirk J. Duncker, Heleen M.M. van Beusekom, Mohsen Ghanbari, Jan H.J. Hoeijmakers, Radislav Sedlacek, Rhian M. Touyz, Augusto C. Montezano, Ingrid van der Pluijm, A.H. Jan Danser, Kristian A. Haanes, Anton J.M. Roks
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 727–746.
https://doi.org/10.1042/CS20190124
Published: 07 April 2020
View article titled, Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction
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Includes: Supplementary data
Articles

Clinical Science : translating molecular bioscience and experimental research into medical insights

Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (4): 435–437.
https://doi.org/10.1042/CS20200182
Published: 28 February 2020
View article titled, Clinical Science : translating molecular bioscience and experimental research into medical insights
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Articles

Notch3 signalling and vascular remodelling in pulmonary arterial hypertension

Hannah E. Morris, Karla B. Neves, Augusto C. Montezano, Margaret R. MacLean, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (24): 2481–2498.
https://doi.org/10.1042/CS20190835
Published: 23 December 2019
View article titled, Notch3 signalling and vascular remodelling in pulmonary arterial hypertension
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Articles

Response to the letter regarding the hypothesis paper “Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema”

Giacomo Rossitto, Rhian M. Touyz, Mark C. Petrie, Christian Delles
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (6): 761.
https://doi.org/10.1042/CS20190154
Published: 19 March 2019
View article titled, Response to the letter regarding the hypothesis paper “Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema”
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Articles

Much Ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localized oedema

Giacomo Rossitto, Rhian M. Touyz, Mark C. Petrie, Christian Delles
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (24): 2609–2613.
https://doi.org/10.1042/CS20180575
Published: 13 December 2018
View article titled, Much Ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localized oedema
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Includes: Supplementary data
Articles

Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Karen Horsburgh, Joanna M. Wardlaw, Tom van Agtmael, Stuart M. Allan, Mike L.J. Ashford, Philip M. Bath, Rosalind Brown, Jason Berwick, M. Zameel Cader, Roxana O. Carare, John B. Davis, Jessica Duncombe, Tracy D. Farr, Jill H. Fowler, Jozien Goense, Alessandra Granata, Catherine N. Hall, Atticus H. Hainsworth, Adam Harvey, Cheryl A. Hawkes, Anne Joutel, Rajesh N. Kalaria, Patrick G. Kehoe, Catherine B. Lawrence, Andy Lockhart, Seth Love, Malcolm R. Macleod, I. Mhairi Macrae, Hugh S. Markus, Chris McCabe, Barry W. McColl, Paul J. Meakin, Alyson Miller, Maiken Nedergaard, Michael O'Sullivan, Terry J. Quinn, Rikesh Rajani, Lisa M. Saksida, Colin Smith, Kenneth J. Smith, Rhian M. Touyz, Rebecca C. Trueman, Tao Wang, Anna Williams, Steven C.R. Williams, Lorraine M. Work
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (8): 851–868.
https://doi.org/10.1042/CS20171620
Published: 30 April 2018
View article titled, Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology
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Articles

Aldosterone, SGK1, and ion channels in the kidney

William C. Valinsky, Rhian M. Touyz, Alvin Shrier
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (2): 173–183.
https://doi.org/10.1042/CS20171525
Published: 19 January 2018
View article titled, Aldosterone, SGK1, and ion channels in the kidney
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Articles

Personalized medicine—a modern approach for the diagnosis and management of hypertension

Carmine Savoia, Massimo Volpe, Guido Grassi, Claudio Borghi, Enrico Agabiti Rosei, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (22): 2671–2685.
https://doi.org/10.1042/CS20160407
Published: 06 November 2017
View article titled, Personalized medicine—a modern approach for the diagnosis and management of hypertension
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Articles

Clinical Science: showcasing the breadth of the journal

Mark E. Cooper, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1559.
https://doi.org/10.1042/CS20171099
Published: 30 June 2017
View article titled, Clinical Science: showcasing the breadth of the journal
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Articles

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications

Angela K. Lucas-Herald, Rheure Alves-Lopes, Augusto C. Montezano, S. Faisal Ahmed, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1405–1418.
https://doi.org/10.1042/CS20170090
Published: 23 June 2017
View article titled, Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
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Articles

Clinical Science –linking basic science to disease mechanisms

Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (7): 511–513.
https://doi.org/10.1042/CS20170139
Published: 17 March 2017
View article titled, Clinical Science –linking basic science to disease mechanisms
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Articles

PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases

Martin Kolisek, Augusto C. Montezano, Gerhard Sponder, Aikaterini Anagnostopoulou, Juergen Vormann, Rhian M. Touyz, Joerg R. Aschenbach
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1143–1150.
https://doi.org/10.1042/CS20150355
Published: 30 October 2015
View article titled, PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases
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Articles

Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus

Marcondes Alves B. Silva, Stefany Bruno A. Cau, Rheure Alves M. Lopes, Carla P. Manzato, Karla B. Neves, Thiago Bruder-Nascimento, Fabiola Leslie Antunes C. Mestriner, Augusto C. Montezano, Aurelie Nguyen Dinh Cat, Rhian M. Touyz, Rita C. Tostes
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (7): 533–545.
https://doi.org/10.1042/CS20140758
Published: 03 July 2015
View article titled, Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus
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Articles

Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms

Andreia Z. Chignalia, Maria Aparecida Oliveira, Victor Debbas, Randal O. Dull, Francisco R.M. Laurindo, Rhian M. Touyz, Maria Helena C. Carvalho, Zuleica B. Fortes, Rita C. Tostes
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (1): 39–48.
https://doi.org/10.1042/CS20140548
Published: 01 April 2015
View article titled, Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms
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Includes: Supplementary data
Articles

Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways

Thiago Bruder-Nascimento, Glaucia E. Callera, Augusto C. Montezano, Ying He, Tayze T. Antunes, Aurelie Nguyen Dinh Cat, Rita C. Tostes, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (7): 411–423.
https://doi.org/10.1042/CS20140456
Published: 09 December 2014
View article titled, Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways
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Includes: Supplementary data
Articles

Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension

Dylan Burger, Timothy L. Reudelhuber, Aman Mahajan, Kelly Chibale, Edward D. Sturrock, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (1): 57–63.
https://doi.org/10.1042/CS20130808
Published: 10 March 2014
View article titled, Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension
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Articles

Microparticles: biomarkers and beyond

Dylan Burger, Sarah Schock, Charlie S. Thompson, Augusto C. Montezano, Antoine M. Hakim, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (7): 423–441.
https://doi.org/10.1042/CS20120309
Published: 07 December 2012
View article titled, Microparticles: biomarkers and beyond
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Articles

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

Mona Sedeek, Alex Gutsol, Augusto C. Montezano, Dylan Burger, Aurelie Nguyen Dinh Cat, Chris R. J. Kennedy, Kevin D. Burns, Mark E. Cooper, Karin Jandeleit-Dahm, Patrick Page, Cedric Szyndralewiez, Freddy Heitz, Richard L. Hebert, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (3): 191–202.
https://doi.org/10.1042/CS20120330
Published: 17 October 2012
View article titled, Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes
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Includes: Supplementary data
Articles

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

Augusto C. Montezano, Dylan Burger, Graziela S. Ceravolo, Hiba Yusuf, Maria Montero, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (4): 131–141.
https://doi.org/10.1042/CS20100384
Published: 02 November 2010
View article titled, Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5
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Articles

Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms

Alvaro Yogi, Glaucia E. Callera, Ulisses V. Hipólito, Catiane R. Silva, Rhian M. Touyz, Carlos R. Tirapelli
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (11): 657–668.
https://doi.org/10.1042/CS20090352
Published: 09 March 2010
View article titled, Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms
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Articles

Endothelin, sex and hypertension

Rita C. Tostes, Zuleica B. Fortes, Glaucia E. Callera, Augusto C. Montezano, Rhian M. Touyz, R. Clinton Webb, Maria Helena C. Carvalho
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (2): 85–97.
https://doi.org/10.1042/CS20070169
Published: 11 December 2007
View article titled, Endothelin, sex and hypertension
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Articles

Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support

Michel White, Anique Ducharme, Reda Ibrahim, Lucette Whittom, Joel Lavoie, Marie-Claude Guertin, Normand Racine, Ying He, Guoying Yao, Jean L. Rouleau, Ernesto L. Schiffrin, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (4): 483–489.
https://doi.org/10.1042/CS20050317
Published: 15 March 2006
View article titled, Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support
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Articles

Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms

Glaucia E. Callera, Rita C. Tostes, Alvaro Yogi, Augusto C. I. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 243–253.
https://doi.org/10.1042/CS20050307
Published: 17 January 2006
View article titled, Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms
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Articles

Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger

Rhian M. TOUYZ, Guoying YAO
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (2): 235–242.
https://doi.org/10.1042/CS20030033
Published: 01 August 2003
View article titled, Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger
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Articles

Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension

Rita C A TOSTES, Rhian M TOUYZ, Gang HE, Xin CHEN, Ernesto L. SCHIFFRIN
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 25S–30S.
https://doi.org/10.1042/CS103S025S
Published: 01 September 2002
View article titled, Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension
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