... of prostaglandin synthesis indomethacin (2 mg day −1 kg −1 ) was given orally for 7 days. This dose decreased urinary excretion of prostaglandin E-like immunoreactivity by 70%. 3. The number of α-adrenoreceptors was measured by the specific binding of [ 3 H]dihydroergocryptine to platelet membranes and that of β...

...]Dihydroalprenolol was used to characterize β–adrenoreceptor sites and [ 3 H]prazosin to identify α–adrenoreceptor sites. Binding of both ligands showed saturability, high affinity, rapid kinetics, reversibility and stereospecificity. The rank order of agonists and antagonists inhibiting specific binding correlated...

...W. Kiowski; P. Van Brummelen; F. R. Bühler 1. The relationships between plasma noradrenaline concentration at rest and blood pressure, as well as increase in forearm blood flow in response to a brachial artery infusion of the α-adrenoreceptor-blocking agent phentolamine, were investigated...