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Articles

CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p

Jia-Wen Gao, Min-Kai Song, Di-Zheng Wu, Tao Yan, Kai Zhao, Yu-Sheng Huang, Xing-Yu Chen, Chen Tu, Guang-Xu Deng, Zi-Shuo Chen, Ming-Ming Zhang, Jun-Long Huang, Chao Zhang, Zhao-Ming Zhong
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 495–510.
https://doi.org/10.1042/CS20220833
Published: 24 March 2023
View article titled, CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p
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Includes: Supplementary data
Articles

The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

In Collection
Reproductive Physiology and Disease
Matthew Kang, Cherie Blenkiron, Lawrence W. Chamley
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (5): 385–399.
https://doi.org/10.1042/CS20220301
Published: 15 March 2023
View article titled, The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation
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Articles

Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3

Jianbo Liu, Kaixuan Liu, Shiquan Chai, Runze Xu, Ying Wang, Yundi Zhang, Shuanglian Wang, Chuanyong Liu, Bing Xue
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 109–127.
https://doi.org/10.1042/CS20220392
Published: 05 January 2023
View article titled, Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3
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Includes: Supplementary data
Articles

Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair

Nathalia C. de Almeida Oliveira, Elida A. Neri, Caio M. Silva, Iuri C. Valadão, Miriam H. Fonseca-Alaniz, Camila Zogbi, Débora Levy, Sergio P. Bydlowski, Jose Eduardo Krieger
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1281–1301.
https://doi.org/10.1042/CS20220216
Published: 05 September 2022
View article titled, Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair
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Includes: Supplementary data
Articles

The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation

Eleonora Cianflone, Mariangela Scalise, Fabiola Marino, Luca Salerno, Nadia Salerno, Konrad Urbanek, Daniele Torella
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1179–1203.
https://doi.org/10.1042/CS20220391
Published: 18 August 2022
View article titled, The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation
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Articles

Visualization of regenerating and repairing hearts

Nevan Powers, Guo N. Huang
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 787–798.
https://doi.org/10.1042/CS20211116
Published: 27 May 2022
View article titled, Visualization of regenerating and repairing hearts
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Articles

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 197–222.
https://doi.org/10.1042/CS20201474
Published: 04 February 2022
View article titled, The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
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Articles

High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity

Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Oliveira Edilamar Menezes
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2377–2391.
https://doi.org/10.1042/CS20210739
Published: 19 October 2021
View article titled, High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity
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Includes: Supplementary data
Articles

Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression

Carolina Manganeli Polonio, Carla Longo de Freitas, Marília Garcia de Oliveira, Cristiano Rossato, Wesley Nogueira Brandão, Nágela Ghabdan Zanluqui, Lilian Gomes de Oliveira, Luiza Ayumi Nishiyama Mimura, Maysa Braga Barros Silva, Vera Lúcia Garcia Calich, Marcelo Gil Nisenbaum, Silvio Halpern, Lucila Evangelista, Mariangela Maluf, Paulo Perin, Carlos Eduardo Czeresnia, Jean Pierre Schatzmann Peron
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1065–1082.
https://doi.org/10.1042/CS20201544
Published: 07 May 2021
View article titled, Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression
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Articles

ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34 + cells derived from diabetic older adults

In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus
Shrinidh Joshi, Ildamaris Montes de Oca, Ahmad Maghrabi, Christine Lopez-Yang, Julio Quiroz-Olvera, Charles A. Garcia, Yagna Prasada Rao Jarajapu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (2): 367–385.
https://doi.org/10.1042/CS20201133
Published: 27 January 2021
View article titled, ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34 + cells derived from diabetic older adults
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Articles

Prematurity negatively affects regenerative properties of human amniotic epithelial cells in the context of lung repair

Dandan Zhu, Gina D. Kusuma, Renate Schwab, Siow Teng Chan, Jean Tan, Mohamed I. Saad, Kristen T. Leeman, Carla Kim, Euan M. Wallace, Rebecca Lim
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (20): 2665–2679.
https://doi.org/10.1042/CS20200859
Published: 20 October 2020
View article titled, Prematurity negatively affects regenerative properties of human amniotic epithelial cells in the context of lung repair
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Includes: Supplementary data
Articles

Cyclosporine A promotes the therapeutic effect of mesenchymal stem cells on transplantation reaction

Michaela Hajkova, Filip Jaburek, Bianka Porubska, Pavla Bohacova, Vladimir Holan, Magdalena Krulova
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2143–2157.
https://doi.org/10.1042/CS20190294
Published: 08 November 2019
View article titled, Cyclosporine A promotes the therapeutic effect of mesenchymal stem cells on transplantation reaction
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Includes: Supplementary data
Articles

Adipocyte dedifferentiation in health and diseases

Tongxing Song, Shihuan Kuang
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (20): 2107–2119.
https://doi.org/10.1042/CS20190128
Published: 25 October 2019
View article titled, Adipocyte dedifferentiation in health and diseases
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Articles

Synovium-derived stromal cell-induced osteoclastogenesis: a potential osteoarthritis trigger

Manuela Dicarlo, Gabriella Teti, Giorgia Cerqueni, Iolanda Iezzi, Antonio Gigante, Mirella Falconi, Monica Mattioli-Belmonte
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (16): 1813–1824.
https://doi.org/10.1042/CS20190169
Published: 21 August 2019
View article titled, Synovium-derived stromal cell-induced osteoclastogenesis: a potential osteoarthritis trigger
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Articles

Endothelial progenitor cell-derived exosomes facilitate vascular endothelial cell repair through shuttling miR-21-5p to modulate Thrombospondin-1 expression

Hui Hu, Boshi Wang, Chunyu Jiang, Ruiting Li, Jungong Zhao
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1629–1644.
https://doi.org/10.1042/CS20190188
Published: 25 July 2019
View article titled, Endothelial progenitor cell-derived exosomes facilitate vascular endothelial cell repair through shuttling miR-21-5p to modulate Thrombospondin-1 expression
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Includes: Supplementary data
Articles

Engineering blood vessels and vascularized tissues: technology trends and potential clinical applications

Prafulla Chandra, Anthony Atala
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1115–1135.
https://doi.org/10.1042/CS20180155
Published: 14 May 2019
View article titled, Engineering blood vessels and vascularized tissues: technology trends and potential clinical applications
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Articles

Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling

Yifang Xie, Anyun Ma, Boshi Wang, Rui Peng, Yingchun Jing, Deqian Wang, Richard H. Finnell, Bin Qiao, Yongming Wang, Hongyan Wang, Yufang Zheng
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (2): 225–238.
https://doi.org/10.1042/CS20180842
Published: 22 January 2019
View article titled, Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling
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Includes: Supplementary data
Articles

Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction

Vidya K. Nagalakshmi, Minghong Li, Soham Shah, Joseph C. Gigliotti, Alexander L. Klibanov, Frederick H. Epstein, Robert L. Chevalier, R. Ariel Gomez, Maria Luisa S. Sequeira-Lopez
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (23): 2519–2545.
https://doi.org/10.1042/CS20180623
Published: 05 December 2018
View article titled, Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction
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Includes: Supplementary data
Articles

Prevention of perinatal nicotine-induced bone marrow mesenchymal stem cell myofibroblast differentiation by augmenting the lipofibroblast phenotype

Reiko Sakurai, Jie Liu, Ying Wang, John S. Torday, Virender K. Rehan
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2357–2368.
https://doi.org/10.1042/CS20180749
Published: 13 November 2018
View article titled, Prevention of perinatal nicotine-induced bone marrow mesenchymal stem cell myofibroblast differentiation by augmenting the lipofibroblast phenotype
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Articles

The use of hydrogels for cell-based treatment of chronic kidney disease

Meg L. McFetridge, Mark P. Del Borgo, Marie-Isabel Aguilar, Sharon D. Ricardo
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1977–1994.
https://doi.org/10.1042/CS20180434
Published: 14 September 2018
View article titled, The use of hydrogels for cell-based treatment of chronic kidney disease
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Articles

The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro

Patricia E. Martin, Erin M. O’Shaughnessy, Catherine S. Wright, Annette Graham
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1629–1643.
https://doi.org/10.1042/CS20171483
Published: 14 August 2018
View article titled, The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro
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Articles

Neurovascular dysfunction in dementia – human cellular models and molecular mechanisms

Isobel Parkes, Satyan Chintawar, M. Zameel Cader
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (3): 399–418.
https://doi.org/10.1042/CS20160720
Published: 14 February 2018
View article titled, Neurovascular dysfunction in dementia – human cellular models and molecular mechanisms
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Articles

DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis

Na Zhao, Li Zeng, Yang Liu, Dong Han, Haochen Liu, Jian Xu, Yuxi Jiang, Cuiying Li, Tao Cai, Hailan Feng, Yixiang Wang
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (22): 2721–2735.
https://doi.org/10.1042/CS20171231
Published: 13 November 2017
View article titled, DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis
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Includes: Supplementary data
Articles

Embryonic stem cell derived germ cells induce spermatogenesis after transplantation into the testes of an adult mouse azoospermia model

Zohreh Makoolati, Mansoureh Movahedin, Mehdi Forouzandeh-Moghadam, Majid Naghdi, Morteza Koruji
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (18): 2381–2395.
https://doi.org/10.1042/CS20171074
Published: 08 September 2017
View article titled, Embryonic stem cell derived germ cells induce spermatogenesis after transplantation into the testes of an adult mouse azoospermia model
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Articles

Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional vascular smooth muscle cells

Sarah K. Steinbach, Terrence M. Yau, Maral Ouzounian, Husam Abdel-Qadir, Mark Chandy, Thomas K. Waddell, Mansoor Husain
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1801–1814.
https://doi.org/10.1042/CS20170239
Published: 05 July 2017
View article titled, Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional vascular smooth muscle cells
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Articles

Biophysical stimulation for in vitro engineering of functional cardiac tissues

Anastasia Korolj, Erika Yan Wang, Robert A. Civitarese, Milica Radisic
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1393–1404.
https://doi.org/10.1042/CS20170055
Published: 23 June 2017
View article titled, Biophysical stimulation for in vitro engineering of functional cardiac tissues
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Articles

Human DPSCs fabricate vascularized woven bone tissue: a new tool in bone tissue engineering

Francesca Paino, Marcella La Noce, Alessandra Giuliani, Alfredo De Rosa, Serena Mazzoni, Luigi Laino, Evzen Amler, Gianpaolo Papaccio, Vincenzo Desiderio, Virginia Tirino
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (8): 699–713.
https://doi.org/10.1042/CS20170047
Published: 06 April 2017
View article titled, Human DPSCs fabricate vascularized woven bone tissue: a new tool in bone tissue engineering
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Includes: Supplementary data
Articles

Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway

Yujia Yuan, Meimei Shi, Lan Li, Jingping Liu, Bo Chen, Younan Chen, Xingxing An, Shuyun Liu, Ruixi Luo, Dan Long, Wengeng Zhang, Philip Newsholme, Jingqiu Cheng, Yanrong Lu
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (23): 2181–2198.
https://doi.org/10.1042/CS20160235
Published: 26 October 2016
View article titled, Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway
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Includes: Supplementary data
Articles

Ultrasound-targeted microbubble destruction enhances delayed BMC delivery and attenuates post-infarction cardiac remodelling by inducing engraftment signals

Yanmei Chen, Chuanxi Zhang, Shuxin Shen, Shengcun Guo, Lintao Zhong, Xinzhong Li, Guojun Chen, Gangbin Chen, Xiang He, Chixiong Huang, Nvqin He, Wangjun Liao, Yulin Liao, Jianping Bin
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (23): 2105–2120.
https://doi.org/10.1042/CS20160085
Published: 20 October 2016
View article titled, Ultrasound-targeted microbubble destruction enhances delayed BMC delivery and attenuates post-infarction cardiac remodelling by inducing engraftment signals
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Includes: Supplementary data
Articles

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

Simon G. Royce, Anna M. Tominaga, Matthew Shen, Krupesh P. Patel, Brooke M. Huuskes, Rebecca Lim, Sharon D. Ricardo, Chrishan S. Samuel
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (23): 2151–2165.
https://doi.org/10.1042/CS20160328
Published: 20 October 2016
View article titled, Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease
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Articles

Endothelial progenitor cells and hypertension: current concepts and future implications

Shengyuan Luo, Wenhao Xia, Cong Chen, Eric A. Robinson, Jun Tao
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2029–2042.
https://doi.org/10.1042/CS20160587
Published: 11 October 2016
View article titled, Endothelial progenitor cells and hypertension: current concepts and future implications
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Articles

Myeloid-derived suppressor cells contribute to systemic lupus erythaematosus by regulating differentiation of Th17 cells and Tregs

Jianjian Ji, Jingjing Xu, Shuli Zhao, Fei Liu, Jingjing Qi, Yuxian Song, Jing Ren, Tingting Wang, Huan Dou, Yayi Hou
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (16): 1453–1467.
https://doi.org/10.1042/CS20160311
Published: 07 July 2016
View article titled, Myeloid-derived suppressor cells contribute to systemic lupus erythaematosus by regulating differentiation of Th17 cells and Tregs
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Includes: Supplementary data