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Articles

Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure

Craig A. Lygate
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (8): 491–514.
https://doi.org/10.1042/CS20230616
Published: 19 April 2024
View article titled, Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure
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Articles

Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning

Limin Shi, Jinying Yang, Zhipeng Tao, Louise Zheng, Tyler F. Bui, Ramon L. Alonso, Feng Yue, Zhiyong Cheng
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (6): 371–385.
https://doi.org/10.1042/CS20230973
Published: 12 March 2024
View article titled, Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning
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Includes: Supplementary data
Articles

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Luís F. Grilo, João D. Martins, Mariana S. Diniz, Carolina Tocantins, Chiara H. Cavallaro, Inês Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, Peter W. Nathanielsz, Paulo J. Oliveira, Susana P. Pereira
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1347–1372.
https://doi.org/10.1042/CS20230048
Published: 01 September 2023
View article titled, Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress
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Includes: Supplementary data
Articles

Essential metabolism required for T and B lymphocyte functions: an update

Vinicius Leonardo Sousa Diniz, Anuska Marcelino Alvares-Saraiva, Tamires Duarte Afonso Serdan, Laiane Cristina dos Santos-Oliveira, Vinicius Cruzat, Tiago Bertola Lobato, Richelieau Manoel, Amanda Lins Alecrim, Otavio Augusto Machado, Sandro M. Hirabara, Laureane Nunes Masi, Tania Cristina Pithon-Curi, Rui Curi, Renata Gorjão, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 807–821.
https://doi.org/10.1042/CS20220869
Published: 23 May 2023
View article titled, Essential metabolism required for T and B lymphocyte functions: an update
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Articles

Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

William P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1485–1511.
https://doi.org/10.1042/CS20220205
Published: 03 November 2022
View article titled, Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats
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Includes: Supplementary data
Articles

Targeting skeletal muscle mitochondrial health in obesity

Chantal A. Pileggi, Breana G. Hooks, Ruth McPherson, Robert R.M. Dent, Mary-Ellen Harper
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (14): 1081–1110.
https://doi.org/10.1042/CS20210506
Published: 27 July 2022
View article titled, Targeting skeletal muscle mitochondrial health in obesity
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Articles

Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Andris Elksnis, Tomas A Schiffer, Fredrik Palm, Yun Wang, Jing Cen, Kyril Turpaev, Anongnad Ngamjariyawat, Shady Younis, Suling Huang, Yu Shen, Ying Leng, Peter Bergsten, Tony Karlsborn, Nils Welsh, Xuan Wang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (19): 2243–2263.
https://doi.org/10.1042/CS20210604
Published: 08 October 2021
View article titled, Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
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Includes: Supplementary data
Articles

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Susana P. Pereira, Ludgero C. Tavares, Ana I. Duarte, Inês Baldeiras, Teresa Cunha-Oliveira, João D. Martins, Maria S. Santos, Alina Maloyan, António J. Moreno, Laura A. Cox, Cun Li, Peter W. Nathanielsz, Mark J. Nijland, Paulo J. Oliveira
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1103–1126.
https://doi.org/10.1042/CS20201339
Published: 11 May 2021
View article titled, Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction
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Includes: Supplementary data
Articles

Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2161–2175.
https://doi.org/10.1042/CS20200530
Published: 24 August 2020
View article titled, Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice
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Includes: Supplementary data
Articles

UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis

Brahmchetna Bedi, Kuo-Chuan. Lin, Nicholas M. Maurice, Zhihong Yuan, Kaiser Bijli, Michael Koval, C. Michael Hart, Joanna B. Goldberg, Arlene Stecenko, Ruxana T. Sadikot
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1911–1934.
https://doi.org/10.1042/CS20200066
Published: 23 July 2020
View article titled, UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis
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Includes: Supplementary data
Articles

Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model

Andressa Manfredini, Larissa Constantino, Milton Castro Pinto, Monique Michels, Henrique Burger, Luiza W. Kist, Milena Carvalho Silva, Lara Mezzari Gomes, Diogo Dominguini, Amanda Steckert, Carmen Simioni, Mauricio Bogo, Emílio Streck, Tatiana Barichello, João de Quevedo, Mervyn Singer, Cristiane Ritter, Felipe Dal-Pizzol
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (18): 1993–2004.
https://doi.org/10.1042/CS20190351
Published: 24 September 2019
View article titled, Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model
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Includes: Supplementary data
Articles

Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease

Jia Guo, Zhangsuo Liu, Rujun Gong
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (12): 1321–1339.
https://doi.org/10.1042/CS20190372
Published: 20 June 2019
View article titled, Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease
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Articles

Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways

Wenxue Huang, Yalin Zhan, Yunfei Zheng, Ye Han, Wenjie Hu, Jianxia Hou
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (1): 135–148.
https://doi.org/10.1042/CS20180679
Published: 11 January 2019
View article titled, Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways
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Articles

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

Gargi Mahapatra, S. Carrie Smith, Timothy M. Hughes, Benjamin Wagner, Joseph A. Maldjian, Barry I. Freedman, Anthony J. A. Molina
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (23): 2509–2518.
https://doi.org/10.1042/CS20180690
Published: 05 December 2018
View article titled, Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes
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Articles

Exacerbated metabolic changes in skeletal muscle of sickle cell mice submitted to an acute ischemia–reperfusion paradigm

Benjamin Chatel, Laurent A. Messonnier, Christophe Vilmen, Monique Bernard, Vincent Pialoux, David Bendahan
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2103–2115.
https://doi.org/10.1042/CS20180268
Published: 02 October 2018
View article titled, Exacerbated metabolic changes in skeletal muscle of sickle cell mice submitted to an acute ischemia–reperfusion paradigm
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Articles

Validity of predictive equations for resting metabolic rate in healthy humans

Jose E. Galgani, Mauricio Castro-Sepulveda, Cristian Pérez-Luco, Rodrigo Fernández-Verdejo
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1741–1751.
https://doi.org/10.1042/CS20180317
Published: 22 August 2018
View article titled, Validity of predictive equations for resting metabolic rate in healthy humans
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Includes: Supplementary data
Articles

High α-tocopherol dosing increases lipid metabolism by changing redox state in damaged rat gastric mucosa and liver after ethanol treatment

Marisela Olguín-Martínez, Diego R. Hernández-Espinosa, Rolando Hernández-Muñoz
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1281–1296.
https://doi.org/10.1042/CS20180154
Published: 26 June 2018
View article titled, High α-tocopherol dosing increases lipid metabolism by changing redox state in damaged rat gastric mucosa and liver after ethanol treatment
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Articles

Recent advances in the detection of brown adipose tissue in adult humans: a review

Frank J. Ong, Basma A. Ahmed, Stephan M. Oreskovich, Denis P. Blondin, Tahniyah Haq, Norman B. Konyer, Michael D. Noseworthy, Francois Haman, Andre C. Carpentier, Katherine M. Morrison, Gregory R. Steinberg
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1039–1054.
https://doi.org/10.1042/CS20170276
Published: 25 May 2018
View article titled, Recent advances in the detection of brown adipose tissue in adult humans: a review
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Includes: Supplementary data
Articles

The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right

Matthew Kerr, Michael S. Dodd, Lisa C. Heather
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2079–2094.
https://doi.org/10.1042/CS20160671
Published: 24 July 2017
View article titled, The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right
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Articles

Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease

Gareth A. Nye, Giorgos K. Sakellariou, Hans Degens, Adam P. Lightfoot
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1919–1922.
https://doi.org/10.1042/CS20160940
Published: 07 July 2017
View article titled, Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease
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Articles

Mitochondria: a central target for sex differences in pathologies

Renée Ventura-Clapier, Maryline Moulin, Jérôme Piquereau, Christophe Lemaire, Mathias Mericskay, Vladimir Veksler, Anne Garnier
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (9): 803–822.
https://doi.org/10.1042/CS20160485
Published: 19 April 2017
View article titled, Mitochondria: a central target for sex differences in pathologies
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Articles

Synergistic effects of citrulline supplementation and exercise on performance in male rats: evidence for implication of protein and energy metabolisms

Arthur Goron, Frédéric Lamarche, Valérie Cunin, Hervé Dubouchaud, Christophe Hourdé, Philippe Noirez, Christelle Corne, Karine Couturier, Michel Sève, Eric Fontaine, Christophe Moinard
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (8): 775–790.
https://doi.org/10.1042/CS20170088
Published: 06 April 2017
View article titled, Synergistic effects of citrulline supplementation and exercise on performance in male rats: evidence for implication of protein and energy metabolisms
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Includes: Supplementary data
Articles

The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease

Kathleen Atkins, Asish Dasgupta, Kuang-Hueih Chen, Jeff Mewburn, Stephen L. Archer
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (21): 1861–1874.
https://doi.org/10.1042/CS20160030
Published: 22 September 2016
View article titled, The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease
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Articles

Exercise-induced mitochondrial dysfunction: a myth or reality?

Sergej M. Ostojic
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (16): 1407–1416.
https://doi.org/10.1042/CS20160200
Published: 07 July 2016
View article titled, Exercise-induced mitochondrial dysfunction: a myth or reality?
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