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Articles

Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics

Wang-Hsin Lee, Zachary A. Kipp, Sally N. Pauss, Genesee J. Martinez, Evelyn A. Bates, Olufunto O. Badmus, David E. Stec, Terry D. Hinds, Jr
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (02): 171–198.
https://doi.org/10.1042/CS20242825
Published: 28 January 2025
View articletitled, Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics
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Articles

Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge

Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt Jr.
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (02): 85–113.
https://doi.org/10.1042/CS20243515
Published: 23 January 2025
View articletitled, Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge
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Includes: Supplementary data
Articles

Sex-mediated effects of transglutaminase 2 inhibition on endothelial function in human resistance arteries from diabetic and non-diabetic patients

Khatera Saii, Judit Prat-Duran, Ulf Simonsen, Anders Riegels Knudsen, Jonas Amstrup Funder, Niels Henrik Buus, Estéfano Pinilla
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (1): 1–14.
https://doi.org/10.1042/CS20242001
Published: 15 January 2025
View articletitled, Sex-mediated effects of transglutaminase 2 inhibition on endothelial function in human resistance arteries from diabetic and non-diabetic patients
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Includes: Supplementary data
Articles

Distinct effects of obesity and diabetes on the action potential waveform and inward currents in rat ventricular myocytes

Anatoliy Shmygol, Gilles Bru-Mercier, Ahmed S. Sultan, Frank C. Howarth
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (1): 55–67.
https://doi.org/10.1042/CS20242144
Published: 15 January 2025
View articletitled, Distinct effects of obesity and diabetes on the action potential waveform and inward currents in rat ventricular myocytes
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Articles

Serpina3c Deficiency Promotes Obesity-related Hypertriglyceridemia and Inflammation through Activation of the Hif1α - glycolysis Axis in Adipose Tissue

Jiaqi Guo, Zhenjun Ji, Yu Jiang, Ya Wu, Shaofan Wang, Peng Zheng, Mengchen Yang, Yongjun Li, Genshan Ma, Yuyu Yao
Journal: Clinical Science
Clin Sci (Lond) (2024) CS20242610.
https://doi.org/10.1042/CS20242610
Published: 18 December 2024
View articletitled, Serpina3c Deficiency Promotes Obesity-related Hypertriglyceridemia and Inflammation through Activation of the Hif1α - glycolysis Axis in Adipose Tissue
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Articles

Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes

Federica Barutta, Beatrice Corbetta, Stefania Bellini, Roberto Gambino, Stefania Bruno, Shunsuke Kimura, Koji Hase, Hiroshi Ohno, Gabriella Gruden
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (23): 1537–1559.
https://doi.org/10.1042/CS20242064
Published: 29 November 2024
View articletitled, Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes
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Includes: Supplementary data
Articles

New discoveries in bile acids, gut microbiota and host interactions in health and diseases

In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Justine Gillard, Isabelle Leclercq
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (23): 1521–1523.
https://doi.org/10.1042/CS20240940
Published: 26 November 2024
View articletitled, New discoveries in bile acids, gut microbiota and host interactions in health and diseases
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Articles

Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells

Faheem Seedat, Neva Kandzija, Michael J. Ellis, Shuhan Jiang, Asselzhan Sarbalina, James Bancroft, Edward Drydale, Svenja S. Hester, Roman Fischer, Alisha N. Wade, M. Irina Stefana, John A. Todd, Manu Vatish
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (22): 1481–1502.
https://doi.org/10.1042/CS20241782
Published: 20 November 2024
View articletitled, Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells
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Includes: Supplementary data
Articles

Cardiac-derived CTRP9 mediates the protection of empagliflozin against diabetes-induced male subfertility in mice

Yang Mu, Ling-Bo Luo, Rong Huang, Zhuo-Yu Shen, Dan Huang, Shu-Hong Zhao, Jing Yang, Zhen-Guo Ma
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (21): 1421–1440.
https://doi.org/10.1042/CS20241477
Published: 04 November 2024
View articletitled, Cardiac-derived CTRP9 mediates the protection of empagliflozin against diabetes-induced male subfertility in mice
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Includes: Supplementary data
Articles

When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models

Sebastian Bott, Justine Lallement, Alice Marino, Evangelos-Panagiotis Daskalopoulos, Christophe Beauloye, Hrag Esfahani, Chantal Dessy, Isabelle Anne Leclercq
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (18): 1151–1171.
https://doi.org/10.1042/CS20240833
Published: 18 September 2024
View articletitled, When the liver is in poor condition, so is the heart – cardiac remodelling in MASH mouse models
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Includes: Supplementary data
Articles

The role of microRNAs in pregnancies complicated by maternal diabetes

Manon D. Owen, Margeurite G. Kennedy, Rachel C. Quilang, Eleanor M. Scott, Karen Forbes
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (18): 1179–1207.
https://doi.org/10.1042/CS20230681
Published: 18 September 2024
View articletitled, The role of microRNAs in pregnancies complicated by maternal diabetes
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Articles

Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate

Ling Zhang, Shixuan Zhang, Wenyu Zou, Yongyan Hu, Ying Gao, Junqing Zhang, Jia Zheng
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (17): 1039–1054.
https://doi.org/10.1042/CS20240997
Published: 23 August 2024
View articletitled, Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate
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Articles

Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway

Roberto Palacios-Ramirez, Matthieu Soulié, Amaya Fernandez-Celis, Toshifumi Nakamura, Nabiha Boujardine, Benjamin Bonnard, Krister Bamberg, Natalia Lopez-Andres, Frederic Jaisser
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (16): 1025–1038.
https://doi.org/10.1042/CS20240302
Published: 22 August 2024
View articletitled, Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway
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Includes: Supplementary data
Articles

Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions

In Collection
Endothelin XVIII Conference Collection
Mia Edgerton-Fulton, Yasir Abdul, Sarah Jamil, Adviye Ergul
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (16): 1009–1022.
https://doi.org/10.1042/CS20240328
Published: 21 August 2024
View articletitled, Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions
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Includes: Supplementary data
Articles

To target cellular senescence in diabetic kidney disease: the known and the unknown

Yuehan Wei, Shan Mou, Qing Yang, Fang Liu, Mark E. Cooper, Zhonglin Chai
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (16): 991–1007.
https://doi.org/10.1042/CS20240717
Published: 14 August 2024
View articletitled, To target cellular senescence in diabetic kidney disease: the known and the unknown
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Articles

Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase

John Tengbom, Eftychia Kontidou, Aida Collado, Jiangning Yang, Michael Alvarsson, Jonas Brinck, Sophia Rössner, Zhichao Zhou, John Pernow, Ali Mahdi
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (15): 975–985.
https://doi.org/10.1042/CS20240447
Published: 05 August 2024
View articletitled, Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase
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Articles

Astrocytes at the intersection of ageing, obesity, and neurodegeneration

In Collection
The biology of ageing: Geroscience and the exposome
Wyn Firth, Katherine R Pye, Paul G Weightman Potter
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (8): 515–536.
https://doi.org/10.1042/CS20230148
Published: 23 April 2024
View articletitled, Astrocytes at the intersection of ageing, obesity, and neurodegeneration
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Articles

Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration

Aya Al-Saidi, Ibrahim F. Alzaim, Safaa H. Hammoud, Ghida Al Arab, Samaya Abdalla, Nahed Mougharbil, Ali H. Eid, Ahmed F. El-Yazbi
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (5): 289–308.
https://doi.org/10.1042/CS20231186
Published: 05 March 2024
View articletitled, Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration
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Articles

Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury

Gregory H. Tesch, Frank Y. Ma, Elyce Ozols, David J. Nikolic-Paterson
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (5): 309–326.
https://doi.org/10.1042/CS20231698
Published: 05 March 2024
View articletitled, Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury
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Includes: Supplementary data
Articles

Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice

Sing-Young Chen, Aiden J. Telfser, Ellen M. Olzomer, Calum S. Vancuylenberg, Mingyan Zhou, Martina Beretta, Catherine Li, Stephanie J. Alexopoulos, Nigel Turner, Frances L. Byrne, Webster L. Santos, Kyle L. Hoehn
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (4): 173–187.
https://doi.org/10.1042/CS20231016
Published: 19 February 2024
View articletitled, Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice
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Includes: Supplementary data
Articles

Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche

Samar Salem, Lopa Leach
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (2): 87–102.
https://doi.org/10.1042/CS20230657
Published: 12 January 2024
View articletitled, Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche
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Articles

Nasogastric bolus administration of a protein-rich drink augments insulinaemia and aminoacidaemia but not whole-body protein turnover or muscle protein synthesis versus oral administration

George F. Pavis, Doaa R. Abdelrahman, Andrew J. Murton, Benjamin T. Wall, Francis B. Stephens, Marlou L. Dirks
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (1): 43–60.
https://doi.org/10.1042/CS20231126
Published: 05 January 2024
View articletitled, Nasogastric bolus administration of a protein-rich drink augments insulinaemia and aminoacidaemia but not whole-body protein turnover or muscle protein synthesis versus oral administration
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Articles

A normative microbiome is not restored following kidney transplantation

In Collection
The biology of ageing: Geroscience and the exposome
Hannah Craven, Helen Erlandsson, Dagmara McGuinness, David H. McGuinness, Denise Mafra, Umer Zeeshan Ijaz, Peter Bergman, Paul G. Shiels, Peter Stenvinkel
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (20): 1563–1575.
https://doi.org/10.1042/CS20230779
Published: 17 October 2023
View articletitled, A normative microbiome is not restored following kidney transplantation
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Includes: Supplementary data
Articles

Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D 1 R expression

Yu Tao, Wenbin Luo, Yue Chen, Caiyu Chen, Shengnan Chen, Xiaoping Li, Ken Chen, Chunyu Zeng
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1391–1407.
https://doi.org/10.1042/CS20230664
Published: 07 September 2023
View articletitled, Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D 1 R expression
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Includes: Supplementary data
Articles

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Luís F. Grilo, João D. Martins, Mariana S. Diniz, Carolina Tocantins, Chiara H. Cavallaro, Inês Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, Peter W. Nathanielsz, Paulo J. Oliveira, Susana P. Pereira
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1347–1372.
https://doi.org/10.1042/CS20230048
Published: 01 September 2023
View articletitled, Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress
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Includes: Supplementary data
Articles

Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis

Roy Taylor, Alison C. Barnes, Kieren G. Hollingsworth, Keaton M. Irvine, Alexandra S. Solovyova, Lucy Clark, Tara Kelly, Carmen Martin-Ruiz, Davide Romeres, Albert Koulman, Claire M. Meek, Benjamin Jenkins, Claudio Cobelli, Rury R. Holman
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1333–1346.
https://doi.org/10.1042/CS20230586
Published: 31 August 2023
View articletitled, Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis
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Includes: Supplementary data
Articles

Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

Soumyalekshmi Nair, Valeska Ormazabal, Flavio Carrion, Aase Handberg, H David McIntyre, Carlos Salomon
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1311–1332.
https://doi.org/10.1042/CS20220150
Published: 31 August 2023
View articletitled, Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes
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Articles

ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy via restraining endothelial–mesenchymal transition

Mengwen Wang, Yujian Liu, Lei Dai, Xiaodan Zhong, Wenjun Zhang, Yang Xie, Hesong Zeng, Hongjie Wang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1297–1309.
https://doi.org/10.1042/CS20230732
Published: 22 August 2023
View articletitled, ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy via restraining endothelial–mesenchymal transition
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Includes: Supplementary data
Articles

Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis

Qiaoli Tang, Wanting Shi, Ming Liu, Liqin Tang, Wei Ren, Shaolin Shi
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1195–1208.
https://doi.org/10.1042/CS20230164
Published: 10 August 2023
View articletitled, Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis
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Includes: Supplementary data
Articles

Maternal voluntary wheel running modulates glucose homeostasis, the gut microbiota and its derived fecal metabolites in offspring

In Collection
Reproductive Physiology and Disease
Ling Zhang, Wenyu Zou, Yongyan Hu, Honghua Wu, Ying Gao, Junqing Zhang, Jia Zheng
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1151–1166.
https://doi.org/10.1042/CS20230372
Published: 09 August 2023
View articletitled, Maternal voluntary wheel running modulates glucose homeostasis, the gut microbiota and its derived fecal metabolites in offspring
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Includes: Supplementary data
Articles

Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70 -deficient mice with a human-like bile acid composition

In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Wilhelm Sjöland, Annika Wahlström, Kassem Makki, Marc Schöler, Antonio Molinaro, Lisa Olsson, Thomas Uwe Greiner, Robert Caesar, Jan Freark de Boer, Folkert Kuipers, Fredrik Bäckhed, Hanns-Ulrich Marschall
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (13): 995–1011.
https://doi.org/10.1042/CS20230413
Published: 14 July 2023
View articletitled, Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70 -deficient mice with a human-like bile acid composition
Open the PDF for Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70 -deficient mice with a human-like bile acid composition in another window
Includes: Supplementary data
Articles

DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity

Ming Yang, Qin Zhang, Shilu Luo, Yachun Han, Hao Zhao, Na Jiang, Yan Liu, Li Li, Chenrui Li, Chongbin Liu, Liyu He, Xuejing Zhu, Yu Liu, Lin Sun
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (12): 931–945.
https://doi.org/10.1042/CS20220787
Published: 20 June 2023
View articletitled, DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity
Open the PDF for DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity in another window
Includes: Supplementary data
Articles

Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

Weixian Kong, Yue Peng, Caoyu Ji, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Fuqun Wang, Zhe Li, Xiaohong Bian, Junmei Ye
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 823–841.
https://doi.org/10.1042/CS20230433
Published: 31 May 2023
View articletitled, Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity
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Includes: Supplementary data
Articles

NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Alena Karnošová, Veronika Strnadová, Blanka Železná, Jaroslav Kuneš, Petr Kašpárek, Lenka Maletínská
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 847–862.
https://doi.org/10.1042/CS20220880
Published: 31 May 2023
View articletitled, NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose
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Includes: Supplementary data
Articles

Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

Xiaodi Zhang, Jean L.J.M. Scheijen, Coen D.A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 697–706.
https://doi.org/10.1042/CS20220753
Published: 26 April 2023
View articletitled, Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose
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Includes: Supplementary data
Articles

Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity

In Collection
Reproductive Physiology and Disease
Jerad H. Dumolt, Fredrick J. Rosario, Avery C. Kramer, Stacee Horwitz, Theresa L. Powell, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 663–678.
https://doi.org/10.1042/CS20220890
Published: 21 April 2023
View articletitled, Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity
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Articles

Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy

Wenyan Gong, Qibin Jiao, Jinghua Yuan, Hui Luo, Yingying Liu, Yuanyuan Zhang, Zhen Chen, Xiaoling Xu, Lin Bai, Xingwei Zhang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 511–525.
https://doi.org/10.1042/CS20220874
Published: 24 March 2023
View articletitled, Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy
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Articles

Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome

Jinshan Xing, Gan Qiao, Xin Luo, Shuang Liu, Shaokun Chen, Geng Ye, Chunxiang Zhang, Jingyan Yi
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 453–468.
https://doi.org/10.1042/CS20220408
Published: 21 March 2023
View articletitled, Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome
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Articles

Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Zhipeng Tao, Zhiyong Cheng
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 415–434.
https://doi.org/10.1042/CS20210519
Published: 21 March 2023
View articletitled, Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen
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Articles

The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy

Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 87–104.
https://doi.org/10.1042/CS20220447
Published: 05 January 2023
View articletitled, The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy
Open the PDF for The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy in another window
Includes: Supplementary data
Articles

Set7 methyltransferase roles in myocardial protection from chronic stressors

James T. Pearson
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 105–108.
https://doi.org/10.1042/CS20220773
Published: 05 January 2023
View articletitled, Set7 methyltransferase roles in myocardial protection from chronic stressors
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Articles

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Justine Gillard, Isabelle A. Leclercq
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 65–85.
https://doi.org/10.1042/CS20220697
Published: 05 January 2023
View articletitled, Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease
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Articles

Small extracellular vesicles: a new player in GDM pathogenesis

In Collection
Reproductive Physiology and Disease
Agafe Bless Reyes, Dylan Burger
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1873–1875.
https://doi.org/10.1042/CS20220658
Published: 22 December 2022
View articletitled, Small extracellular vesicles: a new player in GDM pathogenesis
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Articles

Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Gourabamani Swalsingh, Punyadhara Pani, Naresh C. Bal
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1851–1871.
https://doi.org/10.1042/CS20220636
Published: 22 December 2022
View articletitled, Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases
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Articles

Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1711–1730.
https://doi.org/10.1042/CS20220242
Published: 30 November 2022
View articletitled, Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling
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Includes: Supplementary data
Articles

Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1631–1651.
https://doi.org/10.1042/CS20220404
Published: 16 November 2022
View articletitled, Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease
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Articles

Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia

Raghavendar Chandran, Lianying He, Xingju Nie, Joshua Voltin, Sarah Jamil, Caren Doueiry, Maria Fatima Falangola, Adviye Ergul, Weiguo Li
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1555–1570.
https://doi.org/10.1042/CS20220465
Published: 10 November 2022
View articletitled, Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia
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Includes: Supplementary data
Articles

A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice

In Collection
Reproductive Physiology and Disease
Laura B James-Allan, Frederick J Rosario, Lana Madi, Kelsey Barner, Soumyalekshmi Nair, Andrew Lai, Flavio Carrion, Theresa L Powell, Carlos Salomon, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1535–1549.
https://doi.org/10.1042/CS20220484
Published: 03 November 2022
View articletitled, A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice
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Includes: Supplementary data
Articles

Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

William P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1485–1511.
https://doi.org/10.1042/CS20220205
Published: 03 November 2022
View articletitled, Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats
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Includes: Supplementary data
Articles

Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms

Kalie L. Tommerdahl, Jessica Kendrick, Robert G. Nelson, Petter Bjornstad
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1471–1483.
https://doi.org/10.1042/CS20210627
Published: 02 November 2022
View articletitled, Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms
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