... with a solution hybridization assay. 2. Lipolytic sensitivity (ED 50 ) to isoprenaline, a nonselective β-adrenoceptor agonist, increased 50-fold after treatment ( P = 0.04). Sensitivity to terbutaline, a selective β 2 -adrenoceptor agonist, increased 25-fold ( P =0.01), whereas the ED 50 values for dobutamine...

... ) in 10 patients undergoing diagnostic cardiac catheterization, in whom β-adrenoceptor antagonists had been discontinued for 7 days. 2. Coronary haemodynamics were measured in these 10 patients plus two others. Compared with saline placebo, metoprolol administration was associated with decreases in heart...

... ) and matching saline placebo were determined at rest and during supine bicycle exercise in 16 patients undergoing cardiac catheterization, in whom β-adrenoceptor antagonists had been discontinued for 72 h. 2. At rest and compared with placebo, infusion of adrenaline was associated with a small increase...

...Rajiev K. Sharma; Peter K. Jeffery 1. Maximal binding capacity ( B max. ) and the dissociation constant ( K D ) for the β-adrenoceptor antagonist 125 I-cyanopindol were estimated in membrane preparations of hilar, lobar/main bronchi (level 1) and peripheral lung (level 11) of grossly normal lungs...

... of adrenaline on coupled active transport of ions is mediated by β 2 -adrenoceptors. 26 11 1984 18 12 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 adenosine triphosphatase β-adrenoceptors catecholamines hypokalaemia ion channels leucocytes potassium...

...S. Titinchi; M. Al Shamma; K. R. Patel; J. W. Kerr; B. Clark 1. To determine whether circadian variation in adrenoceptor function might underlie the ‘morning dip’ in peak expiratory flow (PEF) rate and its abolition by salbutamol we measured indices of β-adrenoceptor function (B max. and K d...

... β-adrenoceptors bronchodilator nocturnal asthma 15 6 1981 19 10 1981 Clinical Science (1982) 62,349-354 349 Circadian variation in adrenergic responses in asthmatic subjects P. J . BARNES, G. A. F ITZGERALD* A N D C. T. DOLLERY Departments of Medicine and Clinical Pharmacology...

...C. A. Kraft; C. M. Castleden 1. Responsiveness of the β-adrenoceptor adenylate cyclase system was measured in lymphocytes from healthy young and old subjects by incubating the cells with isoprenaline in the presence of a phosphodiesterase inhibitor and by measuring production of adenosine 3′:5...

... in cardiac, peripheral vascular and renal β-adrenoceptor-mediated responses. 13 6 1980 21 11 1980 8 1 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 β-adrenoceptors isoprenaline plasma catecholamines plethysmography renin Clinical Science (1981...