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Articles

Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD

Open Access
Eduardo I. Cardenas, Kristina Andelid, Nikolaos Pournaras, Ann Ekberg- Jansson, Nicola Orsini, Georgios Stratelis, Tomas Jernberg, Anders Lindén
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (09): 449–462.
https://doi.org/10.1042/CS20255852
Published: 09 May 2025
View articletitled, Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD
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Includes: Supplementary data
Articles

Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement

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Shuai Zhao, Xander H.T. Wehrens
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (18): 1173–1177.
https://doi.org/10.1042/CS20241421
Published: 18 September 2024
View articletitled, Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement
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Articles

The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys

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Lashodya V. Dissanayake, Olha Kravtsova, Melissa Lowe, Marice K. McCrorey, Justin P. Van Beusecum, Oleg Palygin, Alexander Staruschenko
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (5): 269–288.
https://doi.org/10.1042/CS20231144
Published: 27 February 2024
View articletitled, The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys
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Includes: Supplementary data
Articles

Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy

Open Access
Michael F. Hammer, Collin T. Krzyzaniak, Erfan Bahramnejad, Kiran J. Smelser, Joshua B. Hack, Joseph C. Watkins, Patrick T. Ronaldson
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (4): 205–223.
https://doi.org/10.1042/CS20231572
Published: 21 February 2024
View articletitled, Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy
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Includes: Supplementary data
Articles

Physiological response to fetal intravenous lipid emulsion

Open Access
In Collection
Reproductive Physiology and Disease
Brian D. Piccolo, Athena Chen, Samantha Louey, Kent L.R. Thornburg, Sonnet S. Jonker
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (3): 117–134.
https://doi.org/10.1042/CS20231419
Published: 02 February 2024
View articletitled, Physiological response to fetal intravenous lipid emulsion
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Includes: Supplementary data
Articles

A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst

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In Collection
Reproductive Physiology and Disease
Huajuan Shi, Min Pan, Erteng Jia, Wenxiang Lu, Ying Zhou, Yuqi Sheng, Xiangwei Zhao, Lingbo Cai, Qinyu Ge
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (2): 129.
https://doi.org/10.1042/CS20220495
Published: 18 January 2023
View articletitled, A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst
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Includes: Supplementary data
Articles

The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy

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Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 87–104.
https://doi.org/10.1042/CS20220447
Published: 05 January 2023
View articletitled, The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy
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Includes: Supplementary data
Articles

Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

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William P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1485–1511.
https://doi.org/10.1042/CS20220205
Published: 03 November 2022
View articletitled, Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats
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Includes: Supplementary data
Articles

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

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Dominic J. Corkill, Alan N. Hunt, Mary Jane Hinrichs, Nicholas White, Marlon Rebelatto, Lorin Roskos, Josquin Nys, Alison Scott, Matthew J. Robinson, Patricia Ryan, Anthony D. Postle, Matthew A. Sleeman
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (22): 2559–2573.
https://doi.org/10.1042/CS20210713
Published: 26 November 2021
View articletitled, Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover
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Includes: Supplementary data
Articles

The immune niche of the liver

Open Access
Michael L. Cheng, Diana Nakib, Catia T. Perciani, Sonya A. MacParland
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2445–2466.
https://doi.org/10.1042/CS20190654
Published: 28 October 2021
View articletitled, The immune niche of the liver
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Articles

Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection

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Samuele Iesari, Isabelle Leclercq, Nicolas Joudiou, Mina Komuta, Aurélie Daumerie, Jérôme Ambroise, Alexandra Dili, Natacha Feza-Bingi, Daela Xhema, Caroline Bouzin, Bernard Gallez, Francesco Pisani, Eliano Bonaccorsi-Riani, Pierre Gianello
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (19): 2285–2305.
https://doi.org/10.1042/CS20210183
Published: 13 October 2021
View articletitled, Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection
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Includes: Supplementary data
Articles

Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress

Open Access
Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1689–1706.
https://doi.org/10.1042/CS20210198
Published: 20 July 2021
View articletitled, Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress
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Includes: Supplementary data
Articles

Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress

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In Collection
Celebrating 100 years of insulin research
Joshua A. Beckman, Jiun-Ruey Hu, Shi Huang, Eric Farber-Eger, Quinn S. Wells, Thomas J. Wang, Robert E. Gerszten, Jane F. Ferguson
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2369–2379.
https://doi.org/10.1042/CS20191227
Published: 16 September 2020
View articletitled, Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress
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Includes: Supplementary data
Articles

Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury

Open Access
Jose L. Viñas, Christopher J. Porter, Adrianna Douvris, Matthew Spence, Alex Gutsol, Joseph A. Zimpelmann, Karishma Tailor, Pearl A. Campbell, Kevin D. Burns
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1887–1909.
https://doi.org/10.1042/CS20200168
Published: 23 July 2020
View articletitled, Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury
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Includes: Supplementary data
Articles

Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women

Open Access
In Collection
Clinical and translational research highlights
Kenny Schlosser, Amanpreet Kaur, Natalie Dayan, Duncan J. Stewart, Louise Pilote, Christian Delles
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (2): 87–101.
https://doi.org/10.1042/CS20190920
Published: 21 January 2020
View articletitled, Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women
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Includes: Supplementary data
Articles

Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: an in vitro and in vivo study in aortic stenosis

Available to Purchase
In Collection
Clinical and translational research highlights
Lara Matilla, Jaime Ibarrola, Vanessa Arrieta, Amaia Garcia-Peña, Ernesto Martinez-Martinez, Rafael Sádaba, Virginia Alvarez, Adela Navarro, Amaya Fernández-Celis, Alicia Gainza, Enrique Santamaría, Joaquín Fernández-Irigoyen, Antoni Bayes-Genis, Patrick Rossignol, Natalia López-Andrés
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1537–1548.
https://doi.org/10.1042/CS20190475
Published: 17 July 2019
View articletitled, Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: an in vitro and in vivo study in aortic stenosis
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Includes: Supplementary data
Articles

Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients

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Isaac Rosado-Sánchez, Esther Rodríguez-Gallego, Joaquim Peraire, Consuelo Viladés, Pol Herrero, Fran Fanjul, Félix Gutiérrez, Enrique Bernal, Ricardo Pelazas, Manuel Leal, Sergi Veloso, Miguel López-Dupla, Julià Blanco, Francesc Vidal, Yolanda María Pacheco, Anna Rull
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (8): 997–1010.
https://doi.org/10.1042/CS20190111
Published: 29 April 2019
View articletitled, Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients
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Includes: Supplementary data
Articles

Metabolomic analysis reveals metabolic characteristics of children with short stature caused by growth hormone deficiency

Available to Purchase
Rui Xu, Hongwei Zhu, Cuiying Zhang, Guiping Shen, Jianghua Feng
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (6): 777–788.
https://doi.org/10.1042/CS20181005
Published: 25 March 2019
View articletitled, Metabolomic analysis reveals metabolic characteristics of children with short stature caused by growth hormone deficiency
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Articles

Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies

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Boris Novakovic, Toby Mansell, Richard Saffery
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (2): 315–319.
https://doi.org/10.1042/CS20180901
Published: 25 January 2019
View articletitled, Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies
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Articles

Early isolated V-lesion may not truly represent rejection of the kidney allograft

Open Access
Mariana Wohlfahrtova, Petra Hruba, Jiri Klema, Marek Novotny, Zdenek Krejcik, Viktor Stranecky, Eva Honsova, Petra Vichova, Ondrej Viklicky
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2269–2284.
https://doi.org/10.1042/CS20180745
Published: 29 October 2018
View articletitled, Early isolated V-lesion may not truly represent rejection of the kidney allograft
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Includes: Supplementary data
Articles

Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing

Available to Purchase
Lawrence C. Johnson, Christopher R. Martens, Jessica R. Santos-Parker, Candace J. Bassett, Talia R. Strahler, Charmion Cruickshank-Quinn, Nichole Reisdorph, Matthew B. McQueen, Douglas R. Seals
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1765–1777.
https://doi.org/10.1042/CS20180409
Published: 30 August 2018
View articletitled, Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing
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Includes: Supplementary data
Articles

Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage

Available to Purchase
Jaime Ibarrola, Vanessa Arrieta, Rafael Sádaba, Ernesto Martinez-Martinez, Amaia Garcia-Peña, Virginia Alvarez, Amaya Fernández-Celis, Alicia Gainza, Enrique Santamaría, Joaquin Fernández-Irigoyen, Victoria Cachofeiro, Guillermo Zalba, Renaud Fay, Patrick Rossignol, Natalia López-Andrés
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (13): 1471–1485.
https://doi.org/10.1042/CS20171389
Published: 18 July 2018
View articletitled, Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage
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Includes: Supplementary data
Articles

Intratubular and intracellular renin–angiotensin system in the kidney: a unifying perspective in blood pressure control

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Xiao C. Li, Dongmin Zhu, Xiaowen Zheng, Jiangfeng Zhang, Jia L. Zhuo
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
https://doi.org/10.1042/CS20180121
Published: 09 July 2018
View articletitled, Intratubular and intracellular renin–angiotensin system in the kidney: a unifying perspective in blood pressure control
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Articles

Translational science in albuminuria: a new view of de novo albuminuria under chronic RAS suppression

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Montserrat Baldan-Martin, Elena Rodríguez-Sánchez, Laura González-Calero, Luis M. Ruilope, Gloria Alvarez-Llamas, María G. Barderas, Gema Ruiz-Hurtado
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (7): 739–758.
https://doi.org/10.1042/CS20180097
Published: 06 April 2018
View articletitled, Translational science in albuminuria: a new view of de novo albuminuria under chronic RAS suppression
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Articles

Personalized medicine—a modern approach for the diagnosis and management of hypertension

Open Access
Carmine Savoia, Massimo Volpe, Guido Grassi, Claudio Borghi, Enrico Agabiti Rosei, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (22): 2671–2685.
https://doi.org/10.1042/CS20160407
Published: 06 November 2017
View articletitled, Personalized medicine—a modern approach for the diagnosis and management of hypertension
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Articles

Urinary glycated uromodulin in diabetic kidney disease

Open Access
Chia-Chu Chang, Chen-Yu Chen, Ching-Hui Huang, Chia-Lin Wu, Hung-Ming Wu, Ping-Fang Chiu, Chew-Teng Kor, Ting-Huan Chen, Geen-Dong Chang, Cheng-Chin Kuo, Hui-Chin Wen, Chih-Yang Huang, Chung-Ho Chang
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1815–1829.
https://doi.org/10.1042/CS20160978
Published: 05 July 2017
View articletitled, Urinary glycated uromodulin in diabetic kidney disease
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Articles

En route to precision medicine through the integration of biological sex into pharmacogenomics

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Lea Gaignebet, Georgios Kararigas
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (4): 329–342.
https://doi.org/10.1042/CS20160379
Published: 03 February 2017
View articletitled, En route to precision medicine through the integration of biological sex into pharmacogenomics
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