... with a solution hybridization assay. 2. Lipolytic sensitivity (ED 50 ) to isoprenaline, a nonselective β-adrenoceptor agonist, increased 50-fold after treatment ( P = 0.04). Sensitivity to terbutaline, a selective β 2 -adrenoceptor agonist, increased 25-fold ( P =0.01), whereas the ED 50 values for dobutamine...

... ) in 10 patients undergoing diagnostic cardiac catheterization, in whom β-adrenoceptor antagonists had been discontinued for 7 days. 2. Coronary haemodynamics were measured in these 10 patients plus two others. Compared with saline placebo, metoprolol administration was associated with decreases in heart...

... ) and matching saline placebo were determined at rest and during supine bicycle exercise in 16 patients undergoing cardiac catheterization, in whom β-adrenoceptor antagonists had been discontinued for 72 h. 2. At rest and compared with placebo, infusion of adrenaline was associated with a small increase...

...Rajiev K. Sharma; Peter K. Jeffery 1. Maximal binding capacity ( B max. ) and the dissociation constant ( K D ) for the β-adrenoceptor antagonist 125 I-cyanopindol were estimated in membrane preparations of hilar, lobar/main bronchi (level 1) and peripheral lung (level 11) of grossly normal lungs...

.... potassium flux rates in normal human leucocytes in 436-444. Rindfleisch, G.E. & Hannig, K. (1982) Different 1330-1 33 1. 26 11 1984 18 12 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 adenosine triphosphatase β-adrenoceptors catecholamines hypokalaemia...

...S. Titinchi; M. Al Shamma; K. R. Patel; J. W. Kerr; B. Clark 1. To determine whether circadian variation in adrenoceptor function might underlie the ‘morning dip’ in peak expiratory flow (PEF) rate and its abolition by salbutamol we measured indices of β-adrenoceptor function (B max. and K d...

... to inhaled adrenaline was greater at night. 6. We conclude that there is no significant circadian change in adrenergic responses in asthma and that adrenoreceptor dysfunction is not important in the pathogenesis of nocturnal asthma. β-adrenoceptors bronchodilator nocturnal asthma 15 6 1981...

...C. A. Kraft; C. M. Castleden 1. Responsiveness of the β-adrenoceptor adenylate cyclase system was measured in lymphocytes from healthy young and old subjects by incubating the cells with isoprenaline in the presence of a phosphodiesterase inhibitor and by measuring production of adenosine 3′:5...

... in cardiac, peripheral vascular and renal β-adrenoceptor-mediated responses. 13 6 1980 21 11 1980 8 1 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 β-adrenoceptors isoprenaline plasma catecholamines plethysmography renin Clinical Science (1981...