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Articles

Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm

Rafael Almendra-Pegueros, Cristina Rodríguez, Mercedes Camacho, David Sánchez-Infantes, Jose Luis Sanchez-Quesada, Susana Cancer, Elvira Pérez-Marlasca, Gema Medina-Gomez, José Martínez-González, Ana Belén García-Redondo, María Galán
Journal: Clinical Science
Clin Sci (Lond) (2025) CS20242476.
https://doi.org/10.1042/CS20242476
Published: 12 March 2025
View article titled, Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm
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Articles

Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts

Bo Pan, Di Hu, Yao Wei Lu, Jing Luo, Xiao Hui Xu, Haipeng Guo, Rui Deng, Zhuomin Liang, Yi Wang, Qing Ma, John D. Mably, Jie Tian, Da-Zhi Wang
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (05): 235–338.
https://doi.org/10.1042/CS20242397
Published: 11 March 2025
View article titled, Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts
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Includes: Supplementary data
Articles

Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy

Anna Liu, Natalia Ruetalo, Janet P. Raja Xavier, Aditya Kumar Lankapalli, Jakob Admard, Miguel Camarena-Sainz, Sara Y. Brucker, Yogesh Singh, Michael Schindler, Madhuri S. Salker
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (04): 287–307.
https://doi.org/10.1042/CS20241215
Published: 19 February 2025
View article titled, Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
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Includes: Supplementary data
Articles

Renal damage-induced hepcidin accumulation contributes to anemia in angiotensinogen-deficient mice

André F. Rodrigues, Laura Boreggio, Tetiana Lahuta, Fatimunnisa Qadri, Natalia Alenina, Carlos C. Barros, Mihail Todiras, Michael Bader
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (03): 247–258.
https://doi.org/10.1042/CS20241789
Published: 07 February 2025
View article titled, Renal damage-induced hepcidin accumulation contributes to anemia in angiotensinogen-deficient mice
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Includes: Supplementary data
Articles

Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis

Jin-Ling Huo, Wenjia Fu, Qi Feng, Shaokang Pan, Dongwei Liu, Zhangsuo Liu
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (03): 229–246.
https://doi.org/10.1042/CS20243221
Published: 06 February 2025
View article titled, Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis
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Includes: Supplementary data
Articles

Metabolically stable apelin analogs: development and functional role in water balance and cardiovascular function

Pierre Couvineau, Catherine Llorens-Cortes
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (02): 131–149.
https://doi.org/10.1042/CS20240955
Published: 29 January 2025
View article titled, Metabolically stable apelin analogs: development and functional role in water balance and cardiovascular function
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Articles

Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge

Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt Jr.
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (02): 85–113.
https://doi.org/10.1042/CS20243515
Published: 23 January 2025
View article titled, Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge
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Includes: Supplementary data
Articles

SMAD5 as a novel gene for familial pulmonary arterial hypertension

Ding Cao, Ekkehard Grünig, Yuriy Sirenko, Ganna Radchenko, Henning Gall, Ayat Ahmed, Susanne Theiß, Mareike Lankeit, Benjamin Meder, Magdalena Laugsch, Christina A. Eichstaedt
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (1): 15–27.
https://doi.org/10.1042/CS20241340
Published: 15 January 2025
View article titled, SMAD5 as a novel gene for familial pulmonary arterial hypertension
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Includes: Supplementary data
Articles

Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients

Mark C. Chappell, Christopher L. Schaich, Laurence W. Busse, D. Clark Files, Greg S. Martin, Jonathan E. Sevransky, Jeremiah S. Hinson, Richard E. Rothman, Ashish K. Khanna, Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Investigators
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (1): 43–53.
https://doi.org/10.1042/CS20242168
Published: 15 January 2025
View article titled, Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients
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Includes: Supplementary data
Articles

New discoveries in bile acids, gut microbiota and host interactions in health and diseases

In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Justine Gillard, Isabelle Leclercq
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (23): 1521–1523.
https://doi.org/10.1042/CS20240940
Published: 26 November 2024
View article titled, New discoveries in bile acids, gut microbiota and host interactions in health and diseases
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Articles

Enhanced vasoconstriction in sickle cell disease is dependent on ET A receptor activation

In Collection
Endothelin XVIII Conference Collection
John Miller Allan, Brandon M. Fox, Malgorzata Kasztan, Gillian C. Kelly, Patrick A. Molina, McKenzi A. King, Jackson Colson, Leigh Wells, Latanya Bowman, Marsha Blackburn, Abdullah Kutlar, Ryan A. Harris, David M. Pollock, Jennifer S. Pollock
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (23): 1505–1520.
https://doi.org/10.1042/CS20240625
Published: 26 November 2024
View article titled, Enhanced vasoconstriction in sickle cell disease is dependent on ET A receptor activation
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Includes: Supplementary data
Articles

Evaluation of the cell death markers for aberrated cell free DNA release in high altitude pulmonary edema

Manzoor Ali, Krishna G. Kumar, Kanika Singh, Stanzen Rabyang, Tashi Thinlas, Aastha Mishra
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (22): 1467–1480.
https://doi.org/10.1042/CS20242052
Published: 15 November 2024
View article titled, Evaluation of the cell death markers for aberrated cell free DNA release in high altitude pulmonary edema
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Includes: Supplementary data
Articles

Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease

Rachel M. Barker, Alfie Chambers, Patrick G. Kehoe, Edward Rowe, Claire M. Perks
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (21): 1357–1369.
https://doi.org/10.1042/CS20230317
Published: 29 October 2024
View article titled, Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease
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Articles

IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53

Shiyu Wang, Tingting Cheng, Xu Chen, Cong Zeng, Wei Qin, Yajing Xu
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (20): 1287–1304.
https://doi.org/10.1042/CS20241144
Published: 11 October 2024
View article titled, IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53
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Includes: Supplementary data
Articles

SDMA as a marker and mediator in cerebrovascular disease

Alexandra Riddell, Arun Flynn, Hugo Bergugnat, Laura B. Dowsett, Alyson A. Miller
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (20): 1305–1323.
https://doi.org/10.1042/CS20241021
Published: 11 October 2024
View article titled, SDMA as a marker and mediator in cerebrovascular disease
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Articles

Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency

Ronan M.N. Noble, Shubham Soni, Si Ning Liu, Jad-Julian Rachid, Heather E. Mast, Alyssa Wiedemeyer, Claudia D. Holody, Richard Mah, Andrew G. Woodman, Mourad Ferdaoussi, Helene Lemieux, Jason R.B. Dyck, Stephane L. Bourque
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (19): 1249–1264.
https://doi.org/10.1042/CS20241386
Published: 01 October 2024
View article titled, Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency
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Includes: Supplementary data
Articles

Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model

Vincent Chiu, Christine Yee, Nathan Main, Igor Stevanovski, Matthew Watt, Trevor Wilson, Peter Angus, Tara Roberts, Nicholas Shackel, Chandana Herath
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (19): 1227–1248.
https://doi.org/10.1042/CS20240560
Published: 26 September 2024
View article titled, Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model
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Includes: Supplementary data
Articles

REV-ERBα agonist SR10067 attenuates Th2 cytokine-mediated barrier dysfunction in human bronchial epithelial cells

Santhosh Kumar Duraisamy, Isaac Kirubakaran Sundar
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (19): 1209–1226.
https://doi.org/10.1042/CS20240064
Published: 25 September 2024
View article titled, REV-ERBα agonist SR10067 attenuates Th2 cytokine-mediated barrier dysfunction in human bronchial epithelial cells
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Includes: Supplementary data
Articles

The role of microRNAs in pregnancies complicated by maternal diabetes

Manon D. Owen, Margeurite G. Kennedy, Rachel C. Quilang, Eleanor M. Scott, Karen Forbes
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (18): 1179–1207.
https://doi.org/10.1042/CS20230681
Published: 18 September 2024
View article titled, The role of microRNAs in pregnancies complicated by maternal diabetes
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Articles

Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement

Shuai Zhao, Xander H.T. Wehrens
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (18): 1173–1177.
https://doi.org/10.1042/CS20241421
Published: 18 September 2024
View article titled, Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement
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Articles

Candesartan restores blood–brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis

Michael F. Hammer, Erfan Bahramnejad, Joseph C. Watkins, Patrick T. Ronaldson
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (17): 1089–1110.
https://doi.org/10.1042/CS20240771
Published: 03 September 2024
View article titled, Candesartan restores blood–brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis
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Includes: Supplementary data
Articles

TGFβ1, SMAD and β-catenin in pulmonary arteries of smokers, patients with small airway disease and COPD: potential drivers of EndMT

Prem Bhattarai, Wenying Lu, Ashutosh Hardikar, Archana Vijay Gaikwad, Surajit Dey, Affan Mahmood Shahzad, Stephen Myers, Andrew Williams, Darren Sutherland, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Mathew S. Eapen, Sukhwinder Singh Sohal
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (17): 1055–1070.
https://doi.org/10.1042/CS20240721
Published: 28 August 2024
View article titled, TGFβ1, SMAD and β-catenin in pulmonary arteries of smokers, patients with small airway disease and COPD: potential drivers of EndMT
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Articles

Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway

Roberto Palacios-Ramirez, Matthieu Soulié, Amaya Fernandez-Celis, Toshifumi Nakamura, Nabiha Boujardine, Benjamin Bonnard, Krister Bamberg, Natalia Lopez-Andres, Frederic Jaisser
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (16): 1025–1038.
https://doi.org/10.1042/CS20240302
Published: 22 August 2024
View article titled, Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway
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Includes: Supplementary data
Articles

Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions

In Collection
Endothelin XVIII Conference Collection
Mia Edgerton-Fulton, Yasir Abdul, Sarah Jamil, Adviye Ergul
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (16): 1009–1022.
https://doi.org/10.1042/CS20240328
Published: 21 August 2024
View article titled, Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions
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Includes: Supplementary data
Articles

To target cellular senescence in diabetic kidney disease: the known and the unknown

Yuehan Wei, Shan Mou, Qing Yang, Fang Liu, Mark E. Cooper, Zhonglin Chai
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (16): 991–1007.
https://doi.org/10.1042/CS20240717
Published: 14 August 2024
View article titled, To target cellular senescence in diabetic kidney disease: the known and the unknown
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Articles

Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation

Yi Ching Chen, Seka Wijekoon, Aya Matsumoto, Jieting Luo, Helen Kiriazis, Emma Masterman, Gunes Yildiz, Jonathon Cross, Adam C. Parslow, Roger Chooi, Junichi Sadoshima, David W. Greening, Kate L. Weeks, Julie R. McMullen
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (15): 941–962.
https://doi.org/10.1042/CS20240178
Published: 30 July 2024
View article titled, Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation
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Includes: Supplementary data
Articles

Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4

Jianzhen Lei, Fen Zheng, Luyao Chen, Ruyi Zhang, Yang Yang, Zhimin Yin, Lan Luo
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (14): 883–900.
https://doi.org/10.1042/CS20241113
Published: 12 July 2024
View article titled, Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4
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Includes: Supplementary data
Articles

Molecular regulators of defective placental and cardiovascular development in fetal growth restriction

Anandita Umapathy, Alys Clark, Arvind Sehgal, Vijaya Karanam, Gayathri Rajaraman, Bill Kalionis, Helen N. Jones, Jo James, Padma Murthi
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (13): 761–775.
https://doi.org/10.1042/CS20220428
Published: 21 June 2024
View article titled, Molecular regulators of defective placental and cardiovascular development in fetal growth restriction
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Articles

Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies

In Collection
The biology of ageing: Geroscience and the exposome
Colleen S. Deane, Matthew Piasecki, Philip J. Atherton
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (12): 741–756.
https://doi.org/10.1042/CS20231198
Published: 19 June 2024
View article titled, Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies
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Articles

Endothelin-1 impairs skeletal muscle myogenesis and development via ET B receptors and p38 MAPK signaling pathway

In Collection
Endothelin XVIII Conference Collection
Shui-Yu Liu, Luei-Kui Chen, Yi-Ting Jhong, Chien-Wei Chen, Li-En Hsiao, Huei-Chi Ku, Pin-Hsuan Lee, Guey-Shyang Hwang, Chi-Chang Juan
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (12): 711–723.
https://doi.org/10.1042/CS20240341
Published: 11 June 2024
View article titled, Endothelin-1 impairs skeletal muscle myogenesis and development via ET B receptors and p38 MAPK signaling pathway
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Articles

Precision diagnostics in transplanted organs using microarray-assessed gene expression: concepts and technical methods of the Molecular Microscope ® Diagnostic System (MMDx)

Katelynn S. Madill-Thomsen, Philip F. Halloran
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (11): 663–685.
https://doi.org/10.1042/CS20220530
Published: 31 May 2024
View article titled, Precision diagnostics in transplanted organs using microarray-assessed gene expression: concepts and technical methods of the Molecular Microscope ® Diagnostic System (MMDx)
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Articles

Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo

Joshua J. Cull, Susanna T.E. Cooper, Hajed O. Alharbi, Sonia P. Chothani, Owen J.L. Rackham, Daniel N. Meijles, Philip R. Dash, Risto Kerkelä, Neil Ruparelia, Peter H. Sugden, Angela Clerk
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (10): 573–597.
https://doi.org/10.1042/CS20240496
Published: 22 May 2024
View article titled, Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo
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Includes: Supplementary data
Articles

Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy

Paula Virginia Sarchi, Dante Gomez Cuautle, Alicia Rossi, Alberto Javier Ramos
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (9): 555–572.
https://doi.org/10.1042/CS20231621
Published: 29 April 2024
View article titled, Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy
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Articles

Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure

Craig A. Lygate
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (8): 491–514.
https://doi.org/10.1042/CS20230616
Published: 19 April 2024
View article titled, Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure
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Articles

The complement system in neurodegenerative diseases

Jacqui Nimmo, Robert A.J. Byrne, Nikoleta Daskoulidou, Lewis M. Watkins, Sarah M. Carpanini, Wioleta M. Zelek, B. Paul Morgan
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (6): 387–412.
https://doi.org/10.1042/CS20230513
Published: 20 March 2024
View article titled, The complement system in neurodegenerative diseases
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Articles

Cardiotoxic effects of common and emerging drugs: role of cannabinoid receptors

Yiming Bo, Xin Zhao, Liliang Li
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (6): 413–434.
https://doi.org/10.1042/CS20231156
Published: 20 March 2024
View article titled, Cardiotoxic effects of common and emerging drugs: role of cannabinoid receptors
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Articles

Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning

Limin Shi, Jinying Yang, Zhipeng Tao, Louise Zheng, Tyler F. Bui, Ramon L. Alonso, Feng Yue, Zhiyong Cheng
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (6): 371–385.
https://doi.org/10.1042/CS20230973
Published: 12 March 2024
View article titled, Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning
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Includes: Supplementary data
Articles

Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis

Mitsuyoshi Yamagata, Mutsumi Tsuchishima, Takashi Saito, Mikihiro Tsutsumi, Joseph George
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (5): 327–349.
https://doi.org/10.1042/CS20230533
Published: 05 March 2024
View article titled, Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis
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Articles

COVID-19 and abnormal uterine bleeding: potential associations and mechanisms

Jacqueline A. Maybin, Marianne Watters, Bethan Rowley, Catherine A. Walker, Gemma C. Sharp, Alexandra Alvergne
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (4): 153–171.
https://doi.org/10.1042/CS20220280
Published: 19 February 2024
View article titled, COVID-19 and abnormal uterine bleeding: potential associations and mechanisms
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Articles

Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4

Amanda A. de Oliveira, Emma Elder, Floor Spaans, Murilo E. Graton, Anita Quon, Raven Kirschenman, Amy L. Wooldridge, Christy-Lynn M. Cooke, Sandra T. Davidge
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (4): 137–151.
https://doi.org/10.1042/CS20231442
Published: 14 February 2024
View article titled, Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4
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Includes: Supplementary data
Articles

Destabilisation of T cell-dependent humoral immunity in sepsis

Kate Davies, James E. McLaren
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (1): 65–85.
https://doi.org/10.1042/CS20230517
Published: 10 January 2024
View article titled, Destabilisation of T cell-dependent humoral immunity in sepsis
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Articles

Regulation of Na + -K + -ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca 2+ -dependent cardiac metabolism

Xiaofei Yan, Meihe Li, Ping Lan, Meng Xun, Ying Zhang, Jinghui Shi, Ruijia Wang, Jin Zheng
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (1): 23–42.
https://doi.org/10.1042/CS20231039
Published: 05 January 2024
View article titled, Regulation of Na + -K + -ATPase leads to disturbances of isoproterenol-induced cardiac dysfunction via interference of Ca 2+ -dependent cardiac metabolism
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Includes: Supplementary data
Articles

β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage

Marharyta Semenikhina, Mykhailo Fedoriuk, Mariia Stefanenko, Christine A. Klemens, Alena Cherezova, Brendan Marshall, Gentzon Hall, Vladislav Levchenko, Ashish K. Solanki, Joshua H. Lipschutz, Daria V. Ilatovskaya, Alexander Staruschenko, Oleg Palygin
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (24): 1789–1804.
https://doi.org/10.1042/CS20230313
Published: 21 December 2023
View article titled, β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage
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Articles

Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease

William J. Kalusche, Clinton T. Case, Erin B. Taylor
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (23): 1771–1785.
https://doi.org/10.1042/CS20230924
Published: 14 December 2023
View article titled, Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease
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Includes: Supplementary data
Articles

Endothelial progenitor cells in pregnancy-related diseases

Yangyang Chen, Gui Wan, Zeyun Li, Xiaoxia Liu, Yin Zhao, Li Zou, Weifang Liu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (22): 1699–1719.
https://doi.org/10.1042/CS20230853
Published: 21 November 2023
View article titled, Endothelial progenitor cells in pregnancy-related diseases
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Articles

Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men

In Collection
The biology of ageing: Geroscience and the exposome
Antoneta Granic, Karen Suetterlin, Tea Shavlakadze, Miranda D. Grounds, Avan A. Sayer
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (22): 1721–1751.
https://doi.org/10.1042/CS20230319
Published: 21 November 2023
View article titled, Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men
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Articles

USP38 regulates inflammatory cardiac remodeling after myocardial infarction

Yang Gong, Bin Kong, Wei Shuai, Tao Chen, Jing Jing Zhang, He Huang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1665–1681.
https://doi.org/10.1042/CS20230728
Published: 15 November 2023
View article titled, USP38 regulates inflammatory cardiac remodeling after myocardial infarction
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Includes: Supplementary data
Articles

Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition

In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Esther Verkade, Wenqiang Shen, Milaine V. Hovingh, Niels L. Mulder, Krisztina de Bruyn, Martijn Koehorst, Hilde D. de Vries, Vincent W. Bloks, Folkert Kuipers, Jan Freark de Boer
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1637–1650.
https://doi.org/10.1042/CS20230812
Published: 10 November 2023
View article titled, Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition
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Includes: Supplementary data
Articles

High-fructose corn syrup aggravates colitis via microbiota dysbiosis-mediated Th17/Treg imbalance

In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Mingxia Zhou, Xiaoman Liu, Jing He, Xinyu Xu, Chenxi Ju, Shangjian Luo, Xiajuan Lu, Peng Du, Yingwei Chen
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (20): 1619–1635.
https://doi.org/10.1042/CS20230788
Published: 31 October 2023
View article titled, High-fructose corn syrup aggravates colitis via microbiota dysbiosis-mediated Th17/Treg imbalance
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Includes: Supplementary data
Articles

Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury

Ama D. Okyere, Tapas K. Nayak, Viren Patwa, David Teplitsky, Erin McEachern, Rhonda L. Carter, Heli Xu, Erhe Gao, Yan Zhou, Douglas G. Tilley
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1513–1531.
https://doi.org/10.1042/CS20230804
Published: 28 September 2023
View article titled, Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury
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Includes: Supplementary data