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Keywords: α2A-adrenoceptor
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α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome

Zhukai Cong, Dan Li, Xiangpeng Lv, Cui Yang, Qiang Zhang, Changyi Wu, Zongyu Wang, Xi Zhu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1957–1971.
https://doi.org/10.1042/CS20200586
Published: 23 July 2020
... research attention. Blockade of α-2 or α2A-adrenoceptor (α 2A -AR) has been shown to attenuate lung injury induced by lipopolysaccharide (LPS) in rats. However, the mechanism is unclear. We confirmed the role of α 2A -AR in ARDS using knockout mice and alveolar macrophages following LPS stimulation...
View article titled, <span class="search-highlight">α2A</span>-<span class="search-highlight">adrenoceptor</span> deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome
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