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CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2

Xudong Wang, Yanshi Li, Min Pan, Tao Lu, Min Wang, Zhihai Wang, Chuan Liu, Guohua Hu

Clin Sci (Lond) (2022) 136 (22): 1691–1710.

DOI: https://doi.org/10.1042/CS20220581

Published: 25 November 2022

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Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon

Clin Sci (Lond) (2022) 136 (22): 1591–1614.

DOI: https://doi.org/10.1042/CS20220491

Published: 14 November 2022

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Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma

Zhanzhan Li, Yanyan Li, Na Li, Liangfang Shen, Aibin Liu

Clin Sci (Lond) (2022) 136 (11): 895–909.

DOI: https://doi.org/10.1042/CS20220128

Published: 06 June 2022

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The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen

Clin Sci (Lond) (2022) 136 (3): 197–222.

DOI: https://doi.org/10.1042/CS20201474

Published: 04 February 2022

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WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway

Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue

Clin Sci (Lond) (2022) 136 (1): 29–44.

DOI: https://doi.org/10.1042/CS20210663

Published: 05 January 2022

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Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection

Samuele Iesari, Isabelle Leclercq, Nicolas Joudiou, Mina Komuta, Aurélie Daumerie, Jérôme Ambroise, Alexandra Dili, Natacha Feza-Bingi, Daela Xhema, Caroline Bouzin, Bernard Gallez, Francesco Pisani, Eliano Bonaccorsi-Riani, Pierre Gianello

Clin Sci (Lond) (2021) 135 (19): 2285–2305.

DOI: https://doi.org/10.1042/CS20210183

Published: 13 October 2021

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A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang, Cheng Yang, Li Yu

Clin Sci (Lond) (2021) 135 (14): 1751–1765.

DOI: https://doi.org/10.1042/CS20210571

Published: 27 July 2021

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NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia

Jianmin Liu, Daoquan Liu, Xueneng Zhang, Yan Li, Xun Fu, Weixiang He, Mingzhou Li, Ping Chen, Guang Zeng, Michael E. DiSanto, Xinghuan Wang, Xinhua Zhang

Clin Sci (Lond) (2021) 135 (13): 1591–1608.

DOI: https://doi.org/10.1042/CS20210476

Published: 07 July 2021

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Human placental villous stromal extracellular matrix regulates fetoplacental angiogenesis in severe fetal growth restriction

Shuhan Ji, Diane Gumina, Kathryn McPeak, Radu Moldovan, Miriam D. Post, Emily J. Su

Clin Sci (Lond) (2021) 135 (9): 1127–1143.

DOI: https://doi.org/10.1042/CS20201533

Published: 11 May 2021

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Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway

Yijin Chen, Tong Xu, Mengsha Li, Chuling Li, Yusheng Ma, Guojun Chen, Yili Sun, Hao Zheng, Guangkai Wu, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

Clin Sci (Lond) (2021) 135 (6): 811–828.

DOI: https://doi.org/10.1042/CS20201408

Published: 23 March 2021

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The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis -activation and the consequent initiation of Rho GTPase-mediated signaling

Xueying Hu, Liang Xiang, Dong He, Rongrong Zhu, Jianing Fang, Zhanwang Wang, Ke Cao

Clin Sci (Lond) (2021) 135 (3): 555–574.

DOI: https://doi.org/10.1042/CS20200908

Published: 03 February 2021

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Protective role of serpina3c as a novel thrombin inhibitor against atherosclerosis in mice

Ling-lin Qian, Jing-jing Ji, Jia-qi Guo, Yan-ping Wu, Gen-shan Ma, Yu-yu Yao

Clin Sci (Lond) (2021) 135 (3): 447–463.

DOI: https://doi.org/10.1042/CS20201235

Published: 01 February 2021

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The GCN5: its biological functions and therapeutic potentials

Md. Ezazul Haque, Md. Jakaria, Mahbuba Akther, Duk-Yeon Cho, In-Su Kim, Dong-Kug Choi

Clin Sci (Lond) (2021) 135 (1): 231–257.

DOI: https://doi.org/10.1042/CS20200986

Published: 14 January 2021

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Changes in the expression and functional activities of Myosin II isoforms in human hyperplastic prostate

In Collection

Protein structure and function

Weixiang He, Xiao Wang, Daxing Zhan, Mingzhou Li, Qian Wang, Jianmin Liu, Daoquan Liu, Xun Fu, Qiaofeng Qian, Yan Li, Ping Chen, Guang Zeng, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang

Clin Sci (Lond) (2021) 135 (1): 167–183.

DOI: https://doi.org/10.1042/CS20201283

Published: 08 January 2021

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Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

Kaj E.C. Blokland, Simon D. Pouwels, Michael Schuliga, Darryl A. Knight, Janette K. Burgess

Clin Sci (Lond) (2020) 134 (20): 2681–2706.

DOI: https://doi.org/10.1042/CS20190893

Published: 21 October 2020

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miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute tubular injury

Wenjuan Yu, Honghui Zeng, Junzhe Chen, Sha Fu, Qiuyan Huang, Yanchun Xu, Anping Xu, Hui-yao Lan, Ying Tang

Clin Sci (Lond) (2020) 134 (16): 2223–2234.

DOI: https://doi.org/10.1042/CS20200288

Published: 28 August 2020

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RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer

Huaiming Wang, Rongkang Huang, Wentai Guo, Xiusen Qin, Zifeng Yang, Zixu Yuan, Yingqi Wei, Chunlin Mo, Zhantao Zeng, Jian Luo, Jian Cai, Hui Wang

Clin Sci (Lond) (2020) 134 (14): 1973–1990.

DOI: https://doi.org/10.1042/CS20191174

Published: 28 July 2020

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Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway

Yongjie Zhou, Qing Xu, Lv Tao, Yuwei Chen, Yuke Shu, Zhenru Wu, Changli Lu, Yujun Shi, Hong Bu

Clin Sci (Lond) (2020) 134 (12): 1457–1472.

DOI: https://doi.org/10.1042/CS20200244

Published: 18 June 2020

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Homocysteine induces melanocytes apoptosis via PERK–eIF2α–CHOP pathway in vitiligo

Jiaxi Chen, Tongtian Zhuang, Jianru Chen, Yangzi Tian, Xiuli Yi, Qingrong Ni, Weigang Zhang, Pu Song, Zhe Jian, Ling Liu, Tingting Cui, Kai Li, Tianwen Gao, Chunying Li, Shuli Li

Clin Sci (Lond) (2020) 134 (10): 1127–1141.

DOI: https://doi.org/10.1042/CS20200218

Published: 21 May 2020

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Albendazole negatively regulates keratinocyte proliferation

Davide Di Fusco, Carmine Stolfi, Antonio Di Grazia, Vincenzo Dinallo, Federica Laudisi, Irene Marafini, Alfredo Colantoni, Ivan Monteleone, Giovanni Monteleone

Clin Sci (Lond) (2020) 134 (7): 907–920.

DOI: https://doi.org/10.1042/CS20191215

Published: 17 April 2020

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Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs

Jinhui Lü, Qian Zhao, Xin Ding, Yuefan Guo, Yuan Li, Zhen Xu, Shujun Li, Zhongrui Wang, Lei Shen, Huang-wen Chen, Zuoren Yu, Richard G. Pestell

Clin Sci (Lond) (2020) 134 (7): 791–805.

DOI: https://doi.org/10.1042/CS20191318

Published: 09 April 2020

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Interleukin-17A induces vascular remodeling of small arteries and blood pressure elevation

Macarena Orejudo, Ana B. García-Redondo, Raúl R. Rodrigues-Diez, Raquel Rodrigues-Díez, Laura Santos-Sanchez, Antonio Tejera-Muñoz, Jesús Egido, Rafael Selgas, Mercedes Salaices, Ana M. Briones, Marta Ruiz-Ortega

Clin Sci (Lond) (2020) 134 (5): 513–527.

DOI: https://doi.org/10.1042/CS20190682

Published: 09 March 2020

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CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation

Chen-Chen Han, Qian Liu, Yu Zhang, Yi-Fan Li, Dong-Qian Cui, Ting-Ting Luo, Yu-Wen Zhang, Xin-Ming Wang, Chun Wang, Yang Ma, Wei Wei

Clin Sci (Lond) (2020) 134 (3): 331–347.

DOI: https://doi.org/10.1042/CS20191032

Published: 04 February 2020

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Tumor-associated macrophage-derived exosomal microRNA-155-5p stimulates intracranial aneurysm formation and macrophage infiltration

Zhengzhe Feng, Xiaoxi Zhang, Li Li, Chuanchuan Wang, Mingtao Feng, Kaijun Zhao, Rui Zhao, Jianmin Liu, Yibin Fang

Clin Sci (Lond) (2019) 133 (22): 2265–2282.

DOI: https://doi.org/10.1042/CS20190680

Published: 19 November 2019

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GDF11 impairs liver regeneration in mice after partial hepatectomy

Wenjie Wang, Xiao Yang, Jiankun Yang, Shenpei Liu, Yongman Lv, Cuntai Zhang, Wei Dong, Anding Liu

Clin Sci (Lond) (2019) 133 (20): 2069–2084.

DOI: https://doi.org/10.1042/CS20190441

Published: 22 October 2019

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SETD3 is regulated by a couple of microRNAs and plays opposing roles in proliferation and metastasis of hepatocellular carcinoma

Liangliang Xu, Peng Wang, Xinfu Feng, Jianwei Tang, Lian Li, Xiaobo Zheng, Jinfu Zhang, Yitao Hu, Tian Lan, Kefei Yuan, Yanfang Zhang, Shengsheng Ren, Xiangyong Hao, Ming Zhang, Mingqing Xu

Clin Sci (Lond) (2019) 133 (20): 2085–2105.

DOI: https://doi.org/10.1042/CS20190666

Published: 22 October 2019

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BMSC-derived exosomes carrying microRNA-122-5p promote proliferation of osteoblasts in osteonecrosis of the femoral head

Wen Liao, Yu Ning, Hai-Jia Xu, Wen-Zhong Zou, Jing Hu, Xiang-Zhong Liu, Yi Yang, Zhang-Hua Li

Clin Sci (Lond) (2019) 133 (18): 1955–1975.

DOI: https://doi.org/10.1042/CS20181064

Published: 19 September 2019

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Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication

Shuming Wang, Yilin Hu, Xiurui Lv, Bin Li, Dianhua Gu, Yang Li, Yong Sun, Yang Su

Clin Sci (Lond) (2019) 133 (18): 1935–1953.

DOI: https://doi.org/10.1042/CS20190589

Published: 17 September 2019

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Fatty acid oxidation inhibitor etomoxir suppresses tumor progression and induces cell cycle arrest via PPARγ-mediated pathway in bladder cancer

Songtao Cheng, Gang Wang, Yejinpeng Wang, Liwei Cai, Kaiyu Qian, Lingao Ju, Xuefeng Liu, Yu Xiao, Xinghuan Wang

Clin Sci (Lond) (2019) 133 (15): 1745–1758.

DOI: https://doi.org/10.1042/CS20190587

Published: 07 August 2019

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Down-regulation of lncRNA XIST inhibits cell proliferation via regulating miR-744/RING1 axis in non-small cell lung cancer

Jinglu Wang, Haibo Cai, Zhaoxia Dai, Gang Wang

Clin Sci (Lond) (2019) 133 (14): 1567–1579.

DOI: https://doi.org/10.1042/CS20190519

Published: 18 July 2019

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CircRNA-104718 acts as competing endogenous RNA and promotes hepatocellular carcinoma progression through microRNA-218-5p/TXNDC5 signaling pathway

Jiaze Yu, Minjie Yang, Bo Zhou, Jianjun Luo, Zihan Zhang, Wen Zhang, Zhiping Yan

Clin Sci (Lond) (2019) 133 (13): 1487–1503.

DOI: https://doi.org/10.1042/CS20190394

Published: 15 July 2019

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The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA

Yanxian Lai, Jianyong Li, Lintao Zhong, Xiang He, Xiaoyun Si, Yili Sun, Yanmei Chen, Jiayuan Zhong, Yinlan Hu, Bing Li, Wangjun Liao, Cheng Liu, Yulin Liao, Jiancheng Xiu, Jianping Bin

Clin Sci (Lond) (2019) 133 (13): 1439–1455.

DOI: https://doi.org/10.1042/CS20190156

Published: 15 July 2019

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MicroRNA-302d promotes the proliferation of human pluripotent stem cell-derived cardiomyocytes by inhibiting LATS2 in the Hippo pathway

Fei Xu, Jingcheng Yang, Jun Shang, Feng Lan, Miaomiao Li, Leming Shi, Li Shen, Yongming Wang, Junbo Ge

Clin Sci (Lond) (2019) 133 (13): 1387–1399.

DOI: https://doi.org/10.1042/CS20190099

Published: 02 July 2019

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Advances in heart regeneration based on cardiomyocyte proliferation and regenerative potential of binucleated cardiomyocytes and polyploidization

Marina Leone, Felix B. Engel

Clin Sci (Lond) (2019) 133 (11): 1229–1253.

DOI: https://doi.org/10.1042/CS20180560

Published: 07 June 2019

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Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis

Zhongzheng Sun, Hao Xue, Yan Wei, Chaochao Wang, Rui Yu, Chengwei Wang, Shaobo Wang, Jianye Xu, Mingyu Qian, Qinghu Meng, Gang Li

Clin Sci (Lond) (2019) 133 (10): 1167–1184.

DOI: https://doi.org/10.1042/CS20190145

Published: 21 May 2019

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STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer

Chao Liu, Jiaqi Shi, Qingwei Li, Zhiwei Li, Changjie Lou, Qi Zhao, Yuanyuan Zhu, Fei Zhan, Jie Lian, Bojun Wang, Xin Guan, Lin Fang, Zengxun Li, Yifei Wang, Bodong Zhou, Yuanfei Yao, Yanqiao Zhang

Clin Sci (Lond) (2019) 133 (5): 645–663.

DOI: https://doi.org/10.1042/CS20180816

Published: 01 March 2019

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Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2

Yinlan Hu, Guoqing Jin, Bing Li, Yanmei Chen, Lintao Zhong, Guojun Chen, Xiaoqiang Chen, Jiayuan Zhong, Wangjun Liao, Yulin Liao, Yuegang Wang, Jianping Bin

Clin Sci (Lond) (2019) 133 (3): 425–441.

DOI: https://doi.org/10.1042/CS20181002

Published: 05 February 2019

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LncRNA DCST1-AS1 functions as a competing endogenous RNA to regulate FAIM2 expression by sponging miR-1254 in hepatocellular carcinoma

Jing Chen, Di Wu, Yue Zhang, Yong Yang, Yunfei Duan, Yong An

Clin Sci (Lond) (2019) 133 (2): 367–379.

DOI: https://doi.org/10.1042/CS20180814

Published: 30 January 2019

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Novel treatment avenues for uterine leiomyoma: a new implication for endothelin?

Kedra Wallace, Krystal Chatman, Venessia Johnson, Alexis Brookins, John Rushing, Babbette LaMarca

Clin Sci (Lond) (2018) 132 (20): 2261–2267.

DOI: https://doi.org/10.1042/CS20180474

Published: 29 October 2018

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Blebbistatin modulates prostatic cell growth and contrapctility through myosin II signaling

Ping Chen, De-qiang Xu, Sheng-li Xu, He Xiao, Sheng-hong Wan, Xing-huan Wang, Michael E. DiSanto, Xin-hua Zhang

Clin Sci (Lond) (2018) 132 (20): 2189–2205.

DOI: https://doi.org/10.1042/CS20180294

Published: 19 October 2018

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Gemcitabine resistance mediated by ribonucleotide reductase M2 in lung squamous cell carcinoma is reversed by GW8510 through autophagy induction

Ping Chen, Jian-Nong Wu, Yang Shu, He-Guo Jiang, Xiao-Hui Zhao, Hai Qian, Kang Chen, Ting Lan, Chen-Guo Chen, Jian Li

Clin Sci (Lond) (2018) 132 (13): 1417–1433.

DOI: https://doi.org/10.1042/CS20180010

Published: 09 July 2018

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Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice

Bo Hang, Yunshan Wang, Yurong Huang, Pin Wang, Sasha A. Langley, Lei Bi, Altaf H. Sarker, Suzaynn F. Schick, Christopher Havel, Peyton Jacob, III, Neal Benowitz, Hugo Destaillats, Xiaochen Tang, Yankai Xia, Kuang-Yu Jen, Lara A. Gundel, Jian-Hua Mao, Antoine M. Snijders

Clin Sci (Lond) (2018) 132 (4): 475–488.

DOI: https://doi.org/10.1042/CS20171521

Published: 28 February 2018

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Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction

Dezhong Yang, Wenbin Fu, Liangpeng Li, Xuewei Xia, Qiao Liao, Rongchuan Yue, Hongmei Chen, Xiongwen Chen, Songzhu An, Chunyu Zeng, Wei Eric Wang

Clin Sci (Lond) (2017) 131 (24): 2919–2932.

DOI: https://doi.org/10.1042/CS20171256

Published: 08 December 2017

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DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis

Na Zhao, Li Zeng, Yang Liu, Dong Han, Haochen Liu, Jian Xu, Yuxi Jiang, Cuiying Li, Tao Cai, Hailan Feng, Yixiang Wang

Clin Sci (Lond) (2017) 131 (22): 2721–2735.

DOI: https://doi.org/10.1042/CS20171231

Published: 13 November 2017

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The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review

Sheila V. Graham

Clin Sci (Lond) (2017) 131 (17): 2201–2221.

DOI: https://doi.org/10.1042/CS20160786

Published: 10 August 2017

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Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation

Imad Al Ghouleh, Sanghamitra Sahoo, Daniel N. Meijles, Jefferson H. Amaral, Daniel S. de Jesus, John Sembrat, Mauricio Rojas, Dmitry A. Goncharov, Elena A. Goncharova, Patrick J. Pagano

Clin Sci (Lond) (2017) 131 (15): 2019–2035.

DOI: https://doi.org/10.1042/CS20160812

Published: 17 July 2017

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Mycobacterium tuberculosis Rv3615c is a highly immunodominant antigen and specifically induces potent Th1-type immune responses in tuberculosis pleurisy

Jiangping Li, Juan Shen, Suihua Lao, Xiaomin Li, Jie Liu, Changyou Wu

Clin Sci (Lond) (2017) 131 (15): 1859–1876.

DOI: https://doi.org/10.1042/CS20170205

Published: 05 July 2017

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Sex differences in micro- and macro-vascular complications of diabetes mellitus

Christine Maric-Bilkan

Clin Sci (Lond) (2017) 131 (9): 833–846.

DOI: https://doi.org/10.1042/CS20160998

Published: 19 April 2017

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Human DPSCs fabricate vascularized woven bone tissue: a new tool in bone tissue engineering

Francesca Paino, Marcella La Noce, Alessandra Giuliani, Alfredo De Rosa, Serena Mazzoni, Luigi Laino, Evzen Amler, Gianpaolo Papaccio, Vincenzo Desiderio, Virginia Tirino

Clin Sci (Lond) (2017) 131 (8): 699–713.

DOI: https://doi.org/10.1042/CS20170047

Published: 06 April 2017

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BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis

Natasha Irrera, Mario Vaccaro, Alessandra Bitto, Giovanni Pallio, Gabriele Pizzino, Maria Lentini, Vincenzo Arcoraci, Letteria Minutoli, Michele Scuruchi, Giuseppina Cutroneo, Giuseppe Pio Anastasi, Roberta Ettari, Francesco Squadrito, Domenica Altavilla

Clin Sci (Lond) (2017) 131 (6): 487–498.

DOI: https://doi.org/10.1042/CS20160645

Published: 06 March 2017

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