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Articles

Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis

Yue Gao, Hang Zhang, Yinnong Jia, Yuanfang Chen, Luna Wang, Jie Ding, Wen Wang, Baoli Zhu, Liu Ouyang, Xu He, Yan An, Tingting Yu, Hengdong Zhang, Ming Xu

Clin Sci (Lond) (2025) 139 (07): 389–410.

https://doi.org/10.1042/CS20243438

Published: 10 April 2025

View articletitled, Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis

Articles

Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis

Jin-Ling Huo, Wenjia Fu, Qi Feng, Shaokang Pan, Dongwei Liu, Zhangsuo Liu

Clin Sci (Lond) (2025) 139 (03): 229–246.

https://doi.org/10.1042/CS20243221

Published: 06 February 2025

View articletitled, Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis

Includes: Supplementary data

Articles

Therapeutic strategies to ameliorate mitochondrial oxidative stress in ischaemia-reperfusion injury: A narrative review

Khalid Alotaibi, Nishkantha Arulkumaran, Alex Dyson, Mervyn Singer

Clin Sci (Lond) (2025) 139 (03): 259–280.

https://doi.org/10.1042/CS20242074

Published: 03 February 2025

View articletitled, Therapeutic strategies to ameliorate mitochondrial oxidative stress in ischaemia-reperfusion injury: A narrative review

Articles

Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics

Wang-Hsin Lee, Zachary A. Kipp, Sally N. Pauss, Genesee J. Martinez, Evelyn A. Bates, Olufunto O. Badmus, David E. Stec, Terry D. Hinds, Jr

Clin Sci (Lond) (2025) 139 (02): 171–198.

https://doi.org/10.1042/CS20242825

Published: 28 January 2025

View articletitled, Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics

Articles

RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147

Simeng Liu, Renfei Luo, Davey Li, Anna Tang, Yuli Qiu, Ryan P. Sherrier, Jeffrey Aube, Xiaoqing Wu, Liang Xu, Yufeng Huang

Clin Sci (Lond) (2025) 139 (1): 69–84.

https://doi.org/10.1042/CS20241756

Published: 15 January 2025

View articletitled, RNA-binding protein HuR regulates the transition of septic AKI to CKD by modulating CD147

Articles

Cardiac-derived CTRP9 mediates the protection of empagliflozin against diabetes-induced male subfertility in mice

Yang Mu, Ling-Bo Luo, Rong Huang, Zhuo-Yu Shen, Dan Huang, Shu-Hong Zhao, Jing Yang, Zhen-Guo Ma

Clin Sci (Lond) (2024) 138 (21): 1421–1440.

https://doi.org/10.1042/CS20241477

Published: 04 November 2024

View articletitled, Cardiac-derived CTRP9 mediates the protection of empagliflozin against diabetes-induced male subfertility in mice

Includes: Supplementary data

Articles

Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway

Roberto Palacios-Ramirez, Matthieu Soulié, Amaya Fernandez-Celis, Toshifumi Nakamura, Nabiha Boujardine, Benjamin Bonnard, Krister Bamberg, Natalia Lopez-Andres, Frederic Jaisser

Clin Sci (Lond) (2024) 138 (16): 1025–1038.

https://doi.org/10.1042/CS20240302

Published: 22 August 2024

View articletitled, Mineralocorticoid receptor (MR) antagonist eplerenone and MR modulator balcinrenone prevent renal extracellular matrix remodeling and inflammation via the MR/proteoglycan/TLR4 pathway

Includes: Supplementary data

Articles

Cardiotoxic effects of common and emerging drugs: role of cannabinoid receptors

Yiming Bo, Xin Zhao, Liliang Li

Clin Sci (Lond) (2024) 138 (6): 413–434.

https://doi.org/10.1042/CS20231156

Published: 20 March 2024

View articletitled, Cardiotoxic effects of common and emerging drugs: role of cannabinoid receptors

Articles

Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration

Aya Al-Saidi, Ibrahim F. Alzaim, Safaa H. Hammoud, Ghida Al Arab, Samaya Abdalla, Nahed Mougharbil, Ali H. Eid, Ahmed F. El-Yazbi

Clin Sci (Lond) (2024) 138 (5): 289–308.

https://doi.org/10.1042/CS20231186

Published: 05 March 2024

View articletitled, Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration

Articles

Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species

Zhongqiang Zhu, Jun Li, Zhiyong Song, Tonglu Li, Zongping Li, Xuezhong Gong

Clin Sci (Lond) (2024) 138 (5): 235–249.

https://doi.org/10.1042/CS20231184

Published: 27 February 2024

View articletitled, Tetramethylpyrazine attenuates renal tubular epithelial cell ferroptosis in contrast-induced nephropathy by inhibiting transferrin receptor and intracellular reactive oxygen species

Includes: Supplementary data

Articles

Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H 2 O 2 /PPAR-γ axis

Shaohua Li, Qiang Lyu, Qixin Shi, Yungang Bai, Xinling Ren, Jin Ma

Clin Sci (Lond) (2024) 138 (3): 103–115.

https://doi.org/10.1042/CS20231508

Published: 30 January 2024

View articletitled, Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H 2 O 2 /PPAR-γ axis

Articles

Colchicine protects against the development of experimental abdominal aortic aneurysm

Yi Zhao, Qi-Rui Shen, Yu-Xin Chen, Yu Shi, Wen-Bing Wu, Qiao Li, Dong-Jie Li, Fu-Ming Shen, Hui Fu

Clin Sci (Lond) (2023) 137 (19): 1533–1545.

https://doi.org/10.1042/CS20230499

Published: 03 October 2023

View articletitled, Colchicine protects against the development of experimental abdominal aortic aneurysm

Includes: Supplementary data

Articles

Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1–7)

In Collection

The biology of ageing: Geroscience and the exposome

Kishore Chittimalli, Jesmin Jahan, Anil Sakamuri, Zachary L. McAdams, Aaron C. Ericsson, Yagna P.R. Jarajapu

Clin Sci (Lond) (2023) 137 (11): 913–930.

https://doi.org/10.1042/CS20220904

Published: 14 June 2023

View articletitled, Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1–7)

Includes: Supplementary data

Articles

Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

Weixian Kong, Yue Peng, Caoyu Ji, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Fuqun Wang, Zhe Li, Xiaohong Bian, Junmei Ye

Clin Sci (Lond) (2023) 137 (10): 823–841.

https://doi.org/10.1042/CS20230433

Published: 31 May 2023

View articletitled, Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

Includes: Supplementary data

Articles

Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu

Clin Sci (Lond) (2023) 137 (10): 785–805.

https://doi.org/10.1042/CS20220625

Published: 23 May 2023

View articletitled, Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Includes: Supplementary data

Articles

Antiviral activities of hemp cannabinoids

Richard B. van Breemen, Daniel Simchuk

Clin Sci (Lond) (2023) 137 (8): 633–643.

https://doi.org/10.1042/CS20220193

Published: 21 April 2023

View articletitled, Antiviral activities of hemp cannabinoids

Articles

Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

In Collection

New discoveries in bile acids, gut microbiota and host interactions in health and diseases

Guochao Song, Fengyi Weng, Bin Zou, Jing Zhao, Jingyi Jin, Dongming Yan, Kai Huang, Xin Sun, Chenghai Liu, Yiyang Hu, Yue Li, Furong Qiu

Clin Sci (Lond) (2023) 137 (7): 561–577.

https://doi.org/10.1042/CS20220674

Published: 13 April 2023

View articletitled, Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

Includes: Supplementary data

Articles

Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

In Collection

Reproductive Physiology and Disease

Hana Horackova, Veronika Vachalova, Cilia Abad, Rona Karahoda, Frantisek Staud

Clin Sci (Lond) (2023) 137 (2): 149–161.

https://doi.org/10.1042/CS20220726

Published: 18 January 2023

View articletitled, Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

Articles

Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3

Jianbo Liu, Kaixuan Liu, Shiquan Chai, Runze Xu, Ying Wang, Yundi Zhang, Shuanglian Wang, Chuanyong Liu, Bing Xue

Clin Sci (Lond) (2023) 137 (1): 109–127.

https://doi.org/10.1042/CS20220392

Published: 05 January 2023

View articletitled, Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3

Includes: Supplementary data

Articles

Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Kazuhiro Aonuma, DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Yuta Okabe, Zixun Yuan, Siqi Li, Yoshiko Murakata, Kenichi Tominaga, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda, Hiroko Isoda

Clin Sci (Lond) (2022) 136 (24): 1831–1849.

https://doi.org/10.1042/CS20220319

Published: 21 December 2022

View articletitled, Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Articles

Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi

Clin Sci (Lond) (2022) 136 (22): 1631–1651.

https://doi.org/10.1042/CS20220404

Published: 16 November 2022

View articletitled, Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Articles

CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Yazmin M. Restrepo, Natalia M. Noto, Robert C. Speth

Clin Sci (Lond) (2022) 136 (21): 1513–1533.

https://doi.org/10.1042/CS20220261

Published: 03 November 2022

View articletitled, CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Includes: Supplementary data

Articles

Protecting glomerulus: role of angiotensin-II type 2 receptor

Sanket Patel, Kalyani Kulkarni, Tahir Hussain

Clin Sci (Lond) (2022) 136 (20): 1467–1470.

https://doi.org/10.1042/CS20220396

Published: 26 October 2022

View articletitled, Protecting glomerulus: role of angiotensin-II type 2 receptor

Articles

L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway

Xiao Ma, Dechao Cai, Yakun Zhu, Yao Zhao, Xianbo Shang, Chen Wang, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng

Clin Sci (Lond) (2022) 136 (13): 1053–1069.

https://doi.org/10.1042/CS20220082

Published: 06 July 2022

View articletitled, L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway

Articles

Angiotensin Receptors - Affinity and Beyond

Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings

Clin Sci (Lond) (2022) 136 (10): 799–802.

https://doi.org/10.1042/CS20220024

Published: 27 May 2022

View articletitled, Angiotensin Receptors - Affinity and Beyond

Articles

Mechanisms underlying immune-related adverse events during checkpoint immunotherapy

Xiao Zhou, Xiang Chen, Leng Han, Hong Liu

Clin Sci (Lond) (2022) 136 (10): 771–785.

https://doi.org/10.1042/CS20210042

Published: 27 May 2022

View articletitled, Mechanisms underlying immune-related adverse events during checkpoint immunotherapy

Articles

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

In Collection

Cardiovascular-Oncology

Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen

Clin Sci (Lond) (2022) 136 (9): 675–694.

https://doi.org/10.1042/CS20220182

Published: 10 May 2022

View articletitled, Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

Includes: Supplementary data

Articles

Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Kurt Brassington, Stanley M.H. Chan, Simone N. De Luca, Aleksandar Dobric, Suleman A. Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos

Clin Sci (Lond) (2022) 136 (8): 537–555.

https://doi.org/10.1042/CS20211090

Published: 21 April 2022

View articletitled, Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Articles

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Ning Hu, Xiaoyi Zhang, Xuanzhe Zhang, Yongjun Guan, Ruyuan He, Enfu Xue, Xiaoyi Zhang, Wenhong Deng, Jia Yu, Weixing Wang, Qiao Shi

Clin Sci (Lond) (2022) 136 (7): 455–471.

https://doi.org/10.1042/CS20211031

Published: 06 April 2022

View articletitled, Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Includes: Supplementary data

Articles

Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos

Clin Sci (Lond) (2022) 136 (6): 405–423.

https://doi.org/10.1042/CS20210835

Published: 23 March 2022

View articletitled, Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Articles

The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype

Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V. Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos

Clin Sci (Lond) (2022) 136 (5): 329–343.

https://doi.org/10.1042/CS20211151

Published: 02 March 2022

View articletitled, The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype

Includes: Supplementary data

Articles

Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

In Collection

Cardiovascular-Oncology

Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba

Clin Sci (Lond) (2022) 136 (1): 139–161.

https://doi.org/10.1042/CS20210836

Published: 07 January 2022

View articletitled, Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

Includes: Supplementary data

Articles

Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice

Clin Sci (Lond) (2022) 136 (1): 81–101.

https://doi.org/10.1042/CS20210792

Published: 07 January 2022

View articletitled, Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice

Articles

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Dominic J. Corkill, Alan N. Hunt, Mary Jane Hinrichs, Nicholas White, Marlon Rebelatto, Lorin Roskos, Josquin Nys, Alison Scott, Matthew J. Robinson, Patricia Ryan, Anthony D. Postle, Matthew A. Sleeman

Clin Sci (Lond) (2021) 135 (22): 2559–2573.

https://doi.org/10.1042/CS20210713

Published: 26 November 2021

View articletitled, Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Includes: Supplementary data

Articles

Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi

Clin Sci (Lond) (2021) 135 (21): 2503–2520.

https://doi.org/10.1042/CS20210719

Published: 09 November 2021

View articletitled, Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Articles

Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Liyun Feng, Dongdong Que, Zehua Li, Xinglong Zhong, Jing Yan, Jintao Wei, Xiuli Zhang, Pingzhen Yang, Caiwen Ou, Minsheng Chen

Clin Sci (Lond) (2021) 135 (21): 2483–2502.

https://doi.org/10.1042/CS20210259

Published: 08 November 2021

View articletitled, Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Includes: Supplementary data

Articles

Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda

Clin Sci (Lond) (2021) 135 (20): 2409–2422.

https://doi.org/10.1042/CS20210405

Published: 22 October 2021

View articletitled, Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

Articles

Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy

Clin Sci (Lond) (2021) 135 (20): 2341–2356.

https://doi.org/10.1042/CS20210462

Published: 18 October 2021

View articletitled, Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Articles

Oxytocin: much more than childbirth and milk letdown

Morley D. Hollenberg

Clin Sci (Lond) (2021) 135 (17): 2121–2126.

https://doi.org/10.1042/CS20210180

Published: 10 September 2021

View articletitled, Oxytocin: much more than childbirth and milk letdown

Articles

Eicosanoid receptors as therapeutic targets for asthma

William S. Powell

Clin Sci (Lond) (2021) 135 (16): 1945–1980.

https://doi.org/10.1042/CS20190657

Published: 17 August 2021

View articletitled, Eicosanoid receptors as therapeutic targets for asthma

Articles

Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

In Collection

Cardiovascular-Oncology

Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba

Clin Sci (Lond) (2021) 135 (15): 1897–1914.

https://doi.org/10.1042/CS20210311

Published: 10 August 2021

View articletitled, Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

Includes: Supplementary data

Articles

Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

Ahmed A. Elmarakby, Jennifer C. Sullivan

Clin Sci (Lond) (2021) 135 (15): 1791–1804.

https://doi.org/10.1042/CS20201017

Published: 02 August 2021

View articletitled, Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

Articles

The traditional herbal formulation, Jianpiyifei II , reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice

Xuhua Yu, Tiantian Cai, Long Fan, Ziyao Liang, Qiuling Du, Qi Wang, Zifeng Yang, Ross Vlahos, Lei Wu, Lin Lin

Clin Sci (Lond) (2021) 135 (14): 1733–1750.

https://doi.org/10.1042/CS20210050

Published: 27 July 2021

View articletitled, The traditional herbal formulation, Jianpiyifei II , reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice

Includes: Supplementary data

Articles

A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang, Cheng Yang, Li Yu

Clin Sci (Lond) (2021) 135 (14): 1751–1765.

https://doi.org/10.1042/CS20210571

Published: 27 July 2021

View articletitled, A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Includes: Supplementary data

Articles

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang

Clin Sci (Lond) (2021) 135 (14): 1707–1726.

https://doi.org/10.1042/CS20210100

Published: 22 July 2021

View articletitled, Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Includes: Supplementary data

Articles

Fifty years of research on the brain renin–angiotensin system: what have we learned?

Edwyn O. Cruz-López, Estrellita Uijl, A.H. Jan Danser

Clin Sci (Lond) (2021) 135 (14): 1727–1731.

https://doi.org/10.1042/CS20210579

Published: 22 July 2021

View articletitled, Fifty years of research on the brain renin–angiotensin system: what have we learned?

Articles

Unravelling the tangled web of hypertension and cancer

In Collection

Cardiovascular-Oncology

Aristeidis Sionakidis, Linsay McCallum, Sandosh Padmanabhan

Clin Sci (Lond) (2021) 135 (13): 1609–1625.

https://doi.org/10.1042/CS20200307

Published: 09 July 2021

View articletitled, Unravelling the tangled web of hypertension and cancer

Articles

Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation

In Collection

Cardiovascular-Oncology

Chenliang Ge, Yang Cheng, Yihao Fan, Yan He

Clin Sci (Lond) (2021) 135 (11): 1409–1426.

https://doi.org/10.1042/CS20210189

Published: 04 June 2021

View articletitled, Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation

Includes: Supplementary data

Articles

Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu, Lin Sun

Clin Sci (Lond) (2021) 135 (10): 1273–1288.

https://doi.org/10.1042/CS20210061

Published: 26 May 2021

View articletitled, Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Articles

Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver

Ying-Yin Sun, Dong-Qing Wu, Na-Na Yin, Lei Yang, Xin Chen, Hai-Di Li, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Hua Wang, Jun Li

Clin Sci (Lond) (2021) 135 (10): 1213–1232.

https://doi.org/10.1042/CS20201363

Published: 20 May 2021

View articletitled, Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver

Includes: Supplementary data

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